Quantitative structure-activity relationships (QSARs) within substrates of human cytochromes P450 involved in drug metabolism

Drug Metabolism and Drug Interactions

Volumn 18, Issue 3-4, 2001, Pages 221-242

  Lewis, D F V ^a   Modi, S ^a   Dickins, M ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Cytochromes P450; Drug metabolism; Homology modelling; Quantitative structure activity relationships (QSARs); Substrate selectivity

Indexed keywords

2 (4 TERT BUTYLCYCLOHEXYL) 3 HYDROXY 1,4 NAPHTHOQUINONE; 3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; AMFEBUTAMONE; BENZPHETAMINE; CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIAZEPAM; DICLOFENAC; ESTRADIOL; ETHOXYCOUMARIN; ETHOXYRESORUFIN; IBUPROFEN; MEPHENYTOIN; PHENACETIN; PHENAZONE; QUINOLINE DERIVATIVE; RESORUFIN DERIVATIVE; TACRINE; TESTOSTERONE; THEOPHYLLINE; TOLBUTAMIDE; UNINDEXED DRUG; WARFARIN; ZOXAZOLAMINE;

ARTICLE; CATALYST; DRUG METABOLISM; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; LIVER MICROSOME; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0035676242     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2001.18.3-4.221     Document Type: Article

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