Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL

Oncogene

Volumn 27, Issue 4, 2008, Pages 490-498

  Bae, S I ^a   Cheriyath, V ^a   Jacobs, B S ^a   Reu, F J ^a   Borden, E C ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

5 AZAdC; Apoptosis; DR4; IFNs; Melanoma

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DEATH RECEPTOR 4; INTERFERON; RETROVIRUS VECTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MEGADOSE; FLOW CYTOMETRY; GENE EXPRESSION; GENE IDENTIFICATION; GENE INDUCTION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; MELANOMA CELL; METHYLATION; NICK END LABELING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECRETION;

APOPTOSIS; AZACITIDINE; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; INTERFERONS; MELANOMA; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 38349041706     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210655     Document Type: Article

References (23)

1. Ashkenazi A, Dixit V. (1998). Death receptors: signaling and modulation. Science 281: 1305.
2. Borden EC. (2003). Interferons. In: Kufe D, Pollock R, Weichselbaum R, Bast R, Gansler T, Holland J, Frei T (eds). Cancer Medicine, 6th ed. Baltimore: Williams and Williams, pp 830-841.
3. Byun D, Cho K, Ryu B, Lee M, Kang M, Kim H et al. (2003). Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res 63: 7068.
4. Chawla-Sarkar M, Bae S, Reu F, Jacobs B, Lindner D, Borden E. (2004). Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ 11: 9 15.
5. Chawla-Sarkar M, Lindner D, Liu Y, Williams B, Sen G, Silverman R et al. (2003). Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8: 237.
6. Der S, Zhou A, Williams B, Silverman R. (1998). Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 95: 15623.
7. Deveraux Q, Takahashi R, Salvesen G, Reed J. (1997). X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388: 300.
8. Egger G, Liang G, Aparicio A, Jones PA. (2004). Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457.
9. Esteller M, Corn P, Baylin S, Herman J. (2001). A gene hypermethylation profile of human cancer. Cancer Res 61: 3225.
10. Herman J, Baylin S. (2003). Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042.
11. Hoon D, Spugnardi M, Kuo C, Huang S, Morton D, Taback B. (2004). Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients. Oncogene 23: 4014.
12. Hopkins-Donaldson S, Ziegler A, Kurtz S, Bigosch C, Kandioler D, Ludwig C et al. (2003). Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation. Cell Death Differ 10: 356.
13. Kulaeva O, Draghici S, Tang L, Kraniak J, Land S, Tainsky M. (2003). Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. Oncogene 22: 4118.
14. Leaman D, Chawla-Sarkar M, Jacobs B, Vyas K, Sun Y, Ozdemir A et al. (2003). Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2. J Interferon Cytokine Res 23: 745.
15. Leaman D, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S et al. (2002). Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. J Biol Chem 277: 28504.
16. Liston P, Fong W, Kelly N, Toji S, Miyazaki T, Conte D et al. (2001). Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat Cell Biol 3: 128.
17. Lu R, Au W, Yeow W, Hageman N, Pitha P. (2000). Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferons and silencing by hypermethylation. J Biol Chem 275: 31805.
18. Ng K, Campos E, Martinka M, Li G. (2004). XAF1 expression is significantly reduced in human melanoma. J Invest Dermatol 123: 1127.
19. Pfeffer L, Dinarello C, Herberman R, Williams B, Borden E, Bordens R et al. (1998). Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res 58: 2489.
20. Reu F, Bae S, Cherkassky L, Leaman D, Lindner D, Beaulieu N et al. (2006a). Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J Clin Oncol 24: 3771.
21. Reu F, Leaman D, Maitra R, Bae S, Cherkassky L, Fox M et al. (2006b). Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons. Cancer Res 66: 2785.
22. Spugnardi M, Tommasi S, Dammann R, Pfeifer G, Hoon D. (2003). Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res 63: 1639.
23. Stark G, Kerr I, Williams B, Silverman R, Schreiber R. (1998). How cells respond to interferons. Annu Rev Biochem 67: 227.