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Volumn 128, Issue 11, 2008, Pages 2575-2595

Melanoma genetics and therapeutic approaches in the 21st century: Moving from the benchside to the bedside

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; 5 AZA 2' DEOXYCYTIDINE; 5,6 DIHYDROAZACITIDINE; ANTHRAX LETHAL TOXIN; ANTISENSE OLIGONUCLEOTIDE; BACTERIAL TOXIN; BORTEZOMIB; CARBOPLATIN; CHIR 265; CISPLATIN; DACARBAZINE; DOCETAXEL; EVEROLIMUS; FAZARABINE; GOSSYPOL; IMATINIB; ISIS 2503; LONAFARNIB; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; OBATOCLAX; OBLIMERSEN; PACLITAXEL; PLX 4032; PROTEIN NOXA; SORAFENIB; STEM CELL FACTOR; TEMOZOLOMIDE; TEMSIROLIMUS; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 53949103143     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.226     Document Type: Note
Times cited : (159)

References (205)
  • 1
    • 20144375230 scopus 로고    scopus 로고
    • Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background
    • Ackermann J, Frutschi M, Kaloulis K, McKee T, Trumpp A, Beermann F (2005) Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res 65:4005-11
    • (2005) Cancer Res , vol.65 , pp. 4005-4011
    • Ackermann, J.1    Frutschi, M.2    Kaloulis, K.3    McKee, T.4    Trumpp, A.5    Beermann, F.6
  • 2
    • 13144281830 scopus 로고    scopus 로고
    • BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience
    • Ahmad T, Marais R, Pyle L, James M, Schwartz B, Gore M et al. (2004) BAY 43-9006 in patients with advanced melanoma: the Royal Marsden experience. J Clin Oncol 22:7506
    • (2004) J Clin Oncol , vol.22 , pp. 7506
    • Ahmad, T.1    Marais, R.2    Pyle, L.3    James, M.4    Schwartz, B.5    Gore, M.6
  • 3
    • 34247149015 scopus 로고    scopus 로고
    • The regulation of cyclin D1 degradation: Roles in cancer development and the potential for therapeutic invention
    • Alao JP (2007) The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 6:24
    • (2007) Mol Cancer , vol.6 , pp. 24
    • Alao, J.P.1
  • 4
    • 0021258276 scopus 로고
    • Transforming ras genes from human melanoma: A manifestation of tumour heterogeneity?
    • Albino AP, Le Strange R, Oliff AI, Furth ME, Old LJ (1984) Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity? Nature 308:69-72
    • (1984) Nature , vol.308 , pp. 69-72
    • Albino, A.P.1    Le Strange, R.2    Oliff, A.I.3    Furth, M.E.4    Old, L.J.5
  • 5
    • 33748349941 scopus 로고    scopus 로고
    • Preliminary results of a randomized phase II study comparing two schedules of temozolomide in combination with sorafenib in patients with advanced melanoma
    • Amaravadi RK, Schuchter LM, Kramer A, Barth SF, Villanueva J, Troxel AB et al. (2006) Preliminary results of a randomized phase II study comparing two schedules of temozolomide in combination with sorafenib in patients with advanced melanoma. J Clin Oncol 24:8009
    • (2006) J Clin Oncol , vol.24 , pp. 8009
    • Amaravadi, R.K.1    Schuchter, L.M.2    Kramer, A.3    Barth, S.F.4    Villanueva, J.5    Troxel, A.B.6
  • 6
    • 3142745263 scopus 로고    scopus 로고
    • Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: Implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma
    • Amiri KI, Horton LW, LaFleur BJ, Sosman JA, Richmond A (2004) Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma. Cancer Res 64:4912-8
    • (2004) Cancer Res , vol.64 , pp. 4912-4918
    • Amiri, K.I.1    Horton, L.W.2    LaFleur, B.J.3    Sosman, J.A.4    Richmond, A.5
  • 7
    • 0033580219 scopus 로고    scopus 로고
    • Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis
    • Arriola EL, Rodriguez-Lopez AM, Hickman JA, Chresta CM (1999) Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis. Oncogene 18:1457-64
    • (1999) Oncogene , vol.18 , pp. 1457-1464
    • Arriola, E.L.1    Rodriguez-Lopez, A.M.2    Hickman, J.A.3    Chresta, C.M.4
  • 8
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281:1305-1308
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 9
    • 53949091699 scopus 로고    scopus 로고
    • Aziz SA, Pick-Golan E, McCarthy MM, Flaherty KT, Camp RL, Rimm DL et al. (2007) 2007 ASCO annual meeting proceedings Part I. J Clin Oncol 25:8521
    • Aziz SA, Pick-Golan E, McCarthy MM, Flaherty KT, Camp RL, Rimm DL et al. (2007) 2007 ASCO annual meeting proceedings Part I. J Clin Oncol 25:8521
  • 10
    • 38349041706 scopus 로고    scopus 로고
    • Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL
    • Bae SI, Cheriyath V, Jacobs BS, Reu FJ, Borden EC (2008) Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL. Oncogene 27:490-8
    • (2008) Oncogene , vol.27 , pp. 490-498
    • Bae, S.I.1    Cheriyath, V.2    Jacobs, B.S.3    Reu, F.J.4    Borden, E.C.5
  • 11
    • 0021934042 scopus 로고
    • Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18
    • Bakhshi A, Jensen JP, Goldman P, Wright JJ, McBride OW, Epstein AL et al. (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41:899-906
    • (1985) Cell , vol.41 , pp. 899-906
    • Bakhshi, A.1    Jensen, J.P.2    Goldman, P.3    Wright, J.J.4    McBride, O.W.5    Epstein, A.L.6
  • 12
    • 0035881074 scopus 로고    scopus 로고
    • Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma
    • Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG et al. (2001) Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19:3635-48
    • (2001) J Clin Oncol , vol.19 , pp. 3635-3648
    • Balch, C.M.1    Buzaid, A.C.2    Soong, S.J.3    Atkins, M.B.4    Cascinelli, N.5    Coit, D.G.6
  • 13
    • 23044441106 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
    • Banerji U, O'Donnell A, Scurr M, Pacey S, Stapleton S, Asad Y et al. (2005) Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 23:4152-61
    • (2005) J Clin Oncol , vol.23 , pp. 4152-4161
    • Banerji, U.1    O'Donnell, A.2    Scurr, M.3    Pacey, S.4    Stapleton, S.5    Asad, Y.6
  • 15
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/ Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova J, Lukas J, Guldberg P, Alsner J, Kirkin AF, Zeuthen J et al. (1996) The p16-cyclin D/ Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 56:5475-83
    • (1996) Cancer Res , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3    Alsner, J.4    Kirkin, A.F.5    Zeuthen, J.6
  • 16
    • 0034072726 scopus 로고    scopus 로고
    • Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin
    • Bastian BC, Kashani-Sabet M, Hamm H, Godfrey T, Moore DH II, Brocker EB et al. (2000a) Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res 60:1968-73
    • (2000) Cancer Res , vol.60 , pp. 1968-1973
    • Bastian, B.C.1    Kashani-Sabet, M.2    Hamm, H.3    Godfrey, T.4    Moore II, D.H.5    Brocker, E.B.6
  • 17
    • 0032523833 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
    • Bastian BC, LeBoit PE, Hamm H, Brocker EB, Pinkel D (1998) Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 58:2170-5
    • (1998) Cancer Res , vol.58 , pp. 2170-2175
    • Bastian, B.C.1    LeBoit, P.E.2    Hamm, H.3    Brocker, E.B.4    Pinkel, D.5
  • 18
    • 0034491067 scopus 로고    scopus 로고
    • Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features
    • Bastian BC, LeBoit PE, Pinkel D (2000b) Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 157:967-72
    • (2000) Am J Pathol , vol.157 , pp. 967-972
    • Bastian, B.C.1    LeBoit, P.E.2    Pinkel, D.3
  • 19
    • 33845726945 scopus 로고    scopus 로고
    • Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations
    • Bauer J, Curtin JA, Pinkel D, Bastian BC (2007) Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J Invest Dermatol 127:179-82
    • (2007) J Invest Dermatol , vol.127 , pp. 179-182
    • Bauer, J.1    Curtin, J.A.2    Pinkel, D.3    Bastian, B.C.4
  • 20
    • 33750600634 scopus 로고    scopus 로고
    • Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The Oblimersen Melanoma Study Group
    • Bedikian AY, Millward M, Pehamberger H, Conry R, Gore M, Trefzer U et al. (2006) Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group. J Clin Oncol 24:4738-45
    • (2006) J Clin Oncol , vol.24 , pp. 4738-4745
    • Bedikian, A.Y.1    Millward, M.2    Pehamberger, H.3    Conry, R.4    Gore, M.5    Trefzer, U.6
  • 21
    • 0038457477 scopus 로고    scopus 로고
    • Human melanocyte senescence and melanoma susceptibility genes
    • Bennett DC (2003) Human melanocyte senescence and melanoma susceptibility genes. Oncogene 22:3063-9
    • (2003) Oncogene , vol.22 , pp. 3063-3069
    • Bennett, D.C.1
  • 22
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6-21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 23
    • 0035992780 scopus 로고    scopus 로고
    • Valproate and valproate-analogues: Potent tools to fight against cancer
    • Blaheta RA, Nau H, Michaelis M, Cinatl J Jr (2002) Valproate and valproate-analogues: potent tools to fight against cancer. Curr Med Chem 9:1417-33
    • (2002) Curr Med Chem , vol.9 , pp. 1417-1433
    • Blaheta, R.A.1    Nau, H.2    Michaelis, M.3    Cinatl Jr, J.4
  • 24
    • 33846205132 scopus 로고    scopus 로고
    • Temozolomide in advanced malignant melanoma with small brain metastases: Can we withhold cranial irradiation?
    • Boogerd W, de Gast GC, Dalesio O (2007) Temozolomide in advanced malignant melanoma with small brain metastases: can we withhold cranial irradiation? Cancer 109:306-12
    • (2007) Cancer , vol.109 , pp. 306-312
    • Boogerd, W.1    de Gast, G.C.2    Dalesio, O.3
  • 26
    • 19544371601 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and malignant melanoma
    • Boyle GM, Martyn AC, Parsons PG (2005) Histone deacetylase inhibitors and malignant melanoma. Pigment Cell Res 18:160-6
    • (2005) Pigment Cell Res , vol.18 , pp. 160-166
    • Boyle, G.M.1    Martyn, A.C.2    Parsons, P.G.3
  • 27
    • 13944273767 scopus 로고    scopus 로고
    • Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    • Carreira S, Goodall J, Aksan I, La Rocca SA, Galibert MD, Denat L et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433:764-9
    • (2005) Nature , vol.433 , pp. 764-769
    • Carreira, S.1    Goodall, J.2    Aksan, I.3    La Rocca, S.A.4    Galibert, M.D.5    Denat, L.6
  • 28
    • 0034698141 scopus 로고    scopus 로고
    • The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
    • Carreira S, Liu B, Goding CR (2000) The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. J Biol Chem 275:21920-7
    • (2000) J Biol Chem , vol.275 , pp. 21920-21927
    • Carreira, S.1    Liu, B.2    Goding, C.R.3
  • 29
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    • Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M et al. (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725-30
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3    Lin, H.K.4    Dotan, Z.A.5    Niki, M.6
  • 30
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T et al. (2001) BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8:705-711
    • (2001) Mol Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lindsten, T.6
  • 31
    • 40749122965 scopus 로고    scopus 로고
    • Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis
    • Chetoui N, Sylla K, Gagnon-Houde JV, Alcaide-Loridan C, Charron D, Al-Daccak R et al. (2008) Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis. Mol Cancer Res 6:42-52
    • (2008) Mol Cancer Res , vol.6 , pp. 42-52
    • Chetoui, N.1    Sylla, K.2    Gagnon-Houde, J.V.3    Alcaide-Loridan, C.4    Charron, D.5    Al-Daccak, R.6
  • 34
    • 0141508024 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade
    • Collisson EA, De A, Suzuki H, Gambhir SS, Kolodney MS (2003) Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade. Cancer Res 63:5669-73
    • (2003) Cancer Res , vol.63 , pp. 5669-5673
    • Collisson1    EA, D.A.2    Suzuki, H.3    Gambhir, S.S.4    Kolodney, M.S.5
  • 35
    • 0023742620 scopus 로고
    • Cytogenetic analysis of melanocytes from premalignant nevi and melanomas
    • Cowan JM, Halaban R, Francke U (1988) Cytogenetic analysis of melanocytes from premalignant nevi and melanomas. J Natl Cancer Inst 80:1159-64
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1159-1164
    • Cowan, J.M.1    Halaban, R.2    Francke, U.3
  • 36
    • 0348014686 scopus 로고    scopus 로고
    • DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
    • Cuconati A, Mukherjee C, Perez D, White E (2003) DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17:2922-32
    • (2003) Genes Dev , vol.17 , pp. 2922-2932
    • Cuconati, A.1    Mukherjee, C.2    Perez, D.3    White, E.4
  • 37
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin JA, Busam K, Pinkel D, Bastian BC (2006a) Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24:4340-4346
    • (2006) J Clin Oncol , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 40
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • Cusack JC Jr, Liu R, Houston M, Abendroth K, Elliott PJ, Adams J et al. (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res 61:3535-40
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr, J.C.1    Liu, R.2    Houston, M.3    Abendroth, K.4    Elliott, P.J.5    Adams, J.6
  • 41
    • 28244444919 scopus 로고    scopus 로고
    • Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
    • da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R (2005) Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res 65:10686-91
    • (2005) Cancer Res , vol.65 , pp. 10686-10691
    • da Rocha Dias, S.1    Friedlos, F.2    Light, Y.3    Springer, C.4    Workman, P.5    Marais, R.6
  • 42
    • 33751162384 scopus 로고    scopus 로고
    • Therapeutic targets: MTOR and related pathways
    • Dancey JE (2006) Therapeutic targets: MTOR and related pathways. Cancer Biol Ther 5:1065-73
    • (2006) Cancer Biol Ther , vol.5 , pp. 1065-1073
    • Dancey, J.E.1
  • 43
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-19
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 44
    • 0037676126 scopus 로고    scopus 로고
    • Randomized phase II study of temozolomide given every 8 hours or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma
    • Danson S, Lorigan P, Arance A, Clamp A, Ranson M, Hodgetts J et al. (2003) Randomized phase II study of temozolomide given every 8 hours or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma. J Clin Oncol 21:2551-7
    • (2003) J Clin Oncol , vol.21 , pp. 2551-2557
    • Danson, S.1    Lorigan, P.2    Arance, A.3    Clamp, A.4    Ranson, M.5    Hodgetts, J.6
  • 46
    • 0348014548 scopus 로고    scopus 로고
    • Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity
    • Del Bufalo D, Trisciuoglio D, Scarsella M, Zangemeister-Wittke U, Zupi G (2003) Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity. Oncogene 22:8441-7
    • (2003) Oncogene , vol.22 , pp. 8441-8447
    • Del Bufalo, D.1    Trisciuoglio, D.2    Scarsella, M.3    Zangemeister-Wittke, U.4    Zupi, G.5
  • 47
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-9
    • (1997) Science , vol.278 , pp. 687-689
    • del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 48
    • 36249026528 scopus 로고    scopus 로고
    • Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
    • Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, Kumasaka M et al. (2007) Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev 21:2923-35
    • (2007) Genes Dev , vol.21 , pp. 2923-2935
    • Delmas, V.1    Beermann, F.2    Martinozzi, S.3    Carreira, S.4    Ackermann, J.5    Kumasaka, M.6
  • 49
    • 0037115394 scopus 로고    scopus 로고
    • Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression
    • Dhawan P, Singh AB, Ellis DL, Richmond A (2002) Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res 62:7335-42
    • (2002) Cancer Res , vol.62 , pp. 7335-7342
    • Dhawan, P.1    Singh, A.B.2    Ellis, D.L.3    Richmond, A.4
  • 50
    • 0042743826 scopus 로고    scopus 로고
    • BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma
    • Dong J, Phelps RG, Qiao R, Yao S, Benard O, Ronai Z et al. (2003) BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res 63:3883-5
    • (2003) Cancer Res , vol.63 , pp. 3883-3885
    • Dong, J.1    Phelps, R.G.2    Qiao, R.3    Yao, S.4    Benard, O.5    Ronai, Z.6
  • 51
    • 0032569852 scopus 로고    scopus 로고
    • Control of neural crest cell fate by the Wnt signalling pathway
    • Dorsky RI, Moon RT, Raible DW (1998) Control of neural crest cell fate by the Wnt signalling pathway. Nature 396:370-3
    • (1998) Nature , vol.396 , pp. 370-373
    • Dorsky, R.I.1    Moon, R.T.2    Raible, D.W.3
  • 52
    • 0344791670 scopus 로고    scopus 로고
    • Randomized trial of treatment with cisplatin and interleukin-2 either alone or in combination with interferon-alpha-2a in patients with metastatic melanoma: A Federation Nationale des Centres de Lutte Contre le Cancer Multicenter, parallel study
    • Dorval T, Negrier S, Chevreau C, Avril MF, Baume D, Cupissol D et al. (1999) Randomized trial of treatment with cisplatin and interleukin-2 either alone or in combination with interferon-alpha-2a in patients with metastatic melanoma: a Federation Nationale des Centres de Lutte Contre le Cancer Multicenter, parallel study. Cancer 85:1060-6
    • (1999) Cancer , vol.85 , pp. 1060-1066
    • Dorval, T.1    Negrier, S.2    Chevreau, C.3    Avril, M.F.4    Baume, D.5    Cupissol, D.6
  • 53
    • 0347503603 scopus 로고    scopus 로고
    • Palliative therapy of disseminated malignant melanoma: A systematic review of 41 randomised clinical trials
    • Eigentler TK, Caroli UM, Radny P, Garbe C (2003) Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. Lancet Oncol 4:748-59
    • (2003) Lancet Oncol , vol.4 , pp. 748-759
    • Eigentler, T.K.1    Caroli, U.M.2    Radny, P.3    Garbe, C.4
  • 54
    • 33748325763 scopus 로고    scopus 로고
    • Sorafenib in advanced melanoma: A Phase II randomised discontinuation trial analysis
    • Eisen T, Ahmad T, Flaherty KT, Gore M, Kaye S, Marais R et al. (2006) Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer 95:581-6
    • (2006) Br J Cancer , vol.95 , pp. 581-586
    • Eisen, T.1    Ahmad, T.2    Flaherty, K.T.3    Gore, M.4    Kaye, S.5    Marais, R.6
  • 55
    • 0346995278 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad
    • Eisenmann KM, VanBrocklin MW, Staffend NA, Kitchen SM, Koo HM (2003) Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad. Cancer Res 63:8330-7
    • (2003) Cancer Res , vol.63 , pp. 8330-8337
    • Eisenmann, K.M.1    VanBrocklin, M.W.2    Staffend, N.A.3    Kitchen, S.M.4    Koo, H.M.5
  • 56
    • 51749088228 scopus 로고
    • The Problems of Melanoma
    • Ewing J (1930) The Problems of Melanoma. B J Med 11:852-6
    • (1930) B J Med , vol.11 , pp. 852-856
    • Ewing, J.1
  • 57
    • 22244454745 scopus 로고    scopus 로고
    • Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: Therapeutic implications
    • Fernandez Y, Verhaegen M, Miller TP, Rush JL, Steiner P, Opipari AW Jr et al. (2005) Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res 65:6294-304
    • (2005) Cancer Res , vol.65 , pp. 6294-6304
    • Fernandez, Y.1    Verhaegen, M.2    Miller, T.P.3    Rush, J.L.4    Steiner, P.5    Opipari Jr, A.W.6
  • 59
    • 53949124201 scopus 로고    scopus 로고
    • Flaherty KT, Brose M, Schuchter L, Tuveson D, Lee R, Schwartz B et al. (2004) Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma. Proceedings from the American Society of Clinical Oncology. New Orleans, LA, 2004. pp. 708: Abstract #7507
    • Flaherty KT, Brose M, Schuchter L, Tuveson D, Lee R, Schwartz B et al. (2004) Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma. Proceedings from the American Society of Clinical Oncology. New Orleans, LA, 2004. pp. 708: Abstract #7507
  • 60
    • 53949089702 scopus 로고    scopus 로고
    • Flaherty KT, Brose M, Shchucter L, Tuveson D, Lee R, Schwartz C et al. (2004) Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma. Journal of Clinical Oncology. ASCO Annual Meeting Proceedings (Post-Meeting Edition). 22, No 14S (July 15 Supplement), 2004: 7507
    • Flaherty KT, Brose M, Shchucter L, Tuveson D, Lee R, Schwartz C et al. (2004) Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma. Journal of Clinical Oncology. ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 22, No 14S (July 15 Supplement), 2004: 7507
  • 63
    • 0035279153 scopus 로고    scopus 로고
    • Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis
    • Fulda S, Meyer E, Friesen C, Susin SA, Kroemer G, Debatin KM (2001) Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 20:1063-75
    • (2001) Oncogene , vol.20 , pp. 1063-1075
    • Fulda, S.1    Meyer, E.2    Friesen, C.3    Susin, S.A.4    Kroemer, G.5    Debatin, K.M.6
  • 64
    • 33746895175 scopus 로고    scopus 로고
    • Mitochondria as therapeutic targets for cancer chemotherapy
    • Galluzzi L, Larochette N, Zamzami N, Kroemer G (2006) Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 25:4812-30
    • (2006) Oncogene , vol.25 , pp. 4812-4830
    • Galluzzi, L.1    Larochette, N.2    Zamzami, N.3    Kroemer, G.4
  • 65
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S et al. (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436:117-22
    • (2005) Nature , vol.436 , pp. 117-122
    • Garraway, L.A.1    Widlund, H.R.2    Rubin, M.A.3    Getz, G.4    Berger, A.J.5    Ramaswamy, S.6
  • 66
    • 0035925537 scopus 로고    scopus 로고
    • Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins
    • Gautschi O, Tschopp S, Olie RA, Leech SH, Simoes-Wust AP, Ziegler A et al. (2001) Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J Natl Cancer Inst 93:463-71
    • (2001) J Natl Cancer Inst , vol.93 , pp. 463-471
    • Gautschi, O.1    Tschopp, S.2    Olie, R.A.3    Leech, S.H.4    Simoes-Wust, A.P.5    Ziegler, A.6
  • 67
    • 0025940323 scopus 로고
    • Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism
    • Giebel LB, Spritz RA (1991) Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc Natl Acad Sci USA 88:8696-9
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8696-8699
    • Giebel, L.B.1    Spritz, R.A.2
  • 68
    • 33846682938 scopus 로고    scopus 로고
    • Chemotherapy for metastatic melanoma: Time for a change?
    • Gogas HJ, Kirkwood JM, Sondak VK (2007) Chemotherapy for metastatic melanoma: time for a change? Cancer 109:455-64
    • (2007) Cancer , vol.109 , pp. 455-464
    • Gogas, H.J.1    Kirkwood, J.M.2    Sondak, V.K.3
  • 69
    • 33748046812 scopus 로고    scopus 로고
    • Phase I trial of sequential low-dose 5-aza-2′- deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
    • Gollob JA, Sciambi CJ, Peterson BL, Richmond T, Thoreson M, Moran K et al. (2006) Phase I trial of sequential low-dose 5-aza-2′- deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin Cancer Res 12:4619-27
    • (2006) Clin Cancer Res , vol.12 , pp. 4619-4627
    • Gollob, J.A.1    Sciambi, C.J.2    Peterson, B.L.3    Richmond, T.4    Thoreson, M.5    Moran, K.6
  • 71
    • 33847220364 scopus 로고    scopus 로고
    • Melanoma biology and new targeted therapy
    • Gray-Schopfer V, Wellbrock C, Marais R (2007) Melanoma biology and new targeted therapy. Nature 445:851-7
    • (2007) Nature , vol.445 , pp. 851-857
    • Gray-Schopfer, V.1    Wellbrock, C.2    Marais, R.3
  • 72
    • 30444441778 scopus 로고    scopus 로고
    • V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
    • Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D et al. (2006) V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc Natl Acad Sci USA 103:57-62
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 57-62
    • Grbovic, O.M.1    Basso, A.D.2    Sawai, A.3    Ye, Q.4    Friedlander, P.5    Solit, D.6
  • 73
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-78
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 74
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind A, Fischer OM, Ullrich A (2004) The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 4:361-70
    • (2004) Nat Rev Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 75
  • 76
    • 40749124035 scopus 로고    scopus 로고
    • The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel
    • Haass NK, Sproesser K, Nguyen TK, Contractor R, Medina CA, Nathanson KL et al. (2008) The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clin Cancer Res 14:230-9
    • (2008) Clin Cancer Res , vol.14 , pp. 230-239
    • Haass, N.K.1    Sproesser, K.2    Nguyen, T.K.3    Contractor, R.4    Medina, C.A.5    Nathanson, K.L.6
  • 77
    • 0029965057 scopus 로고    scopus 로고
    • Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL
    • Han Z, Chatterjee D, Early J, Pantazis P, Hendrickson EA, Wyche JH (1996) Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL. Cancer Res 56:1621-8
    • (1996) Cancer Res , vol.56 , pp. 1621-1628
    • Han, Z.1    Chatterjee, D.2    Early, J.3    Pantazis, P.4    Hendrickson, E.A.5    Wyche, J.H.6
  • 78
    • 0036568524 scopus 로고    scopus 로고
    • Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy
    • Heere-Ress E, Thallinger C, Lucas T, Schlagbauer-Wadl H, Wacheck V, Monia BP et al. (2002) Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy. Int J Cancer 99:29-34
    • (2002) Int J Cancer , vol.99 , pp. 29-34
    • Heere-Ress, E.1    Thallinger, C.2    Lucas, T.3    Schlagbauer-Wadl, H.4    Wacheck, V.5    Monia, B.P.6
  • 80
    • 85047696563 scopus 로고    scopus 로고
    • Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death
    • Henry H, Thomas A, Shen Y, White E (2002) Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death. Oncogene 21:748-60
    • (2002) Oncogene , vol.21 , pp. 748-760
    • Henry, H.1    Thomas, A.2    Shen, Y.3    White, E.4
  • 81
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042-54
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 82
    • 33747878462 scopus 로고    scopus 로고
    • Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model
    • Hersey P, Zhuang L, Zhang XD (2006) Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model. Int Rev Cytol 251:131-58
    • (2006) Int Rev Cytol , vol.251 , pp. 131-158
    • Hersey, P.1    Zhuang, L.2    Zhang, X.D.3
  • 83
    • 34248375532 scopus 로고    scopus 로고
    • Ultraviolet radiation and melanoma: A systematic review and analysis of reported sequence variants
    • Hocker T, Tsao H (2007) Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants. Hum Mutat 28:578-88
    • (2007) Hum Mutat , vol.28 , pp. 578-588
    • Hocker, T.1    Tsao, H.2
  • 84
    • 0027204149 scopus 로고
    • Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
    • Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins NA et al. (1993) Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74:395-404
    • (1993) Cell , vol.74 , pp. 395-404
    • Hodgkinson, C.A.1    Moore, K.J.2    Nakayama, A.3    Steingrimsson, E.4    Copeland, N.G.5    Jenkins, N.A.6
  • 85
    • 0030459095 scopus 로고    scopus 로고
    • Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
    • Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD et al. (1996) Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 13:2339-47
    • (1996) Oncogene , vol.13 , pp. 2339-2347
    • Huang, S.1    Luca, M.2    Gutman, M.3    McConkey, D.J.4    Langley, K.E.5    Lyman, S.D.6
  • 86
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: Tumour resistance to apoptosis
    • Igney FH, Krammer PH (2002) Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2:277-88
    • (2002) Nat Rev Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 89
    • 0031059608 scopus 로고    scopus 로고
    • Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis
    • Jansen B, Schlagbauer-Wadl H, Eichler HG, Wolff K, van Elsas A, Schrier PI et al. (1997) Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis. Cancer Res 57:362-5
    • (1997) Cancer Res , vol.57 , pp. 362-365
    • Jansen, B.1    Schlagbauer-Wadl, H.2    Eichler, H.G.3    Wolff, K.4    van Elsas, A.5    Schrier, P.I.6
  • 92
    • 35448958407 scopus 로고    scopus 로고
    • Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis
    • Jiang CC, Chen LH, Gillespie S, Wang YF, Kiejda KA, Zhang XD et al. (2007) Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer Res 67:9750-61
    • (2007) Cancer Res , vol.67 , pp. 9750-9761
    • Jiang, C.C.1    Chen, L.H.2    Gillespie, S.3    Wang, Y.F.4    Kiejda, K.A.5    Zhang, X.D.6
  • 93
    • 0031738326 scopus 로고    scopus 로고
    • N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin
    • Jiveskog S, Ragnarsson-Olding B, Platz A, Ringborg U (1998) N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J Invest Dermatol 111:757-61
    • (1998) J Invest Dermatol , vol.111 , pp. 757-761
    • Jiveskog, S.1    Ragnarsson-Olding, B.2    Platz, A.3    Ringborg, U.4
  • 97
    • 18744379116 scopus 로고    scopus 로고
    • AKT/PKB signaling mechanisms in cancer and chemoresistance
    • Kim D, Dan HC, Park S, Yang L, Liu Q, Kaneko S et al. (2005) AKT/PKB signaling mechanisms in cancer and chemoresistance. Front Biosci 10:975-87
    • (2005) Front Biosci , vol.10 , pp. 975-987
    • Kim, D.1    Dan, H.C.2    Park, S.3    Yang, L.4    Liu, Q.5    Kaneko, S.6
  • 98
    • 33745288277 scopus 로고    scopus 로고
    • Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene
    • Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B et al. (2006) Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 125:1269-1281
    • (2006) Cell , vol.125 , pp. 1269-1281
    • Kim, M.1    Gans, J.D.2    Nogueira, C.3    Wang, A.4    Paik, J.H.5    Feng, B.6
  • 99
    • 0037022666 scopus 로고    scopus 로고
    • Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase
    • Koo HM, VanBrocklin M, McWilliams MJ, Leppla SH, Duesbery NS, Woude GF (2002) Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. Proc Natl Acad Sci USA 99:3052-7
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3052-3057
    • Koo, H.M.1    VanBrocklin, M.2    McWilliams, M.J.3    Leppla, S.H.4    Duesbery, N.S.5    Woude, G.F.6
  • 100
    • 0038677615 scopus 로고    scopus 로고
    • Epigenetic silencing of multiple interferon pathway genes after cellular immortalization
    • Kulaeva OI, Draghici S, Tang L, Kraniak JM, Land SJ, Tainsky MA (2003) Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. Oncogene 22:4118-27
    • (2003) Oncogene , vol.22 , pp. 4118-4127
    • Kulaeva, O.I.1    Draghici, S.2    Tang, L.3    Kraniak, J.M.4    Land, S.J.5    Tainsky, M.A.6
  • 101
    • 0035877156 scopus 로고    scopus 로고
    • Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling
    • Kumar CC, Diao R, Yin Z, Liu Y, Samatar AA, Madison V et al. (2001) Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling. Biochim Biophys Acta 1526:257-68
    • (2001) Biochim Biophys Acta , vol.1526 , pp. 257-268
    • Kumar, C.C.1    Diao, R.2    Yin, Z.3    Liu, Y.4    Samatar, A.A.5    Madison, V.6
  • 104
    • 0026518279 scopus 로고
    • Loss of c-kit expression in cultured melanoma cells
    • Lassam N, Bickford S (1992) Loss of c-kit expression in cultured melanoma cells. Oncogene 7:51-6
    • (1992) Oncogene , vol.7 , pp. 51-56
    • Lassam, N.1    Bickford, S.2
  • 106
    • 0034125805 scopus 로고    scopus 로고
    • p53-dependent apoptosis in melanoma cells after treatment with camptothecin
    • Li G, Bush JA, Ho VC (2000) p53-dependent apoptosis in melanoma cells after treatment with camptothecin. J Invest Dermatol 114:514-9
    • (2000) J Invest Dermatol , vol.114 , pp. 514-519
    • Li, G.1    Bush, J.A.2    Ho, V.C.3
  • 107
    • 0031942550 scopus 로고    scopus 로고
    • Chemotherapy-induced apoptosis in melanoma cells is p53 dependent
    • Li G, Tang L, Zhou X, Tron V, Ho V (1998) Chemotherapy-induced apoptosis in melanoma cells is p53 dependent. Melanoma Res 8:17-23
    • (1998) Melanoma Res , vol.8 , pp. 17-23
    • Li, G.1    Tang, L.2    Zhou, X.3    Tron, V.4    Ho, V.5
  • 109
    • 33749242914 scopus 로고    scopus 로고
    • Phase II trial of sorafenib combined with dacarbazine in metastatic melanoma patients
    • Lorigan P, Corrie P, Chao D, Nathan P, Ahmad T, Marais R et al. (2006) Phase II trial of sorafenib combined with dacarbazine in metastatic melanoma patients. J Clin Oncol 24:8012
    • (2006) J Clin Oncol , vol.24 , pp. 8012
    • Lorigan, P.1    Corrie, P.2    Chao, D.3    Nathan, P.4    Ahmad, T.5    Marais, R.6
  • 111
    • 23944439944 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
    • Lorusso PM, Adjei AA, Varterasian M, Gadgeel S, Reid J, Mitchell DY et al. (2005b) Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J Clin Oncol 23:5281-93
    • (2005) J Clin Oncol , vol.23 , pp. 5281-5293
    • Lorusso, P.M.1    Adjei, A.A.2    Varterasian, M.3    Gadgeel, S.4    Reid, J.5    Mitchell, D.Y.6
  • 112
  • 113
    • 0029963811 scopus 로고    scopus 로고
    • Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas
    • Maelandsmo GM, Florenes VA, Hovig E, Oyjord T, Engebraaten O, Holm R et al. (1996) Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. Br J Cancer 73:909-16
    • (1996) Br J Cancer , vol.73 , pp. 909-916
    • Maelandsmo, G.M.1    Florenes, V.A.2    Hovig, E.3    Oyjord, T.4    Engebraaten, O.5    Holm, R.6
  • 114
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129:1261-74
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 115
    • 23844476134 scopus 로고    scopus 로고
    • CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium
    • Margolin K, Longmate J, Baratta T, Synold T, Christensen S, Weber J et al. (2005) CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer 104:1045-8
    • (2005) Cancer , vol.104 , pp. 1045-1048
    • Margolin, K.1    Longmate, J.2    Baratta, T.3    Synold, T.4    Christensen, S.5    Weber, J.6
  • 116
    • 20444364475 scopus 로고    scopus 로고
    • A phase II study of bortezomib in the treatment of metastatic malignant melanoma
    • Markovic SN, Geyer SM, Dawkins F, Sharfman W, Albertini M, Maples W et al. (2005) A phase II study of bortezomib in the treatment of metastatic malignant melanoma. Cancer 103:2584-9
    • (2005) Cancer , vol.103 , pp. 2584-2589
    • Markovic, S.N.1    Geyer, S.M.2    Dawkins, F.3    Sharfman, W.4    Albertini, M.5    Maples, W.6
  • 118
    • 18444418797 scopus 로고    scopus 로고
    • Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    • McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109:707-718
    • (2002) Cell , vol.109 , pp. 707-718
    • McGill, G.G.1    Horstmann, M.2    Widlund3    HR, D.J.4    Motyckova, G.5    Nishimura, E.K.6
  • 119
    • 21344456180 scopus 로고    scopus 로고
    • The RAS/RAF/ MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    • Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K et al. (2005) The RAS/RAF/ MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci 10:2986-3001
    • (2005) Front Biosci , vol.10 , pp. 2986-3001
    • Meier, F.1    Schittek, B.2    Busch, S.3    Garbe, C.4    Smalley, K.5    Satyamoorthy, K.6
  • 120
    • 33947236886 scopus 로고    scopus 로고
    • Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway
    • Mhaidat NM, Zhang XD, Jiang CC, Hersey P (2007) Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway. Clin Cancer Res 13:1308-14
    • (2007) Clin Cancer Res , vol.13 , pp. 1308-1314
    • Mhaidat, N.M.1    Zhang, X.D.2    Jiang, C.C.3    Hersey, P.4
  • 122
    • 0031812996 scopus 로고    scopus 로고
    • Enhancement of chemosensitivity in human bladder cancer cells by adenoviral-mediated p53 gene transfer
    • Miyake H, Hara I, Gohji K, Yamanaka K, Arakawa S, Kamidono S (1998) Enhancement of chemosensitivity in human bladder cancer cells by adenoviral-mediated p53 gene transfer. Anticancer Res 18:3087-92
    • (1998) Anticancer Res , vol.18 , pp. 3087-3092
    • Miyake, H.1    Hara, I.2    Gohji, K.3    Yamanaka, K.4    Arakawa, S.5    Kamidono, S.6
  • 123
    • 27744565979 scopus 로고    scopus 로고
    • Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor rapamycin
    • Molhoek KR, Brautigan DL, Slingluff CL Jr (2005) Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor rapamycin. J Transl Med 3:39
    • (2005) J Transl Med , vol.3 , pp. 39
    • Molhoek, K.R.1    Brautigan, D.L.2    Slingluff Jr, C.L.3
  • 124
    • 0030765407 scopus 로고    scopus 로고
    • Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression
    • Montone KT, van Belle P, Elenitsas R, Elder DE (1997) Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Mod Pathol 10:939-44
    • (1997) Mod Pathol , vol.10 , pp. 939-944
    • Montone, K.T.1    van Belle, P.2    Elenitsas, R.3    Elder, D.E.4
  • 125
    • 33748422079 scopus 로고    scopus 로고
    • Oncogene-induced cell senescence - halting on the road to cancer
    • Mooi WJ, Peeper DS (2006) Oncogene-induced cell senescence - halting on the road to cancer. N Engl J Med 355:1037-46
    • (2006) N Engl J Med , vol.355 , pp. 1037-1046
    • Mooi, W.J.1    Peeper, D.S.2
  • 127
    • 5244224827 scopus 로고    scopus 로고
    • X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
    • Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS et al. (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335-41
    • (1996) Nature , vol.381 , pp. 335-341
    • Muchmore, S.W.1    Sattler, M.2    Liang, H.3    Meadows, R.P.4    Harlan, J.E.5    Yoon, H.S.6
  • 129
    • 0026793058 scopus 로고
    • Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor
    • Natali PG, Nicotra MR, Winkler AB, Cavaliere R, Bigotti A, Ullrich A (1992) Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 52:197-201
    • (1992) Int J Cancer , vol.52 , pp. 197-201
    • Natali, P.G.1    Nicotra, M.R.2    Winkler, A.B.3    Cavaliere, R.4    Bigotti, A.5    Ullrich, A.6
  • 132
    • 0038046166 scopus 로고    scopus 로고
    • Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    • Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F et al. (2003) Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17:1475-86
    • (2003) Genes Dev , vol.17 , pp. 1475-1486
    • Nijhawan, D.1    Fang, M.2    Traer, E.3    Zhong, Q.4    Gao, W.5    Du, F.6
  • 134
    • 13244287677 scopus 로고    scopus 로고
    • Mechanisms of hair graying: Incomplete melanocyte stem cell maintenance in the niche
    • Nishimura EK, Granter SR, Fisher DE (2005) Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307:720-4
    • (2005) Science , vol.307 , pp. 720-724
    • Nishimura, E.K.1    Granter, S.R.2    Fisher, D.E.3
  • 136
    • 0035877115 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma
    • Omholt K, Platz A, Ringborg U, Hansson J (2001) Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer 92:839-42
    • (2001) Int J Cancer , vol.92 , pp. 839-842
    • Omholt, K.1    Platz, A.2    Ringborg, U.3    Hansson, J.4
  • 137
    • 38149102519 scopus 로고    scopus 로고
    • GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines
    • Panka DJ, Cho DC, Atkins MB, Mier JW (2008) GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J Biol Chem 283:726-32
    • (2008) J Biol Chem , vol.283 , pp. 726-732
    • Panka, D.J.1    Cho, D.C.2    Atkins, M.B.3    Mier, J.W.4
  • 138
    • 0032767677 scopus 로고    scopus 로고
    • Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi
    • Papp T, Pemsel H, Zimmermann R, Bastrop R, Weiss DG, Schiffmann D (1999) Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi. J Med Genet 36:610-4
    • (1999) J Med Genet , vol.36 , pp. 610-614
    • Papp, T.1    Pemsel, H.2    Zimmermann, R.3    Bastrop, R.4    Weiss, D.G.5    Schiffmann, D.6
  • 139
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD et al. (2005) BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 15:249-54
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3    Kopani, K.R.4    Amatruda, J.F.5    Murphey, R.D.6
  • 140
    • 33746162101 scopus 로고    scopus 로고
    • Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity
    • Petti C, Molla A, Vegetti C, Ferrone S, Anichini A, Sensi M (2006) Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity. Cancer Res 66:6503-11
    • (2006) Cancer Res , vol.66 , pp. 6503-6511
    • Petti, C.1    Molla, A.2    Vegetti, C.3    Ferrone, S.4    Anichini, A.5    Sensi, M.6
  • 142
    • 33750312678 scopus 로고    scopus 로고
    • Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA
    • Qin JZ, Xin H, Sitailo LA, Denning MF, Nickoloff BJ (2006) Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res 66:9636-45
    • (2006) Cancer Res , vol.66 , pp. 9636-9645
    • Qin, J.Z.1    Xin, H.2    Sitailo, L.A.3    Denning, M.F.4    Nickoloff, B.J.5
  • 143
    • 22244452016 scopus 로고    scopus 로고
    • Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
    • Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V et al. (2005) Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res 65:6282-93
    • (2005) Cancer Res , vol.65 , pp. 6282-6293
    • Qin, J.Z.1    Ziffra, J.2    Stennett, L.3    Bodner, B.4    Bonish, B.K.5    Chaturvedi, V.6
  • 145
    • 17444382745 scopus 로고    scopus 로고
    • Epigenetic control in the immune response
    • Reiner SL (2005) Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1 R41-6
    • (2005) Hum Mol Genet , vol.14 , Issue.SPEC 1
    • Reiner, S.L.1
  • 146
    • 33747339752 scopus 로고    scopus 로고
    • Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
    • Reu FJ, Bae SI, Cherkassky L, Leaman DW, Lindner D, Beaulieu N et al. (2006) Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J Clin Oncol 24:3771-9
    • (2006) J Clin Oncol , vol.24 , pp. 3771-3779
    • Reu, F.J.1    Bae, S.I.2    Cherkassky, L.3    Leaman, D.W.4    Lindner, D.5    Beaulieu, N.6
  • 147
    • 0032937232 scopus 로고    scopus 로고
    • Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
    • Rimm DL, Caca K, Hu G, Harrison FB, Fearon ER (1999) Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 154:325-9
    • (1999) Am J Pathol , vol.154 , pp. 325-329
    • Rimm, D.L.1    Caca, K.2    Hu, G.3    Harrison, F.B.4    Fearon, E.R.5
  • 148
    • 27744551009 scopus 로고    scopus 로고
    • Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor
    • Roskoski R Jr (2005) Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor. Biochem Biophys Res Commun 338:1307-15
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 1307-1315
    • Roskoski Jr, R.1
  • 149
  • 154
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt CA, Rosenthal CT, Lowe SW (2000) Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 6:1029-35
    • (2000) Nat Med , vol.6 , pp. 1029-1035
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 155
    • 0031838967 scopus 로고    scopus 로고
    • Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines
    • Selzer E, Schlagbauer-Wadl H, Okamoto I, Pehamberger H, Potter R, Jansen B (1998) Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines. Melanoma Res 8:197-203
    • (1998) Melanoma Res , vol.8 , pp. 197-203
    • Selzer, E.1    Schlagbauer-Wadl, H.2    Okamoto, I.3    Pehamberger, H.4    Potter, R.5    Jansen, B.6
  • 156
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 158
    • 0042785967 scopus 로고    scopus 로고
    • Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo
    • Sharpless NE, Kannan K, Xu J, Bosenberg MW, Chin L (2003) Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene 22:5055-9
    • (2003) Oncogene , vol.22 , pp. 5055-5059
    • Sharpless, N.E.1    Kannan, K.2    Xu, J.3    Bosenberg, M.W.4    Chin, L.5
  • 160
    • 0037431539 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells
    • Smalley KS, Eisen TG (2003) Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. Int J Cancer 105:165-75
    • (2003) Int J Cancer , vol.105 , pp. 165-175
    • Smalley, K.S.1    Eisen, T.G.2
  • 161
    • 33745075558 scopus 로고    scopus 로고
    • Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
    • Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M (2006) Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 5:1136-44
    • (2006) Mol Cancer Ther , vol.5 , pp. 1136-1144
    • Smalley, K.S.1    Haass, N.K.2    Brafford, P.A.3    Lioni, M.4    Flaherty, K.T.5    Herlyn, M.6
  • 163
    • 0038793948 scopus 로고    scopus 로고
    • Apoptosis and melanoma chemoresistance
    • Soengas MS, Lowe SW (2003) Apoptosis and melanoma chemoresistance. Oncogene 22:3138-51
    • (2003) Oncogene , vol.22 , pp. 3138-3151
    • Soengas, M.S.1    Lowe, S.W.2
  • 165
    • 6844226190 scopus 로고    scopus 로고
    • Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group
    • Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A et al. (1998) Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group. Hum Mol Genet 7:209-16
    • (1998) Hum Mol Genet , vol.7 , pp. 209-216
    • Soufir, N.1    Avril, M.F.2    Chompret, A.3    Demenais, F.4    Bombled, J.5    Spatz, A.6
  • 167
    • 34347226348 scopus 로고    scopus 로고
    • Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/ AKT pathways
    • Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V et al. (2007) Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/ AKT pathways. Proc Natl Acad Sci USA 104:5895-900
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5895-5900
    • Stecca, B.1    Mas, C.2    Clement, V.3    Zbinden, M.4    Correa, R.5    Piguet, V.6
  • 168
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356-62
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3    Yung, W.K.4    Lin, H.5    Ligon, A.H.6
  • 169
    • 0036313607 scopus 로고    scopus 로고
    • Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase
    • Straume O, Smeds J, Kumar R, Hemminki K, Akslen LA (2002) Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase. Am J Pathol 161:229-37
    • (2002) Am J Pathol , vol.161 , pp. 229-237
    • Straume, O.1    Smeds, J.2    Kumar, R.3    Hemminki, K.4    Akslen, L.A.5
  • 170
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, Yeh N, Crowl Bancroft C, Sausville E et al. (2001) Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 7:1419-28
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3    Yeh, N.4    Crowl Bancroft, C.5    Sausville, E.6
  • 172
    • 0027943189 scopus 로고
    • Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene
    • Tassabehji M, Newton VE, Read AP (1994) Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. Nat Genet 8:251-5
    • (1994) Nat Genet , vol.8 , pp. 251-255
    • Tassabehji, M.1    Newton, V.E.2    Read, A.P.3
  • 174
    • 33746105691 scopus 로고    scopus 로고
    • Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?
    • Thomas NE, Berwick M, Cordeiro-Stone M (2006) Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation? J Invest Dermatol 126:1693-6
    • (2006) J Invest Dermatol , vol.126 , pp. 1693-1696
    • Thomas, N.E.1    Berwick, M.2    Cordeiro-Stone, M.3
  • 175
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-6
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 176
  • 177
  • 178
    • 0031963952 scopus 로고    scopus 로고
    • Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene
    • Tsao H, Benoit E, Sober AJ, Thiele C, Haluska FG (1998a) Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene. Cancer Res 58:109-13
    • (1998) Cancer Res , vol.58 , pp. 109-113
    • Tsao, H.1    Benoit, E.2    Sober, A.J.3    Thiele, C.4    Haluska, F.G.5
  • 179
    • 1442274619 scopus 로고    scopus 로고
    • Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
    • Tsao H, Goel V, Wu H, Yang G, Haluska FG (2004b) Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol 122:337-41
    • (2004) J Invest Dermatol , vol.122 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3    Yang, G.4    Haluska, F.G.5
  • 180
    • 0032474749 scopus 로고    scopus 로고
    • Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
    • Tsao H, Zhang X, Benoit E, Haluska FG (1998b) Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene 16:3397-402
    • (1998) Oncogene , vol.16 , pp. 3397-3402
    • Tsao, H.1    Zhang, X.2    Benoit, E.3    Haluska, F.G.4
  • 181
    • 0034085811 scopus 로고    scopus 로고
    • Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
    • Tsao H, Zhang X, Fowlkes K, Haluska FG (2000) Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res 60:1800-4
    • (2000) Cancer Res , vol.60 , pp. 1800-1804
    • Tsao, H.1    Zhang, X.2    Fowlkes, K.3    Haluska, F.G.4
  • 182
    • 34247324355 scopus 로고    scopus 로고
    • Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells
    • Valentini A, Gravina P, Federici G, Bernardini S (2007) Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells. Cancer Biol Ther 6:185-91
    • (2007) Cancer Biol Ther , vol.6 , pp. 185-191
    • Valentini, A.1    Gravina, P.2    Federici, G.3    Bernardini, S.4
  • 184
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-2
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 185
    • 33845797913 scopus 로고    scopus 로고
    • A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species
    • Verhaegen M, Bauer JA, Martin de la Vega C, Wang G, Wolter KG, Brenner JC et al. (2006) A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res 66:11348-59
    • (2006) Cancer Res , vol.66 , pp. 11348-11359
    • Verhaegen, M.1    Bauer, J.A.2    Martin de la Vega, C.3    Wang, G.4    Wolter, K.G.5    Brenner, J.C.6
  • 186
    • 0031980540 scopus 로고    scopus 로고
    • Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets
    • Walker GJ, Flores JF, Glendening JM, Lin AH, Markl ID, Fountain JW (1998) Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosomes Cancer 22:157-63
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 157-163
    • Walker, G.J.1    Flores, J.F.2    Glendening, J.M.3    Lin, A.H.4    Markl, I.D.5    Fountain, J.W.6
  • 187
    • 34548096400 scopus 로고    scopus 로고
    • Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
    • Wang YF, Jiang CC, Kiejda KA, Gillespie S, Zhang XD, Hersey P (2007) Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1. Clin Cancer Res 13:4934-42
    • (2007) Clin Cancer Res , vol.13 , pp. 4934-4942
    • Wang, Y.F.1    Jiang, C.C.2    Kiejda, K.A.3    Gillespie, S.4    Zhang, X.D.5    Hersey, P.6
  • 188
    • 0038457556 scopus 로고    scopus 로고
    • Microphthalamia-associated transcription factor: A critical regulator of pigment cell development and survival
    • Widlund HR, Fisher DE (2003) Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene 22:3035-41
    • (2003) Oncogene , vol.22 , pp. 3035-3041
    • Widlund, H.R.1    Fisher, D.E.2
  • 189
    • 0037119948 scopus 로고    scopus 로고
    • Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    • Widlund HR, Horstmann MA, Price ER, Cui J, Lessnick SL, Wu M et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol 158:1079-87
    • (2002) J Cell Biol , vol.158 , pp. 1079-1087
    • Widlund, H.R.1    Horstmann, M.A.2    Price, E.R.3    Cui, J.4    Lessnick, S.L.5    Wu, M.6
  • 190
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-305
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5    Fletcher, J.I.6
  • 192
    • 20144378490 scopus 로고    scopus 로고
    • Human malignant melanoma: Detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis
    • Willmore-Payne C, Holden JA, Tripp S, Layfield LJ (2005) Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis. Hum Pathol 36:486-93
    • (2005) Hum Pathol , vol.36 , pp. 486-493
    • Willmore-Payne, C.1    Holden, J.A.2    Tripp, S.3    Layfield, L.J.4
  • 194
    • 0034142326 scopus 로고    scopus 로고
    • c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
    • Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, Price ER et al. (2000) c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev 14:301-12
    • (2000) Genes Dev , vol.14 , pp. 301-312
    • Wu, M.1    Hemesath, T.J.2    Takemoto, C.M.3    Horstmann, M.A.4    Wells, A.G.5    Price, E.R.6
  • 195
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V, Eton O, McDermott DF, Hubbard F et al. (2006) Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 106:2005-11
    • (2006) Cancer , vol.106 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3    Eton, O.4    McDermott, D.F.5    Hubbard, F.6
  • 196
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada KM, Araki M (2001) Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 114:2375-82
    • (2001) J Cell Sci , vol.114 , pp. 2375-2382
    • Yamada, K.M.1    Araki, M.2
  • 198
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q, Geng Y, Sicinski P (2001) Specific protection against breast cancers by cyclin D1 ablation. Nature 411:1017-21
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 199
    • 0027197555 scopus 로고
    • KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells
    • Zakut R, Perlis R, Eliyahu S, Yarden Y, Givol D, Lyman SD et al. (1993) KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 8:2221-9
    • (1993) Oncogene , vol.8 , pp. 2221-2229
    • Zakut, R.1    Perlis, R.2    Eliyahu, S.3    Yarden, Y.4    Givol, D.5    Lyman, S.D.6
  • 200
    • 44349182097 scopus 로고    scopus 로고
    • Differential regulation of Bax and Bak by anti-apoptotic Bcl-2-family proteins, Bcl-B and Mcl-1
    • Zhai D, Jin C, Huang Z, Satterthwait AC, Reed JC (2008) Differential regulation of Bax and Bak by anti-apoptotic Bcl-2-family proteins, Bcl-B and Mcl-1. J Biol Chem 283:9580-6
    • (2008) J Biol Chem , vol.283 , pp. 9580-9586
    • Zhai, D.1    Jin, C.2    Huang, Z.3    Satterthwait, A.C.4    Reed, J.C.5
  • 201
    • 0030010375 scopus 로고    scopus 로고
    • Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating BCL-2 levels
    • Zhai S, Yaar M, Doyle SM, Gilchrest BA (1996) Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating BCL-2 levels. Exp Cell Res 224:335-43
    • (1996) Exp Cell Res , vol.224 , pp. 335-343
    • Zhai, S.1    Yaar, M.2    Doyle, S.M.3    Gilchrest, B.A.4
  • 202
    • 0038439258 scopus 로고    scopus 로고
    • Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria
    • Zhang XD, Borrow JM, Zhang XY, Nguyen T, Hersey P (2003) Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria. Oncogene 22:2869-81
    • (2003) Oncogene , vol.22 , pp. 2869-2881
    • Zhang, X.D.1    Borrow, J.M.2    Zhang, X.Y.3    Nguyen, T.4    Hersey, P.5
  • 203
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-34
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 204
    • 0033819340 scopus 로고    scopus 로고
    • Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
    • Zhou XP, Gimm O, Hampel H, Niemann T, Walker MJ, Eng C (2000) Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol 157:1123-8
    • (2000) Am J Pathol , vol.157 , pp. 1123-1128
    • Zhou, X.P.1    Gimm, O.2    Hampel, H.3    Niemann, T.4    Walker, M.J.5    Eng, C.6
  • 205
    • 0029664339 scopus 로고    scopus 로고
    • Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
    • Zuo L, Weger J, Yang Q, Goldstein AM, Tucker MA, Walker GJ et al. (1996) Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet 12:97-9
    • (1996) Nat Genet , vol.12 , pp. 97-99
    • Zuo, L.1    Weger, J.2    Yang, Q.3    Goldstein, A.M.4    Tucker, M.A.5    Walker, G.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.