Constitutive activation of protein kinase Bα by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

Diabetes

Volumn 47, Issue 7, 1998, Pages 1006-1013

  Hajduch, Eric ^a   Alessi, Dario R ^a   Hemmings, Brian A ^b   Hundal, Harinder S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE; PROTEIN KINASE;

AMINO ACID TRANSPORT; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; ENZYME INACTIVATION; GENE TARGETING; GLUCOSE METABOLISM; GLYCOLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RAT; SEQUENCE HOMOLOGY; SKELETAL MUSCLE;

AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL MEMBRANE; ENZYME ACTIVATION; GENE EXPRESSION; GENE TARGETING; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TRANSFECTION;

EID: 0031782480     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.7.1006     Document Type: Article

References (45)

1. Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA: Molecular-cloning and identification of a serine threonine protein-kinase of the 2nd-messenger subfamily. Proc Natl Acad Sci USA 88:4171-4175, 1991
2. Coffer PJ, Woodgett JR: Molecular-cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein-kinase-C families. Eur J Biochem 201:475-481, 1991
3. Hemmings BA: Update: signal transduction; PtdIns(3,4,5)P-3 gets its message across. Science 277:534, 1997
4. Datta K, Franke TF, Chan TO, Makris A, Yang SI, Kaplan DR, Monison DK, Golemis EA, Tsichlis PN: AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol Cell Biol 15:2304-2310, 1995
5. Cross DAE, Alessi DR, Cohen P, Andjelkovic M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin-mediated protein kinase B. Nature 378:785-789, 1995
6. Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Proud CG, Denton RM: Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in ral epididymal fat cells: activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms. J Biol Chem 272:7713-7719, 1997
7. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN: The protein-kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736, 1995
8. Burgering BMT, Coffer PJ: Protein-kinase-B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602, 1995
9. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551, 1996
10. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA: Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524, 1997
11. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB, Cohen P: Characterization of a 3-phosphatidylinositol-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7:261-269, 1997
12. Stokoe D, Stephens LR, Copeland T, Gafney PRJ, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-570, 1997
13. Alessi DR, Deak M, Casamayor C, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reece C, Macdougall CN, Harbison D, Ashworth A, Bownes M: 3-phosphoinositide dependent protein kinase-1 (PDK1): structural and functional homology with the drosophila DSTPK61 kinase. Curr Biol 7:776-789, 1997
14. Toker A, Cantley LC: Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673-676, 1997
15. Cohen P, Alessi DR, Cross DAE: The 10th Datta Lecture: PDK1, one of the missing links in insulin signal transduction? FEBS Lett 410:3-10, 1997
16. Shaw M, Cohen P, Alessi DR: Further evidence that the inhibition of glycogen synthase kinase 3β by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser 9 and not by dephosphorylation of Tyr-216. FEBS Lett 416:307-311, 1997
17. Lefebvre V, Mechin MC, Louckx MP, Rider MH, Hue L: Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin. J Biol Chem 271:22289-22292, 1996
18. Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH: Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem 272:17269-17275, 1997
19. Welsh GI, Proud CG: Glycogen-synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation-factor elf-2b. Biochem J 294:625-629, 1993
20. Nikolakaki E, Coffer PJ, Hemelsoet R, Woodgett JR, Defize LHK: Glycogen-synthase kinase-3 phosphorylates jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene 8:833-840, 1993
21. de Groot RP, Auwerx J, Bourouis M, Sassonecorsi P: Negative regulation of jun/AP-1-conserved function of glycogen-synthase kinase-3 and the drosophila kinase shaggy. Oncogene 8:841-847, 1993
22. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao RJ, Cooper GM, Segal RA, Kaplan DR, Greenberg ME: Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665, 1997
23. Franke TF, Kaplan DR, Cantley LC: PI3k: downstream action blocks apoptosis. Cell 88:435-437, 1997
24. Magun R, Burgering BMT, Coffer PJ, Pardasani D, Lin Y, Chabot J, Sorisky A: Expression of a constitutively activated form of protein-kinase-B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137:3590-3593, 1996
25. Kohn AD, Summers SA, Birnbaum MJ, Roth RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose-uptake and glucose-transporter-4 translocation. J Biol Chem 271:31372-31378, 1996
26. Holman GD, Kasuga M: From receptor to transporter; insulin signalling to glucose transport. Diabetologia 40:991-1003, 1997
27. Tanti JF, Grillo S, Gremeaux T, Coffer PJ, Vanobberghen E, Lemarchand-brustel Y: Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology 138:2005-2010, 1997
28. Cong L, Chen H, Li Y, Zhou L, McGibbon MA, Taylor SI, Quon MJ: Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose tissue. Mol Endocrinol 11:1881-1890, 1997
29. DeFronzo RA, Gunnarsson R, Bjorkman O, Wahren J: Effect of insulin on peripheral and splanchnic glucose metabolism in non-insulin dependent (type II) diabetes mellitus. J Clin Invest 76:149-155, 1985
30. Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA: Activation and phosphorylation of a pleckstrin homology domain-cobtaining protein-kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci U S A 93:5699-5704, 1996
31. Cross DAE, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P: The inhibition of glycogen synthase kinase-3 by insulin or IGF-1 in the rat skeletal muscle cell line L6 by wortmannin, but not rapamycin; evidence that wortmannin blocks activation of the MAP kinase pathway in L6 cells between Ras and Raf Biochem J 303:21-26, 1994
32. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 71:248-254, 1976
33. Hundal HS, Bilan PJ, Tsakridis T, Marette A, Klip A: Structural disruption of the trans-Golgi network does not interfere with the acute stimulation of glu cose and amino acid uptake by insulin-like growth factor I in muscle cells Biochem J 297:289-295, 1994
34. Mitsumoto L, Burdett E, Grant A, Klip A: Differential regulation of GLUT and GLUT4 glucose transporters during differentiation of L6 muscle cells. Biochem Biophys Res Commun 175:652-659, 1991
35. Bilan PJ, Mitsumoto Y, Ramlal T, Klip A: Acute and long term effects of insulin-like growth factor-I on glucose transporters In muscle cells: translocation and biosynthesis. FEBS Lett 298:285-290, 1992
36. Hundal HS, Ramlal T, Reyes R, Leiter LA, Klip A: Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells. Endocrinology 131:1165-1173, 1992
37. McDowell HE, Walker T, Hajduch E, Christie G, Batty IH, Downes CP, Hundal HS: Inositol phospholipid 3-kinase is activated by cellular stress but is not required for the stress-induced activation of glucose transport in L6 rat skeletal muscle cells. Eur J Biochem 247:306-313, 1997
38. McDowell HE, Christie GR, Stenhouse G, Hundal HS: Leucine activates system A amino acid transport in L6 rat skeietal muscle cells. Am J Physiol 269:C1287-C1294, 1995
39. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurements with the folin phenol reagent. J Biol Chem 193:265-275, 1951
40. Tsakiridis T, McDowell HE, Walker T, Downes CP, Hundal HS, Vranic M, Klip A: Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose-transport, amino-acid-transport, and glucose transporters in L6 skeletal-muscle cells. Endocrinology 136:4315-4322, 1995
41. Southern BG, Palmer RM, Garlick PJ: Acute effects of corticosterone on tissue protein synthesis and insulin sensitivity in rats in vivo. Biochem J 272:187-191, 1990
42. McDowell HE, Walker T, Downes CP, Hundal HS: Inhibition of IGF-1 stimulated glucose and System A amino acid transport in L6 rat skeletal muscle cells: effects of wortmannin (WM) and Rapamycin (RAP) (Abstract). J Physiol 482:5P, 1994
43. Cross DAE, Watt PW, Shaw M, vanderKaay J, Downes CP, Holder JC, Cohen P: Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett 201:475-481, 1997
44. Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR: Activation of protein kinase B βand γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase Bα. Biochem 331:299-308, 1998
45. Proud CG, Denton RM: Molecular mechanisms for the control of translation by insulin, Biochem J 328:329-341, 1997