메뉴 건너뛰기




Volumn 3, Issue 3, 2008, Pages 195-205

GSK-3 inhibitors: Recent developments and therapeutic potential

Author keywords

Alzheimer's disease; Bipolar disorder; Diabetes; GSK 3; GSK 3 inhibitors

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 603281 21 8; ANTIDEPRESSANT AGENT; AR A 014418; AR A 025028; CT 118637; CT 20026; CT 98014; CT 98024; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; HYMENIALDISINE; INDIRUBIN; INSULIN RECEPTOR SUBSTRATE 1; L 803 MTS; LITHIUM; MOOD STABILIZER; NEUROLEPTIC AGENT; NP 031112; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; WNT PROTEIN; ZINC;

EID: 54849441461     PISSN: 15743624     EISSN: None     Source Type: Journal    
DOI: 10.2174/157436208785699712     Document Type: Review
Times cited : (7)

References (127)
  • 2
    • 0026353474 scopus 로고
    • cDNA cloning and properties of glycogen synthase kinase-3
    • Woodgett JR. cDNA cloning and properties of glycogen synthase kinase-3. Methods Enzymol 1991; 200: 564-77.
    • (1991) Methods Enzymol , vol.200 , pp. 564-577
    • Woodgett, J.R.1
  • 3
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/Factor A
    • Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/Factor A. EMBO J 1990; 9: 2431-438.
    • (1990) EMBO J , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 4
    • 0344245499 scopus 로고    scopus 로고
    • Expression analysis of glycogen synthase kinase-3 in human tissues
    • Lau KF, Miller CC, Anderton BH, Shaw PC. Expression analysis of glycogen synthase kinase-3 in human tissues. J Pept Res 1999; 54: 85-91.
    • (1999) J Pept Res , vol.54 , pp. 85-91
    • Lau, K.F.1    Miller, C.C.2    Anderton, B.H.3    Shaw, P.C.4
  • 5
    • 0032989714 scopus 로고    scopus 로고
    • Developmental expression and localization of glycogen synthase kinase-3β in rat brain
    • Leroy K, Brion JP. Developmental expression and localization of glycogen synthase kinase-3β in rat brain. J Chem Neuroanat 1999; 16: 279-93.
    • (1999) J Chem Neuroanat , vol.16 , pp. 279-293
    • Leroy, K.1    Brion, J.P.2
  • 6
    • 0035983533 scopus 로고    scopus 로고
    • Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3β
    • Mukai F, Ishiguro K, Sano Y, Fujita SC. Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3β. J Neurochem 2002; 81: 1073-83.
    • (2002) J Neurochem , vol.81 , pp. 1073-1083
    • Mukai, F.1    Ishiguro, K.2    Sano, Y.3    Fujita, S.C.4
  • 7
    • 0037413694 scopus 로고    scopus 로고
    • Gene structure and alternative splicing of glycogen synthase kinase 3β(GSK-3β) in neural and non-neural tissues
    • Schaffer B, Wiedau-Pazos M, Geschwind DH. Gene structure and alternative splicing of glycogen synthase kinase 3β(GSK-3β) in neural and non-neural tissues. Gene 2003; 302: 73-81.
    • (2003) Gene , vol.302 , pp. 73-81
    • Schaffer, B.1    Wiedau-Pazos, M.2    Geschwind, D.H.3
  • 8
    • 4544341116 scopus 로고    scopus 로고
    • Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    • Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB. Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem 2004; 279: 39541-54.
    • (2004) J Biol Chem , vol.279 , pp. 39541-39554
    • Takada, Y.1    Fang, X.2    Jamaluddin, M.S.3    Boyd, D.D.4    Aggarwal, B.B.5
  • 9
    • 0035967897 scopus 로고    scopus 로고
    • Regulation of GSK-3: A Cellular Multiprocessor
    • Harwood AJ. Regulation of GSK-3: A Cellular Multiprocessor. Cell 2001; 105: 821-24.
    • (2001) Cell , vol.105 , pp. 821-824
    • Harwood, A.J.1
  • 10
    • 0037414833 scopus 로고    scopus 로고
    • Glycogen Synthase Kinase 3β Phosphorylates Tau at Both Primed and Unprimed Sites
    • Cho J-H, Johnson GVW. Glycogen Synthase Kinase 3β Phosphorylates Tau at Both Primed and Unprimed Sites. J Biol Chem 2003; 278: 187-93.
    • (2003) J Biol Chem , vol.278 , pp. 187-193
    • Cho, J.-H.1    Johnson, G.V.W.2
  • 11
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 2003; 116: 1175-86.
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 12
    • 1642494586 scopus 로고    scopus 로고
    • Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event
    • Cole A, Frame S, Cohen P. Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event. Biochem J 2004; 377: 249-55.
    • (2004) Biochem J , vol.377 , pp. 249-255
    • Cole, A.1    Frame, S.2    Cohen, P.3
  • 13
    • 34247865533 scopus 로고    scopus 로고
    • A Chaperone-Dependent GSK3β Transitional Intermediate Mediates Activation-Loop Autophosphorylation
    • Lochhead PA, Kinstrie R, Sibbet G, Rawjee T, Morrice N, Cleghon V. A Chaperone-Dependent GSK3β Transitional Intermediate Mediates Activation-Loop Autophosphorylation. Mol Cell 2006; 24: 627-33.
    • (2006) Mol Cell , vol.24 , pp. 627-633
    • Lochhead, P.A.1    Kinstrie, R.2    Sibbet, G.3    Rawjee, T.4    Morrice, N.5    Cleghon, V.6
  • 14
    • 0034805180 scopus 로고    scopus 로고
    • Related Articles, Links Lithium inhibits glycogen synthase kinase-3 by competition for magnesium
    • Ryves WJ, Harwood AJ. Related Articles, Links Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 2001; 280: 720-5.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 720-725
    • Ryves, W.J.1    Harwood, A.J.2
  • 15
    • 0030868557 scopus 로고    scopus 로고
    • Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
    • Hong M, Chen DC, Klein PS, Lee VM. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem 1997; 272: 25326-32.
    • (1997) J Biol Chem , vol.272 , pp. 25326-25332
    • Hong, M.1    Chen, D.C.2    Klein, P.S.3    Lee, V.M.4
  • 16
    • 21044449225 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tanopathy and degeneration in vivo
    • Noble W, Planel E, Zehr C, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tanopathy and degeneration in vivo. Proc Natl Acad Sci U S A 2005; 102: 6990-5.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6990-6995
    • Noble, W.1    Planel, E.2    Zehr, C.3
  • 17
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3alpha regulates production of Alzheimer's disease amyloid-β peptides
    • Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-β peptides. Nature 2003; 423: 435-9.
    • (2003) Nature , vol.423 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 18
    • 0016243393 scopus 로고
    • Actions of lithium ions and insulin on glucose utilization, glycogen synthesis and glycogen synthase in the isolated rat diaphragm
    • Haugaard ES, Mickel RA, Haugaard N. Actions of lithium ions and insulin on glucose utilization, glycogen synthesis and glycogen synthase in the isolated rat diaphragm. Biochem Pharmacol 1974; 23: 1675-85.
    • (1974) Biochem Pharmacol , vol.23 , pp. 1675-1685
    • Haugaard, E.S.1    Mickel, R.A.2    Haugaard, N.3
  • 19
    • 0021064785 scopus 로고
    • Insulin-like' effects of lithium ion on isolated rat adipocytes. II. Specific activation of glycogen synthase
    • Cheng K, Creacy S, Larner J. 'Insulin-like' effects of lithium ion on isolated rat adipocytes. II. Specific activation of glycogen synthase. Mol Cell Biochem 1983; 56: 183-9.
    • (1983) Mol Cell Biochem , vol.56 , pp. 183-189
    • Cheng, K.1    Creacy, S.2    Larner, J.3
  • 20
    • 0033580912 scopus 로고
    • The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism
    • Summers SA, Kao AW, Kohn AD, et al. The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism. J Biol Chem 1990; 274: 17934-40.
    • (1990) J Biol Chem , vol.274 , pp. 17934-17940
    • Summers, S.A.1    Kao, A.W.2    Kohn, A.D.3
  • 21
    • 0034717141 scopus 로고    scopus 로고
    • Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes
    • Orena SJ, Torchia AJ, Garofalo RS. Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes. J Biol Chem 2000; 275: 15765-72.
    • (2000) J Biol Chem , vol.275 , pp. 15765-15772
    • Orena, S.J.1    Torchia, A.J.2    Garofalo, R.S.3
  • 22
    • 33745351850 scopus 로고    scopus 로고
    • More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle
    • Fürnsinn C, Noe C, Herdlicka R, et al. More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle. Am J Physiol Endocrinol Metab 1997; 273: E514-20.
    • (1997) Am J Physiol Endocrinol Metab , vol.273
    • Fürnsinn, C.1    Noe, C.2    Herdlicka, R.3
  • 23
    • 0028233347 scopus 로고
    • Lithium increases susceptibility of muscle glucose transport to stimulation by various agents
    • Tabata I, Schluter J, Gulve EA, Holloszy JO. Lithium increases susceptibility of muscle glucose transport to stimulation by various agents. Diabetes 1994; 43: 903-7.
    • (1994) Diabetes , vol.43 , pp. 903-907
    • Tabata, I.1    Schluter, J.2    Gulve, E.A.3    Holloszy, J.O.4
  • 24
    • 0031869859 scopus 로고    scopus 로고
    • Stimulatory effect of lithium on glucose transport in rat adipocytes it not mediated by elevation of IPI
    • Chen X, McMahon EG, Gulve EA. Stimulatory effect of lithium on glucose transport in rat adipocytes it not mediated by elevation of IPI. Am J Physiol Endocrinol Metab 1998; 275: E272-7.
    • (1998) Am J Physiol Endocrinol Metab , vol.275
    • Chen, X.1    McMahon, E.G.2    Gulve, E.A.3
  • 25
    • 0019988330 scopus 로고
    • Antidiabetic effects of lithium
    • Saran AS. Antidiabetic effects of lithium. J Clin Psychiatry 1982; 43: 383-4.
    • (1982) J Clin Psychiatry , vol.43 , pp. 383-384
    • Saran, A.S.1
  • 26
    • 0024583736 scopus 로고
    • Normalization of insulin sensitivity with lithium in diabetic rats
    • Rossetti L. Normalization of insulin sensitivity with lithium in diabetic rats. Diabetes 1989; 38: 648-52.
    • (1989) Diabetes , vol.38 , pp. 648-652
    • Rossetti, L.1
  • 27
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 1996; 93: 8455-9.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 28
    • 0037075791 scopus 로고    scopus 로고
    • First non-ATP competitive glycogen synthase kinase 3 β (GSK3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease
    • Martinez A, Alonso M, Castro A, Pérez C, Moreno FJ. First non-ATP competitive glycogen synthase kinase 3 β (GSK3β) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 2002; 45: 1292-9.
    • (2002) J Med Chem , vol.45 , pp. 1292-1299
    • Martinez, A.1    Alonso, M.2    Castro, A.3    Pérez, C.4    Moreno, F.J.5
  • 29
    • 34250615440 scopus 로고    scopus 로고
    • NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disorders
    • Luna-Medina R, Cortes-Canteli M, Sanchez-Galiano S, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci 2007; 27: 5766-76.
    • (2007) J Neurosci , vol.27 , pp. 5766-5776
    • Luna-Medina, R.1    Cortes-Canteli, M.2    Sanchez-Galiano, S.3
  • 30
    • 0242664588 scopus 로고    scopus 로고
    • Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418
    • Bhat R, Xue Y, Berg S, et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem 2003; 278: 45937-45.
    • (2003) J Biol Chem , vol.278 , pp. 45937-45945
    • Bhat, R.1    Xue, Y.2    Berg, S.3
  • 31
    • 34249689633 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3β protects dopaminergic neurons from MPTP toxicity
    • Wang W, Yang Y, Ying C, et al. Inhibition of glycogen synthase kinase-3β protects dopaminergic neurons from MPTP toxicity. Neuropharmacology 2007; 52: 1678-84.
    • (2007) Neuropharmacology , vol.52 , pp. 1678-1684
    • Wang, W.1    Yang, Y.2    Ying, C.3
  • 32
    • 0346875916 scopus 로고    scopus 로고
    • GSK-3-selective inhibitors derived from Tyrian purple indirubins
    • Meijer L, Skaltsounis AL, Magiatis P, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol 2003; 10: 1255-66.
    • (2003) Chem Biol , vol.10 , pp. 1255-1266
    • Meijer, L.1    Skaltsounis, A.L.2    Magiatis, P.3
  • 33
    • 0035808457 scopus 로고    scopus 로고
    • Indirubins inhibit glycogen synthase kinase-3 β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
    • Leclerc S, Garnier M, Hansel R, et al. Indirubins inhibit glycogen synthase kinase-3 β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem 2001; 276: 251-60.
    • (2001) J Biol Chem , vol.276 , pp. 251-260
    • Leclerc, S.1    Garnier, M.2    Hansel, R.3
  • 34
    • 1842588303 scopus 로고    scopus 로고
    • Discovery and development of GSK-3 inhibitors for the treatment of type 2 diabetes
    • Wagman AS, Johnson KW, Bussiere DE. Discovery and development of GSK-3 inhibitors for the treatment of type 2 diabetes. Curr Pharm Des 2004; 10: 1105-37.
    • (2004) Curr Pharm Des , vol.10 , pp. 1105-1137
    • Wagman, A.S.1    Johnson, K.W.2    Bussiere, D.E.3
  • 35
    • 9144224945 scopus 로고    scopus 로고
    • Evaluation and comparison of 3DQSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones
    • Kunick C, Lauenroth K, Wieking K, et al. Evaluation and comparison of 3DQSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones. J Med Chem 2004; 47: 22-36.
    • (2004) J Med Chem , vol.47 , pp. 22-36
    • Kunick, C.1    Lauenroth, K.2    Wieking, K.3
  • 36
    • 0029782186 scopus 로고    scopus 로고
    • Progress in the discovery of biosynthetic anticancer drugs
    • Pettit GR. Progress in the discovery of biosynthetic anticancer drugs. J Nat Prod 1996: 812-21.
    • (1996) J Nat Prod , pp. 812-821
    • Pettit, G.R.1
  • 37
    • 0034010742 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinases, GSK3β and CK1 by hymenialdisine, a marine sponge constituent
    • Meijer L, Thunnissen AM, White AW, et al. Inhibition of cyclin-dependent kinases, GSK3β and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol 2000; 7: 51-63.
    • (2000) Chem Biol , vol.7 , pp. 51-63
    • Meijer, L.1    Thunnissen, A.M.2    White, A.W.3
  • 38
    • 0032705583 scopus 로고    scopus 로고
    • The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
    • Hers I, Tavaré JM, Denton RM. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett 1999; 460: 433-6.
    • (1999) FEBS Lett , vol.460 , pp. 433-436
    • Hers, I.1    Tavaré, J.M.2    Denton, R.M.3
  • 39
    • 0033776383 scopus 로고    scopus 로고
    • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    • Coghlan MP, Culbert AA, Cross DAE, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 2000; 7: 793-803.
    • (2000) Chem Biol , vol.7 , pp. 793-803
    • Coghlan, M.P.1    Culbert, A.A.2    Cross, D.A.E.3
  • 40
    • 0037339766 scopus 로고    scopus 로고
    • Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo
    • Ring DB, Johnson KW, Henriksen EJ, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003; 52: 588-95.
    • (2003) Diabetes , vol.52 , pp. 588-595
    • Ring, D.B.1    Johnson, K.W.2    Henriksen, E.J.3
  • 41
    • 0033958644 scopus 로고    scopus 로고
    • Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR. Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes 2000; 49: 263-71.
    • (2000) Diabetes , vol.49 , pp. 263-271
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Mohideen, P.4    Carter, L.5    Henry, R.R.6
  • 42
    • 19444371720 scopus 로고    scopus 로고
    • Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle
    • Dokken BB, Sloniger JA, Henriksen EJ. Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab 2005; 288: E1188-94.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Dokken, B.B.1    Sloniger, J.A.2    Henriksen, E.J.3
  • 43
    • 33745870108 scopus 로고    scopus 로고
    • Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats
    • Dokken BB, Henriksen EJ. Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats. Am J Physiol Endocrinol Metab 2006; 291: E207-13.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Dokken, B.B.1    Henriksen, E.J.2
  • 44
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351: 95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 45
    • 0023656594 scopus 로고
    • Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3
    • Fiol CJ, Mahrenholz AM, Wang Y, Roeske RW, Roach PJ. Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem 1987; 262: 14042-8.
    • (1987) J Biol Chem , vol.262 , pp. 14042-14048
    • Fiol, C.J.1    Mahrenholz, A.M.2    Wang, Y.3    Roeske, R.W.4    Roach, P.J.5
  • 46
    • 0025241896 scopus 로고
    • Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates
    • Fiol CJ, Wang A, Roeske RW, Roach PJ. Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates. J Biol Chem 1990; 265: 6061-5.
    • (1990) J Biol Chem , vol.265 , pp. 6061-6065
    • Fiol, C.J.1    Wang, A.2    Roeske, R.W.3    Roach, P.J.4
  • 47
    • 0027163324 scopus 로고
    • Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase
    • Zhang W, DePaoli-Roach AA, Roach PJ. Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase. Arch Biochem Biophys 1993; 304: 219-25.
    • (1993) Arch Biochem Biophys , vol.304 , pp. 219-225
    • Zhang, W.1    DePaoli-Roach, A.A.2    Roach, P.J.3
  • 48
    • 0038811796 scopus 로고    scopus 로고
    • Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3
    • Plotkin B, Kaidanovich O, Tailor I, Eldar-Finkelman H. Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J Pharmacol Exp Ther 2003; 305: 974-80.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 974-980
    • Plotkin, B.1    Kaidanovich, O.2    Tailor, I.3    Eldar-Finkelman, H.4
  • 49
    • 29244456731 scopus 로고    scopus 로고
    • Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ ob mice: Molecular characterization in liver and muscle
    • Kaidanovich-Beilin O, Eldar-Finkelman H. Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther 2006; 316: 17-24.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 17-24
    • Kaidanovich-Beilin, O.1    Eldar-Finkelman, H.2
  • 50
    • 0036079974 scopus 로고    scopus 로고
    • Glycogen and its metabolism
    • Roach PJ. Glycogen and its metabolism. Curr Mol Med 2002; 2: 101-20.
    • (2002) Curr Mol Med , vol.2 , pp. 101-120
    • Roach, P.J.1
  • 51
    • 0038199736 scopus 로고    scopus 로고
    • Control of glycogen deposition
    • Ferrer JC, Favre C, Gomis RR, et al. Control of glycogen deposition. FEBS Lett 2003; 546: 127-32.
    • (2003) FEBS Lett , vol.546 , pp. 127-132
    • Ferrer, J.C.1    Favre, C.2    Gomis, R.R.3
  • 52
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White MF, Kahn CR. The insulin signaling system. J Biol Chem 1994; 269: 1-4.
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 53
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
    • Araki E, Lipes MA, Patti ME, et al. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 1994; 372: 186-90.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3
  • 54
    • 0028308412 scopus 로고
    • Phosphatylinositol 3-kinase activation is required for insulin stimulation off pp70, s6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR. Phosphatylinositol 3-kinase activation is required for insulin stimulation off pp70, s6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 1994; 14: 4902-11.
    • (1994) Mol Cell Biol , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 55
    • 0029122720 scopus 로고
    • Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose-transport, amino-acid-transport, and glucose transporters in L6 skeletal-muscle cells
    • Tsakiridis T, McDowell HE, Walker T, et al. Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose-transport, amino-acid-transport, and glucose transporters in L6 skeletal-muscle cells. Endocrinology 1995; 136: 4315-22.
    • (1995) Endocrinology , vol.136 , pp. 4315-4322
    • Tsakiridis, T.1    McDowell, H.E.2    Walker, T.3
  • 56
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 1997; 7: 261-9.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3
  • 57
    • 0031782480 scopus 로고    scopus 로고
    • Constitutive activation of protein kinase B α by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
    • Hajduch E, Alessi DR, Hemmings BA, Hundal HS. Constitutive activation of protein kinase B α by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 1998; 47: 1006-13.
    • (1998) Diabetes , vol.47 , pp. 1006-1013
    • Hajduch, E.1    Alessi, D.R.2    Hemmings, B.A.3    Hundal, H.S.4
  • 58
    • 0030951346 scopus 로고    scopus 로고
    • Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue
    • Cross DA, Watt P, Shaw M, et al. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett 1997; 406: 211-5.
    • (1997) FEBS Lett , vol.406 , pp. 211-215
    • Cross, D.A.1    Watt, P.2    Shaw, M.3
  • 59
    • 0033609812 scopus 로고    scopus 로고
    • Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle
    • Markuns JF, Wojtaszewski JF, Goodyear LJ. Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle. J Biol Chem 1999; 274: 24896-900.
    • (1999) J Biol Chem , vol.274 , pp. 24896-24900
    • Markuns, J.F.1    Wojtaszewski, J.F.2    Goodyear, L.J.3
  • 60
    • 0027430039 scopus 로고
    • Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B
    • Welsh GI, Proud CG. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochem J 1993; 294: 625-9.
    • (1993) Biochem J , vol.294 , pp. 625-629
    • Welsh, G.I.1    Proud, C.G.2
  • 61
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-9.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 62
    • 0032802629 scopus 로고    scopus 로고
    • Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice
    • Eldar-Finkelman H, Schreyer SA, Shinohara MM, LeBoeuf RC, Krebs EG. Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes 1999; 48: 1662-6.
    • (1999) Diabetes , vol.48 , pp. 1662-1666
    • Eldar-Finkelman, H.1    Schreyer, S.A.2    Shinohara, M.M.3    LeBoeuf, R.C.4    Krebs, E.G.5
  • 63
    • 0036302960 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Carter L, Johnson K, Henry RR. Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Diabetes 2002; 51: 2190-8.
    • (2002) Diabetes , vol.51 , pp. 2190-2198
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Carter, L.4    Johnson, K.5    Henry, R.R.6
  • 64
    • 4544317872 scopus 로고    scopus 로고
    • Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter
    • Pearce NJ, Arch JR, Clapham JC, et al. Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter. Metabolism 2004; 53: 1322-30.
    • (2004) Metabolism , vol.53 , pp. 1322-1330
    • Pearce, N.J.1    Arch, J.R.2    Clapham, J.C.3
  • 65
    • 0030931560 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate I by glycogen synthase kinase 3 impairs insulin action
    • Eldar-Finkelman H, Krebs EG. Phosphorylation of insulin receptor substrate I by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci USA 1997; 94: 9660-4.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9660-9664
    • Eldar-Finkelman, H.1    Krebs, E.G.2
  • 66
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002; 277: 1531-7.
    • (2002) J Biol Chem , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 67
    • 0037135547 scopus 로고    scopus 로고
    • In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents
    • Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ. In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. J Biol Chem 2002; 277: 26530-9.
    • (2002) J Biol Chem , vol.277 , pp. 26530-26539
    • Qiao, L.Y.1    Zhande, R.2    Jetton, T.L.3    Zhou, G.4    Sun, X.J.5
  • 68
    • 2942623679 scopus 로고    scopus 로고
    • Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-I (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
    • Moeschel K, Beck A, Weigert C, et al. Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-I (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J Biol Chem 2004; 279: 25157-63.
    • (2004) J Biol Chem , vol.279 , pp. 25157-25163
    • Moeschel, K.1    Beck, A.2    Weigert, C.3
  • 69
    • 15844389443 scopus 로고    scopus 로고
    • Mothe I, Van Obberghen E. Phosphorylation of insulin receptor substrate-I on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 1996; 271: 11222-7.
    • Mothe I, Van Obberghen E. Phosphorylation of insulin receptor substrate-I on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 1996; 271: 11222-7.
  • 70
    • 45549089352 scopus 로고    scopus 로고
    • Phosphorylation of Ser357 of Rat Insulin Receptor Substrate-1 Mediates Adverse Effects of Protein Kinase C-{delta} on Insulin Action in Skeletal Muscle Cells
    • Waraich RS, Weigert C, Kalbacher H, et al. Phosphorylation of Ser357 of Rat Insulin Receptor Substrate-1 Mediates Adverse Effects of Protein Kinase C-{delta} on Insulin Action in Skeletal Muscle Cells. J Biol Chem 2008; 283: 11226-33.
    • (2008) J Biol Chem , vol.283 , pp. 11226-11233
    • Waraich, R.S.1    Weigert, C.2    Kalbacher, H.3
  • 71
    • 14244255271 scopus 로고    scopus 로고
    • Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling
    • Liberman Z, Eldar-Finkelman H. Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling. J Biol Chem 2005; 280: 4422-8.
    • (2005) J Biol Chem , vol.280 , pp. 4422-4428
    • Liberman, Z.1    Eldar-Finkelman, H.2
  • 73
    • 32044447659 scopus 로고    scopus 로고
    • An Estimate of the worldwide prevalence and direct costs of dementia in 2003
    • Wimo A, Jonsson L, Winblad B. An Estimate of the worldwide prevalence and direct costs of dementia in 2003. Dement Geriatr Cogn Disord 2006; 21: 175-81.
    • (2006) Dement Geriatr Cogn Disord , vol.21 , pp. 175-181
    • Wimo, A.1    Jonsson, L.2    Winblad, B.3
  • 74
    • 27744574179 scopus 로고    scopus 로고
    • GSK-3 inhibitors and their potential in the treatment of Alzheimer's disease
    • Kypta RM. GSK-3 inhibitors and their potential in the treatment of Alzheimer's disease. Expert Opin Ther Patents 2005; 15: 1315-31.
    • (2005) Expert Opin Ther Patents , vol.15 , pp. 1315-1331
    • Kypta, R.M.1
  • 75
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    • Lewis J, Dickson DW, Lin WL, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001; 293: 1487-91.
    • (2001) Science , vol.293 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.L.3
  • 76
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Aβ42 fibrils
    • Götz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Aβ42 fibrils. Science 2001; 293: 1491-5.
    • (2001) Science , vol.293 , pp. 1491-1495
    • Götz, J.1    Chen, F.2    van Dorpe, J.3    Nitsch, R.M.4
  • 77
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and α-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
    • Suh YH, Checler F. Amyloid precursor protein, presenilins, and α-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev 2002; 54: 469-525.
    • (2002) Pharmacol Rev , vol.54 , pp. 469-525
    • Suh, Y.H.1    Checler, F.2
  • 78
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 2005; 120: 545-55.
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 79
    • 33750466180 scopus 로고    scopus 로고
    • Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus
    • Yoshida S, Maeda M, Kaku S, Ikeya H, Yamada K, Nakaike S. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. J Neural Transm 2006; 113: 1803-14.
    • (2006) J Neural Transm , vol.113 , pp. 1803-1814
    • Yoshida, S.1    Maeda, M.2    Kaku, S.3    Ikeya, H.4    Yamada, K.5    Nakaike, S.6
  • 80
    • 0037160134 scopus 로고    scopus 로고
    • Central role of glycogen synthase kinase-3β in endoplasmic reticulum stress-induced caspase-3 activation
    • Song L, De Sarno P, Jope RS. Central role of glycogen synthase kinase-3β in endoplasmic reticulum stress-induced caspase-3 activation. J Biol Chem 2002; 277: 44701-8.
    • (2002) J Biol Chem , vol.277 , pp. 44701-44708
    • Song, L.1    De Sarno, P.2    Jope, R.S.3
  • 81
    • 14044261099 scopus 로고    scopus 로고
    • Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3
    • Kim AJ, Shi Y, Austin RC, Werstuck GH. Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci 2005; 118: 89-99.
    • (2005) J Cell Sci , vol.118 , pp. 89-99
    • Kim, A.J.1    Shi, Y.2    Austin, R.C.3    Werstuck, G.H.4
  • 82
    • 0035900197 scopus 로고    scopus 로고
    • Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium
    • King TD, Bijur GN, Jope RS. Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium. Brain Res 2001; 919: 106-14.
    • (2001) Brain Res , vol.919 , pp. 106-114
    • King, T.D.1    Bijur, G.N.2    Jope, R.S.3
  • 83
    • 1642373092 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3β is involved in the resistance to oxidative stress in neuronal HT22 cells
    • Schäfer M, Goodenough S, Moosmann B, Behl C. Inhibition of glycogen synthase kinase 3β is involved in the resistance to oxidative stress in neuronal HT22 cells. Brain Res 2004; 1005: 84-9.
    • (2004) Brain Res , vol.1005 , pp. 84-89
    • Schäfer, M.1    Goodenough, S.2    Moosmann, B.3    Behl, C.4
  • 84
    • 0041831195 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity
    • Facci L, Stevens DA, Skaper SD. Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity. Neuroreport 2003; 14: 1467-70.
    • (2003) Neuroreport , vol.14 , pp. 1467-1470
    • Facci, L.1    Stevens, D.A.2    Skaper, S.D.3
  • 85
    • 5144234244 scopus 로고    scopus 로고
    • M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway
    • Farias GG, Godoy JA, Hernanández F, Avila J, Fisher A, Inestrosa NC. M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway. Neurobiol Dis 2004; 17: 337-48.
    • (2004) Neurobiol Dis , vol.17 , pp. 337-348
    • Farias, G.G.1    Godoy, J.A.2    Hernanández, F.3    Avila, J.4    Fisher, A.5    Inestrosa, N.C.6
  • 86
    • 3042558276 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A drug target for CNS therapies
    • Bhat RV, Budd Haeberlein SL, Avila J. Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 2084; 89: 1313-7.
    • J Neurochem , vol.2084 , Issue.89 , pp. 1313-1317
    • Bhat, R.V.1    Budd Haeberlein, S.L.2    Avila, J.3
  • 87
    • 0033014180 scopus 로고    scopus 로고
    • The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3
    • Chen G, Huang LD, Jiang YM, Manji BK. The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. J Neurochem 1999; 72: 1327-30.
    • (1999) J Neurochem , vol.72 , pp. 1327-1330
    • Chen, G.1    Huang, L.D.2    Jiang, Y.M.3    Manji, B.K.4
  • 88
    • 3242761438 scopus 로고    scopus 로고
    • In vivo regulation of glycogen synthase kinase-3β (GSK3β) by serotonergic activity in mouse brain
    • Li X, Zhu W, Roh MS, Friedman AB, Rosborough K, Jope RS. In vivo regulation of glycogen synthase kinase-3β (GSK3β) by serotonergic activity in mouse brain. Neuropsychopharmacology 2004; 29: 1426-31.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1426-1431
    • Li, X.1    Zhu, W.2    Roh, M.S.3    Friedman, A.B.4    Rosborough, K.5    Jope, R.S.6
  • 89
    • 14644389398 scopus 로고    scopus 로고
    • Antipsychotics alter the protein expression levels of β-catenin and GSK-3 in the rat medial prefrontal cortex and striatum
    • Alimohamad H, Rajakumar N, Seah YH, Rushlow W. Antipsychotics alter the protein expression levels of β-catenin and GSK-3 in the rat medial prefrontal cortex and striatum. Biol Psychiatry 2005; 57: 533-42.
    • (2005) Biol Psychiatry , vol.57 , pp. 533-542
    • Alimohamad, H.1    Rajakumar, N.2    Seah, Y.H.3    Rushlow, W.4
  • 90
    • 0037304480 scopus 로고    scopus 로고
    • Biphasic changes in the Ser-9 phosphorylation of glycogen synthase kinase-3β after electroconvulsive shock in the rat brain
    • Roh MS, Kang UG, Shin SY, et al. Biphasic changes in the Ser-9 phosphorylation of glycogen synthase kinase-3β after electroconvulsive shock in the rat brain. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27: 1-5.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 1-5
    • Roh, M.S.1    Kang, U.G.2    Shin, S.Y.3
  • 91
    • 1642503034 scopus 로고    scopus 로고
    • Effect of zinc supplementation on antidepressant therapy in unipolar depression: A preliminary placebo-controlled study
    • Nowak G, Siwek M, Dudek D, Zieba A, Pilc A. Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Pol J Pharmacol 2003; 55: 1143-7.
    • (2003) Pol J Pharmacol , vol.55 , pp. 1143-1147
    • Nowak, G.1    Siwek, M.2    Dudek, D.3    Zieba, A.4    Pilc, A.5
  • 92
    • 0037707701 scopus 로고    scopus 로고
    • Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
    • Nowak G, Szewczyk B, Wieronska JM, et al. Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res Bull 2003; 61: 159-64.
    • (2003) Brain Res Bull , vol.61 , pp. 159-164
    • Nowak, G.1    Szewczyk, B.2    Wieronska, J.M.3
  • 93
    • 14844299775 scopus 로고    scopus 로고
    • Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells
    • An WL, Bjorkdahl C, Liu R, Cowburn RF, Winblad B, Pei JJ. Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells. J Neurochem 2005; 92: 1104-15.
    • (2005) J Neurochem , vol.92 , pp. 1104-1115
    • An, W.L.1    Bjorkdahl, C.2    Liu, R.3    Cowburn, R.F.4    Winblad, B.5    Pei, J.J.6
  • 94
    • 1842787936 scopus 로고    scopus 로고
    • Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    • Beaulieu JM, Sotnikova TD, Yao WD, et al. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A 2004; 101: 5099-104.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 5099-5104
    • Beaulieu, J.M.1    Sotnikova, T.D.2    Yao, W.D.3
  • 95
    • 10644255687 scopus 로고    scopus 로고
    • AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test
    • Gould TD, Einat H, Bhat R, Manji HK. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol 2004; 7: 387-90.
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 387-390
    • Gould, T.D.1    Einat, H.2    Bhat, R.3    Manji, H.K.4
  • 96
    • 33748280959 scopus 로고    scopus 로고
    • Transgenic mice overexpressing glycogen synthase kinase 3β: A putative model of hyperactivity and mania
    • Prickaerts J, Moechars D, Cryns K, et al. Transgenic mice overexpressing glycogen synthase kinase 3β: a putative model of hyperactivity and mania. J Neurosci 2006; 26: 9022-9.
    • (2006) J Neurosci , vol.26 , pp. 9022-9029
    • Prickaerts, J.1    Moechars, D.2    Cryns, K.3
  • 97
    • 1842420631 scopus 로고    scopus 로고
    • Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus
    • Kaidanovich-Beilin O, Milman A, Weizman A, Pick CG, Eldar-Finkelman H. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus. Biol Psychiatry 2004; 55: 781-4.
    • (2004) Biol Psychiatry , vol.55 , pp. 781-784
    • Kaidanovich-Beilin, O.1    Milman, A.2    Weizman, A.3    Pick, C.G.4    Eldar-Finkelman, H.5
  • 98
    • 3342955475 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium
    • O'Brien WT, Harper AD, Jové F, et al. Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 2004; 24: 6791-8.
    • (2004) J Neurosci , vol.24 , pp. 6791-6798
    • O'Brien, W.T.1    Harper, A.D.2    Jové, F.3
  • 99
    • 0346688565 scopus 로고    scopus 로고
    • In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3
    • Gould TD, Chen G, Manji HK. In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 2004; 29: 32-8.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 32-38
    • Gould, T.D.1    Chen, G.2    Manji, H.K.3
  • 100
    • 0242391951 scopus 로고    scopus 로고
    • Chronic electroconvulsive seizure up-regulates β-catenin expression in rat hippocampus: Role in adult neurogenesis
    • Madsen TM, Newton SS, Eaton ME, Russell DS, Duman RS. Chronic electroconvulsive seizure up-regulates β-catenin expression in rat hippocampus: role in adult neurogenesis. Biol Psychiatry 2003; 54: 1006-14.
    • (2003) Biol Psychiatry , vol.54 , pp. 1006-1014
    • Madsen, T.M.1    Newton, S.S.2    Eaton, M.E.3    Russell, D.S.4    Duman, R.S.5
  • 102
    • 1842785189 scopus 로고    scopus 로고
    • Signaling by insulin-like growth factor I in brain
    • Bondy CA, Cheng CM. Signaling by insulin-like growth factor I in brain. Eur J Pharmacol 2004; 490: 25-31.
    • (2004) Eur J Pharmacol , vol.490 , pp. 25-31
    • Bondy, C.A.1    Cheng, C.M.2
  • 103
    • 0028815653 scopus 로고
    • Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
    • Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995; 15: 7539-47.
    • (1995) J Neurosci , vol.15 , pp. 7539-7547
    • Nibuya, M.1    Morinobu, S.2    Duman, R.S.3
  • 104
    • 14944358464 scopus 로고    scopus 로고
    • Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
    • Hoshaw BA, Malberg JE, Lucki I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res 2005; 1037: 204-8.
    • (2005) Brain Res , vol.1037 , pp. 204-208
    • Hoshaw, B.A.1    Malberg, J.E.2    Lucki, I.3
  • 105
    • 34447134271 scopus 로고    scopus 로고
    • Increasing the Levels of Insulin-Like Growth Factor-I by an IGF Binding Protein Inhibitor Produces Anxiolytic and Antidepressant-Like Effects
    • Malberg JE, Platt B, Rizzo SJ, et al. Increasing the Levels of Insulin-Like Growth Factor-I by an IGF Binding Protein Inhibitor Produces Anxiolytic and Antidepressant-Like Effects. Neuropsychopharmacology 2007; 32: 2360-8.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2360-2368
    • Malberg, J.E.1    Platt, B.2    Rizzo, S.J.3
  • 106
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope RS, Johnson GV. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 2004; 29: 95-102.
    • (2004) Trends Biochem Sci , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 107
    • 0034602160 scopus 로고    scopus 로고
    • Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3β-dependent phosphorylation of beta-catenin and down-regulates β-catenin
    • Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A. Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3β-dependent phosphorylation of beta-catenin and down-regulates β-catenin. J Biol Chem 2000; 275: 34399-406.
    • (2000) J Biol Chem , vol.275 , pp. 34399-34406
    • Hinoi, T.1    Yamamoto, H.2    Kishida, M.3    Takada, S.4    Kishida, S.5    Kikuchi, A.6
  • 108
    • 0035666362 scopus 로고    scopus 로고
    • Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinoma
    • Johnson CD, Puntis M, Davidson N, Todd S, Bryce R. Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinoma. Br J Surg 2001; 88: 662-8.
    • (2001) Br J Surg , vol.88 , pp. 662-668
    • Johnson, C.D.1    Puntis, M.2    Davidson, N.3    Todd, S.4    Bryce, R.5
  • 109
    • 0038289005 scopus 로고    scopus 로고
    • Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice
    • Gould TD, Gray NA, Manji HK. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacol Res 2003; 48: 49-53.
    • (2003) Pharmacol Res , vol.48 , pp. 49-53
    • Gould, T.D.1    Gray, N.A.2    Manji, H.K.3
  • 110
    • 16844374033 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β participates in nuclear factor κB-mediated gene transcription and cell survival in pancreatic cancer cells
    • Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD. Glycogen synthase kinase-3β participates in nuclear factor κB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res 2005; 65: 2076-81.
    • (2005) Cancer Res , vol.65 , pp. 2076-2081
    • Ougolkov, A.V.1    Fernandez-Zapico, M.E.2    Savoy, D.N.3    Urrutia, R.A.4    Billadeau, D.D.5
  • 111
    • 2542472390 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β activity is required for androgen-stimulated gene expression in prostate cancer
    • Liao X, Thrasher JB, Holzbeierlein J, Stanley S, Li B. Glycogen synthase kinase-3β activity is required for androgen-stimulated gene expression in prostate cancer. Endocrinology 2004; 145: 2941-9.
    • (2004) Endocrinology , vol.145 , pp. 2941-2949
    • Liao, X.1    Thrasher, J.B.2    Holzbeierlein, J.3    Stanley, S.4    Li, B.5
  • 112
    • 7644220896 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth
    • Mazor M, Kawano Y, Zhu H, Waxman J, Kypta RM. Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. Oncogene 2004; 23: 7882-92.
    • (2004) Oncogene , vol.23 , pp. 7882-7892
    • Mazor, M.1    Kawano, Y.2    Zhu, H.3    Waxman, J.4    Kypta, R.M.5
  • 113
    • 3543019648 scopus 로고    scopus 로고
    • Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3β in prostate cells
    • Wang L, Lin HK, Hu YC, Xie S, Yang L, Chang C. Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3β in prostate cells. J Biol Chem 2004; 279: 32444-52.
    • (2004) J Biol Chem , vol.279 , pp. 32444-32452
    • Wang, L.1    Lin, H.K.2    Hu, Y.C.3    Xie, S.4    Yang, L.5    Chang, C.6
  • 114
    • 2342477767 scopus 로고    scopus 로고
    • Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei
    • Iwahana E, Akiyama M, Miyakawa K, et al. Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei. Eur J Neurosci 2004; 19: 2281-7.
    • (2004) Eur J Neurosci , vol.19 , pp. 2281-2287
    • Iwahana, E.1    Akiyama, M.2    Miyakawa, K.3
  • 115
    • 23844460834 scopus 로고    scopus 로고
    • A role for glycogen synthase kinase-3β in the mammalian circadian clock
    • Iitaka C, Miyazaki K, Akaike T, Ishida N. A role for glycogen synthase kinase-3β in the mammalian circadian clock. J Biol Chem 2005; 280: 29397-402.
    • (2005) J Biol Chem , vol.280 , pp. 29397-29402
    • Iitaka, C.1    Miyazaki, K.2    Akaike, T.3    Ishida, N.4
  • 116
    • 24744436847 scopus 로고    scopus 로고
    • Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3β
    • Harada Y, Sakai M, Kurabayashi N, Hirota T, Fukada Y. Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3β. J Biol Chem 2005; 280: 31714-21.
    • (2005) J Biol Chem , vol.280 , pp. 31714-31721
    • Harada, Y.1    Sakai, M.2    Kurabayashi, N.3    Hirota, T.4    Fukada, Y.5
  • 117
    • 33646414025 scopus 로고    scopus 로고
    • Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
    • Kulkarni NH, Onyia JE, Zeng QQ, et al. Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J Bone Miner Res 2006; 21: 910-20.
    • (2006) J Bone Miner Res , vol.21 , pp. 910-920
    • Kulkarni, N.H.1    Onyia, J.E.2    Zeng, Q.Q.3
  • 118
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348: 138-50.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 119
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • Kaisho T, Akita S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117: 979-87.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 979-987
    • Kaisho, T.1    Akita, S.2
  • 120
    • 23944486750 scopus 로고    scopus 로고
    • Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    • Martin M, Rehani K, Jope KS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005; 6: 777-84.
    • (2005) Nat Immunol , vol.6 , pp. 777-784
    • Martin, M.1    Rehani, K.2    Jope, K.S.3    Michalek, S.M.4
  • 121
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in the critically ill patients
    • van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-67.
    • (2001) N Engl J Med , vol.345 , pp. 1359-1367
    • van den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 123
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004; 10: 55-63.
    • (2004) Nat Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 124
    • 0037596751 scopus 로고    scopus 로고
    • Synthetic small molecules that control stem cell fate
    • Ding S, Wu TY, Brinker A, et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci USA 2003; 100: 7632-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7632-7637
    • Ding, S.1    Wu, T.Y.2    Brinker, A.3
  • 125
    • 30044444251 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
    • Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M. Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med 2006; 12: 89-98.
    • (2006) Nat Med , vol.12 , pp. 89-98
    • Trowbridge, J.J.1    Xenocostas, A.2    Moon, R.T.3    Bhatia, M.4
  • 126
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • Bain J, McLauchlan H, Elliott M, Cohen P. The specificities of protein kinase inhibitors: an update. Biochem J 2003; 371: 199-204.
    • (2003) Biochem J , vol.371 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 127
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats I
    • Cline GW, Johnson K, Regittnig W, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats I: Diabetes 2002; 51: 2903-10.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Cline, G.W.1    Johnson, K.2    Regittnig, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.