The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis

Cancer Research

Volumn 56, Issue 23, 1996, Pages 5475-5483

  Bartkova, Jirina ^a   Lukas, Jiri ^a   Guldberg, Per ^a   Alsner, Jan ^a   Kirkin, Alexei F ^a   Zeuthen, Jesper ^a   Bartek, Jiri ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; NEUTRALIZING ANTIBODY;

ARTICLE; CARCINOGENESIS; CELL CYCLE; CHROMOSOME 9P; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MELANOMA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CARRIER PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; CYCLINS; DISEASE PROGRESSION; G1 PHASE; GENE DELETION; GENES, RETINOBLASTOMA; HUMANS; MELANOMA; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENES; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0030467624     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Kamb, A. Cell-cycle regulators and cancer. Trends Genet, 11. 136-140, 1995
2. 1 cyclin-dependent kinases. Genes Dev., 9 1149-1163, 1995
3. Strauss, M , Lukas, J , and Bartek, J Unrestricted cell cycling and cancer Nat Med., 1 1245-1246, 1995
4. Weinberg, R A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995
5. Hall, M , and Peters, G. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer Adv Cancer Res., 68. 67-108, 1996.
6. Motokura, T., and Arnold, A. Cyclins and oncogenesis Biochim Biophys Acta, 1155; 63-78, 1993
7. Harper, J. W., and Elledge, S J. Cdk inhibitors in development and cancer. Curr. Opin Genet & Dev., 6: 56-64, 1996.
8. Hunter, T., and Pines, J. Cyclins and cancer II: cyclin D and cdk inhibitors come of age. Cell, 79: 573-582, 1994
9. Serrano, M , Hannon, G J , and Beach, D. A regulatory motif in cell-cycle control causing specific inhibition of cyclin D/cdk4. Nature (Lond.), 366: 704-707, 1993
10. Kamb, A , Gruis, N. A , Weaver-Feldhaus, J , Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R S , Johnson, B E., and Skolnick, M. H A cell cycle regulator potentially involved in genesis of many tumor types Science (Washington DC), 264. 436-440, 1994.
11. Nobori, T , Miura, K , Wu, D. J , Lois, A., Takabayashi, K , and Carson, D. A Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers Nature (Lond), 368: 753-756, 1994.
12. Merlo, A , Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S B , and Sidransky, D, 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
13. Herman, J G , Merlo, A , Mao, L , Lapidus, R. G., Issa, J-P J , Davidson, N. E , Sidransky, D , and Baylin, S. B Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers Cancer Res., 55: 4525-4530, 1995
14. Ink4a as a human tumor suppressor. Biochim Biophys Acta, 1242: 165-169, 1996
15. Reed, J A., Loganzo, F., Shea, C R., Walker, G. J., Flores, J F., Glendening, J. M , Bogdany, J. K., Shiel, M J., Haluska, F. G., Fountain, J W., and Albino, A. P. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res., 55. 2713-2718, 1995
16. Hussussian, C. J., Struewing, J. P , Goldstein, A M., Higgins, P A. T., Ally, D. S., Sheahan, M. D , Clark, W H., Tucker, M. A., and Dracopoli, N. C Germline p16 mutations in familial melanoma. Nat Genet., 8: 15-21, 1994.
17. Kamb, A., Shattuck-Eidens, D., Eeles, R., Liu, Q., Gruis, N. A., Ding, W., Hussey, C., Tran, T , Miki, Y., Weaver-Feldhaus, J , McClure, M , Aitken, J F., Anderson, D E., Bergman, W , Frants, R., Goldgar, D. E., Green, A., MacLennan, R., Martin, N G , Meyer, L. J., Youl, P., Zone, J. J., Skolnick, M. H , and Cannon-Albright, L. A. Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nat. Genet., 8: 22-26, 1994.
18. Gruis, N. A., van der Velden, P. A , Sandkuyl, L. A , Prins, D E , Weaver-Feldhaus, J , Kamb, A., Bergman, W., and Frants, R. R. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds. Nat. Genet., 10: 351-353, 1995
19. Gruis, N. A , Sandkuijl, L A., van der Velden, P A , Bergman, W., and Frants, R. R. CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families. Melanoma Res., 5. 169-177, 1995
20. Ink4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (Washington DC), 269. 1281-1284, 1995.
21. INK4a binding domain of CDK4 in familial melanoma. Nat. Genet., 12: 97-99, 1996
22. Kirkin, A F., Petersen, T. R , Olsen, A. C., Li, L., thor Straten, P , and Zeuthen, J Generadon of human-melanoma-specific T lymphocyte clones defining novel cytolytic targets with panels of newly established melanoma cell lines Cancer Immunol Immunother., 41: 71-76, 1995.
23. Katano, M , Saxton, R. E , Cochran, A. J., and Irie, R F Establishment of an ascitic human melanoma cell line that metastasizes to lung and liver in nude mice J. Cancer Res Clin. Oncol., 108. 197-202, 1984.
24. 1 J Cell Biol , 125. 625-638, 1994.
25. 1 control. Cancer Res , 55: 4818-4823, 1995
26. Hogg, A., Onadim, Z , Baird, P. N , and Cowell, J. K Detection of heterozygous mutations in the RB1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing Oncogene, 7 1445-1451, 1992.
27. Lohman, D R , Brandt, B., Hopping, W , Passarge, E , and Horsthemke, B. Distinct RB1 gene mutations with low penetrance in hereditary retinoblastoma. Hum. Genet., 94: 349-354, 1994
28. Abrams, E S., and Stanton, V. P Use of denaturing gradient gel electrophoresis to study conformational transitions in nucleic acids. Methods Enzymol., 212: 71-104, 1992
29. Lerman, L S., and Silverstein, K Computational simulation of DNA melting and its application in denaturing gradient gel electrophoresis Methods Enzymol., 155 482-501, 1987
30. Lukas, J. Pagano, M., Staskova, Z., Draetta, G , and Bartek, J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines Oncogene, 9: 707-718, 1994
31. 1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol., 15. 2600-2611, 1995
32. 1 phase progression in specific cell types. Oncogene, 10: 2125-2134, 1995
33. 1 regulation in human head and neck cancer. Cancer Res., 55: 949-956, 1995
34. Bartkova, J., Zemanova, M., and Bartek, J. Abundance and subcellular localisation of cyclin D3 in human tumours Int J. Cancer, 65: 323-327, 1996
35. Lukas, J , Parry, D , Aagaard, L., Mann, D. J., Bartkova, J., Strauss, M , Peters, G., and Bartek, J Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (Lond.), 375. 503-506, 1995
36. 1 to multiple cell cycles by lovastatin Cancer Res., 51: 3602-3609, 1991.
37. Bartkova, J., Lukas, J , Muller, H., Lützhøft, D., Strauss, M., and Bartek, J Cyclin D1 protein expression and function in human breast cancer. Int. J. Cancer, 57: 353-361, 1994
38. Welcker, M , Lukas, J , Strauss, M., and Bartek, J Enhanced protein stability, a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells. Oncogene, 12: 419-425, 1996
39. Koh, J , Enders, G. H., Dynlacht, B. D , and Harlow, E Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature (Lond.), 375: 506-510, 1995.
40. INK4/MTS1) gene in human melanoma cells: relevance to tumor growth and metastasis. Oncogene, 11: 1399-1402, 1995.
41. Wang, Y., and Becker, D. Differential expression of the cyclin-dependent kinase inhibitors p16 and p21 in the human melanocytic system. Oncogene, 12: 1096-1075, 1996
42. Pollock, P. M., Yu, F., Qiu, L., Parsons, P. G , and Hayward, N. C. Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines Oncogene, 11: 663-668, 1995.
43. Horowitz, J M., Park, S-H., Bogenmann, E., Cheng, J C., Yandell, D. W , Kaye, F. J., Minna, J D , Dryja, T. P., and Weinberg, R. A Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc. Natl. Acad Sci. USA, 87 2775-2779, 1990
44. Bartkova, J , Lukas, J , Strauss, M., and Bartek, J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis Oncogene, 10: 775-778, 1995.
45. Mælandsmo, G. M., Flørenes, V A., Hovig, E., Øyjord, T , Engebraaten, O., Holm, R. Børresen, A-L., and Fodstad, Ø. Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. Br. J. Cancer, 73. 909-916, 1996.
46. Serrano, M , Lee, H-W., Chin, L., Cordon-Cardo, C., Beach, D., and DePinho, R. A Role of the INK4a locus in tumor suppression and cell mortality. Cell, 85: 27-37, 1996
47. Bataille, V , Hiles, R , and Bishop, J A N. Retinoblastoma, melanoma and the atypical mole syndrome Br. J. Dermatol., 132: 134-138, 1995.
48. Ink4/MTS1 tumour suppressor gene product. EMBO J., 14: 503-511, 1995.
49. Li, Y., Nichols, M. A , Shay, J W., and Xiong, Y Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb Cancer Res , 54 6078-6082, 1994.
50. Ink4. Cancer Res., 54: 5816-5820, 1994
51. Ink4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene, 9: 3375-3378, 1994.
52. Aagaard, L., Lukas, J., Bartkova, J., Kjerulff, A-A., Strauss, M., and Bartek, J. Aberrtions of p16 Ink4 and retinoblastoma tumour suppressor genes occur in distinct subsets of human cancer cell lines. Int. J. Cancer, 61: 115-120, 1995
53. INK in human cancer Proc. Natl. Acad. Sci. USA, 91 11045-11049, 1994.
54. Guan, K., Jenkins, C. W , Li, Y , Nichols, M A., Wu, X., O'Keefe, C. L., Matera, A. O., and Xiong, Y Growth suppression by p18, a p16 and p14-related CDK6 inhibitor, correlates with wild-type pRB function. Genes & Dev., 8: 2939-2952, 1994.
55. Ink4 requires functional retinoblastoma protein. Proc Natl. Acad. Sci. USA, 92: 6289-6293, 1995.
56. de Boer, C. J., Schuuring, E., Dreef, E., Peters, G., Bartek, J., Kluin, P. M , and van Krieken, J. H. J. M. Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma. Blood, 86: 2715-2723, 1995.
57. Gillet, C., Smith, P., Gregory, W., Richards, M., Millis, R , Peters, G , and Barnes, D. Cyclin D1 and prognosis in human breast cancer Int. J. Cancer (Pred. Oncol.), 69: 92-99, 1996
58. Michalides, R., van Veelen, N., Hart, A , and Balm, A Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck Cancer Res., 55: 975-978, 1995.