ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 26, 2007, Pages 10968-10973

  Ha, Linan ^a   Lchikawa, Takeshi ^a   Anver, Miriam ^b   Dickins, Ross ^c   Lowe, Scott ^c   Sharpless, Norman E ^d   Krimpenfort, Paul ^e   DePinho, Ronald A ^f   Bennett, Dorothy C ^f   Sviderskaya, Elena V ^f,g   Merlino, Glenn ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e NETHERLANDS CANCER INSTITUTE   (Netherlands)

^f HARVARD MEDICAL SCHOOL   (United States)

^g ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Genetically engineered mice; MET; Nevi; P16INK4A; Rhabdomyosarcoma

Indexed keywords

ARF PROTEIN; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL LINEAGE; FIBROBLAST; GENE DELETION; GENE MUTATION; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MOUSE; NEVUS; NONHUMAN; ONCOGENE N RAS; PRIORITY JOURNAL; PROTEIN FUNCTION; RHABDOMYOSARCOMA; SENESCENCE;

ANIMALS; CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; MELANOCYTES; MELANOMA; MICE; PROTO-ONCOGENE PROTEINS P21(RAS); TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 34447569679     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0611638104     Document Type: Article

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