Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 16, 2005, Pages 5679-5684

  Thomas, Mini ^a   Lu, James J ^a,b   Ge, Qing ^a   Zhang, Chengcheng ^c   Chen, Jianzhu ^a   Klibanov, Alexander M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Flu therapy; Influenza; Linear polyethylenimine; Short interfering RNA; Transfection

Indexed keywords

ACID; LUCIFERASE; NITROGEN; NUCLEIC ACID; NUCLEOCAPSID PROTEIN; OXAZOLINE DERIVATIVE; PLASMID DNA; POLY(2 ETHYL 2 OXAZOLINE); POLYCATION; POLYETHYLENEIMINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DEACYLATION; ENDOSOME; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA; INFLUENZA VIRUS; LUNG; LUNG DISEASE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; SYNTHESIS; TISSUE SPECIFICITY; VIRUS LOAD;

ACYLATION; ANIMALS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; HUMANS; INFLUENZA, HUMAN; LUNG; MICE; ORTHOMYXOVIRIDAE; POLYETHYLENEIMINE; RNA, SMALL INTERFERING;

EID: 17644418754     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502067102     Document Type: Article

References (32)

1. Nathwani, A. C., Davidoff, A. M. & Tuddenham, E. G. (2004) Haemophilia 10, 309-318.
2. Lee, T. W., Matthews, D. A. & Blair, G. E. (January 19, 2005) Biochem. J., 10.1042/BJ20041923.
3. Izquierdo, M. (2005) Cancer Gene Ther. 12, 217-227.
4. Anderson, D. G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R., Langer, R. & Sawicki, J. A. (2004) Proc. Natl. Acad. Sci. USA 101, 16028-16033.
5. Quarck, R. & Holvoet, P. (2004) Curr. Gene Ther. 4, 207-223.
6. Lowenstein, P. R. & Castro, M. G. (2004) Curr. Opin. Pharmacol. 4, 91-97.
7. Fanning, G., Amado, R. & Symonds, G. (2003) J. Gene Med. 5, 645-653.
8. Thomas, M. & Klibanov, A. M. (2003) Appl. Microbiol. Biotechnol. 62, 27-34.
9. Kaiser, J. (2004) Science 304, 1423-1425.
10. Marshall, E. (1999) Science 286, 2244-2245.
11. Check, E. (2005) Nature 433, 561.
12. Marshall, E. (2001) Science 294, 2268-2269.
13. Liu, Y., Fong, S. & Debs, R. J. (2003) Methods Enzymol. 373, 536-550.
14. Thomas, M. & Klibanov, A. M. (2002) Proc. Natl. Acad. Sci. USA 99, 14640-14645.
15. Diebold, S. S., Kursa, M., Wagner, E., Cotten, M. & Zenke, M. (1999) J. Biol. Chem. 274, 19087-19094.
16. Thomas, M., Ge, Q., Lu, J. J., Chen, J. & Klibanov, A. M. (2005) Pharm. Res. 22, in press.
17. Forrest, M. L., Meister, G. E., Koerber, J. T. & Pack, D. W. (2004) Pharm. Res. 21, 365-371.
18. Thomas, M. & Klibanov, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 9138-9143.
19. Akinc, A., Thomas, M., Klibanov, A. M. & Langer, R. (November 15, 2004) J. Gene. Med., 10.1002/jgm.696.
20. Sonawane, N. D., Szoka, F. C. J. & Verkman, A. S. (2003) J. Biol. Chem. 278, 44826-44831.
21. Pham, P. L., Perret, S., Doan, H. C., Cass, B., St-Laurent, G., Kamen, A. & Durocher, Y. (2003) Biotechnol. Bioeng. 84, 332-342.
22. Derouazi, M., Girard, P., Van Tilborgh, F., Iglesias, K., Muller, N., Bertschinger, M. & Wurm, F. M. (2004) Biotechnol. Bioeng. 87, 537-545.
23. Choosakoonkriang, S., Lobo, B. A., Koe, G. S., Koe, J. G. & Middaugh, C. R. (2003) J. Pharm. Sci. 92, 1710-1722.
24. Fischer, D., von Harpe, A., Kunath, K., Petersen, H., Li, Y. & Kissel, T. (2002) Bioconjugate Chem. 13, 1124-1133.
25. Hoogenboom, R., Fijten, M. W. M., Brandli, C., Schroer, J. & Schubert, U. S. (2003) Macromol. Rapid Commun. 24, 98-103.
26. Jeong, J. H., Song, S. H., Lim, D. W., Lee, H. & Park, T. G. (2001) J. Controlled Release 73, 391-399.
27. Kunath, K., von Harpe, A., Fischer, D. & Kissel, T. (2003) J. Controlled Release 88, 159-172.
28. Lee, J. H., Lim, Y. B., Choi, J. S., Lee, Y., Kim, T. I., Kim, H. J., Yoon, J. K., Kim, K. & Park, J. S. (2003) Bioconjugate Chem. 14, 1214-1221.
29. Praia, C. A., Zhao, Y., Barthelemy, P., Li, Y., Luo, D., McIntosh, T. J., Lee, S. J. & Grinstaff, M. W. (2004) J. Am. Chem. Soc. 126, 12196-12197.
30. Agu, R. M., Ugwoke, M. I., Armand, M., Kinget, R. & Verbeke, N. (2001) Respir. Res. 2, 198-209.
31. Ge, Q., McManus, M. T., Nguyen, T., Shen, C. H., Sharp, P. A., Eisen, H. N. & Chen, J. (2003) Proc. Natl. Acad. Sci. USA 100, 2718-2723.
32. Epstein, S. L., Tumpey, T. M., Misplon, J. A., Lo, C. Y., Cooper, L. A., Subbarao, K., Renshaw, M., Sambhara, S. & Katz, J. M. (2002) Emerging Infect. Dis. 8, 796-801.