Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis

Progress in Drug Research

Volumn 54, Issue , 2000, Pages 1-23

  Ren, Shijun ^a   Lien, Eric J ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Caco 2 cells; Calculated partition coefficient (Clog P); Distribution coefficient (log D(oct)); Hydrogen bonding; Oral absorption; Permeability; QSAR

Indexed keywords

ALPRENOLOL; AMINOPHENAZONE; CAFFEINE; CHLORPROMAZINE; CLONIDINE; CORTICOSTERONE; DESIPRAMINE; DEXAMETHASONE; DIAZEPAM; ESTRADIOL; GRISEOFULVIN; HYDROCORTISONE; INDOMETACIN; MELOXICAM; METOPROLOL; NEVIRAPINE; NICOTINE; PHENCYCLIDINE; PHENYTOIN; PINDOLOL; PIROXICAM; PROGESTERONE; PROPRANOLOL; SALICYLIC ACID; SCOPOLAMINE; TELMISARTAN; TESTOSTERONE; TIMOLOL; UNINDEXED DRUG; WARFARIN;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; COMPUTER ANALYSIS; DRUG ABSORPTION; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN CELL; HYDROGEN BOND; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0034068583     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-0348-8391-7_1     Document Type: Article

References (35)

1. Hidalgo J., Raub T.J. and Birchardt R.T.: Gastroenterology 96, 736-749 (1989).
2. Artursson P. and Karlsson J.: Biochem. Biophys. Res. Commun. 175, 880-885 (1991).
3. Artursson P.: J. Pharm. Sci. 79, 476-482 (1990).
4. Wilson G., Hassan I., Dix C., Williamson I., Shah R., Mackay M. and Artursson P.:J. Control. Release 11, 25-40 (1990).
5. Hilgers A., Conradi R. and Burton P.: Pharm. Res. 7, 902-910 (1990).
6. Cogburn J., Donovan M. and Schasteen C.: Pharm. Res. 8, 210-216 (1991).
7. Yee S.: Pharm. Res. 14, 763-766 (1997).
8. Sugawara M., Takekuma Y., Yamada H., Kobayashi M., Iseki K. and Miyazaki K.: J. Pharm. Sci. 87, 960-966 (1998).
9. Burton P.S., Conradi R.A., Ho N.F.H., Hilgers A.R. and Borchardt R.T.: J. Pharm. Sci. 85, 1336-1340 (1996).
10. Norinder U., Osterberg T. and Artursson P.: Pharm. Res. 14, 1786-1791 (1997).
11. van de Waterbeemd H. and Camenisch G.: Quant. Struct.-Act. Relat. 15, 480-490 (1996).
12. Palm K., Luthman K., Ungell A., Strandlund G. and Artursson P.:J. Pharm. Sci. 85, 32-39 (1996).
13. Krarup L.H., Christensen I.T., Hovgaard L. and Frokjaer S.: Pharm. Res. 15, 972-978 (1998).
14. Lien E.J.: Drug Intell. Clin. Pharmacol. 4, 7-9 (1970).
15. Lien E.J., in: J. Maas (ed.): Medicinal Chemistry IV. Proceedings of the 4th international symposium on medicinal chemistry. Amsterdam 1974, 319-342.
16. Lien E.J., in: E.J. Ariens (ed.): Drug Design. Academic Press, New York 1976, 81-132.
17. Lien E.J.: Prog. Drug Res. 29, 67-95 (1985).
18. Lien E.J.: SAR Side Effects and Drug Design. Marcel Dekker, Inc., New York and Basel 1987, 92-154.
19. Lien E.J. and Gao H.: Pharm. Res. 12, 583-587 (1995).
20. Ren S., Das A. and Lien E.J.:J. Drug Target. 4, 103-107 (1996).
21. Chiou W.L. and Barve A.: Pharm. Res. 15, 1792-1795 (1998).
22. Chiou W.L., Robbie G., Chung S.M., Wu T.C. and Ma C.: Pharm. Res. 15, 1474-1479 (1998).
23. Chiou W.L.: Biopharm. Drug Disp. 16, 71-75 (1995).
24. Yazdanian M., Glynn S.L., Wright J.L. and Hawi A.: Pharm. Res. 15, 1490-1494 (1998).
25. Gres M., Julian B., Bourrie M., Meunier V., Roques C., Berger M., Boulenc X., Berger Y. and Fabre G.: Pharm. Res. 15, 726-733 (1998).
26. Chong S., Dando S.A., Soucek K.M. and Morrison R.A.: Pharm. Res. 13, 120-123 (1996).
27. Walter E., Janich S., Roessler B.J., Hilfinger J.M. and Amidon G.L.: J. Pharm. Sci. 85, 1070-1076 (1996).
28. Rubas W., Jezyk N. and Grass G.M.: Pharm. Res. 10, 113-118 (1993).
29. Stewart B.H., Chan O.H., Lu R.H., Reyner E.L., Schmid H.L., Hamilton H.W., Steinbaugn B.A. and Taylor M.D.: Pharm. Res. 12, 693-699 (1995).
30. BioByte Corp.: CQSAR database, 201 W 4th Street, Suite 204, Claremont, CA 91711, USA (1999).
31. Hypercube, Inc.: HyperChem for Window, Version 5.0, 1115 NW 4th Street, Gainesville, FL 32601, USA (1996).
32. Stryer L.: Biochemistry, 3rd edition. W. H. Freeman and Company, New York 1988, 7-8.
33. Foye W.O., Lemke T.L. and Williams D.A.: Principles of Medicinal Chemistry. Williams & Wilkins, Media, PA 1995, 948-961.
34. Lien E.J., in: J. Swarbrick and J.C. Boylan (eds.): Encyclopedia of Pharmaceutical Technology. Marcel Dekker, New York 1995, Vol. 11, 293-307.
35. Masaki B.W., Lien E.J. and Biles J.A.: Acta Pharm. Suecica 10, 43-52 (1973).