The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity

FEBS Letters

Volumn 460, Issue 3, 1999, Pages 433-436

  Hers, Ingeborg ^a   Tavaré, Jeremy M ^a   Denton, Richard M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Adipocyte; Bisindolylmaleimide; Glycogen synthase kinase 3; Insulin; Protein kinase C inhibitor

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BISINDOLYLMALEIMIDE; PROTEIN KINASE; PROTEIN KINASE C INHIBITOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLYCOGEN SYNTHESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ADIPOCYTES; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; INDOLES; MALE; MALEIMIDES; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN KINASE C; RATS; RATS, WISTAR;

EID: 0032705583     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)01389-7     Document Type: Article

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