A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2)

Journal of Biological Chemistry

Volumn 280, Issue 41, 2005, Pages 34813-34822

  Zhang, Xiaohong ^a   Shirahatti, Nikhil V ^a   Mahadevan, Daruka ^a   Wright, Stephen H ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPUTER SIMULATION; CORRELATION METHODS; HYDROPHILICITY; MUTAGENESIS; POSITIVE IONS; PROTEINS;

HOMOLOGY; ORTHOLOGS; PUTATIVE DOCKING REGION; SUBSTRATE BINDING;

IONIC DRUGS;

1 METHYL 4 PHENYLPYRIDINIUM; AMINO ACID; ARGININE; ASPARAGINE; CARRIER PROTEIN; CIMETIDINE; GLUTAMIC ACID; ISOLEUCINE; LEUCINE; LYSINE; OCTAMER TRANSCRIPTION FACTOR 2; PROTEIN OCT1; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG ELIMINATION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; RABBIT; SITE DIRECTED MUTAGENESIS;

1-METHYL-4-PHENYLPYRIDINIUM; AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CATIONS; CHO CELLS; CRICETINAE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; GLUTAMIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; KINETICS; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORGANIC CATION TRANSPORT PROTEINS; PHENOTYPE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; SUBSTRATE SPECIFICITY; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 27144555426     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506342200     Document Type: Article

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