Negligible induction of IFN-γ, IL-12 and TNF-α by DNA-PEI 750 kDa/albumin complexes

Cytokine

Volumn 29, Issue 6, 2005, Pages 283-287

  Smolarczyk, Ryszard ^a   Cichoń, Tomasz ^a   Sochanik, Aleksander ^a   Szala, Stanisław ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

CpG; PEI 750 kDa; Pro inflammatory cytokines; Pro inflammatory response

Indexed keywords

ALBUMIN; DEXAMETHASONE; DNA; DRUG CARRIER; GAMMA INTERFERON; INTERLEUKIN 12; LIPOSOME; PLASMID DNA; POLYETHYLENEIMINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA SEQUENCE; DNA TRANSFER; GENE TRANSFER; IN VIVO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REPORTER GENE; SEQUENCE ANALYSIS; SERUM;

EID: 14644414242     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2004.11.010     Document Type: Article

References (22)

1. A. Bragonzi, G. Dina, A. Villa, G. Calori, A. Biffi, and C. Bordignon Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs Gene Ther 7 2000 1753 1760
2. F.M. Orson, L. Song, A. Gautam, C.L. Densmore, B.S. Bhogal, and B.M. Kinsey Gene delivery to the lung using protein/polyethylenimine/plasmid complexes Gene Ther 9 2002 463 471
3. Y.-K. Oh, J.-P. Kim, H. Yoon, J.-S. Yang, and C.-K. Kim Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexes Gene Ther 8 2001 1587 1592
4. M.A. Ilies, and A.T. Balaban Recent developments in cationic lipid-mediated gene delivery and gene therapy Expert Opin Ther Patents 11 2001 1729 1752
5. A. El-Aneed An overview of current delivery systems in cancer gene therapy J Control Release 94 2004 1 14
6. M.C. Pedroso de Lima, S. Simoes, P. Pires, H. Faneca, and N. Duzgunes Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications Adv Drug Deliv Rev 47 2001 277 294
7. W.T. Godbey, and A.G. Mikos Recent progress in gene delivery using non-viral transfer complexes J Control Release 72 2001 115 125
8. R. Kircheis, L. Wightman, M. Kursa, E. Ostermann, and E. Wagner Tumor-targeted gene delivery: an attractive strategy to use highly active effector molecules in cancer treatment Gene Ther 9 2002 731 735
9. S. Li, W.-C. Tseng, D. Beer Stolz, S.-P. Wu, S.C. Watkins, and L. Huang Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection Gene Ther 6 1999 585 594
10. S. Li, S.P. Wu, M. Whitmore, E.J. Loeffert, L. Wang, and S.C. Watkins Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors Am J Physiol 276 1999 L796 L804
11. F. Sakurai, T. Terada, K. Yasuda, F. Yamashita, Y. Takakura, and M. Hashida The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes Gene Ther 9 2002 1120 1126
12. J.D. Tousignant, A.L. Gates, L.A. Ingram, C.L. Johnson, J.B. Nietupski, and S.H. Cheng Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice Hum Gene Ther 11 2000 2493 2513
13. J.D. Tousignant, H. Zhao, N.S. Yew, S.H. Cheng, S.J. Eastman, and R.K. Scheule DNA sequences in cationic lipid:pDNA-mediated systemic toxicities Hum Gene Ther 14 2003 203 214
14. D.M. Klinman Immunotherapeutic uses of CpG oligodeoxynucleotides Nature 4 2004 1 10
15. A.M. Krieg CpG Motifs: the active ingredient in bacterial extracts? Nat Med 9 2003 831 835
16. C.R. Hofman, J.P. Dileo, Z. Li, S. Li, and L. Huang Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity Gene Ther 8 2001 71 74
17. Y. Tan, F. Liu, Z. Li, S. Li, and L. Huang Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity Mol Ther 3 2001 673 682
18. N.S. Yew, K.X. Wang, M. Przybylska, R.G. Bagley, M. Stedman, and J. Marshall Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes Hum Gene Ther 10 1999 223 224
19. M. Whitmore, S. Li, and L. Huang LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth Gene Ther 6 1999 1867 1875
20. N.S. Yew, H. Zhao, I.H. Wu, A. Song, J.D. Tousignant, and M. Przybylska Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs Mol Ther 1 2000 255 262
21. A. Bragonzi, A. Boletta, A. Biffi, A. Muggia, G. Sersale, and S.H. Cheng Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs Gene Ther 6 1999 1995 2004
22. Y. Tan, S. Li, B.R. Pitt, and L. Huang The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo Hum Gene Ther 10 1999 2153 2161