Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity

NeuroReport

Volumn 14, Issue 11, 2003, Pages 1467-1470

  Facci, Laura ^a   Stevens, David A ^a   Skaper, Stephen D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cerebellar granule neurons; Glutamate; Glycogen synthase kinase 3; Hippocampus; Ischemia; Kainate; Neurodegeneration; Neuroprotection; Neurotoxicity; P1 3 K protein kinase B

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; EXCITOTOXIN; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; ENZYME INHIBITION; FETUS; GENETIC TRANSCRIPTION; GRANULE CELL; HIPPOCAMPUS; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION;

AMINOPHENOLS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CEREBELLUM; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; INDOLES; KAINIC ACID; MALEIMIDES; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0041831195     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200308060-00012     Document Type: Article

References (25)

1. Choi DW. J Neurobiol 23, 1261-1276 (1992).
2. Meldrum B and Garthwaite J. Trends Pharmacol Sci 11, 379-387 (1990).
3. Blandini F, Greenamyre JT and Nappi G. Funct Neurol 11, 3-15 (1996).
4. Dudek H, Datta SR, Franke TF et al. Science 275, 661-665 (1997).
5. Crowder RJ and Freeman RS. J Neurosci 18, 2933-2943 (1998).
6. Cross DAE, Alessi DR, Cohen P et al. Nature 378, 785-789 (1995).
7. van Weeren PC, de Bruyn KMT, de Vries-Smits AMM et al. J Biol Chem 273, 13150-13156 (1998).
8. Pap M and Cooper GM. J Biol Chem 273, 19929-19932 (1998).
9. Crowder RJ and Freeman RS. J Biol Chem 275, 34266-34271 (2000).
10. Hetman M, Cavanaugh JE, Kimelman D et al. J Neurosci 20, 2567-2574 (2000).
11. Cross DAE, Culbert AA, Chalmers KA et al. J Neurochem 77, 94-102 (2001).
12. Stambolic V, Ruel L and Woodgett JR. Curr Biol 6, 1664-1668 (1996).
13. Nonaka S, Hough CJ and Chuang DM. Proc Natl Acad Sci USA 95, 2642-2647 (1998).
14. Chalecka-Franaszek E and Chuang DM. Proc Natl Acad Sci USA 96, 8745-8750 (1999).
15. Coghlan MP, Culbert AA, Cross DAE et al. Chem Biol 7, 793-803 (2000).
16. Skaper SD, Facci L, Milani D et al. Culture and use of primary and clonal neural cells. In: Conn PM (ed.). Methods in Neurosciences, Vol. 2. San Diego: Academic Press; 1990, pp. 17-33.
17. Gallo V, Kingsbury A, Balazs R et al. J Neurosci 7, 2203-2213 (1987).
18. Brewer G, Torricelli JR, Evege EK et al. J Neurosci Res 35, 567-576 (1993).
19. Patel J, Zinkand WC, Thompson C et al. J Neurochem 54, 849-854 (1990).
20. Miller TM, Tansey MG, Johnson EM Jr et al. J Biol Chem 272, 9847-9853 (1997).
21. Nonaka S and Chuang DM. Neuroreport 9, 2081-2084 (1998).
22. Yuan P, Chen G and Manjii HK. J Neurochem 73, 2299-2309.
23. Woodgett JR. Trends Biochem Sci 16, 177-181 (1991).
24. Chen RW and Chuang DM. J Biol Chem 274, 6039-6042 (1999).
25. Baldessarini RJ, Tondo L and Hennen J. J Clin Pharmacol 60, 77-84 (1999).