Palmitate stimulation of glucagon secretion in mouse pancreatic α-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium

Diabetes

Volumn 53, Issue 11, 2004, Pages 2836-2843

  Olofsson, Charlotta S ^a,c   Salehi, Albert ^a   Göpel, Sven O ^a   Holm, Cecilia ^a   Rorsman, Patrik ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c BMC B11 ^*  (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; DIAZOXIDE; FORSKOLIN; GLUCAGON; GLUCOSE; ISRADIPINE; PALMITIC ACID; PALMITOYL COENZYME A; POTASSIUM ION; SOMATOSTATIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; EXOCYTOSIS; FATTY ACID METABOLISM; FEMALE; GLUCAGON RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET DELTA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL;

ANIMALS; DIAZOXIDE; FORSKOLIN; GLUCAGON; ISLETS OF LANGERHANS; ISRADIPINE; KINETICS; MEMBRANE POTENTIALS; MICE; MICE, INBRED STRAINS; PALMITIC ACID; POTASSIUM; TRIAZENES;

EID: 7044249536     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.11.2836     Document Type: Article

References (49)

1. Boden G, Shulman GI: Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32 (Suppl. 3):14-23, 2002
2. Cryer PE, Gerich JE: Relevance of glucose counterregulatory systems to patients with diabetes: critical roles of glucagon and epinephrine. Diabetes Care 6:95-99, 1983
3. Gross R, Mialhe P: Free fatty acid-glucagon feed-back mechanism. Diabetologia 10:277-283, 1974
4. Gross R, Mialhe P: Free fatty acids and pancreatic function in the duck. Acta Endocrinol (Copenh) 112:100-104, 1986
5. McGarry JD, Dobbins RL: Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42:128-138, 1999
6. Koyama K, Chen G, Wang MY, Lee Y, Shimabukuro M, Newgard CB, Unger RH: Beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46:1276-1280, 1997
7. Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, Daniels MB, Chen S, McGarry JD: Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97:2728-2735, 1996
8. Gopel SO, Kanno T, Barg S, Rorsman P: Patch-clamp characterisation of somatostatin-secreting δ-cells in intact mouse pancreatic islets. J Physiol 528:497-507, 2000
9. + channels. J Physiol 528:509-520, 2000
10. 2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. J Physiol 5557:935-948, 2004
11. Gopel S, Kanno T, Barg S, Galvanovskis J, Rorsman P: Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. J Physiol 521:717-728, 1999
12. Olofsson CS, Gopel SO, Barg S, Galvanovskis J, Ma X, Salehi A, Rorsman P, Eliasson L: Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch 444:43-51, 2002
13. (2+) channels in insulin-secreting mouse pancreatic B cells. Biophys J 81:3308-3323, 2001
14. 2+ oscillations in glucagon-producing alpha 2-cells by insulin/glucose and amino acids. Biochim Biophys Acta 1310:212-216, 1996
15. Panagiotidis G, Salehi AA, Westermark P, Lundquist I: Homologous islet amyloid polypeptide: effects on plasma levels of glucagon, insulin and glucose in the mouse. Diabetes Res Clin Pract 18:167-171, 1992
16. Etzrodt H, Rosenthal J, Schroder KE, Pfeiffer EF: Radioimmunoassay of somatostatin in human plasma. Clin Chim Acta 133:241-251, 1983
17. Eliasson L, Ma X, Renstrom E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P: SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol 121:181-197, 2003
18. Pipeleers DG, Schuit FC, Van Schravendijk CF, Van de Winkel M: Interplay of nutrients and hormones in the regulation of glucagon release. Endocrinology 117:817-823, 1985
19. Gromada J, Hoy M, Buschard K, Salehi A, Rorsman P: Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. J Physiol 535:519-532, 2001
20. Tomoda H, Igarashi K, Omura S: Inhibition of acyl-CoA synthetase by triacsins. Biochim Biophys Acta 921:595-598, 1987
21. Hartman EJ, Omura S, Laposata M: Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase. Prostaglandins 37:655-671, 1989
22. Gopel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P: Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol 556:711-726, 2004
23. 2+ microdomains: new tools for understanding their roles in neurotransmitter release. Neuron 20:389-399, 1998
24. O'Connor MD, Landahl H, Grodsky GM: Comparison of storage- and signal-limited models of pancreatic insulin secretion. Am J Physiol 238:R378-R389, 1980
25. Nesher R, Praiss M, Cerasi E: Immediate and time-dependent effects of glucose on insulin release: differential calcium requirements. Acta Endocrinol (Copenh) 117:409-416, 1988
26. Gillis KD, Mossner R, Neher E: Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron 16:1209-1220, 1996
27. Barg S, Galvanovskis J, Gopel SO, Rorsman P, Eliasson L: Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting a-cells. Diabetes 49:1500-1510, 2000
28. Wollheim CB, Blondel B, Renold AE, Sharp GW: Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium. Diabetologia 12:269-277, 1976
29. 2+ channels. J Gen Physiol 110:217-228, 1997
30. Standen N, Davies N, Langton P: Separation and analysis of macroscopic currents. In Microelectrode Techniques, The Plymouth Workshop Handbook. 1st ed. Standen NB, Gray PTA, Wbitaker MJ, Eds. Cambridge, U.K., Company of Biologists, 1987, p. 29-40
31. Iversen J: Inhibition of pancreatic glucagon release by somatostatin: in vitro. Scand J Clin Lab Invest 33:125-129, 1974
32. Gerich JE, Lorenzi M, Schneider V, Kwan CW, Karam JH, Guillemin R, Forsham PH: Inhibition of pancreatic glucagon responses to arginine by somatostatin in normal man and in insulin-dependent diabetics. Diabetes 23:876-880, 1974
33. Yaney GC, Corkey BE: Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia 46:1297-1312, 2003
34. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278:11303-11311, 2003
35. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M: Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 23:23, 2003
36. Kotarsky K, Nilsson NE, Flodgren E, Owman C, Olde B: A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun 301:406-410, 2003
37. + channels in rat pancreatic A-cells. Pflugers Arch 438:428-436, 1999
38. Branstrom R, Leibiger IB, Leibiger B, Corkey BE, Berggren PO, Larsson O: Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel. J Biol Chem 273:31395-31400, 1998
39. Gribble FM, Proks P, Corkey BE, Ashcroft FM: Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J Biol Chem 273:26383-26387, 1998
40. Baukrowitz T, Fakler B: KATP channels gated by intracellular nucleotides and phospholipids. Eur J Biochem 267:5842-5848, 2000
41. Schmider W, Fahr A, Blum HE, Kurz G: Transport of heptafluorostearate across model membranes: membrane transport of long-chain fatty acid anions I. J Lipid Res 41:775-787, 2000
42. Donovan JM, Jackson AA: Transbilayer movement of fully ionized taurine-conjugated bile salts depends upon bile salt concentration, hydrophobicity, and membrane cholesterol content. Biochemistry 36:11444-11451, 1997
43. 2+-dependent action potentials. J Gen Physiol 91:223-242, 1988
44. Cejvan K, Coy DH, Efendic S: Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. Diabetes 52:1176-1181, 2003
45. Taborsky GJ Jr: Evidence of a paracrine role for pancreatic somatostatin in vivo. Am J Physiol 245:E598-E603, 1983
46. Kim JH, Lewin TM, Coleman RA: Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5: selective inhibition by triacsin C and thiazolidinediones. J Biol Chem. 276:24667-24673, 2001
47. Bishop AE, Polak JM: The anatomy, organisation and ultrastructure of the islets of Langerhans. In Textbook of Diabetes. Vol. 1. Pickup J, Williams G, Eds. Oxford, U.K., Blackwell Science, 1997, p. 6.1-6.16
48. Grill V, Gutniak M, Roovete A, Efendic S: A stimulating effect of glucose on somatostatin release is impaired in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 59:293-297, 1984
49. Lefebvre PJ, Luyckx AS: Glucagon and diabetes: a reappraisal. Diabetologia 16:347-354, 1979