Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: Molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9

Biochemistry

Volumn 35, Issue 50, 1996, Pages 16205-16212

  Mancy, Annah ^a   Dijols, Sylvie ^a   Poli, Sonia ^a   Guengerich, F Peter ^b   Mansuy, Daniel ^a  

^a CNRS   (France)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE; CYTOCHROME P450; ETHOXYRESORUFIN DEETHYLASE; SULFAPHENAZOLE; TESTOSTERONE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; INHIBITION KINETICS; MICROSOME; NONHUMAN; PKA; PRIORITY JOURNAL; YEAST;

ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KINETICS; LIVER; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SPECTROPHOTOMETRY; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFAPHENAZOLE;

EID: 0030456054     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961950t     Document Type: Article

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