Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines

Melanoma Research

Volumn 8, Issue 3, 1998, Pages 197-203

  Selzer, E ^a   Schlagbauer Wadl, H ^b   Okamoto, I ^b   Pehamberger, H ^b   Potter R ^a   Jansen, B ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Bcl 2 family; Melanocytes; Melanoma

Indexed keywords

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL LINE; DNA DEGRADATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE; SPLICEOSOME;

ADULT; ALTERNATIVE SPLICING; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; DNA FRAGMENTATION; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; LYMPHATIC METASTASIS; MELANOCYTES; MELANOMA; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0031838967     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-199806000-00001     Document Type: Article

References (31)

1. Koh HN. Cutaneous melanoma. N Engl J Med 1991; 325: 171-182.
2. Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994; 78: 539-542.
3. Bakhshi A, Jensen JP, Goldman P, et al. Cloning the chromosomal breakpoint of the t(14:18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on chromosome 18. Cell 1985; 41: 889-906.
4. Hockenbery DM, Oltvai XN, Xiao-Ming Y, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-251.
5. Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 1992; 11: 121-139.
6. Lowe StW, Ruley HE, Jacks T, et al. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74: 957-967.
7. Lowe StW, Schmitt E, Smith SW, et al. p53 is required for radiation induced apoptosis in mouse thymocytes. Nature 1993; 362: 847-849.
8. Aguilar-Santelises M, Rottenberg M, Lewin N, et al. Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression. Int J Cancer 1996; 69: 114-119.
9. Gazzaniga P, Gradilone A, Vercillo R, et al. Bcl-2/Bax mRNA expression ratio as a prognostic factor in low-grade urinary bladder cancer. Int J Cancer 1996; 69: 100-104.
10. Krajewska M, Moss St, Krajewski St, et al. Elevated expression of Bcl-x and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 1996; 56: 2422-2427.
11. Thomas A, El Rouby S, Reed JC, et al. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and the Bcl-2/bax proteins in drug resistance. Oncogene 1996; 12(5): 1055-1062.
12. Cerroni L, Soyer HP, Kerl H. Bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi. Am J Dermatopathol 1995; 17: 7-11.
13. Collins KA, White WL. Intercellular adhesion molecule 1 (ICAM-1) and bcl-2 are differentially expressed in early evolving malignant melanoma. Am J Dermatopathol 1995; 17: 429-438.
14. Morales-Ducret CR, van-de-Rijn M, LeBrun DP, et al. Bcl-2 expression in primary malignancies of the skin. Arch Dermatol 1995; 131: 909-912.
15. Plettenberg A, Ballaun C, Pammer J, et al. Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture. Am J Pathol 1995; 146: 651-659.
16. Ramsay JA, From L, Kahn HJ. Bcl 2 protein expression in melanocytic neoplasms of the skin. Mod Pathol 1995; 8: 150-154.
17. Saenz-Santamaria M, Reed JC, McNutt N, et al. Immunohistochemical expression of Bcl-2 in melanomas and intradermal naevi. J Cutan Pathol 1994; 21: 393-397.
18. Van den Oord J, Vandeghinste N, De Ley M, et al. Bcl-2 expression in human melanocytes and melanocytic tumors. Am J Pathol 1995; 145: 294-300.
19. Tron V, Krajewski S, Klein-Parker H, et al. Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma. Am J Pathol 1995; 146: 643-650.
20. Grover R, Wilson GD. Bcl-2 expression in malignant melanoma and its prognostic significance. Eur J Surg Oncol 1996; 22: 347-349.
21. Mooney E, Peris J, O'Neill A, et al. Apoptotic and mitotic indices in malignant melanoma and basal cell carcinoma. J Clin Pathol 1995; 48: 242-244.
22. Grandilone A, Greco G, Gazzaniga P, et al. BAX gene expression in melanoma metastases. J Invest Dermatol 1996; 106: 382(letter).
23. Hartmann A, Blaszyk H, Cunningham J, et al. Over-expression and mutations of p53 in metastatic malignant melanomas. Int J Cancer 1996; 67: 313-317.
24. 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci USA 1994; 91: 8856-8860.
25. Huang S, Luca M, Gutman M, et al. Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 1996; 5: 2339-2347.
26. Jansen B, Inoue SA, Wadl H, et al. N-ras oncogene expression changes the growth characteristics of human melanoma in two independent SCID-hu mouse models. Int J Cancer 1996; 67: 821-825.
27. Jansen B, Schlagbauer-Wadl H, Eichler H, et al. Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis. Cancer Res 1997; 57: 362-365.
28. Van Elsas A, Nijman H, Van der Minne C, et al. Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21 ras presented by HLA-A*0201. Int J Cancer 1995; 61: 389-396.
29. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning. Cold Spring Harbor Laboratory Press, 1989.
30. Krajewski S, Bodrug S, Krajewska M, et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 1995; 146: 1309-1319.
31. Maroto R, Perez-Polo JR. Bcl-2 related protein expression in apoptosis: oxidative stress versus serum deprivation in PC12 cells. J Neurochem 1997; 69: 514-523.