메뉴 건너뛰기




Volumn 9, Issue 12, 2008, Pages 1960-1967

Relating chemical and biological diversity space: A tunable system for efficient gene transfection

Author keywords

Chemical space; Combinatorial chemistry; Gene technology; Nonviral gene delivery; Polyethyleneimine

Indexed keywords

LIPOFECTAMINE; POLYETHYLENEIMINE;

EID: 54349109353     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800003     Document Type: Article
Times cited : (11)

References (85)
  • 9
    • 32444450342 scopus 로고    scopus 로고
    • J. Dobson, Gene Ther. 2006, 13, 283-287.
    • (2006) Gene Ther , vol.13 , pp. 283-287
    • Dobson, J.1
  • 20
    • 54349124982 scopus 로고    scopus 로고
    • A. J. Kirby, P. Camilleri, J. B. Engberts, M. C. Feiters, R. J. Nolte, O. Soderman, M. Bergsma, P. C. Bell, M. L. Fielden, C. L. Garcia Rodriguez, P. Guedat, A. Kremer, C. McGregor, C. Perrin, G. Ronsin, M. C. van Eijk, Angew. Chem. 2003, 715, 1486-1496; Angew Chem. Int. Ed. 2003, 42, 1448-1457.
    • A. J. Kirby, P. Camilleri, J. B. Engberts, M. C. Feiters, R. J. Nolte, O. Soderman, M. Bergsma, P. C. Bell, M. L. Fielden, C. L. Garcia Rodriguez, P. Guedat, A. Kremer, C. McGregor, C. Perrin, G. Ronsin, M. C. van Eijk, Angew. Chem. 2003, 715, 1486-1496; Angew Chem. Int. Ed. 2003, 42, 1448-1457.
  • 30
    • 54349117865 scopus 로고    scopus 로고
    • A. D. Miller, Angew. Chem. 1998, 110, 1862-1880; Angew. Chem. Int. Ed. 1998, 37, 1768-1785.
    • A. D. Miller, Angew. Chem. 1998, 110, 1862-1880; Angew. Chem. Int. Ed. 1998, 37, 1768-1785.
  • 34
    • 54349088874 scopus 로고    scopus 로고
    • Ph.D. thesis, University of Cambridge
    • C. McGregor, Ph.D. thesis, University of Cambridge, 2001.
    • (2001)
    • McGregor, C.1
  • 40
    • 54349101409 scopus 로고    scopus 로고
    • D. G. Anderson, D. M. Lynn, R. Langer, Angew. Chem. 2003, 115, 3261-3266; Angew. Chem. Int. Ed. 2003, 42, 3153-3158.
    • b) D. G. Anderson, D. M. Lynn, R. Langer, Angew. Chem. 2003, 115, 3261-3266; Angew. Chem. Int. Ed. 2003, 42, 3153-3158.
  • 46
    • 54349102192 scopus 로고    scopus 로고
    • M. Mammen, S. K. Choi, G. M. Whitesides, Angew. Chem. 1998, 110, 2908-2953; Angew. Chem. Int. Ed. 1998, 37, 2754-2794;
    • a) M. Mammen, S. K. Choi, G. M. Whitesides, Angew. Chem. 1998, 110, 2908-2953; Angew. Chem. Int. Ed. 1998, 37, 2754-2794;
  • 47
    • 54349124475 scopus 로고    scopus 로고
    • R. Haag, F. Kratz, Angew. Chem. 2006, 118, 1218-1237; Angew. Chem. Int. Ed. 2006, 45, 1198-1215.
    • b) R. Haag, F. Kratz, Angew. Chem. 2006, 118, 1218-1237; Angew. Chem. Int. Ed. 2006, 45, 1198-1215.
  • 53
    • 11144341956 scopus 로고    scopus 로고
    • b) C. M. Dobson, Nature 2004, 432, 824-828.
    • (2004) Nature , vol.432 , pp. 824-828
    • Dobson, C.M.1
  • 57
    • 0002508948 scopus 로고    scopus 로고
    • a) J. Suh, Synlett 2001, 1343-1363;
    • (2001) Synlett , pp. 1343-1363
    • Suh, J.1
  • 60
    • 54349106306 scopus 로고    scopus 로고
    • I. Klotz in Enzyme Mechanisms (Eds.: M. I. Page, A. Williams), Royal Society of Chemistry, London, 1987, pp. 14-34;
    • d) I. Klotz in Enzyme Mechanisms (Eds.: M. I. Page, A. Williams), Royal Society of Chemistry, London, 1987, pp. 14-34;
  • 61
    • 84890994442 scopus 로고    scopus 로고
    • Ed, R. Breslow, Wiley-Vch, Weinheim
    • e) I. M. Klotz, J. Suh in Artificial Enzymes (Ed.: R. Breslow), Wiley-Vch, Weinheim, 2005, pp. 63-88.
    • (2005) Artificial Enzymes , pp. 63-88
    • Klotz, I.M.1    Suh, J.2
  • 62
    • 54349126073 scopus 로고    scopus 로고
    • Figure S9 in the Supporting Information shows a comparison between the percentage of cells that express EGFP and total fluorescence intensity used frequently in other studies
    • Figure S9 in the Supporting Information shows a comparison between the percentage of cells that express EGFP and total fluorescence intensity (used frequently in other studies). These parameters are linearly related for the set of conditions used in this study.
    • These parameters are linearly related for the set of conditions used in this study
  • 67
    • 54349121454 scopus 로고    scopus 로고
    • [30] However, the DNA at the concentration used in this study does not transfect significantly.
    • [30] However, the DNA at the concentration used in this study does not transfect significantly.
  • 72
    • 19444372923 scopus 로고    scopus 로고
    • S. M. Moghimi, P. Symonds, J. C. Murray, A. C. Hunter, G. Debska, A. Szewczyk, Mol. Ther. 2005, 11, 990-995.
    • S. M. Moghimi, P. Symonds, J. C. Murray, A. C. Hunter, G. Debska, A. Szewczyk, Mol. Ther. 2005, 11, 990-995.
  • 85
    • 54349094179 scopus 로고    scopus 로고
    • Propidium iodide stained cells that have survived a washing step could have internal damage that leads to a long-term (overnight) effect of a particular compound that has entered the cell. This common toxicity measure merely describes the amount of damage to cells that die as the transfection reagents enter the cell. After overnight incubation these cells are no longer viable, and would be washed away. To account for this, we measured the total count of cells per unit per well
    • Propidium iodide stained cells that have survived a washing step could have internal damage that leads to a "long-term" (overnight) effect of a particular compound that has entered the cell. This common toxicity measure merely describes the amount of damage to cells that die as the transfection reagents enter the cell. After overnight incubation these cells are no longer viable, and would be washed away. To account for this, we measured the total count of cells per unit per well.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.