Toward minimalistic modeling of oral drug absorption

Journal of Molecular Graphics and Modelling

Volumn 17, Issue 5-6, 1999, Pages

  Oprea, Tudor I ^a   Gottfries, Johan ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Caco 2; Drug absorption; Hydrogen bonding; Intestinal absorption; Lipophilicity; Mannitol; Nonlinear model; Permeability; PLS; Polar surface area; QSAR; Sulfasalazine

Indexed keywords

DRUG DOSAGE; MECHANICAL PERMEABILITY; MOLECULAR STRUCTURE; ABSORPTION; ALCOHOLS; COMPUTER SIMULATION; HYDROGEN BONDS; MATHEMATICAL MODELS; NONLINEAR EQUATIONS; PHARMACODYNAMICS;

CANDIDATE DRUGS; HUMAN INTESTINAL ABSORPTION (HIA); HYDROGEN-BONDING CAPACITY; LIPOPHILICITY; MANNITOL; ORAL DRUG ABSORPTION; SULFASALAZINE;

MOLECULAR GRAPHICS; DRUG INFUSION;

ACEBUTOLOL; ACETYLSALICYLIC ACID; ACRIVASTINE; ALPRENOLOL; AMFEBUTAMONE; AMOXICILLIN; ATENOLOL; BETAXOLOL; BROMAZEPAM; BUMETANIDE; CAFFEINE; CAPTOPRIL; CEFALEXIN; CEFATRIZINE; CEFUROXIME; CEFUROXIME AXETIL; CHLORAMPHENICOL; CIMETIDINE; CLONIDINE; CORTICOSTERONE; CROMOGLYCATE DISODIUM; DESIPRAMINE; DEXAMETHASONE; DIAZEPAM; DOXORUBICIN; ENALAPRILAT; ETOPOSIDE; PARACETAMOL; PHENAZONE; UNINDEXED DRUG;

ARTICLE; DRUG ABSORPTION; DRUG PENETRATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; LIPOPHILICITY; MATHEMATICAL MODEL; MOLECULAR SIZE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY;

EID: 0033300143     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(99)00034-0     Document Type: Article

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