Transgenic mice overexpressing glycogen synthase kinase 3β: A putative model of hyperactivity and mania

Journal of Neuroscience

Volumn 26, Issue 35, 2006, Pages 9022-9029

  Prickaerts, Jos ^a,b   Moechars, Dieder ^a   Cryns, Kim ^a   Lenaerts, Ilse ^a   Van Craenendonck, Hansfried ^a   Goris, Ilse ^a   Daneels, Guy ^a   Bouwknecht, J Adriaan ^a   Steckler, Thomas ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Akt 1; Bipolar disorder; Dopamine; Lithium; Mania; Schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CORTICOTROPIN; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BIPOLAR DISORDER; BRAIN WEIGHT; CONTROLLED STUDY; DNA SYNTHESIS; FLUID INTAKE; FOOD INTAKE; HABITUATION; HIPPOCAMPUS; HYPERACTIVITY; HYPOPHAGIA; IMMOBILIZATION; LOCOMOTION; MANIA; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STARTLE REFLEX; STRESS; TRANSGENIC ANIMAL; UPREGULATION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; DISEASE MODELS, ANIMAL; DNA; DRINKING; EATING; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; HYPERKINESIS; MALE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; PHOTOPERIOD; SIGNAL TRANSDUCTION; STARTLE REACTION; SWIMMING;

EID: 33748280959     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5216-05.2006     Document Type: Article

References (58)

1. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551.
2. Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA (1996) Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 93:5699-5704.
3. Beaulieu JM, Sotnikova TD, Yao WD, Kockeritz L, Woodgett JR, Gainetdinov RR, Caron MG (2004) Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci USA 101:5099-5104.
4. Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122:261-273.
5. Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F (1995) Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron 14:717-730.
6. Berridge MJ, Downes CP, Hanley MR (1989) Neural and developmental actions of lithium: a unifying hypothesis. Cell 59:411-419.
7. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343.
8. Bray GA (2000) A concise review on the therapeutics of obesity. Nutrition 16:953-960.
9. Cannon CM, Abdallah L, Tecott LH, During MJ, Palmiter RD (2004) Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice. Neuron 44:509-520.
10. Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK (2000) Enhancement of hippocampal neurogenesis by lithium. J Neurochem 75:1729-1734.
11. Cheng CM, Reinhardt RR, Lee WH, Joncas G, Patel SC, Bondy CA (2000) Insulin-like growth factor 1 regulates developing brain glucose metabolism. Proc Natl Acad Sci USA 97:10236-10241.
12. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789.
13. D'Aquila PS, Collu M, Gessa GL, Serra G (2000) The role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol 405:365-373.
14. De Montigny C, Grunberg F, Mayer A, Deschenes JP (1981) Lithium induces rapid relief of depression in tricyclic antidepressant drug non-responders. Br J Psychiatry 138:252-256.
15. Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116:1175-1186.
16. Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA (2004) Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36:131-137.
17. Foulon C (2003) Schizophrenia and eating disorders. Encephale 29:463-466.
18. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359:1-16.
19. Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG (1999) Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 283:397-401.
20. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
21. Gould TD, Manji HK (2005) Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology 30:1223-1237.
22. Gould TD, Chen G, Manji HK (2004a) In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29:32-38.
23. Gould TD, Zarate CA, Manji HK (2004b) Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. J Clin Psychiatry 65:10-21.
24. Gould TD, Einat H, Bhat R, Manji HK (2004c) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol 7:387-390.
25. Greengard P, Allen PB, Nairn AC (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23:435-447.
26. Grimes CA, Jope RS (2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65:391-426.
27. Jacobsen JP, Mork A (2004) The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels. Brain Res 1024:183-192.
28. Jiang H, Guo W, Liang X, Rao Y (2005) Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell 120:123-135.
29. Kaidanovich-Beilin O, Milman A, Weizman A, Pick CG, Eldar-Finkelman H (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry 55:781-784.
30. Kishi T, Elmquist JK (2005) Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry 10:132-146.
31. Klamer D, Palsson E, Revesz A, Engel JA, Svensson L (2004) Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms. Psychopharmacology (Berl) 176:440-450.
32. Klein PS, Melton DA (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93:8455-8459.
33. Koch M (1999) The neurobiology of startle. Prog Neurobiol 59:107-128.
34. Krishnan KR (2005) Psychiatric and medical comorbidities of bipolar disorder. Psychosom Med 67:1-8.
35. Lewis MC, Gould TJ (2003) Nicotine and ethanol enhancements of acoustic startle reflex are mediated in part by dopamine in C57BL/6J mice. Pharmacol Biochem Behav 76:179-186.
36. Li X, Bijur GN, Jope RS (2002) Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection. Bipolar Disord 4:137-144.
37. Lyon M (1999) Animal models for the symptoms of mania. In: Animal models in psychiatry (Boulton AA, ed), pp 197-244. Clifton, NJ: Humana.
38. Machado-Vieira R, Kapczinski F, Soares JC (2004) Perspectives for the development of animal models of bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 28:209-224.
39. Mai L, Jope RS, Li X (2002) BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents. J Neurochem 82:75-83.
40. Manji HK, Gottesman II, Gould TD (2003) Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Sci STKE 2003:pe49.
41. Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 16:2365-2372.
42. Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers Jr MG, Seeley RJ, Schwartz MW (2003) Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52:227-231.
43. Perry W, Minassian A, Feifel D, Braff DL (2001) Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 50:418-424.
44. Pogorelov VM, Rodriguiz RM, Insco ML, Caron MG, Wetsel WC (2005) Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene. Neuropsychopharmacology 30:1818-1831.
45. 2 receptor antagonists. J Neurosci 21:305-313.
46. Ralph-Williams RJ, Paulus MP, Zhuang X, Hen R, Geyer MA (2003) Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biol Psychiatry 53:352-359.
47. Redrobe JP, Bourin M (1999) The effect of lithium administration in animal models of depression: a short review. Fundam Clin Pharmacol 13:293-299.
48. Salas TR, Reddy SA, Clifford JL, Davis RJ, Kikuchi A, Lippman SM, Menter DG (2003) Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei. J Biol Chem 278:41338-41346.
49. Scheepens A, Van De Waarenburg M, Van Den Hove HD, Blanco CE (2003) A single course of prenatal betamethasone in the rat alters postnatal brain cell proliferation but not apoptosis. J Physiol (Lond) 552:163-175.
50. Spittaels K, Van den Haute C, Van Dorpe J, Geerts H, Mercken M, Bruynseels K, Lasrado R, Vandezande K, Laenen I, Boon T, Van Lint J, Vandenheede J, Moechars D, Loos R, Van Leuven F (2000) Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem 275:41340-41349.
51. Spittaels K, Van den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R, Bruynseels K, Irizarry M, Verhoye M, Van Lint J, Vandenheede JR, Ashton D, Mercken M, Loos R, Hyman B, Van der Linden A, Geerts H, Van Leuven F (2002) Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. Neuroscience 113:797-808.
52. Steckler T, Holsboer F, Reul JM (1999) Glucocorticoids and depression. Baillieres Best Pract Res Clin Endocrinol Metab 13:597-614.
53. Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL (1990) Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology (Berl) 100:413-416.
54. Tao Y, Black IB, DiCicco-Bloom E (1997) In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor. J Neurobiol 33:289-296.
55. Van Wauwe J, Haefner B (2003) Glycogen synthase kinase-3 as drug target: from wallflower to center of attention. Drug News Perspect 16:557-565.
56. Wagner JP, Black IB, DiCicco-Bloom E (1999) Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J Neurosci 19:6006-6016.
57. Zhang J, Forkstam C, Engel JA, Svensson L (2000) Role of dopamine in prepulse inhibition of acoustic startle. Psychopharmacology (Berl) 149:181-188.
58. Zhuang X, Oosting RS, Jones SR, Gainetdinov RR, Miller GW, Caron MG, Hen R (2001) Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci USA 98:1982-1987.