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Volumn 2, Issue 3, 2008, Pages 215-228

Advancements in predictive in silico models for ADME

Author keywords

ADME; Drug metabolism; In silico; Pharmacokinetics; Protein transporters; QSAR; Statistical methods

Indexed keywords


EID: 54749091722     PISSN: 18723136     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231308785739747     Document Type: Review
Times cited : (18)

References (109)
  • 1
    • 0034899540 scopus 로고    scopus 로고
    • ADMET - turning chemicals into drugs
    • Hodgson J. ADMET - turning chemicals into drugs. Nat Biotechnol 2001; 19(8): 722-726.
    • (2001) Nat Biotechnol , vol.19 , Issue.8 , pp. 722-726
    • Hodgson, J.1
  • 2
    • 0034837087 scopus 로고    scopus 로고
    • High-throughput screening approaches for investigating drug metabolism and pharmacokinetics
    • Roberts SA. High-throughput screening approaches for investigating drug metabolism and pharmacokinetics. Xenobiotica 2001; 31: 557-89.
    • (2001) Xenobiotica , vol.31 , pp. 557-589
    • Roberts, S.A.1
  • 3
    • 0042330313 scopus 로고    scopus 로고
    • Yu H. Adedoyin A. ADME-Tox in drug discovery: Integration of experimental and computational technologies. Drug Discov Today 2003; 8: 852-861.
    • Yu H. Adedoyin A. ADME-Tox in drug discovery: Integration of experimental and computational technologies. Drug Discov Today 2003; 8: 852-861.
  • 4
    • 0037364162 scopus 로고    scopus 로고
    • ADMET in silico modelling: Towards prediction paradise?
    • Van de Waterbeemd H, Gifford E. ADMET in silico modelling: Towards prediction paradise? Nat Rev Drug Discov 2003; 2: 192-204.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 192-204
    • Van de Waterbeemd, H.1    Gifford, E.2
  • 5
    • 0036513590 scopus 로고    scopus 로고
    • The role of QSAR in biomolecular discovery
    • Winkler DA. The role of QSAR in biomolecular discovery. Brief Bioinfo 2002; 3: 73.
    • (2002) Brief Bioinfo , vol.3 , pp. 73
    • Winkler, D.A.1
  • 7
    • 1442293369 scopus 로고    scopus 로고
    • Current state and perspectives of 3D-QSAR
    • Akamatsu M. Current state and perspectives of 3D-QSAR. Curr Top Med Chem 2002; 2: 1381-1394.
    • (2002) Curr Top Med Chem , vol.2 , pp. 1381-1394
    • Akamatsu, M.1
  • 8
    • 2942620237 scopus 로고    scopus 로고
    • Building predictive ADMET models for early decisions in drug discovery
    • Penzotti JE, Landrum GA, Putta S. Building predictive ADMET models for early decisions in drug discovery. Drug Discov Dev 2004; 7: 49-61.
    • (2004) Drug Discov Dev , vol.7 , pp. 49-61
    • Penzotti, J.E.1    Landrum, G.A.2    Putta, S.3
  • 9
    • 28844493408 scopus 로고    scopus 로고
    • Musings of ADME Predictions and structure-activity relations
    • Testa B, Vistoli G, Pedretti A. Musings of ADME Predictions and structure-activity relations. Chem Biodivers 2005; 2: 1411-1427.
    • (2005) Chem Biodivers , vol.2 , pp. 1411-1427
    • Testa, B.1    Vistoli, G.2    Pedretti, A.3
  • 10
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 1997; 23: 3-25.
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 11
    • 0032795192 scopus 로고    scopus 로고
    • Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena
    • Clark DE. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. J Pharm Sci 1999; 88: 807-814.
    • (1999) J Pharm Sci , vol.88 , pp. 807-814
    • Clark, D.E.1
  • 12
    • 0025804183 scopus 로고
    • Correlation between oral drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson P, Karlsson J. Correlation between oral drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 1991; 175: 880-885.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 15
    • 0036786448 scopus 로고    scopus 로고
    • Quantitative structure/property relationship analysis of Caco-2 permeability using a genetic algorithm-based partial least squares method
    • Yamashita F, Wanchana S, Hashida M. Quantitative structure/property relationship analysis of Caco-2 permeability using a genetic algorithm-based partial least squares method. J Pharm Sci 2002; 91: 2230-2239.
    • (2002) J Pharm Sci , vol.91 , pp. 2230-2239
    • Yamashita, F.1    Wanchana, S.2    Hashida, M.3
  • 16
    • 0030914681 scopus 로고    scopus 로고
    • Polar molecular surface properties predict and the intestinal absorption of drugs in humans
    • Palm K, Stenberg P, Luthman K, Artursson P. Polar molecular surface properties predict and the intestinal absorption of drugs in humans. Pharm Res 1997; 14: 568-571.
    • (1997) Pharm Res , vol.14 , pp. 568-571
    • Palm, K.1    Stenberg, P.2    Luthman, K.3    Artursson, P.4
  • 18
    • 0031877469 scopus 로고    scopus 로고
    • A general approach for the prediction of intestinal absorption of drugs: Regression analysis using the physiochemical properties and drug-membrane electrostatic interaction
    • Sugawara M, Takekuma Y, Yamada H, Kobayashi M, Iseki K, Miyazaki K. A general approach for the prediction of intestinal absorption of drugs: Regression analysis using the physiochemical properties and drug-membrane electrostatic interaction. J Pharm Sci 1998; 87: 960-966.
    • (1998) J Pharm Sci , vol.87 , pp. 960-966
    • Sugawara, M.1    Takekuma, Y.2    Yamada, H.3    Kobayashi, M.4    Iseki, K.5    Miyazaki, K.6
  • 19
    • 0033300143 scopus 로고    scopus 로고
    • Toward minimalistic modelling of oral drug absorption
    • Oprea TI, Gottfries J. Toward minimalistic modelling of oral drug absorption. J Mol Graph Mod 1999; 94: 261-274.
    • (1999) J Mol Graph Mod , vol.94 , pp. 261-274
    • Oprea, T.I.1    Gottfries, J.2
  • 20
    • 0035081938 scopus 로고    scopus 로고
    • Theoretically-derived molecular descriptors important in human intestinal absorption
    • Agatonovic-Kustrin S, Beresford R, Yusof APM. Theoretically-derived molecular descriptors important in human intestinal absorption. J Pharm Biomed Anal 2001; 25: 227-237.
    • (2001) J Pharm Biomed Anal , vol.25 , pp. 227-237
    • Agatonovic-Kustrin, S.1    Beresford, R.2    Yusof, A.P.M.3
  • 21
    • 0034992583 scopus 로고    scopus 로고
    • Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors
    • Zhao YH, Le J, Abraham MH, et al. Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors. J Pharm Sci 2001; 90: 749-784.
    • (2001) J Pharm Sci , vol.90 , pp. 749-784
    • Zhao1    YH, L.J.2    Abraham, M.H.3
  • 22
    • 0036806339 scopus 로고    scopus 로고
    • Rate-limited steps of human oral absorption and QSAR studies
    • Zhao YH, Abraham MH, Le J, et al. Rate-limited steps of human oral absorption and QSAR studies. Pharm Res 2002; 19: 1446-1457.
    • (2002) Pharm Res , vol.19 , pp. 1446-1457
    • Zhao, Y.H.1    Abraham2    MH, L.J.3
  • 23
    • 0035739018 scopus 로고    scopus 로고
    • A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity
    • Raevsky OA, Schaper KJ, Artursson P, McFarland JW. A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity. Struct-Act Relat 2002; 20: 402-413.
    • (2002) Struct-Act Relat , vol.20 , pp. 402-413
    • Raevsky, O.A.1    Schaper, K.J.2    Artursson, P.3    McFarland, J.W.4
  • 25
    • 0036891365 scopus 로고    scopus 로고
    • ADME evaluation 2. A computer model for the prediction of intestinal absorption in humans
    • Klopman G, Stefan LR, Saiakhov RD. ADME evaluation 2. A computer model for the prediction of intestinal absorption in humans. Eur J Pharm Sci 2002; 17: 253-263.
    • (2002) Eur J Pharm Sci , vol.17 , pp. 253-263
    • Klopman, G.1    Stefan, L.R.2    Saiakhov, R.D.3
  • 26
    • 0037369815 scopus 로고    scopus 로고
    • Classification structure-activity relations (C-SAR) in prediction of human intestinal absorption
    • Zmuidinavicius D, Didziapetris R, Japertas P, Avdeef A, Petrauskas A. Classification structure-activity relations (C-SAR) in prediction of human intestinal absorption. J Pharm Sci 2003; 92: 621-633.
    • (2003) J Pharm Sci , vol.92 , pp. 621-633
    • Zmuidinavicius, D.1    Didziapetris, R.2    Japertas, P.3    Avdeef, A.4    Petrauskas, A.5
  • 28
    • 23444442253 scopus 로고    scopus 로고
    • Classification of drugs in absorption classes using the classification and regression trees (CART) methodology
    • Deconinck E, Hancock T, Coomans D, Massart DL, Vander Heyden Y. Classification of drugs in absorption classes using the classification and regression trees (CART) methodology. J Pharm Biol Anal 2005; 39: 91-103.
    • (2005) J Pharm Biol Anal , vol.39 , pp. 91-103
    • Deconinck, E.1    Hancock, T.2    Coomans, D.3    Massart, D.L.4    Vander Heyden, Y.5
  • 29
    • 26944488000 scopus 로고    scopus 로고
    • Use of surface charges from DFT calculations to predict intestinal absorption
    • Jones R, Connolly PC, Klamt A, Diedenhofen M. Use of surface charges from DFT calculations to predict intestinal absorption. J Chem Inf Model 2005; 45: 1337-1342.
    • (2005) J Chem Inf Model , vol.45 , pp. 1337-1342
    • Jones, R.1    Connolly, P.C.2    Klamt, A.3    Diedenhofen, M.4
  • 30
    • 29144484633 scopus 로고    scopus 로고
    • Predictive human intestinal absorption QSAR models using Bayesian regularized neural networks
    • Polley MJ, Burden FR, Winkler DA. Predictive human intestinal absorption QSAR models using Bayesian regularized neural networks. Aust J Chem 2005; 58: 859-863.
    • (2005) Aust J Chem , vol.58 , pp. 859-863
    • Polley, M.J.1    Burden, F.R.2    Winkler, D.A.3
  • 31
    • 33746461831 scopus 로고    scopus 로고
    • Computational approaches for modelling human intestinal absorption and permeability
    • Subramanian G, Kitchen DB. Computational approaches for modelling human intestinal absorption and permeability. J Mol Model 2006; 12: 577-589.
    • (2006) J Mol Model , vol.12 , pp. 577-589
    • Subramanian, G.1    Kitchen, D.B.2
  • 32
    • 3042781869 scopus 로고    scopus 로고
    • In silico ADME prediction: Data, models, facts and myths
    • Lombardo F, Gifford E, Shalaeva MY. In silico ADME prediction: Data, models, facts and myths. Mini Rev Med Chem 2003; 3: 861-875.
    • (2003) Mini Rev Med Chem , vol.3 , pp. 861-875
    • Lombardo, F.1    Gifford, E.2    Shalaeva, M.Y.3
  • 34
    • 12244273713 scopus 로고    scopus 로고
    • Quantitative structure-pharmacokinetic relationships for drug distribution properties by using general regression neural network
    • Yap CW, Chen YZ. Quantitative structure-pharmacokinetic relationships for drug distribution properties by using general regression neural network. J Pharm Sci 2005; 94: 153-168.
    • (2005) J Pharm Sci , vol.94 , pp. 153-168
    • Yap, C.W.1    Chen, Y.Z.2
  • 35
    • 1042275637 scopus 로고    scopus 로고
    • In silico prediction models for blood-brain barrier permeation
    • Ecker GF, Noe CR. In silico prediction models for blood-brain barrier permeation. Curr Med Chem 2004; 11: 1617-1628.
    • (2004) Curr Med Chem , vol.11 , pp. 1617-1628
    • Ecker, G.F.1    Noe, C.R.2
  • 37
    • 1242273811 scopus 로고    scopus 로고
    • Prediction of human volume of distribution values for neutral and basic drugs. 2: Extended data set and leave-class-out statistics
    • Lombardo F, Obach RS, Shalaeva MY, Gao F. Prediction of human volume of distribution values for neutral and basic drugs. 2: Extended data set and leave-class-out statistics. J Med Chem 2004; 47: 1242-1250.
    • (2004) J Med Chem , vol.47 , pp. 1242-1250
    • Lombardo, F.1    Obach, R.S.2    Shalaeva, M.Y.3    Gao, F.4
  • 38
    • 0346391120 scopus 로고    scopus 로고
    • Pharmacokinetic parameter prediction from drug structure using artificial neural networks
    • Turner JV, Maddalena DJ, Cutler DJ. Pharmacokinetic parameter prediction from drug structure using artificial neural networks. Int J Pharm 2004; 270: 209-219.
    • (2004) Int J Pharm , vol.270 , pp. 209-219
    • Turner, J.V.1    Maddalena, D.J.2    Cutler, D.J.3
  • 39
    • 33645404135 scopus 로고    scopus 로고
    • In silico human and rat Vss quantitative structure - activity relationship models
    • Gleeson MP, Waters NJ, Paine SW, Davis AM. In silico human and rat Vss quantitative structure - activity relationship models. J Med Chem 2006; 49: 1953-1963.
    • (2006) J Med Chem , vol.49 , pp. 1953-1963
    • Gleeson, M.P.1    Waters, N.J.2    Paine, S.W.3    Davis, A.M.4
  • 40
    • 33645675081 scopus 로고    scopus 로고
    • A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human
    • Lombardo F, Obach RS, DiCapua FM, et al. A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human. J Med Chem 2006; 49: 2262-2267.
    • (2006) J Med Chem , vol.49 , pp. 2262-2267
    • Lombardo, F.1    Obach, R.S.2    DiCapua, F.M.3
  • 41
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • Wrighton SA, Stevens JC. The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 1992; 22: 1-21.
    • (1992) Crit Rev Toxicol , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 43
    • 0037980382 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships (QSARs) within the cytochrome P450 system: QSARs describing substrate binding, inhibition and induction of P450s
    • Lewis DFV. Quantitative structure-activity relationships (QSARs) within the cytochrome P450 system: QSARs describing substrate binding, inhibition and induction of P450s. Inflammopharmacology 2003; 11(1): 43-73.
    • (2003) Inflammopharmacology , vol.11 , Issue.1 , pp. 43-73
    • Lewis, D.F.V.1
  • 44
    • 0142057081 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships for predicting metabolism and modelling cytochrome P450 enzyme activities
    • Long A, Walker JD. Quantitative structure-activity relationships for predicting metabolism and modelling cytochrome P450 enzyme activities. Environ Toxicol Chem 2003; 22(8): 1894-1899.
    • (2003) Environ Toxicol Chem , vol.22 , Issue.8 , pp. 1894-1899
    • Long, A.1    Walker, J.D.2
  • 45
    • 2942585265 scopus 로고    scopus 로고
    • Towards integrated ADME prediction: Past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases
    • Smith PA, Sorich MJ, Low LSC, McKinnon RA, Miners JO. Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases. J Mol Graph Mod 2004; 22: 507-517.
    • (2004) J Mol Graph Mod , vol.22 , pp. 507-517
    • Smith, P.A.1    Sorich, M.J.2    Low, L.S.C.3    McKinnon, R.A.4    Miners, J.O.5
  • 46
    • 0032822383 scopus 로고    scopus 로고
    • Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Analysis of CYP 3A4 Substrates
    • Ekins S, Bravi G, Wikel JH, Wrighton SA. Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Analysis of CYP 3A4 Substrates. J Pharmacol Exp Ther 1999; 291: 424-433.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 424-433
    • Ekins, S.1    Bravi, G.2    Wikel, J.H.3    Wrighton, S.A.4
  • 47
    • 0033011395 scopus 로고    scopus 로고
    • Three- and Four-Dimensional Quantitative Structure Activity Relationship Analyses of Cytochrome P-450 3A4 Inhibitors
    • Ekins S, Bravi G, Binkley S, et al. Three- and Four-Dimensional Quantitative Structure Activity Relationship Analyses of Cytochrome P-450 3A4 Inhibitors. J Pharmacol Exp Ther 1999; 290: 429-438.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 429-438
    • Ekins, S.1    Bravi, G.2    Binkley, S.3
  • 48
    • 0141789965 scopus 로고    scopus 로고
    • QSAR Analysis of the Inhibition of Recombinant CYP 3A4 Activity by Structurally Diverse Compounds Using a Genetic Algorithm-Combined Partial Least Squares Method
    • Wanchana S, Yamashita F, Hashida M. QSAR Analysis of the Inhibition of Recombinant CYP 3A4 Activity by Structurally Diverse Compounds Using a Genetic Algorithm-Combined Partial Least Squares Method. Pharm Res 2003; 20: 1401-1408.
    • (2003) Pharm Res , vol.20 , pp. 1401-1408
    • Wanchana, S.1    Yamashita, F.2    Hashida, M.3
  • 49
    • 0037059925 scopus 로고    scopus 로고
    • A Neural Network Based Virtual Screening of Cytochrome P450 3A4 Inhibitors
    • Molnar L, Keseru GM. A Neural Network Based Virtual Screening of Cytochrome P450 3A4 Inhibitors. Bioorg Med Chem Lett 2002; 12: 419-421.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 419-421
    • Molnar, L.1    Keseru, G.M.2
  • 50
    • 0033529017 scopus 로고    scopus 로고
    • Novel Approach to Predicting P450 Mediated Drug Metabolism. The Development of a Combined Protein and Pharmacophore Model for CYP2D6
    • de Groot MJ, Ackland MJ, Horne VA, Alex AA, Jones BC. Novel Approach to Predicting P450 Mediated Drug Metabolism. The Development of a Combined Protein and Pharmacophore Model for CYP2D6. J Med Chem 1999; 42: 1515-1524.
    • (1999) J Med Chem , vol.42 , pp. 1515-1524
    • de Groot, M.J.1    Ackland, M.J.2    Horne, V.A.3    Alex, A.A.4    Jones, B.C.5
  • 51
    • 0345282980 scopus 로고    scopus 로고
    • Comparative Molecular Field Analysis and QSAR on Substrates Binding to Cytochrome P450 2D6
    • Haji-Momenian S, Rieger JM, Macdonald TL, Brown ML. Comparative Molecular Field Analysis and QSAR on Substrates Binding to Cytochrome P450 2D6. Bioorg Med Chem 2003; 11: 5545-5554.
    • (2003) Bioorg Med Chem , vol.11 , pp. 5545-5554
    • Haji-Momenian, S.1    Rieger, J.M.2    Macdonald, T.L.3    Brown, M.L.4
  • 52
    • 0042357537 scopus 로고    scopus 로고
    • Generation and Validation of Rapid Computational Filters for CYP2D6 and CYP3A4
    • Ekins S, Berbaum J, Harrison RK. Generation and Validation of Rapid Computational Filters for CYP2D6 and CYP3A4. Drug Metab Dispos 2003; 31: 1077-1080.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1077-1080
    • Ekins, S.1    Berbaum, J.2    Harrison, R.K.3
  • 53
    • 6044232040 scopus 로고    scopus 로고
    • Validation of Model of Cytochrome P450 2D6: An in silico Tool for Predicting Metabolism and Inhibition
    • Kemp CA, Flanagan JU, van Eldik AJ, et al. Validation of Model of Cytochrome P450 2D6: An in silico Tool for Predicting Metabolism and Inhibition. J Med Chem 2004; 47: 5340-5346.
    • (2004) J Med Chem , vol.47 , pp. 5340-5346
    • Kemp, C.A.1    Flanagan, J.U.2    van Eldik, A.J.3
  • 54
    • 0041698413 scopus 로고    scopus 로고
    • Use of Robust Classification Techniques for the Prediction of Human Cytochrome P450 2D6 Inhibition
    • Susnow RG, Dixon SL. Use of Robust Classification Techniques for the Prediction of Human Cytochrome P450 2D6 Inhibition. J Chem Inf Comput Sci 2003; 43: 1308-1315.
    • (2003) J Chem Inf Comput Sci , vol.43 , pp. 1308-1315
    • Susnow, R.G.1    Dixon, S.L.2
  • 55
    • 13944268698 scopus 로고    scopus 로고
    • Greater Than the Sum of Its Parts: Combining Models for Useful ADMET Prediction
    • O'Brien SE, de Groot MJ. Greater Than the Sum of Its Parts: Combining Models for Useful ADMET Prediction. J Med Chem 2005; 48: 1287-1291.
    • (2005) J Med Chem , vol.48 , pp. 1287-1291
    • O'Brien, S.E.1    de Groot, M.J.2
  • 56
    • 0029145903 scopus 로고
    • Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2
    • Brosen K. Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet 1995; 29: 20-25.
    • (1995) Clin Pharmacokinet , vol.29 , pp. 20-25
    • Brosen, K.1
  • 57
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich FP, Shimada T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol 1991; 4: 391-407.
    • (1991) Chem Res Toxicol , vol.4 , pp. 391-407
    • Guengerich, F.P.1    Shimada, T.2
  • 59
    • 0029781370 scopus 로고    scopus 로고
    • Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices
    • So FV, Guthrie N, Chambers AF, Moussa M, Carroll KK. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 1996; 26: 167-181.
    • (1996) Nutr Cancer , vol.26 , pp. 167-181
    • So, F.V.1    Guthrie, N.2    Chambers, A.F.3    Moussa, M.4    Carroll, K.K.5
  • 60
    • 0026590679 scopus 로고
    • Inhibition of carcinogenesis by minor dietary constituents
    • Wattenberg LW. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 1992; 52: 2085-2091.
    • (1992) Cancer Res , vol.52 , pp. 2085-2091
    • Wattenberg, L.W.1
  • 61
    • 0026246632 scopus 로고
    • Vegetables, fruit, and cancer. II. Mechanisms
    • Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 1991; 2: 427-442.
    • (1991) Cancer Causes Control , vol.2 , pp. 427-442
    • Steinmetz, K.A.1    Potter, J.D.2
  • 62
    • 0035676242 scopus 로고    scopus 로고
    • Quantitative Structure-Activity Relationships (QSARs) Within Substrates of Human Cytochrome P450 Involved in Drug Metabolism
    • Lewis FV, Modi S, Dickins M. Quantitative Structure-Activity Relationships (QSARs) Within Substrates of Human Cytochrome P450 Involved in Drug Metabolism. Drug Metab Drug Interact 2001; 18: 221-242.
    • (2001) Drug Metab Drug Interact , vol.18 , pp. 221-242
    • Lewis, F.V.1    Modi, S.2    Dickins, M.3
  • 63
    • 0033934402 scopus 로고    scopus 로고
    • Quantitative Structure-Activity Relationships (QSAR) Study of Flavonoid Derivatives for Inhibition of Cytochrome P450 1A2
    • Moon T, Chi MH, Kim DH, Yoon CN, Choi YS. Quantitative Structure-Activity Relationships (QSAR) Study of Flavonoid Derivatives for Inhibition of Cytochrome P450 1A2. Quant Struct-Act Relat 2000; 19: 257-263.
    • (2000) Quant Struct-Act Relat , vol.19 , pp. 257-263
    • Moon, T.1    Chi, M.H.2    Kim, D.H.3    Yoon, C.N.4    Choi, Y.S.5
  • 64
    • 20444481352 scopus 로고    scopus 로고
    • Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes
    • Iori F, da Fonseca R, João Ramos M, Menziani MC. Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. Bioorg Med Chem 2005; 13: 4366-4374.
    • (2005) Bioorg Med Chem , vol.13 , pp. 4366-4374
    • Iori, F.1    da Fonseca, R.2    João Ramos, M.3    Menziani, M.C.4
  • 65
    • 23444437988 scopus 로고    scopus 로고
    • A Rapid Computational Filter for Cytochrome P450 1A2 Inhibition Potential of Compound Libraries
    • Chohan KK, Paine SW, Mistry J, Barton P, Davis AM. A Rapid Computational Filter for Cytochrome P450 1A2 Inhibition Potential of Compound Libraries. J Med Chem 2005; 48: 5154-5161.
    • (2005) J Med Chem , vol.48 , pp. 5154-5161
    • Chohan, K.K.1    Paine, S.W.2    Mistry, J.3    Barton, P.4    Davis, A.M.5
  • 66
    • 20144370197 scopus 로고    scopus 로고
    • Predictive Three-Dimensional Quantitative Structure-Activity Relationship of Cytochrome P450 1A2 Inhibitors
    • Korhonen LE, Minna R, Mähönen NJ, Wittekindt C, Poso A. Predictive Three-Dimensional Quantitative Structure-Activity Relationship of Cytochrome P450 1A2 Inhibitors. J Med Chem 2005; 48: 3808-3815.
    • (2005) J Med Chem , vol.48 , pp. 3808-3815
    • Korhonen, L.E.1    Minna, R.2    Mähönen, N.J.3    Wittekindt, C.4    Poso, A.5
  • 67
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic S, di Carlo F. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997; 29: 413-580.
    • (1997) Drug Metab Rev , vol.29 , pp. 413-580
    • Rendic, S.1    di Carlo, F.2
  • 68
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners J, Birkett D. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol 1998; 45: 525-538.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 525-538
    • Miners, J.1    Birkett, D.2
  • 69
    • 0037204551 scopus 로고    scopus 로고
    • Computer systems for the prediction of xenobiotic metabolism
    • Langowski J, Long A. Computer systems for the prediction of xenobiotic metabolism. Adv Drug Deliv Rev 2002; 54: 407-415.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 407-415
    • Langowski, J.1    Long, A.2
  • 70
    • 0030456054 scopus 로고    scopus 로고
    • Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: Molecular origin of the specific inhibitory effects of sulfaphenazole on CYP2C9 and consequences for the substrate binding site topology of CYP 2C9
    • Mancy A, Dijols S, Poli S, Guengerich P, Mansuy D. Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP2C9 and consequences for the substrate binding site topology of CYP 2C9. Biochemistry 1996; 35: 16205-16212.
    • (1996) Biochemistry , vol.35 , pp. 16205-16212
    • Mancy, A.1    Dijols, S.2    Poli, S.3    Guengerich, P.4    Mansuy, D.5
  • 71
    • 0033373389 scopus 로고    scopus 로고
    • Potentiation of anticoagulant effect of warfarin caused by enantioselective metabolic inhibition by the uricosuric agent benzbromarone
    • Takahashi H, Sato T, Shimoyama Y, et al. Potentiation of anticoagulant effect of warfarin caused by enantioselective metabolic inhibition by the uricosuric agent benzbromarone. Clin Pharmacol Ther 1999; 66: 569-581.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 569-581
    • Takahashi, H.1    Sato, T.2    Shimoyama, Y.3
  • 72
    • 0037636387 scopus 로고    scopus 로고
    • A new class of CYP2C9 inhibitors: Probing 2C9 specificity with high-affinity benzbromarone derivatives
    • Locuson CW, Wahlstrom JL, Rock DA, Jones JP. A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives. Drug Metab Dispos 2003; 31: 967-971.
    • (2003) Drug Metab Dispos , vol.31 , pp. 967-971
    • Locuson, C.W.1    Wahlstrom, J.L.2    Rock, D.A.3    Jones, J.P.4
  • 73
    • 0031934315 scopus 로고    scopus 로고
    • Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: Rationalization in the CYP2C subfamily
    • Lewis DFV, Dickins M, Weaver RJ, Eddershaw PJ, Goldfarb PS, Tarbit MH. Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization in the CYP2C subfamily. Xenobiotica 1998; 28: 235-268.
    • (1998) Xenobiotica , vol.28 , pp. 235-268
    • Lewis, D.F.V.1    Dickins, M.2    Weaver, R.J.3    Eddershaw, P.J.4    Goldfarb, P.S.5    Tarbit, M.H.6
  • 74
    • 12244310480 scopus 로고    scopus 로고
    • Discriminant and qualitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors
    • Afzelius L, Masimirembwa CM, Karlen A, Andersson TB, Zamora I. Discriminant and qualitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors. J Comput-Aided Mol Des 2002; 16: 443-458.
    • (2002) J Comput-Aided Mol Des , vol.16 , pp. 443-458
    • Afzelius, L.1    Masimirembwa, C.M.2    Karlen, A.3    Andersson, T.B.4    Zamora, I.5
  • 75
    • 0842304425 scopus 로고    scopus 로고
    • Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors
    • Afzelius L, Zamora I, Masimirembwa CM, et al. Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors. J Med Chem 2004; 47: 907-914.
    • (2004) J Med Chem , vol.47 , pp. 907-914
    • Afzelius, L.1    Zamora, I.2    Masimirembwa, C.M.3
  • 76
    • 2642518851 scopus 로고    scopus 로고
    • Locuson CW, Rock DA, Jones JP. Quantitative Binding Models for CYP2C9 Based on Benzbromarone Analogues. Biochemistry 2004; 43: 6948-6958.
    • Locuson CW, Rock DA, Jones JP. Quantitative Binding Models for CYP2C9 Based on Benzbromarone Analogues. Biochemistry 2004; 43: 6948-6958.
  • 77
    • 23844460948 scopus 로고    scopus 로고
    • Prediction of Cytochrome P450 3A4, 2D6, and 2C9 Inhibitors and Substrates by Using Support Vector Machines
    • Yap CW, Chen YZ. Prediction of Cytochrome P450 3A4, 2D6, and 2C9 Inhibitors and Substrates by Using Support Vector Machines. J Chem Inf Model 2005; 45: 982-992.
    • (2005) J Chem Inf Model , vol.45 , pp. 982-992
    • Yap, C.W.1    Chen, Y.Z.2
  • 78
    • 11144223711 scopus 로고    scopus 로고
    • Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors
    • Locuson CW, Suzuki H, Rettie AE, Jones JP. Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors. J Med Chem 2004; 47: 6768-6776.
    • (2004) J Med Chem , vol.47 , pp. 6768-6776
    • Locuson, C.W.1    Suzuki, H.2    Rettie, A.E.3    Jones, J.P.4
  • 79
    • 27444434892 scopus 로고    scopus 로고
    • MetaSite: Understanding metabolism in human cytochromes from the perspective of the chemist
    • Cruciani G, Carosati E, De Boeck B, et al. MetaSite: Understanding metabolism in human cytochromes from the perspective of the chemist. J Med Chem 2005; 48: 6970-6979.
    • (2005) J Med Chem , vol.48 , pp. 6970-6979
    • Cruciani, G.1    Carosati, E.2    De Boeck, B.3
  • 80
    • 23044488827 scopus 로고    scopus 로고
    • Predicting drug metabolism - An evaluation of the expert system METEOR
    • Testa B, Balmat A-L, Long A, Judson P. Predicting drug metabolism - An evaluation of the expert system METEOR. Chem Biodivers 2005; 2: 872-885.
    • (2005) Chem Biodivers , vol.2 , pp. 872-885
    • Testa, B.1    Balmat, A.-L.2    Long, A.3    Judson, P.4
  • 81
    • 33847395360 scopus 로고    scopus 로고
    • Classification of metabolites with kernel partial least squares (K-PLS)
    • in press
    • Embrechts MJ, Ekins S. Classification of metabolites with kernel partial least squares (K-PLS). Drug Metab Dispos 2007; in press.
    • (2007) Drug Metab Dispos
    • Embrechts, M.J.1    Ekins, S.2
  • 82
    • 8544224973 scopus 로고    scopus 로고
    • The UDP-glycosyltransferase gene superfamily-recommended nomenclature update based on evolutionary divergence
    • MacKenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A. The UDP-glycosyltransferase gene superfamily-recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 1997; 7: 255-269.
    • (1997) Pharmacogenetics , vol.7 , pp. 255-269
    • MacKenzie, P.I.1    Owens, I.S.2    Burchell, B.3    Bock, K.W.4    Bairoch, A.5    Belanger, A.6
  • 83
    • 0026008487 scopus 로고
    • Cloning of two human liver bilirubin UDP-glucuronosyl-transferase cDNAs with expression in COS-1 cells
    • Ritter JK, Crawford JM, Owens IS. Cloning of two human liver bilirubin UDP-glucuronosyl-transferase cDNAs with expression in COS-1 cells. J Biol Chem 1991; 266: 1043-1047.
    • (1991) J Biol Chem , vol.266 , pp. 1043-1047
    • Ritter, J.K.1    Crawford, J.M.2    Owens, I.S.3
  • 84
    • 0027521059 scopus 로고
    • Human bilirubin UDP-glucuronosyltransferase catalyses the glucuronidation of ethinylestradiol
    • Ebner T, Remmel RP, Burchell B. Human bilirubin UDP-glucuronosyltransferase catalyses the glucuronidation of ethinylestradiol. Mol Pharmacol 1993; 43: 649-654.
    • (1993) Mol Pharmacol , vol.43 , pp. 649-654
    • Ebner, T.1    Remmel, R.P.2    Burchell, B.3
  • 85
    • 0027991904 scopus 로고
    • Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation
    • Senafi SB, Clarke DJ, Burchell B. Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem J 1994; 303: 233-240.
    • (1994) Biochem J , vol.303 , pp. 233-240
    • Senafi, S.B.1    Clarke, D.J.2    Burchell, B.3
  • 86
    • 12244277451 scopus 로고    scopus 로고
    • Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates
    • Sorich MJ, Smith PA, McKinnon RA, Miners JO. Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates. Pharmacogenetics 2002; 12: 635-645.
    • (2002) Pharmacogenetics , vol.12 , pp. 635-645
    • Sorich, M.J.1    Smith, P.A.2    McKinnon, R.A.3    Miners, J.O.4
  • 87
    • 0029962074 scopus 로고    scopus 로고
    • Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalysed by expressed human UGT1.4 protein
    • Green MD, Telphy TR. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalysed by expressed human UGT1.4 protein. Drug Metab Dispos 1996; 24: 356-363.
    • (1996) Drug Metab Dispos , vol.24 , pp. 356-363
    • Green, M.D.1    Telphy, T.R.2
  • 88
    • 0028948889 scopus 로고
    • Expressed Human UGT1.4 Protein Catalyses the Formation of Quaternary Ammonium-Linked Glucuronides
    • Green MD, Bishop WP, Telphy TR. Expressed Human UGT1.4 Protein Catalyses the Formation of Quaternary Ammonium-Linked Glucuronides. Drug Metab Dispos 1995; 23: 299-302.
    • (1995) Drug Metab Dispos , vol.23 , pp. 299-302
    • Green, M.D.1    Bishop, W.P.2    Telphy, T.R.3
  • 89
    • 0242668347 scopus 로고    scopus 로고
    • Pharmacophore and quantitative structure activity relationship (QSAR) modelling: Complementary approaches to the rationalisation and prediction of UDP-glucuronosyltransferase 1A4 (UGT1A4) substrate selectivity
    • Smith PA, Sorich MJ, McKinnon RA, Miners JO. Pharmacophore and quantitative structure activity relationship (QSAR) modelling: complementary approaches to the rationalisation and prediction of UDP-glucuronosyltransferase 1A4 (UGT1A4) substrate selectivity. J Med Chem 2002; 46: 1617-1626.
    • (2002) J Med Chem , vol.46 , pp. 1617-1626
    • Smith, P.A.1    Sorich, M.J.2    McKinnon, R.A.3    Miners, J.O.4
  • 90
    • 0036266180 scopus 로고    scopus 로고
    • Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9
    • Ethel BT, Ekins S, Wang JB, Burchell B. Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9. Drug Metab Dispos 2002; 30: 734-738.
    • (2002) Drug Metab Dispos , vol.30 , pp. 734-738
    • Ethel, B.T.1    Ekins, S.2    Wang, J.B.3    Burchell, B.4
  • 91
    • 0345117343 scopus 로고    scopus 로고
    • Comparison of linear and non-linear classification algorithms for the prediction of chemical metabolism by UDP-glucuronosyltransferase isoforms
    • Sorich MJ, McKinnon RA, Miners JO, Smith PA. Comparison of linear and non-linear classification algorithms for the prediction of chemical metabolism by UDP-glucuronosyltransferase isoforms. J Chem Inform Comp Sci 2003; 43: 2019-2024.
    • (2003) J Chem Inform Comp Sci , vol.43 , pp. 2019-2024
    • Sorich, M.J.1    McKinnon, R.A.2    Miners, J.O.3    Smith, P.A.4
  • 92
    • 4744373627 scopus 로고    scopus 로고
    • Rapid Prediction of Chemical Metabolism by Human UDP-glucuronosyltransferase Isoforms Using Quantum Chemical Descriptors Derived with the Electronegativity Equalisation Method
    • Sorich MJ, McKinnon RA, Miners JO, Winkler DA, Smith PA. Rapid Prediction of Chemical Metabolism by Human UDP-glucuronosyltransferase Isoforms Using Quantum Chemical Descriptors Derived with the Electronegativity Equalisation Method. J Med Chem 2004; 47: 5311-5317.
    • (2004) J Med Chem , vol.47 , pp. 5311-5317
    • Sorich, M.J.1    McKinnon, R.A.2    Miners, J.O.3    Winkler, D.A.4    Smith, P.A.5
  • 93
    • 33745798151 scopus 로고    scopus 로고
    • Methods to evaluate biliary excretion of drugs in humans: An updated review
    • Ghibellini G, Leslie EM, Brouwer KLR. Methods to evaluate biliary excretion of drugs in humans: An updated review. Mol Pharmaceut 2006; 3: 198-211.
    • (2006) Mol Pharmaceut , vol.3 , pp. 198-211
    • Ghibellini, G.1    Leslie, E.M.2    Brouwer, K.L.R.3
  • 94
    • 6944221357 scopus 로고    scopus 로고
    • Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
    • Williams JA, Hyland R, Jones BC, et al. Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos 2004; 32: 1201-1208.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1201-1208
    • Williams, J.A.1    Hyland, R.2    Jones, B.C.3
  • 97
    • 0030877478 scopus 로고    scopus 로고
    • Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates
    • Proost JH, Roggeveld J, Wierda JMKH, Meijer DKF. Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates. J Pharmacol Exp Ther 1997; 282: 715-726.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 715-726
    • Proost, J.H.1    Roggeveld, J.2    Wierda, J.M.K.H.3    Meijer, D.K.F.4
  • 98
    • 0015405449 scopus 로고
    • Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions
    • Hirom PC, Millburn P, Smith RL, Williams RT. Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions. Biochem J 1972; 129: 1071-1077.
    • (1972) Biochem J , vol.129 , pp. 1071-1077
    • Hirom, P.C.1    Millburn, P.2    Smith, R.L.3    Williams, R.T.4
  • 99
    • 0016915142 scopus 로고
    • Bile and urine as complementary pathways for the excretion of foreign organic compounds
    • Hirom PC, Millburn P, Smith RL. Bile and urine as complementary pathways for the excretion of foreign organic compounds. Xenobiotica 1976; 6: 55-64.
    • (1976) Xenobiotica , vol.6 , pp. 55-64
    • Hirom, P.C.1    Millburn, P.2    Smith, R.L.3
  • 100
    • 0033017134 scopus 로고    scopus 로고
    • Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats
    • Liu X, Chism JP, LeCluyse EL, Brouwer KR, Brouwer KL. Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats. Drug Metab Dispos 1999; 27: 637-644.
    • (1999) Drug Metab Dispos , vol.27 , pp. 637-644
    • Liu, X.1    Chism, J.P.2    LeCluyse, E.L.3    Brouwer, K.R.4    Brouwer, K.L.5
  • 101
    • 33747841593 scopus 로고    scopus 로고
    • Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport
    • Bi Y, Kazolias D, Duignan DB. Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport. Drug Metab Dispos 2006; 34: 1658-1665.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1658-1665
    • Bi, Y.1    Kazolias, D.2    Duignan, D.B.3
  • 102
    • 33644674142 scopus 로고    scopus 로고
    • Computational models for identifying potential P-glycoprotein substrates and inhibitors
    • Crivori P, Reinach B, Pezzetta D, Poggesi I. Computational models for identifying potential P-glycoprotein substrates and inhibitors. Mol Pharmaceut 2006; 3: 33-44.
    • (2006) Mol Pharmaceut , vol.3 , pp. 33-44
    • Crivori, P.1    Reinach, B.2    Pezzetta, D.3    Poggesi, I.4
  • 103
    • 33745786364 scopus 로고    scopus 로고
    • High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (Bile salt export pump) to predict drug-induced intrahepatic cholestasis
    • Hirano H, Kurata A, Onishi Y, et al. High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (Bile salt export pump) to predict drug-induced intrahepatic cholestasis. Mol Pharmaceut 2006; 3: 252-265.
    • (2006) Mol Pharmaceut , vol.3 , pp. 252-265
    • Hirano, H.1    Kurata, A.2    Onishi, Y.3
  • 104
    • 33748670458 scopus 로고    scopus 로고
    • Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    • Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 2006; 443: 173-179.
    • (2006) Nature , vol.443 , pp. 173-179
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Matsumoto, T.4    Yamaguchi, A.5
  • 105
    • 34247246745 scopus 로고    scopus 로고
    • Molecular modeling of PepT1 - Towards a structure
    • Meredith D, Price RA. Molecular modeling of PepT1 - Towards a structure. J Membr Biol 2006; 213: 79-88.
    • (2006) J Membr Biol , vol.213 , pp. 79-88
    • Meredith, D.1    Price, R.A.2
  • 106
    • 27144555426 scopus 로고    scopus 로고
    • A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2)
    • Zhang X, Shirahatti NV, Mahadevan D, Wright SH. A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2). J Biol Chem 2005; 280: 34813-34822.
    • (2005) J Biol Chem , vol.280 , pp. 34813-34822
    • Zhang, X.1    Shirahatti, N.V.2    Mahadevan, D.3    Wright, S.H.4
  • 107
    • 33846010171 scopus 로고    scopus 로고
    • A Three-dimensional model of human organic anion transporter 1
    • Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB. A Three-dimensional model of human organic anion transporter 1. J Biol Chem 2006; 281: 38071-38079.
    • (2006) J Biol Chem , vol.281 , pp. 38071-38079
    • Perry, J.L.1    Dembla-Rajpal, N.2    Hall, L.A.3    Pritchard, J.B.4
  • 108
    • 0036913910 scopus 로고    scopus 로고
    • Remarkable structural similarities between diverse glycosyltransferases
    • Hu YN, Walker S. Remarkable structural similarities between diverse glycosyltransferases. Chem Biol 2002; 9: 1287-1296.
    • (2002) Chem Biol , vol.9 , pp. 1287-1296
    • Hu, Y.N.1    Walker, S.2
  • 109
    • 0029853943 scopus 로고    scopus 로고
    • Structure-activity relationships for chemical and glutathione S-transferase-catalysed glutathione conjugation reactions of a series of 2-substituted 1-chloro-4-nitrobenzenes
    • Van der Aar EM, Bouwman T, Commandeur JNM, Vermeulen NPE. Structure-activity relationships for chemical and glutathione S-transferase-catalysed glutathione conjugation reactions of a series of 2-substituted 1-chloro-4-nitrobenzenes. J Biochem 1996; 320: 531-540.
    • (1996) J Biochem , vol.320 , pp. 531-540
    • Van der Aar, E.M.1    Bouwman, T.2    Commandeur, J.N.M.3    Vermeulen, N.P.E.4


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