Quantitative structure-activity relationships for predicting metabolism and modeling cytochrome P450 enzyme activities

Environmental Toxicology and Chemistry

Volumn 22, Issue 8, 2003, Pages 1894-1899

  Long, Anthony ^a   Walker, John D ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b TSCA Interagency Test Comm ITC   (United States)

Author keywords

Cytochrome P450; Lipophilicity; Quantitative structure activity relationships; Xenobiotic metabolism

Indexed keywords

HISTOLOGY; METABOLISM; MOLECULAR STRUCTURE; SUBSTRATES;

MOLECULAR FIELD ANALYSIS;

ENZYME KINETICS;

ALCOHOL DERIVATIVE; BENZENE DERIVATIVE; BENZOIC ACID DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; GLUCURONOSYLTRANSFERASE; ISOENZYME; NITROBENZENE DERIVATIVE; PHENOL DERIVATIVE; THIOL DERIVATIVE; LIPID; XENOBIOTIC AGENT;

DETOXIFICATION; ENZYME ACTIVITY; LIPOPHILICITY; MODEL; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; TOXICOKINETICS; XENOBIOTIC METABOLISM; ANIMAL; CHEMICAL STRUCTURE; FORECASTING; HUMAN; METABOLISM; SOLUBILITY; THEORETICAL MODEL;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; FORECASTING; HUMANS; LIPIDS; MODELS, THEORETICAL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOLUBILITY; XENOBIOTICS;

EID: 0142057081     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/01-480     Document Type: Review

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