-
1
-
-
0003151360
-
Pathophysiology of type II diabetes mellitus
-
Porte D Jr, Sherwin RS, Eds. Stamford, CT, Appleton & Lange
-
Kahn SE, Porte D Jr: Pathophysiology of type II diabetes mellitus. In Diabetes Mellitus. 5th ed. Porte D Jr, Sherwin RS, Eds. Stamford, CT, Appleton & Lange, 1985, p. 487-512
-
(1985)
Diabetes Mellitus. 5th Ed.
, pp. 487-512
-
-
Kahn, S.E.1
Porte Jr., D.2
-
2
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794, 1999
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
3
-
-
0034524938
-
Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
-
Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA: Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 85:4053-4059, 2000
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 4053-4059
-
-
Shah, P.1
Vella, A.2
Basu, A.3
Basu, R.4
Schwenk, W.F.5
Rizza, R.A.6
-
4
-
-
0034880655
-
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
-
Toft-Nielsen MB, Damholt MB, Madsbad S, Hilsted LM, Hughes TE, Michelsen BK, Holst JJ: Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 86:3717-3723, 2001
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3717-3723
-
-
Toft-Nielsen, M.B.1
Damholt, M.B.2
Madsbad, S.3
Hilsted, L.M.4
Hughes, T.E.5
Michelsen, B.K.6
Holst, J.J.7
-
5
-
-
0028817815
-
U.K. Prospective Diabetes Study 16: Overview of 6 years' therapy of type II diabetes: A progressive disease
-
UK Prospective Diabetes Study Group: U.K. Prospective Diabetes Study 16: overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44:1249-1258, 1995
-
(1995)
Diabetes
, vol.44
, pp. 1249-1258
-
-
-
6
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837-853, 1998
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
7
-
-
0033578476
-
Pharmacologic therapy for type 2 diabetes mellitus
-
DeFronzo RA: Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 131:281-303, 1999
-
(1999)
Ann Intern Med
, vol.131
, pp. 281-303
-
-
DeFronzo, R.A.1
-
8
-
-
0032972676
-
Racial and ethnic differences in glycemic control of adults with type 2 diabetes
-
Harris MI, Eastman RC, Cowie CC, Flegal KM, Eberhardt MS: Racial and ethnic differences in glycemic control of adults with type 2 diabetes. Diabetes Care 22:403-408, 1999
-
(1999)
Diabetes Care
, vol.22
, pp. 403-408
-
-
Harris, M.I.1
Eastman, R.C.2
Cowie, C.C.3
Flegal, K.M.4
Eberhardt, M.S.5
-
9
-
-
0031936954
-
Glucagon-like peptides
-
Drucker DJ: Glucagon-like peptides. Diabetes 47:159-169, 1998
-
(1998)
Diabetes
, vol.47
, pp. 159-169
-
-
Drucker, D.J.1
-
10
-
-
0347360186
-
Pharmacology of exenatide (synthetic exendin-4): A potential therapeutic for improved glycemic control of type 2 diabetes
-
Nielsen LL, Young AA, Parkes DG: Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul Pept 117:77-88, 2004
-
(2004)
Regul Pept
, vol.117
, pp. 77-88
-
-
Nielsen, L.L.1
Young, A.A.2
Parkes, D.G.3
-
11
-
-
0347081275
-
Glucagon-like peptide-1, exendin and insulin sensitivity
-
Hansen B, Shafrir E, Eds. New York, Harwood Academic Press
-
Young AA: Glucagon-like peptide-1, exendin and insulin sensitivity. In Insulin Resistance and Insulin Resistance Syndrome. Hansen B, Shafrir E, Eds. New York, Harwood Academic Press, 2002, p. 235-262
-
(2002)
Insulin Resistance and Insulin Resistance Syndrome
, pp. 235-262
-
-
Young, A.A.1
-
12
-
-
0027184119
-
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells
-
Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Goke B: Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells. J Biol Chem 268:19650-19655, 1993
-
(1993)
J Biol Chem
, vol.268
, pp. 19650-19655
-
-
Göke, R.1
Fehmann, H.C.2
Linn, T.3
Schmidt, H.4
Krause, M.5
Eng, J.6
Goke, B.7
-
13
-
-
0038519125
-
Pharmacology of exenatide (synthetic exendin-4) for the treatment of type 2 diabetes
-
Nielsen LL, Baron AD: Pharmacology of exenatide (synthetic exendin-4) for the treatment of type 2 diabetes. Curr Opin Investig Drugs 4:401-405, 2003
-
(2003)
Curr Opin Investig Drugs
, vol.4
, pp. 401-405
-
-
Nielsen, L.L.1
Baron, A.D.2
-
14
-
-
0037850667
-
Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
-
Fineman MS, Bicsak TA, Shen LZ, Taylor K, Gaines E, Varns A, Kim D, Baron AD: Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 26:2370-2377, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 2370-2377
-
-
Fineman, M.S.1
Bicsak, T.A.2
Shen, L.Z.3
Taylor, K.4
Gaines, E.5
Varns, A.6
Kim, D.7
Baron, A.D.8
-
15
-
-
0038497464
-
Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
-
Kolterman OG, Buse JB, Fineman MS, Gaines E, Heintz S, Bicsak TA, Taylor K, Kim D, Aisporna M, Wang Y, Baron AD: Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 88:3082-3089, 2003
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3082-3089
-
-
Kolterman, O.G.1
Buse, J.B.2
Fineman, M.S.3
Gaines, E.4
Heintz, S.5
Bicsak, T.A.6
Taylor, K.7
Kim, D.8
Aisporna, M.9
Wang, Y.10
Baron, A.D.11
-
16
-
-
34548144946
-
Effects of exenatide (synthetic exendin-4) on glucose control and safety in patients with type 2 diabetes treated with metformin, a sulfonylurea, or both: An ongoing, open-label phase 3 trial
-
Taylor K, Poon T, Nielsen L, Cole L, Han J, Varns A, Kin D, Baron, A, Fineman M, Kolterman O: Effects of exenatide (synthetic exendin-4) on glucose control and safety in patients with type 2 diabetes treated with metformin, a sulfonylurea, or both: an ongoing, open-label phase 3 trial (Abstract). Diabetes Metab 29:4S265, 2003
-
(2003)
Diabetes Metab
, vol.29
-
-
Taylor, K.1
Poon, T.2
Nielsen, L.3
Cole, L.4
Han, J.5
Varns, A.6
Kin, D.7
Baron, A.8
Fineman, M.9
Kolterman, O.10
-
17
-
-
0029867855
-
Acute effects of the human amylin analog AC137 on basal and insulin-stimulated euglycemic and hypoglycemic fuel metabolism in patients with insulin-dependent diabetes mellitus
-
Nyholm B, Moller N, Gravholt CH, Orskov L, Mengel A, Bryan G, Moyses C, Alberti KG, Schmitz O: Acute effects of the human amylin analog AC137 on basal and insulin-stimulated euglycemic and hypoglycemic fuel metabolism in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81:1083-1089, 1996
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 1083-1089
-
-
Nyholm, B.1
Moller, N.2
Gravholt, C.H.3
Orskov, L.4
Mengel, A.5
Bryan, G.6
Moyses, C.7
Alberti, K.G.8
Schmitz, O.9
-
18
-
-
0029991868
-
IGF-I alters skeletal muscle substrate metabolism and blunts recovery from insulin-induced hypoglycemia
-
Hussain MA, Schmitz O, Christiansen JS, Christensen NJ, Alberti KG, Froesch ER: IGF-I alters skeletal muscle substrate metabolism and blunts recovery from insulin-induced hypoglycemia. Am J Physiol 270:E545-E551, 1996
-
(1996)
Am J Physiol
, vol.270
-
-
Hussain, M.A.1
Schmitz, O.2
Christiansen, J.S.3
Christensen, N.J.4
Alberti, K.G.5
Froesch, E.R.6
-
19
-
-
0028123730
-
Platelet catecholamine concentrations after short-term stress in normal subjects
-
Carstensen E, Yudkin JS: Platelet catecholamine concentrations after short-term stress in normal subjects. Clin Sci (Lond) 86:35-41, 1994
-
(1994)
Clin Sci (Lond)
, vol.86
, pp. 35-41
-
-
Carstensen, E.1
Yudkin, J.S.2
-
20
-
-
0022572232
-
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients
-
Polonsky KS, Licinio-Paixao J, Given BD, Pugh W, Rue P, Galloway J, Karrison T, Frank B: Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77:98-105, 1986
-
(1986)
J Clin Invest
, vol.77
, pp. 98-105
-
-
Polonsky, K.S.1
Licinio-Paixao, J.2
Given, B.D.3
Pugh, W.4
Rue, P.5
Galloway, J.6
Karrison, T.7
Frank, B.8
-
21
-
-
0036959991
-
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
-
Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hufner M, Schmiegel WH: Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 87:1239-1246, 2002
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1239-1246
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Behle, K.3
Holst, J.J.4
Nauck, M.S.5
Ritzel, R.6
Hufner, M.7
Schmiegel, W.H.8
-
22
-
-
0027409194
-
The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans
-
Davis SN, Goldstein RE, Jacobs J, Price L, Wolfe R, Cherrington AD: The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. Diabetes 42:263-272, 1993
-
(1993)
Diabetes
, vol.42
, pp. 263-272
-
-
Davis, S.N.1
Goldstein, R.E.2
Jacobs, J.3
Price, L.4
Wolfe, R.5
Cherrington, A.D.6
-
23
-
-
4344708602
-
No impairment of hypoglycemia counterregulation via glucagon with NN2211, a GLP-1 derivative, in subjects with type 2-diabetes
-
Nauck MA, El-Ouaghlidi A, Hompesch M, Jacobson J, Bodil E: No impairment of hypoglycemia counterregulation via glucagon with NN2211, a GLP-1 derivative, in subjects with type 2-diabetes (Abstract). Diabetes 52 (Suppl. 1):A128, 2003
-
(2003)
Diabetes
, vol.52
, Issue.SUPPL. 1
-
-
Nauck, M.A.1
El-Ouaghlidi, A.2
Hompesch, M.3
Jacobson, J.4
Bodil, E.5
-
24
-
-
0029761505
-
Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): Characterization of binding sites for GLP-1 on alpha-TSH cells
-
Beak SA, Small CJ, Ilovaiskaia I, Hurley JD, Ghatei MA, Bloom SR, Smith DM: Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on alpha-TSH cells. Endocrinol 137:4130-4138, 1996
-
(1996)
Endocrinol
, vol.137
, pp. 4130-4138
-
-
Beak, S.A.1
Small, C.J.2
Ilovaiskaia, I.3
Hurley, J.D.4
Ghatei, M.A.5
Bloom, S.R.6
Smith, D.M.7
-
25
-
-
0032521530
-
Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line
-
Beak SA, Heath MM, Small CJ, Morgan DG, Ghatei MA, Taylor AD, Buckingham JC, Bloom SR, Smith DM: Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line. J Clin Invest 101:1334-1341, 1998
-
(1998)
J Clin Invest
, vol.101
, pp. 1334-1341
-
-
Beak, S.A.1
Heath, M.M.2
Small, C.J.3
Morgan, D.G.4
Ghatei, M.A.5
Taylor, A.D.6
Buckingham, J.C.7
Bloom, S.R.8
Smith, D.M.9
-
26
-
-
0036628929
-
Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion
-
Djurhuus CB, Hansen TK, Gravholt C, Orskov L, Hosoda H, Kangawa K, Jorgensen JO, Holst JJ, Schmitz O: Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion. Horm Metab Res 34:411-413, 2002
-
(2002)
Horm Metab Res
, vol.34
, pp. 411-413
-
-
Djurhuus, C.B.1
Hansen, T.K.2
Gravholt, C.3
Orskov, L.4
Hosoda, H.5
Kangawa, K.6
Jorgensen, J.O.7
Holst, J.J.8
Schmitz, O.9
-
27
-
-
0035123797
-
Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes
-
Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk FW, Holst JJ, Rizza RA: Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes. Diabetes 50:565-572, 2001
-
(2001)
Diabetes
, vol.50
, pp. 565-572
-
-
Vella, A.1
Shah, P.2
Basu, R.3
Basu, A.4
Camilleri, M.5
Schwenk, F.W.6
Holst, J.J.7
Rizza, R.A.8
-
28
-
-
0036035521
-
Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans
-
Vella A, Shah P, Reed AS, Adkins AS, Basu R, Rizza RA: Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans. Diabetologia 45:1410-1415, 2002
-
(2002)
Diabetologia
, vol.45
, pp. 1410-1415
-
-
Vella, A.1
Shah, P.2
Reed, A.S.3
Adkins, A.S.4
Basu, R.5
Rizza, R.A.6
-
29
-
-
0018744356
-
Effect of intermittent endogenous hyperglucagonemia on glucose homeostasis in normal and diabetic man
-
Rizza R, Verdonk C, Miles J, Service FJ, Gerich J: Effect of intermittent endogenous hyperglucagonemia on glucose homeostasis in normal and diabetic man. J Clin Invest 63:1119-1123, 1979
-
(1979)
J Clin Invest
, vol.63
, pp. 1119-1123
-
-
Rizza, R.1
Verdonk, C.2
Miles, J.3
Service, F.J.4
Gerich, J.5
-
30
-
-
0028363238
-
Increased epinephrine and skeletal muscle responses to hypoglycemia in non-insulin-dependent diabetes mellitus
-
Shamoon H, Friedman S, Canton C, Zacharowicz L, Hu M, Rossetti L: Increased epinephrine and skeletal muscle responses to hypoglycemia in non-insulin-dependent diabetes mellitus. J Clin Invest 93:2562-2571, 1994
-
(1994)
J Clin Invest
, vol.93
, pp. 2562-2571
-
-
Shamoon, H.1
Friedman, S.2
Canton, C.3
Zacharowicz, L.4
Hu, M.5
Rossetti, L.6
-
31
-
-
0021263283
-
Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus: Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions
-
Bolli GB, Tsalikian E, Haymond MW, Cryer PE, Gerich JE: Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus: paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions. J Clin Invest 73:1532-1541, 1984
-
(1984)
J Clin Invest
, vol.73
, pp. 1532-1541
-
-
Bolli, G.B.1
Tsalikian, E.2
Haymond, M.W.3
Cryer, P.E.4
Gerich, J.E.5
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