메뉴 건너뛰기




Volumn 305, Issue 3, 2003, Pages 974-980

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; L803; N MYRISTOYLGLYCYLLYSYLGLUTAMYLALANYLPROLYLPROLYLALANYLPROLYLPROLYLGLUTAMINYLSERYLP ROLINE; PEPTIDE DERIVATIVE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0038811796     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.047381     Document Type: Article
Times cited : (145)

References (43)
  • 1
    • 0021064785 scopus 로고
    • 'Insulin-like' effects of lithium ion on isolated rat adipocytes. II. Specific activation of glycogen synthase
    • Cheng K, Creacy S, and Larner J (1983) 'Insulin-like' effects of lithium ion on isolated rat adipocytes. II. Specific activation of glycogen synthase. Mol Cell Biochem 56:183-189.
    • (1983) Mol Cell Biochem , vol.56 , pp. 183-189
    • Cheng, K.1    Creacy, S.2    Larner, J.3
  • 2
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats
    • Cline GW, Johnson K, Regittnig W, Perret P, Tozzo E, Xiano L, Damico C, and Shulman GI (2002) Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes 51:2903-2910.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Cline, G.W.1    Johnson, K.2    Regittnig, W.3    Perret, P.4    Tozzo, E.5    Xiano, L.6    Damico, C.7    Shulman, G.I.8
  • 5
    • 0036797590 scopus 로고    scopus 로고
    • Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
    • Covic L, Misra M, Badar J, Singh C, and Kuliopulos A (2002) Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation. Nat Med 10:1161-1165.
    • (2002) Nat Med , vol.10 , pp. 1161-1165
    • Covic, L.1    Misra, M.2    Badar, J.3    Singh, C.4    Kuliopulos, A.5
  • 6
    • 0027978816 scopus 로고
    • The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor-1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
    • Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, and Cohen P (1994) The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor-1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 303:21-26.
    • (1994) Biochem J , vol.303 , pp. 21-26
    • Cross, D.A.1    Alessi, D.R.2    Vandenheede, J.R.3    McDowell, H.E.4    Hundal, H.S.5    Cohen, P.6
  • 7
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother-Nielsen O, and Beck-Nielsen H (1991) Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:239-245.
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 8
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, and Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 10
    • 0029811140 scopus 로고    scopus 로고
    • Expression and Characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity
    • Eldar-Finkelman H, Agrast GM, Foord O, Fischer EH, and Krebs EG (1996) Expression and Characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity. Proc Natl Acad Sci USA 93:10228-10233.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10228-10233
    • Eldar-Finkelman, H.1    Agrast, G.M.2    Foord, O.3    Fischer, E.H.4    Krebs, E.G.5
  • 11
    • 0030931560 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 impairs insulin action
    • Eldar-Finkelman H and Krebs EG (1997) Phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 impairs insulin action. Proc Natl Acad Sci 94:9660-9664.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 9660-9664
    • Eldar-Finkelman, H.1    Krebs, E.G.2
  • 12
    • 0032802629 scopus 로고    scopus 로고
    • Increased glycogen synthase kinase-3 activity in diabetes and obesity prone C57BL/6J mice
    • Eldar-Finkelman H, Schreyer SA, Shinohara MM, LeBoeuf RC, and Krebs EG (1999) Increased glycogen synthase kinase-3 activity in diabetes and obesity prone C57BL/6J mice. Diabetes 48:1662-1666.
    • (1999) Diabetes , vol.48 , pp. 1662-1666
    • Eldar-Finkelman, H.1    Schreyer, S.A.2    Shinohara, M.M.3    LeBoeuf, R.C.4    Krebs, E.G.5
  • 13
    • 0035815710 scopus 로고    scopus 로고
    • A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes
    • Emote M, Langille SE, and Czech MP (2001) A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes. J Biol Chem 276:10677-10682.
    • (2001) J Biol Chem , vol.276 , pp. 10677-10682
    • Emote, M.1    Langille, S.E.2    Czech, M.P.3
  • 14
    • 0023656594 scopus 로고
    • Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3
    • Fiol CJ, Mahrenholz AM, Wang Y, Roeske RW, and Roach PJ (1987) Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem 262:14042-14048.
    • (1987) J Biol Chem , vol.262 , pp. 14042-14048
    • Fiol, C.J.1    Mahrenholz, A.M.2    Wang, Y.3    Roeske, R.W.4    Roach, P.J.5
  • 15
    • 0035990910 scopus 로고    scopus 로고
    • Designing specific protein kinase inhibitors: Insights from computer simulations and comparative sequence/structure analysis
    • Gould C and Wong CF (2002) designing specific protein kinase inhibitors: insights from computer simulations and comparative sequence/structure analysis. Pharmacol Ther 93:1690178.
    • (2002) Pharmacol Ther , vol.93 , pp. 1690178
    • Gould, C.1    Wong, C.F.2
  • 16
    • 0033023173 scopus 로고    scopus 로고
    • Noninvasive intracellular delivery of functional peptides and proteins
    • Hawiger J (1999) Noninvasive intracellular delivery of functional peptides and proteins. Curr Opin Chem Biol 3:89-94.
    • (1999) Curr Opin Chem Biol , vol.3 , pp. 89-94
    • Hawiger, J.1
  • 17
    • 0034844734 scopus 로고    scopus 로고
    • Alternative routes of administration as an approach to improve insulin therapy: Update on dermal, oral, nasal and pulmonary delivery
    • Heinemann L, Pfutzner A, and Heise T (2001) Alternative routes of administration as an approach to improve insulin therapy: update on dermal, oral, nasal and pulmonary delivery. Curr Pharm Des 14:1327-1351.
    • (2001) Curr Pharm Des , vol.14 , pp. 1327-1351
    • Heinemann, L.1    Pfutzner, A.2    Heise, T.3
  • 18
    • 0030054398 scopus 로고    scopus 로고
    • Overexpression of catalytic subunit p110α of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes
    • Katagiri H, Asano T, Ishihara H, Inukai K, Shibasaki Y, Kikuchi M, Yazaki Y, and Oka Y (1996) Overexpression of catalytic subunit p110α of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes. J Biol Chem 271:16987-16990.
    • (1996) J Biol Chem , vol.271 , pp. 16987-16990
    • Katagiri, H.1    Asano, T.2    Ishihara, H.3    Inukai, K.4    Shibasaki, Y.5    Kikuchi, M.6    Yazaki, Y.7    Oka, Y.8
  • 19
    • 0017334673 scopus 로고
    • Activation of rat adipocyte glycogen synthase by insulin
    • Lawrence JC, Guinovart JJ, and Larner J (1977) Activation of rat adipocyte glycogen synthase by insulin. J Biol Chem 252:444-450.
    • (1977) J Biol Chem , vol.252 , pp. 444-450
    • Lawrence, J.C.1    Guinovart, J.J.2    Larner, J.3
  • 20
    • 0036792527 scopus 로고    scopus 로고
    • Peptide-mediated cell delivery: Application in protein target validation
    • Lindsay MA (2002) Peptide-mediated cell delivery: application in protein target validation. Curr Opin Pharmacol 2:587-594.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 587-594
    • Lindsay, M.A.1
  • 23
    • 0036469290 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility
    • Morfini G, Szebenyi G, Elluru R, Ratner N, and Brady ST (2002) Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J 21:281-293.
    • (2002) EMBO J , vol.21 , pp. 281-293
    • Morfini, G.1    Szebenyi, G.2    Elluru, R.3    Ratner, N.4    Brady, S.T.5
  • 24
    • 0030905313 scopus 로고    scopus 로고
    • Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: Role of chronic hyperinsulinemia and hyperglycemia
    • Nikoulina SE, Ciaraldi-TP, Abrams-Carte L, Mudaliar S, Park KS, and Henry RR (1997) Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia. Diabetes 46:1017-1024.
    • (1997) Diabetes , vol.46 , pp. 1017-1024
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Abrams-Carte, L.3    Mudaliar, S.4    Park, K.S.5    Henry, R.R.6
  • 25
    • 0036302960 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Carter L, Johnson K, and Henry RR (2002) Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Diabetes 51:2190-2198.
    • (2002) Diabetes , vol.51 , pp. 2190-2198
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Carter, L.4    Johnson, K.5    Henry, R.R.6
  • 27
    • 0030015109 scopus 로고    scopus 로고
    • Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport
    • Ricort JM, Tanti JF, Van Obberghen E, and Le Marchand-Brustel Y (1996) Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport. Eur J Biochem 239:17-22.
    • (1996) Eur J Biochem , vol.239 , pp. 17-22
    • Ricort, J.M.1    Tanti, J.F.2    Van Obberghen, E.3    Le Marchand-Brustel, Y.4
  • 30
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, and Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science (Wash DC) 285:1569-1572.
    • (1999) Science (Wash DC) , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 31
    • 0035019608 scopus 로고    scopus 로고
    • Delivery of bioactive peptides and proteins across oral (buccal) mucosa
    • Senel S, Kremer M, Nagy K, and Squier C (2001) Delivery of bioactive peptides and proteins across oral (buccal) mucosa. Curr Pharm Biotechnol 2:175-186.
    • (2001) Curr Pharm Biotechnol , vol.2 , pp. 175-186
    • Senel, S.1    Kremer, M.2    Nagy, K.3    Squier, C.4
  • 32
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, and Shulman RG (1990) Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 22:223-228.
    • (1990) N Engl J Med , vol.22 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 35
    • 0037428976 scopus 로고    scopus 로고
    • Arginine containing peptides as delivery vectors
    • Tung C-H and Weissleder R (2003) Arginine containing peptides as delivery vectors. Adv Drug Deliv Rev 55:281-994.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 281-994
    • Tung, C.-H.1    Weissleder, R.2
  • 37
    • 0027448949 scopus 로고
    • Inactivation of rabbit muscle glycogen synthase by glycogen synthase kinase-3. Dominant role of the phosphorylation of Ser-640 (site-3a)
    • Wang Y and Roach PJ (1993) Inactivation of rabbit muscle glycogen synthase by glycogen synthase kinase-3. Dominant role of the phosphorylation of Ser-640 (site-3a). J Biol Chem 268:23876-23880.
    • (1993) J Biol Chem , vol.268 , pp. 23876-23880
    • Wang, Y.1    Roach, P.J.2
  • 38
    • 0036001391 scopus 로고    scopus 로고
    • Structure-activity relationship of reversible lipidized peptides: Studies of fatty acid-desmopression conjugates
    • Wang J, Wu d and Shen W-C (2002) Structure-activity relationship of reversible lipidized peptides: studies of fatty acid-desmopression conjugates. Pharm Res 19:609-614.
    • (2002) Pharm Res , vol.19 , pp. 609-614
    • Wang, J.1    Wu, D.2    Shen, W.-C.3
  • 39
    • 0027430039 scopus 로고
    • Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B
    • Welsh GI and Proud CG (1993) Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochem J 294:625-629.
    • (1993) Biochem J , vol.294 , pp. 625-629
    • Welsh, G.I.1    Proud, C.G.2
  • 40
    • 0036791512 scopus 로고    scopus 로고
    • Latest development in crystallography and structure-based design pf protein kinase inhibitors as drug candidates
    • Williams D and Mitchell T (2002) Latest development in crystallography and structure-based design pf protein kinase inhibitors as drug candidates. Curr Opin Pharmacol 2:567.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 567
    • Williams, D.1    Mitchell, T.2
  • 41
    • 0035909112 scopus 로고    scopus 로고
    • Judging a protein more than its name: GSK-3
    • Woodgett JR (2001) Judging a protein more than its name: GSK-3. Sci STKE 100:RE12.
    • (2001) Sci STKE , vol.100
    • Woodgett, J.R.1
  • 42
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M (2002) Antimicrobial peptides of multicellular organisms. Nature (Lond) 415:389-395.
    • (2002) Nature (Lond) , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 43
    • 0027163324 scopus 로고
    • Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase
    • Zhang W, Depaoli-Roach AA, and Roach PJ (1993) Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase. Arch Biochem Biophys 304:219-225.
    • (1993) Arch Biochem Biophys , vol.304 , pp. 219-225
    • Zhang, W.1    Depaoli-Roach, A.A.2    Roach, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.