Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats

Endocrinology

Volumn 148, Issue 6, 2007, Pages 2863-2869

  Zhou, Huarong ^a   Zhang, Tao ^a   Oseid, Elizabeth ^a   Harmon, Jamie ^a   Tonooka, Naoko ^a   Robertson, R Paul ^a,b  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BIOBREEDING RAT; CELL FUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; DETERIORATION; GLUCOSE TOLERANCE; GROWTH, DEVELOPMENT AND AGING; HORMONE RESPONSE; HYPOGLYCEMIA; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; REGULATORY MECHANISM; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 1; GLUCAGON; HYPOGLYCEMIA; INSULIN; MALE; RATS; RATS, INBRED BB; RATS, WISTAR;

EID: 34250895793     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1375     Document Type: Article

References (17)

1. Cryer PE 2002 Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937-948
2. Gerich J, Davis J, Lorenzi M, Rizza R, Bohannon N, Karam J, Lewis S, Kaplan R, Schultz T, Cryer P 1979 Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol 236:E380-E385
3. Cryer PE 1984 Glucose counterregulation: prevention and correction of hypoglycemia in humans. Am J Physiol 264:E149-E155
4. Cryer PE 1981 Glucose counterregulation in man. Diabetes 30:261-264
5. De Feo P, Perriello G, Torlone E, Fanelli C, Ventura MM, Santeusanio F, Brunetti P, Bolli G 1991 Evidence against important catecholamine compensation for absent glucagon counterregulation. Am J Physiol 260:E203-E212
6. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS 1987 Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med 316:1376-1383
7. Samols E, Tyler J, Marks V 1972 Glucagon-insulin interrelationships. In: LeFebvre PJ, Unger RH, eds. Glucagon, molecular physiology, clinical and therapeutic implications. Elmsford, NY: Pergamon Press; 151-174
8. Maruyama H, Hisatomi A, Orci L, Grodsky GM, Unger RH 1984 Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest 74:2296-2299
9. Banarer S, McGregor VP, Cryer PE 2002 Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 51:958-965
10. Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH 1973 Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic α cell defect. Science 182:171-173
11. Zhou H, Tran PO, Yang S, Zhang T, LeRoy E, Oseid E, Robertson RP 2004 Regulation of α-cell function by the β-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. Diabetes 53:1482-1487
12. Hope KM, Tran PO, Zhou H, Oseid E, Leroy E, Robertson RP 2004 Regulation of α-cell function by the β-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis. Diabetes 53:1488-1495
13. Ahren B 2006 Glucagon secretion in relation to insulin sensitivity in health subjects. Diabetologia 49:117-122
14. Barzilai N, Rossetti L 1995 Relationship between changes in body composition and insulin responsiveness in models of the aging rat. Am J Physiol 269:E591-E597
15. Nishimura H, Kuzuya H, Okamoto M, Yoshimasa Y, Yamada K, Ida T, Kakehi T Imura H 1988 Change of insulin action with aging in conscious rats determined by euglycemic clamp. Am J Physiol 254:E92-E98
16. Jacob RJ, Dziura J, Morgen JP, Shulman GI, Sherwin RS 1996 Time course of the defective α-cell response to hypoglycemia in diabetic BB rats. Metabolism 45:14221426
17. Israelian Z, Gosmanov NR, Szoke E, Schorr M, Bokhari S, Cryer PE, Gerich JE, Meyer C 2005 Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes. Diabetes Care 28:2691-2696