-
1
-
-
0016524715
-
Synthesis of an active hydroxylated glutethimide metabolite and some related analogs with sedative-hypnotic and anticonvulsant properties
-
Aboul-Enein, H. Y., Schauberger, C. W., Hansen, A. R., Fischer, L. J. (1975) Synthesis of an active hydroxylated glutethimide metabolite and some related analogs with sedative-hypnotic and anticonvulsant properties. J. Med. Chem. 18: 736-741
-
(1975)
J. Med. Chem
, vol.18
, pp. 736-741
-
-
Aboul-Enein, H.Y.1
Schauberger, C.W.2
Hansen, A.R.3
Fischer, L.J.4
-
2
-
-
0033912867
-
Effect of zonal transport and metabolism on hepatic removal: Enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation with perfusion data
-
Abu Zahra, T. N., Pang, K. S. (2000) Effect of zonal transport and metabolism on hepatic removal: enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation with perfusion data. Drug Metab. Dispos. 28: 807-813
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 807-813
-
-
Abu Zahra, T.N.1
Pang, K.S.2
-
3
-
-
0031469362
-
Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters
-
Agus, D. B., Gambhir, S. S., Pardridge, W. M., Spielholz, C., Baselga, J., Vera, J. C., Golde, D. W. (1997) Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J. Clin. Invest. 100: 2842-2848
-
(1997)
J. Clin. Invest
, vol.100
, pp. 2842-2848
-
-
Agus, D.B.1
Gambhir, S.S.2
Pardridge, W.M.3
Spielholz, C.4
Baselga, J.5
Vera, J.C.6
Golde, D.W.7
-
4
-
-
0030020934
-
Intestinal absorption of bile acids in the rabbit. Different transport rates in jejunum and ileum
-
Aldini, R., Montagnani, M., Roda, A., Hrelia, S., Biagi, P. L., Roda, E. (1996) Intestinal absorption of bile acids in the rabbit. Different transport rates in jejunum and ileum. Gastroenterology 110: 459-468
-
(1996)
Gastroenterology
, vol.110
, pp. 459-468
-
-
Aldini, R.1
Montagnani, M.2
Roda, A.3
Hrelia, S.4
Biagi, P.L.5
Roda, E.6
-
5
-
-
9444287125
-
Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry
-
Alvarez-Diez, T. M., Zheng, J. (2004) Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry. Drug Metab. Dispos. 32: 1345-1350
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 1345-1350
-
-
Alvarez-Diez, T.M.1
Zheng, J.2
-
6
-
-
0022529466
-
Hydrolysis of organic sulfates in periportal and pericentral regions of the liver lobule: Studies with 4-methylumbelliferyl sulfate in the perfused rat liver
-
Anundi, I. M., Kauffman, F. C., El-Mouelhi, M., Thurman, R. G. (1986) Hydrolysis of organic sulfates in periportal and pericentral regions of the liver lobule: studies with 4-methylumbelliferyl sulfate in the perfused rat liver. Mol. Pharmacol. 29: 599-605
-
(1986)
Mol. Pharmacol
, vol.29
, pp. 599-605
-
-
Anundi, I.M.1
Kauffman, F.C.2
El-Mouelhi, M.3
Thurman, R.G.4
-
7
-
-
14544308826
-
Pharmacokinetics of prednisolone in man during acute and chronic exposure to high altitude
-
Arancibia, A., Gai, M. N., Chávez, J., Paulos, C., Pinilla, E., González, C., Villanueva, S., Ritschel, W. A. (2005) Pharmacokinetics of prednisolone in man during acute and chronic exposure to high altitude. Int. J. Clin. Pharmacol. Ther. 43: 85-91
-
(2005)
Int. J. Clin. Pharmacol. Ther
, vol.43
, pp. 85-91
-
-
Arancibia, A.1
Gai, M.N.2
Chávez, J.3
Paulos, C.4
Pinilla, E.5
González, C.6
Villanueva, S.7
Ritschel, W.A.8
-
8
-
-
18644385994
-
Contemporary issues in toxicology. Drug metabolites in safety
-
Baillie, T. A., Cayen, M. N., Founda, H., Gerson, R. J., Green, J. D., Grosman, S. J., Klunk, L. J., LeBlanc, B., Perkins, D. G., Shipley, L. A. (2002) Contemporary issues in toxicology. Drug metabolites in safety. Toxicol. Appl. Pharmacol. 182: 188-196
-
(2002)
Toxicol. Appl. Pharmacol
, vol.182
, pp. 188-196
-
-
Baillie, T.A.1
Cayen, M.N.2
Founda, H.3
Gerson, R.J.4
Green, J.D.5
Grosman, S.J.6
Klunk, L.J.7
LeBlanc, B.8
Perkins, D.G.9
Shipley, L.A.10
-
9
-
-
0029090947
-
Diclofenac-associated hepatotoxicity: Analysis of 180 cases reported to the Food and Drug Administration as adverse reactions
-
Banks, A. T., Zimmerman, H. J., Ishak, K. G., Harter, J. G. (1995) Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions. Hepatology 22: 820-827
-
(1995)
Hepatology
, vol.22
, pp. 820-827
-
-
Banks, A.T.1
Zimmerman, H.J.2
Ishak, K.G.3
Harter, J.G.4
-
10
-
-
0018126185
-
Immunohistochemical localizations of cytochromes P-450 in rat liver
-
Baron, J., Redick, J. A., Guengerich, F. P. (1978) Immunohistochemical localizations of cytochromes P-450 in rat liver. Life Sci. 23: 2627-2632
-
(1978)
Life Sci
, vol.23
, pp. 2627-2632
-
-
Baron, J.1
Redick, J.A.2
Guengerich, F.P.3
-
11
-
-
0018876721
-
Immunohistochemical localization of epoxide hydratase in rat liver
-
Baron, J., Redick, J. A., Guengerich, F. P. (1980) Immunohistochemical localization of epoxide hydratase in rat liver. Life Sci. 26: 489-493
-
(1980)
Life Sci
, vol.26
, pp. 489-493
-
-
Baron, J.1
Redick, J.A.2
Guengerich, F.P.3
-
12
-
-
0019732980
-
An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats
-
Baron, J., Redick, J. A., Guengerich, F. P. (1981) An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats. J. Biol. Chem. 256: 5931-5937
-
(1981)
J. Biol. Chem
, vol.256
, pp. 5931-5937
-
-
Baron, J.1
Redick, J.A.2
Guengerich, F.P.3
-
13
-
-
0029768927
-
The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites
-
Barry, M. G., Khoo, S. H., Veal, G. J., Hoggard, P. G., Gibbons, S. E., Wilkins, E. G., Williams, O., Breckenridge, A. M., Back, D. J. (1996) The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites. AIDS 10: 1361-1367
-
(1996)
AIDS
, vol.10
, pp. 1361-1367
-
-
Barry, M.G.1
Khoo, S.H.2
Veal, G.J.3
Hoggard, P.G.4
Gibbons, S.E.5
Wilkins, E.G.6
Williams, O.7
Breckenridge, A.M.8
Back, D.J.9
-
14
-
-
33845996187
-
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values on human microsomal protein and hepatocellurity per gram of liver
-
Barter, Z. E., Bayliss, M. K., Beaune, P. H., Boobis, A. R., Carlie, D. J., Edwards, R. J., Houston, J. B., Lake, B. G., Lipscomb, J. C., Pelkonen, O. R., Tucker, G. T., Rostami-Hodjegan, A. (2007) Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values on human microsomal protein and hepatocellurity per gram of liver. Curr. Drug Metab. 8: 33-45
-
(2007)
Curr. Drug Metab
, vol.8
, pp. 33-45
-
-
Barter, Z.E.1
Bayliss, M.K.2
Beaune, P.H.3
Boobis, A.R.4
Carlie, D.J.5
Edwards, R.J.6
Houston, J.B.7
Lake, B.G.8
Lipscomb, J.C.9
Pelkonen, O.R.10
Tucker, G.T.11
Rostami-Hodjegan, A.12
-
15
-
-
0023146745
-
Effect of phenobarbital on the distribution of drug metabolizing enzymes between periportal and perivenous rat hepatocytes prepared by digitonin-collagenase liver perfusion
-
Bengtsson, G., Julkunen, A., Penttilä, K. E., Lindros, K. O. (1987) Effect of phenobarbital on the distribution of drug metabolizing enzymes between periportal and perivenous rat hepatocytes prepared by digitonin-collagenase liver perfusion. J. Pharmacol. Exp. Ther. 240: 663-667
-
(1987)
J. Pharmacol. Exp. Ther
, vol.240
, pp. 663-667
-
-
Bengtsson, G.1
Julkunen, A.2
Penttilä, K.E.3
Lindros, K.O.4
-
16
-
-
0017897407
-
Clinical pharmacokinetics of lignocaine
-
Benowitz, N. L., Meister, W. (1978) Clinical pharmacokinetics of lignocaine. Clin. Pharmacokinet. 3: 177-201
-
(1978)
Clin. Pharmacokinet
, vol.3
, pp. 177-201
-
-
Benowitz, N.L.1
Meister, W.2
-
17
-
-
34247254387
-
Lisdexamfetamine
-
discussion 136-128
-
Blick, S. K., Keating, G. M. (2007) Lisdexamfetamine. Paediatr. Drugs 9: 129-135; discussion 136-128
-
(2007)
Paediatr. Drugs
, vol.9
, pp. 129-135
-
-
Blick, S.K.1
Keating, G.M.2
-
18
-
-
0027957331
-
Renal tubular transport of cimetidine in the isolated perfused kidney of the rat
-
Boom, S. P., Moons, M. M., Russel, F. G. (1994) Renal tubular transport of cimetidine in the isolated perfused kidney of the rat. Drug Metab. Dispos. 22: 148-153
-
(1994)
Drug Metab. Dispos
, vol.22
, pp. 148-153
-
-
Boom, S.P.1
Moons, M.M.2
Russel, F.G.3
-
19
-
-
0019974098
-
Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics
-
Boxenbaum, H. (1982) Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics. J. Pharmacokinet. Biopharm. 10: 201-227
-
(1982)
J. Pharmacokinet. Biopharm
, vol.10
, pp. 201-227
-
-
Boxenbaum, H.1
-
20
-
-
0021010984
-
Interspecies pharmacokinetic scaling and the Dedrick plots
-
Boxenbaum, H., Ronfeld, R. (1983) Interspecies pharmacokinetic scaling and the Dedrick plots. Am. J. Physiol. 245: R768-R775
-
(1983)
Am. J. Physiol
, vol.245
-
-
Boxenbaum, H.1
Ronfeld, R.2
-
21
-
-
0018215446
-
In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes
-
Boyd, M. R., Burka, L. T., Wilson, B. J., Sasame, H. A. (1978) In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes. J. Pharmacol. Exp. Ther. 207: 677-686
-
(1978)
J. Pharmacol. Exp. Ther
, vol.207
, pp. 677-686
-
-
Boyd, M.R.1
Burka, L.T.2
Wilson, B.J.3
Sasame, H.A.4
-
22
-
-
0018828779
-
Pharmacokinetics of benzodiazepines. Short-acting versus long-acting
-
Breimer, D. D., Jochemsen, R., von Albert, H. H. (1980) Pharmacokinetics of benzodiazepines. Short-acting versus long-acting. Arzneimittelforschung 30: 875-881
-
(1980)
Arzneimittelforschung
, vol.30
, pp. 875-881
-
-
Breimer, D.D.1
Jochemsen, R.2
von Albert, H.H.3
-
23
-
-
0032873150
-
Pharmacokinetics of valganciclovir and ganciclovir following multiple oral dosages of valganciclovir in HIV- and CMV-seropositive volunteers
-
Brown, F., Banken, L., Saywell, K., Arum, I. (1999) Pharmacokinetics of valganciclovir and ganciclovir following multiple oral dosages of valganciclovir in HIV- and CMV-seropositive volunteers. Clin. Pharmacokinet. 37: 167-176
-
(1999)
Clin. Pharmacokinet
, vol.37
, pp. 167-176
-
-
Brown, F.1
Banken, L.2
Saywell, K.3
Arum, I.4
-
24
-
-
28144464500
-
Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine
-
Bu, H.-Z., Kang, P., Deese, A. J., Zhao, P., Pool, W. F. (2005) Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine. Drug Metab. Dispos. 33: 1920-1924
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1920-1924
-
-
Bu, H.-Z.1
Kang, P.2
Deese, A.J.3
Zhao, P.4
Pool, W.F.5
-
25
-
-
23444432215
-
-
Bueno, A. B., Collado, I., de Dios, A., Dominguez, C., Martin, J. A., Martin, L. M., Martinez-Grau, M. A., Montero, C., Pedregal, C., Catlow, J., Coffey, D. S., Clay, M. P., Dantzig, A. H., Lindstrom, T., Monn, J. A., Jiang, H., Sehoepp, D. D., Stratford, R. E., Tabas, L. B., Tizzano, J. P., Wright, R. A., Herin, M. F. (2005) Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo-[3.1.0]hexane-2.6-dicarboxylic acid (LY354740). a selective group II metabotropic glutamate receptor agonist. J. Med. Chem. 48: 5305-5320
-
Bueno, A. B., Collado, I., de Dios, A., Dominguez, C., Martin, J. A., Martin, L. M., Martinez-Grau, M. A., Montero, C., Pedregal, C., Catlow, J., Coffey, D. S., Clay, M. P., Dantzig, A. H., Lindstrom, T., Monn, J. A., Jiang, H., Sehoepp, D. D., Stratford, R. E., Tabas, L. B., Tizzano, J. P., Wright, R. A., Herin, M. F. (2005) Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo-[3.1.0]hexane-2.6-dicarboxylic acid (LY354740). a selective group II metabotropic glutamate receptor agonist. J. Med. Chem. 48: 5305-5320
-
-
-
-
26
-
-
0022120977
-
Statistical moment theory in chemical kinetics
-
Chan, K. K., Bolger, M. K., Pang, K. S. (1985) Statistical moment theory in chemical kinetics. Analyt. Chem. 11: 2145-2151
-
(1985)
Analyt. Chem
, vol.11
, pp. 2145-2151
-
-
Chan, K.K.1
Bolger, M.K.2
Pang, K.S.3
-
27
-
-
33751517109
-
The role of P-glycoprotein in the bioactivation of raloxifene
-
Chang, J. H., Kochansky, C. J., Magang, S. (2006) The role of P-glycoprotein in the bioactivation of raloxifene. Drug Metab. Dispos. 34: 2073-2078
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 2073-2078
-
-
Chang, J.H.1
Kochansky, C.J.2
Magang, S.3
-
28
-
-
8244231924
-
Effect of flow on first-pass metabolism of drugs: Single pass studies on 4-methylumbelliferone (4MU) conjugation in the serially perfused rat intestine and liver preparations
-
Chen, J., Pang, K. S. (1997) Effect of flow on first-pass metabolism of drugs: single pass studies on 4-methylumbelliferone (4MU) conjugation in the serially perfused rat intestine and liver preparations. J. Pharmacol. Exp. Ther. 280: 24-31
-
(1997)
J. Pharmacol. Exp. Ther
, vol.280
, pp. 24-31
-
-
Chen, J.1
Pang, K.S.2
-
29
-
-
33745122240
-
3 via the vitamin D receptor (VDR)
-
3 via the vitamin D receptor (VDR). Mol. Pharmacol. 69: 1913-1923
-
(2006)
Mol. Pharmacol
, vol.69
, pp. 1913-1923
-
-
Chen, X.1
Chen, F.2
Liu, S.3
Glaeser, H.4
Dawson, P.A.5
Hofmann, A.F.6
Kim, R.B.7
Shneider, B.L.8
Pang, K.S.9
-
30
-
-
29944433942
-
Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: Identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats
-
Chen, Q., Doss, G. A., Tung, E. C., Liu, W., Tang, Y. S., Braun, M. P., Didolkar, V., Strauss, J. R., Wang, R. W., Stearns, R. A., Evans, D. C., Baillie, T. A., Tang W. (2006b) Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats. Drug Metab. Dispos. 34: 145-151
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 145-151
-
-
Chen, Q.1
Doss, G.A.2
Tung, E.C.3
Liu, W.4
Tang, Y.S.5
Braun, M.P.6
Didolkar, V.7
Strauss, J.R.8
Wang, R.W.9
Stearns, R.A.10
Evans, D.C.11
Baillie, T.A.12
Tang, W.13
-
31
-
-
0028053248
-
Glycine conjugation activity of benzoic acid and its acinar localization in the perfused rat liver
-
Chiba, M., Poon, K., Hollands, J., Pang, K. S. (1994) Glycine conjugation activity of benzoic acid and its acinar localization in the perfused rat liver. J. Pharmacol. Exp. Ther. 268: 409-416
-
(1994)
J. Pharmacol. Exp. Ther
, vol.268
, pp. 409-416
-
-
Chiba, M.1
Poon, K.2
Hollands, J.3
Pang, K.S.4
-
32
-
-
0033984905
-
A new physiologically-based segregated flow model to explain route-dependent intestinal metabolism
-
Cong, D., Doherty, M., Pang, K. S. (2000) A new physiologically-based segregated flow model to explain route-dependent intestinal metabolism. Drug Metab. Dispos. 28: 224-235
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 224-235
-
-
Cong, D.1
Doherty, M.2
Pang, K.S.3
-
33
-
-
0035201323
-
Absorption of benzoic acid (BA) by segmental regions of the in situ perfused rat small intestine
-
Cong, D., Fong, A. K. Y., Lee, R., Pang, K. S. (2001) Absorption of benzoic acid (BA) by segmental regions of the in situ perfused rat small intestine. Drug Metab. Dispos. 29: 1539-1547
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 1539-1547
-
-
Cong, D.1
Fong, A.K.Y.2
Lee, R.3
Pang, K.S.4
-
34
-
-
0020332542
-
Clinical pharmacokinetics of N-acctylprocainamide
-
Connolly, S. J., Kates, R. E. (1982) Clinical pharmacokinetics of N-acctylprocainamide. Clin. Pharmaeokinet. 7: 206-220
-
(1982)
Clin. Pharmaeokinet
, vol.7
, pp. 206-220
-
-
Connolly, S.J.1
Kates, R.E.2
-
35
-
-
0019967061
-
Rates of sulfation and glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule
-
Conway, J. G., Kauffman, F. C., Ji, S., Thurman, R. G. (1982) Rates of sulfation and glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule. Mol. Pharmacol. 22: 509-516
-
(1982)
Mol. Pharmacol
, vol.22
, pp. 509-516
-
-
Conway, J.G.1
Kauffman, F.C.2
Ji, S.3
Thurman, R.G.4
-
36
-
-
0021186540
-
Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule
-
Conway, J. G., Kauffman, F. C., Tsukada, T., Thurma, R. G. (1984) Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule. Mol. Pharmacol. 25: 487-493
-
(1984)
Mol. Pharmacol
, vol.25
, pp. 487-493
-
-
Conway, J.G.1
Kauffman, F.C.2
Tsukada, T.3
Thurma, R.G.4
-
37
-
-
4644251930
-
XP13512 [(+/-)-1-([(alpha-isobutanoyl-oxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys
-
Cundy, K. C., Annamalai, T., Bu, L., De Vera, J., Estrela, J., Luo, W., Shirsat, P., Torneros, A., Yao, F., Zou, J., Barrett, R. W., Gallop, M. A. (2004) XP13512 [(+/-)-1-([(alpha-isobutanoyl-oxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J. Pharmacol. Exp. Ther. 311: 324-333
-
(2004)
J. Pharmacol. Exp. Ther
, vol.311
, pp. 324-333
-
-
Cundy, K.C.1
Annamalai, T.2
Bu, L.3
De Vera, J.4
Estrela, J.5
Luo, W.6
Shirsat, P.7
Torneros, A.8
Yao, F.9
Zou, J.10
Barrett, R.W.11
Gallop, M.A.12
-
38
-
-
39749119900
-
Morphine-6-glucuronide (M6G) for postoperative pain relief
-
Dahan, A., van Dorp, E., Smith, T., Yassen, A. (2008) Morphine-6-glucuronide (M6G) for postoperative pain relief. Eur. J. Pain 12: 403-411
-
(2008)
Eur. J. Pain
, vol.12
, pp. 403-411
-
-
Dahan, A.1
van Dorp, E.2
Smith, T.3
Yassen, A.4
-
39
-
-
0021345926
-
N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
-
Dahlin, D. C., Miwa, G. T., Lu, A. Y., Nelson, S. D. (1984) N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. USA 81: 1327-1331
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.3
Nelson, S.D.4
-
40
-
-
13544276366
-
Vitamin C and 6-amino-vitamin C conjugates of diclofenac: Synthesis and evaluation
-
Dalpiaz, A., Pavan, B., Scaglianti, M., Vitali, F., Bortolotti, F., Biondi, C., Scatturin, A., Manfredini, S. (2005) Vitamin C and 6-amino-vitamin C conjugates of diclofenac: synthesis and evaluation. Int. J. Pharm. 291: 171-181
-
(2005)
Int. J. Pharm
, vol.291
, pp. 171-181
-
-
Dalpiaz, A.1
Pavan, B.2
Scaglianti, M.3
Vitali, F.4
Bortolotti, F.5
Biondi, C.6
Scatturin, A.7
Manfredini, S.8
-
41
-
-
33845734598
-
A regulatory perspective on issues and approaches in characterizing human metabolites
-
Davis-Bruno, K. L., Atrakchi, A. (2006) A regulatory perspective on issues and approaches in characterizing human metabolites. Chem. Res. Toxicol. 19: 1561-1563
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 1561-1563
-
-
Davis-Bruno, K.L.1
Atrakchi, A.2
-
42
-
-
0021967497
-
Alteration of transit time and direction of flow to probe the heterogeneous distribution of conjugating activities for harmol in the perfused rat liver preparation
-
Dawson, J. R., Weitering, J. G., Mulder, G. J., Stillwell, R. N., Pang, K. S. (1985) Alteration of transit time and direction of flow to probe the heterogeneous distribution of conjugating activities for harmol in the perfused rat liver preparation. J. Pharmacol. Exp. Ther. 234: 691-697
-
(1985)
J. Pharmacol. Exp. Ther
, vol.234
, pp. 691-697
-
-
Dawson, J.R.1
Weitering, J.G.2
Mulder, G.J.3
Stillwell, R.N.4
Pang, K.S.5
-
43
-
-
34748925493
-
Prediction of human pharmacokinetics using physiologically based modeling: A retrospective analysis of 26 clinically tested drugs
-
De Buck, S. S., Sinha, V. K., Fenu, L. A., Nijsen, M. J., Mackie, C. E., Gilissen, R. A. H. J. (2007) Prediction of human pharmacokinetics using physiologically based modeling: A retrospective analysis of 26 clinically tested drugs. Drug Metab. Dispos. 35: 1766-1780
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1766-1780
-
-
De Buck, S.S.1
Sinha, V.K.2
Fenu, L.A.3
Nijsen, M.J.4
Mackie, C.E.5
Gilissen, R.A.H.J.6
-
44
-
-
0022552177
-
Presence of a diffusional barrier on metabolite kinetics: Enalaprilat as a generated versus preformed metabolite
-
de Lannoy, I. A. M. Pang, K. S. (1986) Presence of a diffusional barrier on metabolite kinetics: enalaprilat as a generated versus preformed metabolite. Drug Metab. Dispos. 14: 513-520
-
(1986)
Drug Metab. Dispos
, vol.14
, pp. 513-520
-
-
de Lannoy, I.A.M.1
Pang, K.S.2
-
45
-
-
0023136808
-
Effect of diffusional barriers on drug and metabolite kinetics
-
de Lannoy, I. A. M, Pang, K. S. (1987) Effect of diffusional barriers on drug and metabolite kinetics. Drug Metab. Dispos. 15: 51-58
-
(1987)
Drug Metab. Dispos
, vol.15
, pp. 51-58
-
-
de Lannoy, I.A.M.1
Pang, K.S.2
-
46
-
-
0027764286
-
Combined recirculation of the rat liver and kidney: Studies with enalapril and enalaprilat
-
de Lannoy, I. A. M., Pang, K. S (1993) Combined recirculation of the rat liver and kidney: Studies with enalapril and enalaprilat. J. Pharmacokinet. Biopharm. 21: 423-456
-
(1993)
J. Pharmacokinet. Biopharm
, vol.21
, pp. 423-456
-
-
de Lannoy, I.A.M.1
Pang, K.S.2
-
47
-
-
0027752898
-
Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: Studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver
-
de Lannoy, I. A. M., Barker, F. 3rd, Pang, K. S. (1993) Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver. J. Pharmaeokinet. Biopharm. 21: 395-422
-
(1993)
J. Pharmaeokinet. Biopharm
, vol.21
, pp. 395-422
-
-
de Lannoy, I.A.M.1
Barker 3rd, F.2
Pang, K.S.3
-
48
-
-
18044387775
-
Differential contributions of rOat1 (S1c22a6) and rOat3 (S1c22a8) to the in vivo renal uptake of uremic toxins in rats
-
Deguchi, T., Kouno, Y., Terasaki, T., Takadate, A., Otagiri, M. (2005) Differential contributions of rOat1 (S1c22a6) and rOat3 (S1c22a8) to the in vivo renal uptake of uremic toxins in rats. Pharm. Res. 22: 619-627
-
(2005)
Pharm. Res
, vol.22
, pp. 619-627
-
-
Deguchi, T.1
Kouno, Y.2
Terasaki, T.3
Takadate, A.4
Otagiri, M.5
-
49
-
-
0036842822
-
Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine
-
Desmoulin, F., Gilard, V., Malet-Martino, M., Martino, R. (2002) Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine. Drug Metab. Dispos. 30: 1221-1229
-
(2002)
Drug Metab. Dispos
, vol.30
, pp. 1221-1229
-
-
Desmoulin, F.1
Gilard, V.2
Malet-Martino, M.3
Martino, R.4
-
50
-
-
0034003625
-
Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation
-
Doherty, M., Pang, K. S. (2000) Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation. Pharm. Res. 17: 290-297
-
(2000)
Pharm. Res
, vol.17
, pp. 290-297
-
-
Doherty, M.1
Pang, K.S.2
-
51
-
-
33645840145
-
Transport is not rate-limiting in morphine glucuronidation in the single pass perfused rat liver preparation
-
Doherty, M., Poon, K., Tsang, C., Pang, K. S. (2006) Transport is not rate-limiting in morphine glucuronidation in the single pass perfused rat liver preparation. J. Pharmacol. Exp. Ther. 317: 890-900
-
(2006)
J. Pharmacol. Exp. Ther
, vol.317
, pp. 890-900
-
-
Doherty, M.1
Poon, K.2
Tsang, C.3
Pang, K.S.4
-
52
-
-
0017096846
-
Pharmacologically active drug metabolites: Therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure
-
Drayer, D. E. (1976) Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure. Clin. Pharmaeokinet. 1: 423-443
-
(1976)
Clin. Pharmaeokinet
, vol.1
, pp. 423-443
-
-
Drayer, D.E.1
-
53
-
-
0023833285
-
Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine I. Monooxyenases
-
Dubey, R. K., Singh, J. (1988a) Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine I. Monooxyenases. Biochem. Pharmacol. 37: 169-176
-
(1988)
Biochem. Pharmacol
, vol.37
, pp. 169-176
-
-
Dubey, R.K.1
Singh, J.2
-
54
-
-
0023858626
-
Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine II. Conjugases
-
Dubey, R. K., Singh, J. (1988b) Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine II. Conjugases. Biochem. Pharmacol. 37: 177-184
-
(1988)
Biochem. Pharmacol
, vol.37
, pp. 177-184
-
-
Dubey, R.K.1
Singh, J.2
-
55
-
-
0029055363
-
Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
-
Ducharme, M. P., Warbasse, L. H, Edwards. D. J. (1995) Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin. Pharmacol. Ther. 57: 485-491
-
(1995)
Clin. Pharmacol. Ther
, vol.57
, pp. 485-491
-
-
Ducharme, M.P.1
Warbasse, L.H.2
Edwards, D.J.3
-
56
-
-
0032826052
-
Disposition and chemical stability of telmisartan 1-O-acylglucuronide
-
Ebner, T., Heinzel, G., Prox, A., Beschke, K., Wachsmuth, H. (1999) Disposition and chemical stability of telmisartan 1-O-acylglucuronide. Drug Metab. Dispos. 27: 1143-1149
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 1143-1149
-
-
Ebner, T.1
Heinzel, G.2
Prox, A.3
Beschke, K.4
Wachsmuth, H.5
-
57
-
-
0025953783
-
The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors
-
Edwards, C. R., Stewart, P. M. (1991) The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors. J. Steroid. Biochem. Mol. Biol. 39: 859-865
-
(1991)
J. Steroid. Biochem. Mol. Biol
, vol.39
, pp. 859-865
-
-
Edwards, C.R.1
Stewart, P.M.2
-
58
-
-
0022497866
-
Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver
-
El Mouelhi, M., Kauffman, F. C. (1986) Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver. Hepatologx 6: 450-456
-
(1986)
Hepatologx
, vol.6
, pp. 450-456
-
-
El Mouelhi, M.1
Kauffman, F.C.2
-
59
-
-
33750181267
-
Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
-
Englund, G., Rorsman, F., Rönnblom, A., Karlbom, U., Lazorova, L., Gråsjö, J., Kindmark, A., Artursson, P. (2006) Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells. Eur. J. Pharm. Sci. 29: 269-277
-
(2006)
Eur. J. Pharm. Sci
, vol.29
, pp. 269-277
-
-
Englund, G.1
Rorsman, F.2
Rönnblom, A.3
Karlbom, U.4
Lazorova, L.5
Gråsjö, J.6
Kindmark, A.7
Artursson, P.8
-
60
-
-
0034609777
-
A peptide prodrug approach for improving bisphosphonate oral absorption
-
Ezra, A., Hoffman, A., Breuer, E., Alferiev, I. S., Monkkonen, J., El Hanany-Rozen, N., Weiss, G., Stepensky, D., Gati, I., Cohen, H., Tormalehto, S., Amidon, G. L., Golomb, G. (2000) A peptide prodrug approach for improving bisphosphonate oral absorption. J. Med. Chem. 43: 3641-3652
-
(2000)
J. Med. Chem
, vol.43
, pp. 3641-3652
-
-
Ezra, A.1
Hoffman, A.2
Breuer, E.3
Alferiev, I.S.4
Monkkonen, J.5
El Hanany-Rozen, N.6
Weiss, G.7
Stepensky, D.8
Gati, I.9
Cohen, H.10
Tormalehto, S.11
Amidon, G.L.12
Golomb, G.13
-
61
-
-
0025193236
-
Sulfation of minoxidil by human liver phenol sulfotransferase
-
Falany, C. N., Kerl, E. A. (1990) Sulfation of minoxidil by human liver phenol sulfotransferase. Biochem. Pharmacol. 40: 1027-1032
-
(1990)
Biochem. Pharmacol
, vol.40
, pp. 1027-1032
-
-
Falany, C.N.1
Kerl, E.A.2
-
62
-
-
0035020110
-
Bioactivation of tamoxifen to metabolite E quinone methide: Reaction with glutathione and DNA
-
Fan, P. W., Bolton, J. L. (2001) Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA. Drug Metab. Dispos. 29: 891-896
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 891-896
-
-
Fan, P.W.1
Bolton, J.L.2
-
63
-
-
70350255269
-
-
FDA guidance for Industry, February Pharmcology and Toxicology
-
FDA guidance for Industry. Safety testing of drug metabolites. February 2008 Pharmcology and Toxicology. www.fda.gov/cder/guidance/
-
(2008)
Safety testing of drug metabolites
-
-
-
64
-
-
0028333611
-
Expression cloning of a mammalian proton-coupled oligopeptide transporter
-
Fei, Y. J., Kanai, Y., Nussberger, S., Ganapathy, V., Leibach, F. H., Romero, M. F., Singh, S. K., Boron, W. F., Hediger, M. A. (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368: 563-566
-
(1994)
Nature
, vol.368
, pp. 563-566
-
-
Fei, Y.J.1
Kanai, Y.2
Nussberger, S.3
Ganapathy, V.4
Leibach, F.H.5
Romero, M.F.6
Singh, S.K.7
Boron, W.F.8
Hediger, M.A.9
-
65
-
-
0024891564
-
Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: Enalapril and fosinopril
-
Friedman, D. I., Amidon, G. L. (1989) Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril. Pharm. Res. 6: 1043-1047
-
(1989)
Pharm. Res
, vol.6
, pp. 1043-1047
-
-
Friedman, D.I.1
Amidon, G.L.2
-
66
-
-
0036020060
-
Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells
-
Friedrichsen, G. M., Chen, W., Begtrup, M., Lee, C. P., Smith, P. L., Borchardt, R. T. (2002) Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells. Eur. J. Pharm. Sci. 16: 1-13
-
(2002)
Eur. J. Pharm. Sci
, vol.16
, pp. 1-13
-
-
Friedrichsen, G.M.1
Chen, W.2
Begtrup, M.3
Lee, C.P.4
Smith, P.L.5
Borchardt, R.T.6
-
67
-
-
27544515516
-
Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase
-
Fujino, H., Saito, T., Ogawa, S., Kojima, J. (2005) Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J. Pharm. Pharmacol. 57: 1305-1311
-
(2005)
J. Pharm. Pharmacol
, vol.57
, pp. 1305-1311
-
-
Fujino, H.1
Saito, T.2
Ogawa, S.3
Kojima, J.4
-
68
-
-
0035813014
-
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate
-
Funk, C., Pantze, M., Jehle, L., Ponelle, C., Scheuermann, G., Lazendic, M., Gasser, R. (2001) Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology 167: 83-98
-
(2001)
Toxicology
, vol.167
, pp. 83-98
-
-
Funk, C.1
Pantze, M.2
Jehle, L.3
Ponelle, C.4
Scheuermann, G.5
Lazendic, M.6
Gasser, R.7
-
69
-
-
52949135300
-
Oral disposition of ganciclovir amino acid ester prodrugs: Intestinal absorption and transport
-
Gandhi, M. D., Kansara, V., Mitra, A. K. (2005) Oral disposition of ganciclovir amino acid ester prodrugs: intestinal absorption and transport. AAPS J. 7: R6247
-
(2005)
AAPS J
, vol.7
-
-
Gandhi, M.D.1
Kansara, V.2
Mitra, A.K.3
-
70
-
-
0033055442
-
Differences in excretion of hippurate, as a metabolite of benzoate and as an administered species, in the single pass isolated perfused rat kidney explained
-
Geng, W., Pang, K. S. (1999) Differences in excretion of hippurate, as a metabolite of benzoate and as an administered species, in the single pass isolated perfused rat kidney explained. J. Pharmacol. Exp. Ther. 288: 597-606
-
(1999)
J. Pharmacol. Exp. Ther
, vol.288
, pp. 597-606
-
-
Geng, W.1
Pang, K.S.2
-
71
-
-
0029086218
-
Carrier-mediated uptake and excretion of bromosulfophthalein-glutathione in perfused rat liver: A multiple indicator dilution study
-
Geng, W. P., Schwab, A. J., Goresky, C. A., Pang, K. S. (1995) Carrier-mediated uptake and excretion of bromosulfophthalein-glutathione in perfused rat liver: A multiple indicator dilution study. Hepatology 22: 1188-1207
-
(1995)
Hepatology
, vol.22
, pp. 1188-1207
-
-
Geng, W.P.1
Schwab, A.J.2
Goresky, C.A.3
Pang, K.S.4
-
72
-
-
0031933944
-
Hepatic uptake of bromosulfophthalein-glutathione in perfused EHBR mutant liver: A multiple indicator dilution study
-
Geng, W., Schwab, A. J., Horie, T., Goresky, C. A., Pang, K. S. (1998) Hepatic uptake of bromosulfophthalein-glutathione in perfused EHBR mutant liver: A multiple indicator dilution study. J. Pharmacol. Exp. Ther. 284: 480-492
-
(1998)
J. Pharmacol. Exp. Ther
, vol.284
, pp. 480-492
-
-
Geng, W.1
Schwab, A.J.2
Horie, T.3
Goresky, C.A.4
Pang, K.S.5
-
73
-
-
25444509244
-
Expression and membrane localization of MCT isoforms along the length of the human intestine
-
Gill, R. K., Saksena, S., Alrefai, W. A., Sarwar, Z., Goldstein, J. L., Carroll, R. E., Ramaswamy, K., Dudeja, P. K. (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine. Am. J. Physiol. 289: 846-852
-
(2005)
Am. J. Physiol
, vol.289
, pp. 846-852
-
-
Gill, R.K.1
Saksena, S.2
Alrefai, W.A.3
Sarwar, Z.4
Goldstein, J.L.5
Carroll, R.E.6
Ramaswamy, K.7
Dudeja, P.K.8
-
74
-
-
0019288081
-
Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites
-
Gillette, J. R. (1980) Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites. Ciba Found. Symp. 76: 191-217
-
(1980)
Ciba Found. Symp
, vol.76
, pp. 191-217
-
-
Gillette, J.R.1
-
75
-
-
0033912868
-
Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals
-
Gopaul, S. V., Farrell, K., Abbott F. S. (2000) Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals. Drug Metab. Dispos. 28: 823-832
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 823-832
-
-
Gopaul, S.V.1
Farrell, K.2
Abbott, F.S.3
-
76
-
-
0026643720
-
Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver
-
Goresky, C. A., Pang, K. S., Schwab, A. J., Barker, F. 3rd, Cherry, W. F., Bach, G. G. (1992) Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver. Hepatology 15: 173-190
-
(1992)
Hepatology
, vol.15
, pp. 173-190
-
-
Goresky, C.A.1
Pang, K.S.2
Schwab, A.J.3
Barker 3rd, F.4
Cherry, W.F.5
Bach, G.G.6
-
77
-
-
0027177914
-
-
Goresky, C. A., Bach, G. G., Schwab, A. J. (1993a) Distributed-in-space product formation in vivo: linear kinetics. Am. J. Physiol. 264: H2007-H2028
-
Goresky, C. A., Bach, G. G., Schwab, A. J. (1993a) Distributed-in-space product formation in vivo: linear kinetics. Am. J. Physiol. 264: H2007-H2028
-
-
-
-
78
-
-
0027320402
-
Distributed-in-space product formation in vivo: Enzymic kinetics
-
Goresky, C. A., Bach, G. G., Schwab, A. J. (1993b) Distributed-in-space product formation in vivo: enzymic kinetics. Am. J. Physiol. 264: H2029-H2050
-
(1993)
Am. J. Physiol
, vol.264
-
-
Goresky, C.A.1
Bach, G.G.2
Schwab, A.J.3
-
79
-
-
0033958156
-
Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/ multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
-
Gotoh, Y., Suzuki, H., Kinoshita, S., Hirohashi, T., Kato, Y., Sugiyama, Y. (2000) Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/ multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats. J. Pharmacol. Exp. Ther. 292: 433-439
-
(2000)
J. Pharmacol. Exp. Ther
, vol.292
, pp. 433-439
-
-
Gotoh, Y.1
Suzuki, H.2
Kinoshita, S.3
Hirohashi, T.4
Kato, Y.5
Sugiyama, Y.6
-
80
-
-
0028143513
-
Griseofulvin absorption from different sites in the human small intestine
-
Gramatté, T. (1996) Griseofulvin absorption from different sites in the human small intestine. Biopharm. Drug Dispos. 15: 747-759
-
(1996)
Biopharm. Drug Dispos
, vol.15
, pp. 747-759
-
-
Gramatté, T.1
-
81
-
-
0028231334
-
Site-dependent small intestinal absorption of ranitidine
-
Gramatté, T., El Desoky, E., Klotz, U. (1994) Site-dependent small intestinal absorption of ranitidine. Eur. J. Clin. Pharmacol. 46: 253-259
-
(1994)
Eur. J. Clin. Pharmacol
, vol.46
, pp. 253-259
-
-
Gramatté, T.1
El Desoky, E.2
Klotz, U.3
-
82
-
-
0029999340
-
Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans
-
Gramatté, T., Oertel, R., Terhaag, B., Kirch, W. (1996) Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans. Clin. Pharmacol. Ther. 59: 541-549
-
(1996)
Clin. Pharmacol. Ther
, vol.59
, pp. 541-549
-
-
Gramatté, T.1
Oertel, R.2
Terhaag, B.3
Kirch, W.4
-
83
-
-
0021833705
-
Activity of a peptidyl prodrug, alafosfalin, against anaerobic bacteria
-
Grappel, S. F., Giovenella, A. J., Nisbet,. L. J. (1985) Activity of a peptidyl prodrug, alafosfalin, against anaerobic bacteria. Antimicrob. Agents Chemother. 27: 961-963
-
(1985)
Antimicrob. Agents Chemother
, vol.27
, pp. 961-963
-
-
Grappel, S.F.1
Giovenella, A.J.2
Nisbet, L.J.3
-
84
-
-
0142150004
-
Identification of zomepirac-S-acyl- glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile
-
Grillo, M. P., Hua, F. (2003) Identification of zomepirac-S-acyl- glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile. Drug Metab. Dispos. 31: 1429-1436
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 1429-1436
-
-
Grillo, M.P.1
Hua, F.2
-
85
-
-
0142212151
-
Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: Identification of diclofenac-S-acyl- glutathione in rat bile
-
Grillo, M. P., Knutson, C. G., Sanders, P. E., Waldon, D. J., Hua F., Ware, J. A. (2003) Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl- glutathione in rat bile. Drug Metab. Dispos. 31: 1327-1336
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 1327-1336
-
-
Grillo, M.P.1
Knutson, C.G.2
Sanders, P.E.3
Waldon, D.J.4
Hua, F.5
Ware, J.A.6
-
87
-
-
33645100073
-
Binding of drugs to hepatic microsomes: Comments and assessment of current prediction methodology with recommendation for improvement
-
Halifax, D., Houston, J. B. (2006) Binding of drugs to hepatic microsomes: comments and assessment of current prediction methodology with recommendation for improvement. Drug Metab. Dispos. 34: 724-726
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 724-726
-
-
Halifax, D.1
Houston, J.B.2
-
88
-
-
0031662109
-
5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
-
Han, H., de Vrueh, R. L., Rhie, J. K., Covitz, K. M., Smith, P. L., Lee, C. P., Oh, D. M., Sadee, W., Amidon, G. L. (1998) 5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm. Res. 15: 1154-1159
-
(1998)
Pharm. Res
, vol.15
, pp. 1154-1159
-
-
Han, H.1
de Vrueh, R.L.2
Rhie, J.K.3
Covitz, K.M.4
Smith, P.L.5
Lee, C.P.6
Oh, D.M.7
Sadee, W.8
Amidon, G.L.9
-
89
-
-
2442707819
-
Metabolic activation of troglitazone: Identification of a reactive metabolite and mechanisms involved
-
He, K., Talaat, R. E., Pool, W. F., Reily, M. D., Reed, J. E., Bridges, A. J., Woolf, T. F. (2004) Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved. Drug Metab. Dispos. 32: 639-646
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 639-646
-
-
He, K.1
Talaat, R.E.2
Pool, W.F.3
Reily, M.D.4
Reed, J.E.5
Bridges, A.J.6
Woolf, T.F.7
-
90
-
-
85047694348
-
Salicylic acid: An old dog, new tricks, and staphylococcal disease
-
Herrmann, M. (2003) Salicylic acid: an old dog, new tricks, and staphylococcal disease. J. Clin. Invest. 112: 149-151
-
(2003)
J. Clin. Invest
, vol.112
, pp. 149-151
-
-
Herrmann, M.1
-
91
-
-
2442660322
-
Modeling of b-chloroprene metabolism: II. The application of physiologically based modelling for cancer dose response analysis
-
Himmelstein, M. W., Carpenter, S. C. Evans, M. V., Hinderliter, P. M., Kenyon, E. M. (2004) Modeling of b-chloroprene metabolism: II. The application of physiologically based modelling for cancer dose response analysis. Toxicol. Sci. 79: 28-37
-
(2004)
Toxicol. Sci
, vol.79
, pp. 28-37
-
-
Himmelstein, M.W.1
Carpenter, S.C.2
Evans, M.V.3
Hinderliter, P.M.4
Kenyon, E.M.5
-
92
-
-
9444245372
-
Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19
-
Hirani, V. N., Raucy, J. L., Lasker, J. M. (2004) Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. Drug Metab. Dispos. 32: 1462-1467
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 1462-1467
-
-
Hirani, V.N.1
Raucy, J.L.2
Lasker, J.M.3
-
93
-
-
33646536542
-
Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
-
Ho, R. H., Tirona, R. G., Leake, B. F., Glaeser, H., Lee, W., Lemke, C. J., Wang, Y., Kim, R. B. (2006) Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 130: 1793-1806
-
(2006)
Gastroenterology
, vol.130
, pp. 1793-1806
-
-
Ho, R.H.1
Tirona, R.G.2
Leake, B.F.3
Glaeser, H.4
Lee, W.5
Lemke, C.J.6
Wang, Y.7
Kim, R.B.8
-
94
-
-
0016745224
-
Cytochrome P450 and drug metabolism in intestinal villous and crypt cells of rats. Effects of dietary iron
-
Hoensch, H., Woo, C. H., Schmid, R. (1975) Cytochrome P450 and drug metabolism in intestinal villous and crypt cells of rats. Effects of dietary iron. Biochem. Biophys. Res. Commun. 65: 399-406
-
(1975)
Biochem. Biophys. Res. Commun
, vol.65
, pp. 399-406
-
-
Hoensch, H.1
Woo, C.H.2
Schmid, R.3
-
95
-
-
0031105838
-
Heterogeneous zonal distribution of sulfotransferase isoenzymes in rat liver
-
Homma, H., Tada, M., Nakamura, T., Yamagata, S., Matsui, M. (1997) Heterogeneous zonal distribution of sulfotransferase isoenzymes in rat liver. Arch. Biochem. Biophys. 339: 235-241
-
(1997)
Arch. Biochem. Biophys
, vol.339
, pp. 235-241
-
-
Homma, H.1
Tada, M.2
Nakamura, T.3
Yamagata, S.4
Matsui, M.5
-
96
-
-
0024259707
-
Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver
-
Ingelman-Sundberg, M., Johansson, I., Penttilä, K. E., Glaumann, H., Lindros, K. O. (1988) Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver. Biochem. Biophys. Res. Commun. 157: 55-60
-
(1988)
Biochem. Biophys. Res. Commun
, vol.157
, pp. 55-60
-
-
Ingelman-Sundberg, M.1
Johansson, I.2
Penttilä, K.E.3
Glaumann, H.4
Lindros, K.O.5
-
97
-
-
0026497776
-
Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans
-
Ishizawa, T., Sadahiro, S., Hosoi, K., Tamai, I., Terasaki, T., Tsuji, A. (1992) Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans. J. Pharmacobiodyn. 15: 481-489
-
(1992)
J. Pharmacobiodyn
, vol.15
, pp. 481-489
-
-
Ishizawa, T.1
Sadahiro, S.2
Hosoi, K.3
Tamai, I.4
Terasaki, T.5
Tsuji, A.6
-
98
-
-
0032455502
-
Transport of temocaprilat into rat hepatocytes: Role of organic anion transporting polypeptide
-
Ishizuka, H., Konno, K., Naganuma, H., Nishimura, K., Kouzuki, H., Suzuki, H., Stieger, B., Meier, P. J., Sugiyama, Y. (1998) Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 287: 37-42
-
(1998)
J. Pharmacol. Exp. Ther
, vol.287
, pp. 37-42
-
-
Ishizuka, H.1
Konno, K.2
Naganuma, H.3
Nishimura, K.4
Kouzuki, H.5
Suzuki, H.6
Stieger, B.7
Meier, P.J.8
Sugiyama, Y.9
-
99
-
-
3543026365
-
Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes
-
Ito, K., Houston, J. B. (2004) Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes. Pharm. Res. 21: 785-792
-
(2004)
Pharm. Res
, vol.21
, pp. 785-792
-
-
Ito, K.1
Houston, J.B.2
-
100
-
-
17644381224
-
Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches
-
Ito, K., Houston, J. B. (2005) Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches. Pharm. Res. 22: 103-112
-
(2005)
Pharm. Res
, vol.22
, pp. 103-112
-
-
Ito, K.1
Houston, J.B.2
-
101
-
-
0028140393
-
Expression cloning of a rat liver Na(+)-independent organic anion transporter
-
Jacquemin, E., Hagenbuch, B., Stieger, B., Wolkoff, A. W., Meier, P. J. (1994) Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc. Natl Acad. Sci. USA 91: 133-137
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 133-137
-
-
Jacquemin, E.1
Hagenbuch, B.2
Stieger, B.3
Wolkoff, A.W.4
Meier, P.J.5
-
102
-
-
0029093930
-
Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: A review
-
Jones, R. N. (1995) Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review. Diagn Microbiol. Infect. Dis. 22: 19-33
-
(1995)
Diagn Microbiol. Infect. Dis
, vol.22
, pp. 19-33
-
-
Jones, R.N.1
-
103
-
-
33646124969
-
A novel strategy for physiologicallly based predictions of human pharmacokinetics
-
Jones, H. M., Parrott, N., Jorga, K., Lavé, T. (2006) A novel strategy for physiologicallly based predictions of human pharmacokinetics. Clin. Pharmacokinet. 45: 511-542
-
(2006)
Clin. Pharmacokinet
, vol.45
, pp. 511-542
-
-
Jones, H.M.1
Parrott, N.2
Jorga, K.3
Lavé, T.4
-
104
-
-
0017665570
-
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
-
Jordan, V. C., Collins, M. M., Rowsby, L., Prestwich, G. (1977) A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J. Endocrinol. 75: 305-316
-
(1977)
J. Endocrinol
, vol.75
, pp. 305-316
-
-
Jordan, V.C.1
Collins, M.M.2
Rowsby, L.3
Prestwich, G.4
-
105
-
-
33646939259
-
Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance
-
Joulin, D., Blanchard, N., Alexandre, E., Delobel, F., Savid-Pierson, P., Lavé, T., Jaeck, D., Richert, L., Coassolo, P. (2006) Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance. Eur. J. Pharm. Sci. Biopharm. 63 : 347-355
-
(2006)
Eur. J. Pharm. Sci. Biopharm
, vol.63
, pp. 347-355
-
-
Joulin, D.1
Blanchard, N.2
Alexandre, E.3
Delobel, F.4
Savid-Pierson, P.5
Lavé, T.6
Jaeck, D.7
Richert, L.8
Coassolo, P.9
-
106
-
-
20844454730
-
Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinoneimine species in human liver microsomes and recombinant cytochrome P450 3A4
-
Kalgutkar, A. S., Vaz, A. D. N., Lame, M. E., Henne, K. R., Soglia, J., Zhao, S. X., Abramov, Y. A., Lombardo, F., Collin, C., Hendsch, Z. S., Hop, C. E. (2005) Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinoneimine species in human liver microsomes and recombinant cytochrome P450 3A4. Drug Metab. Dispos. 33: 243-253
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 243-253
-
-
Kalgutkar, A.S.1
Vaz, A.D.N.2
Lame, M.E.3
Henne, K.R.4
Soglia, J.5
Zhao, S.X.6
Abramov, Y.A.7
Lombardo, F.8
Collin, C.9
Hendsch, Z.S.10
Hop, C.E.11
-
107
-
-
0032469937
-
Physiologically based pharmacokinetics of cyclosporin A: Extension to tissue distribution kinetics in rats and scale up to human
-
Kawai, R., Mathew D., Tanaka, C., Rowland, M. (1998) Physiologically based pharmacokinetics of cyclosporin A: extension to tissue distribution kinetics in rats and scale up to human. J. Pharmacol. Exp. Ther. 287: 457-468
-
(1998)
J. Pharmacol. Exp. Ther
, vol.287
, pp. 457-468
-
-
Kawai, R.1
Mathew, D.2
Tanaka, C.3
Rowland, M.4
-
108
-
-
0023248470
-
Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes
-
Kera, Y., Sippel, H. W., Penttilä, K. E., Lindros, K, O. (1987) Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes. Biochem. Pharmacol. 36: 2003-2006
-
(1987)
Biochem. Pharmacol
, vol.36
, pp. 2003-2006
-
-
Kera, Y.1
Sippel, H.W.2
Penttilä, K.E.3
Lindros, K.O.4
-
109
-
-
0034053017
-
-
Kido, Y., Tamai, 1., Okamoto, M., Suzuki, F., Tsuji, A. (2000) Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. Pharm. Res. 17: 55-62
-
Kido, Y., Tamai, 1., Okamoto, M., Suzuki, F., Tsuji, A. (2000) Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. Pharm. Res. 17: 55-62
-
-
-
-
110
-
-
0021926518
-
The area under the curve of metabolites for drugs and metabolites cleared by the liver and extrahepatic organs. Its dependence on the administration route of precursor drug
-
Klippert, P. J., Noordhoek, J. (1985) The area under the curve of metabolites for drugs and metabolites cleared by the liver and extrahepatic organs. Its dependence on the administration route of precursor drug. Drug Metab. Dispos. 13: 97-101
-
(1985)
Drug Metab. Dispos
, vol.13
, pp. 97-101
-
-
Klippert, P.J.1
Noordhoek, J.2
-
111
-
-
0023831290
-
Immunohistochemical demonstration of isozyme- and strain-specific differences in the intralobular localizations and distributions of UDP- glucuronosyltransferases in livers of untreated rats
-
Knapp, S. A., Green, M. D., Tephly, T. R., Baron, J. (1988) Immunohistochemical demonstration of isozyme- and strain-specific differences in the intralobular localizations and distributions of UDP- glucuronosyltransferases in livers of untreated rats. Mol. Pharmacol. 33: 14-21
-
(1988)
Mol. Pharmacol
, vol.33
, pp. 14-21
-
-
Knapp, S.A.1
Green, M.D.2
Tephly, T.R.3
Baron, J.4
-
112
-
-
0019953704
-
Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation. Disappearance of aberrancies in glucuronidation kinetics by inhibition of sulfation
-
Koster, H., Halsema, I., Pang, K. S., Scholtens, E., Mulder, G. J. (1982) Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation. Disappearance of aberrancies in glucuronidation kinetics by inhibition of sulfation. Biochem. Pharmacol. 31: 3023-3038
-
(1982)
Biochem. Pharmacol
, vol.31
, pp. 3023-3038
-
-
Koster, H.1
Halsema, I.2
Pang, K.S.3
Scholtens, E.4
Mulder, G.J.5
-
113
-
-
0021915994
-
Glucuronidation of morphine and six β2-sympathominetics in isolated rat intestinal epithelial cells
-
Koster, A. S., Frankhuijzen-Sierevogel, A. C., Noordhoek, J. (1985) Glucuronidation of morphine and six β2-sympathominetics in isolated rat intestinal epithelial cells. Drug Metab. Dispos. 13: 232-237
-
(1985)
Drug Metab. Dispos
, vol.13
, pp. 232-237
-
-
Koster, A.S.1
Frankhuijzen-Sierevogel, A.C.2
Noordhoek, J.3
-
114
-
-
0030838171
-
Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas
-
Kullak-Ublick, G. A., Glasa, J., Boker, C., Oswald, M., Grutzner, U., Hagenbuch, B., Stieger, B., Meier, P. J., Beuers, U., Kramer, W., Wess, G., Paumgartner, G. (1997) Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology 113: 1295-1305
-
(1997)
Gastroenterology
, vol.113
, pp. 1295-1305
-
-
Kullak-Ublick, G.A.1
Glasa, J.2
Boker, C.3
Oswald, M.4
Grutzner, U.5
Hagenbuch, B.6
Stieger, B.7
Meier, P.J.8
Beuers, U.9
Kramer, W.10
Wess, G.11
Paumgartner, G.12
-
115
-
-
0029560982
-
Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions and interindividual variability
-
Lampen, A., Christians, W., Guengerich, F. P., Watkins, P. B., Kolars, J., Bader, A., Gonschior, A.-K., Dralle, H., Hackbarth, I., Sewing, K.-F. (1995) Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions and interindividual variability. Drug Metab. Dispos. 23: 1315-1324
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 1315-1324
-
-
Lampen, A.1
Christians, W.2
Guengerich, F.P.3
Watkins, P.B.4
Kolars, J.5
Bader, A.6
Gonschior, A.-K.7
Dralle, H.8
Hackbarth, I.9
Sewing, K.-F.10
-
116
-
-
0033919417
-
Metabolism of trichloroethylene
-
Lash, L. H., Fisher, J. W., Lipscomb, J. C., Parker, J. C. (2000) Metabolism of trichloroethylene. Environ. Health Perspect. 108 (Suppl 2): 177-200
-
(2000)
Environ. Health Perspect
, vol.108
, Issue.SUPPL. 2
, pp. 177-200
-
-
Lash, L.H.1
Fisher, J.W.2
Lipscomb, J.C.3
Parker, J.C.4
-
117
-
-
0032810558
-
Mechanism of intestinal absorption of an orally active betalactam prodrug: Uptake and transport of carindacillin in Caco-2 cells
-
Li, Y. H., Ito, K., Tsuda, Y., Kohda, R., Yamada, H., Itoh, T. (1999) Mechanism of intestinal absorption of an orally active betalactam prodrug: uptake and transport of carindacillin in Caco-2 cells. J. Pharmacol. Exp. Ther. 290: 958-964
-
(1999)
J. Pharmacol. Exp. Ther
, vol.290
, pp. 958-964
-
-
Li, Y.H.1
Ito, K.2
Tsuda, Y.3
Kohda, R.4
Yamada, H.5
Itoh, T.6
-
118
-
-
0036225166
-
Intestinal metabolism promotes regional differences in apical uptake of indinavir: Coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability
-
Li, L. Y., Amidon, G. L., Kim, J. S., Heimbach, T., Kesisoglou, F., Topliss, J. T., Fleisher, D. (2002) Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability. J. Pharmacol. Exp. Ther. 301: 586-593
-
(2002)
J. Pharmacol. Exp. Ther
, vol.301
, pp. 586-593
-
-
Li, L.Y.1
Amidon, G.L.2
Kim, J.S.3
Heimbach, T.4
Kesisoglou, F.5
Topliss, J.T.6
Fleisher, D.7
-
119
-
-
17644387537
-
Endoxifen (4-hydroxy-N-desmethyltamoxifen) has antiestrogenic effects in breast cancer cells with potency similar to 4-hydroxytamoxifen
-
Lim, Y. C., Desta, Z., Flockhart, D. A., Skaar, T. C. (2005) Endoxifen (4-hydroxy-N-desmethyltamoxifen) has antiestrogenic effects in breast cancer cells with potency similar to 4-hydroxytamoxifen. Cancer Chemother. Pharmacol. 55: 471-478
-
(2005)
Cancer Chemother. Pharmacol
, vol.55
, pp. 471-478
-
-
Lim, Y.C.1
Desta, Z.2
Flockhart, D.A.3
Skaar, T.C.4
-
120
-
-
0033009998
-
Is the role of the small intestine in first-pass metabolism overemphasized?
-
Lin, J. H., Chiba, M., Baillie, T. A. (1999) Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacol. Rev. 51: 135-158
-
(1999)
Pharmacol. Rev
, vol.51
, pp. 135-158
-
-
Lin, J.H.1
Chiba, M.2
Baillie, T.A.3
-
121
-
-
33750183365
-
An integrated approach to model hepatic-drug clearance
-
Liu, L., Pang, K. S. (2006) An integrated approach to model hepatic-drug clearance. Eur. J. Pharm. Sci. 29: 215-230
-
(2006)
Eur. J. Pharm. Sci
, vol.29
, pp. 215-230
-
-
Liu, L.1
Pang, K.S.2
-
122
-
-
25644441718
-
Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver
-
Liu, L., Mak, E., Tirona, R. G., Tan, E., Novikoff, P. M, Wang, P. J., Wolkoff, A. W., Pang, K. S. (2005) Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver. J. Pharmacol. Exp. Ther. 315: 433-448
-
(2005)
J. Pharmacol. Exp. Ther
, vol.315
, pp. 433-448
-
-
Liu, L.1
Mak, E.2
Tirona, R.G.3
Tan, E.4
Novikoff, P.M.5
Wang, P.J.6
Wolkoff, A.W.7
Pang, K.S.8
-
123
-
-
33747821713
-
P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: Induction studies with pregnenolone-16alpha- carbonitrile
-
Liu, S., Tarn, D., Chen, X., Pang, K. S. (2006) P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha- carbonitrile. Drug Metab. Dispos. 34: 1468-1479
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 1468-1479
-
-
Liu, S.1
Tarn, D.2
Chen, X.3
Pang, K.S.4
-
124
-
-
2942612987
-
Membrane transporter/receptor-targeted prodrug design: Strategies for human and veterinary drug development
-
Majumdar, S., Duvvuri, S., Mitra, A. K (2004) Membrane transporter/receptor-targeted prodrug design: strategies for human and veterinary drug development. Adv. Drug Deliv. Rev. 56: 1437-1452
-
(2004)
Adv. Drug Deliv. Rev
, vol.56
, pp. 1437-1452
-
-
Majumdar, S.1
Duvvuri, S.2
Mitra, A.K.3
-
125
-
-
6944226371
-
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance
-
McGinnity, D. F., Soars, M. G, Urbanowicz, R. A., Riley, R. J. (2004) Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab. Dispos. 32: 1247-1253
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 1247-1253
-
-
McGinnity, D.F.1
Soars, M.G.2
Urbanowicz, R.A.3
Riley, R.J.4
-
126
-
-
0025673890
-
Pharmacologic and pharmacokinetic characteristics of norgestimate and its metabolites
-
McGuire, J. L., Phillips, A., Hahn, D. W., Tolman, E. L., Flor, S., Kafrissen, M. E. (1990) Pharmacologic and pharmacokinetic characteristics of norgestimate and its metabolites. Am. J. Obstet. Gynecol. 163: 2127-2131
-
(1990)
Am. J. Obstet. Gynecol
, vol.163
, pp. 2127-2131
-
-
McGuire, J.L.1
Phillips, A.2
Hahn, D.W.3
Tolman, E.L.4
Flor, S.5
Kafrissen, M.E.6
-
127
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
Mizuno, N., Niwa, T., Yotsumoto, Y., Sugiyama, Y. (2003) Impact of drug transporter studies on drug discovery and development. Pharmacol. Rev. 55: 425-461
-
(2003)
Pharmacol. Rev
, vol.55
, pp. 425-461
-
-
Mizuno, N.1
Niwa, T.2
Yotsumoto, Y.3
Sugiyama, Y.4
-
128
-
-
0023430998
-
Competition between two enzymes for substrate removal in liver: Modulating effects of competitive pathways
-
Morris M. E., Pang, K. S. (1987) Competition between two enzymes for substrate removal in liver: modulating effects of competitive pathways. J. Pharmacokinet. Biopharm. 15: 473-496
-
(1987)
J. Pharmacokinet. Biopharm
, vol.15
, pp. 473-496
-
-
Morris, M.E.1
Pang, K.S.2
-
129
-
-
0023937729
-
Competing pathways in drug metabolism. I. Effect of input concentration on the conjugation of gentisamide in the once-through in situ perfused rat liver preparation
-
Morris, M. E., Yuen, V., Tang, B. K. Pang, K. S. (1988a) Competing pathways in drug metabolism. I. Effect of input concentration on the conjugation of gentisamide in the once-through in situ perfused rat liver preparation. J. Pharmacol. Exp. Ther. 245: 614-624
-
(1988)
J. Pharmacol. Exp. Ther
, vol.245
, pp. 614-624
-
-
Morris, M.E.1
Yuen, V.2
Tang, B.K.3
Pang, K.S.4
-
130
-
-
0024263650
-
Competing pathways in drug metabolism. II. An identical, anterior enzymatic distribution for 2- and 5-sulfoconjugation and a posterior localization for 5-glucuronidation of gentisamide in the rat liver
-
Morris, M. E., Yuen, V., Pang, K. S. (1988b) Competing pathways in drug metabolism. II. An identical, anterior enzymatic distribution for 2- and 5-sulfoconjugation and a posterior localization for 5-glucuronidation of gentisamide in the rat liver. J. Pharmacokinet. Biopharm. 16: 633-656
-
(1988)
J. Pharmacokinet. Biopharm
, vol.16
, pp. 633-656
-
-
Morris, M.E.1
Yuen, V.2
Pang, K.S.3
-
131
-
-
0034119967
-
Expression and localization of multidrug resistant protein mrp2 in rat small intestine
-
Mottino, A. D., Hoffman, T., Jennes, L., Vore, M. (2000) Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J. Pharmacol. Exp. Ther. 293: 717-723
-
(2000)
J. Pharmacol. Exp. Ther
, vol.293
, pp. 717-723
-
-
Mottino, A.D.1
Hoffman, T.2
Jennes, L.3
Vore, M.4
-
132
-
-
0017176137
-
-
Nelson, S. D., Mitchell, J. R., Timbrell, J. A., Snodgrass, W. R., Corcoran, G. B. 3rd (1976) Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat. Science 193: 901-903
-
Nelson, S. D., Mitchell, J. R., Timbrell, J. A., Snodgrass, W. R., Corcoran, G. B. 3rd (1976) Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat. Science 193: 901-903
-
-
-
-
133
-
-
0031661419
-
Lumping of whole-body physiologically-based pharmacokinetic models
-
Nestorov, I. A., Aarons, L. J., Arundel, P. A., Rowland, M. (1998) Lumping of whole-body physiologically-based pharmacokinetic models. J. Pharmcokinet. Biopharm. 26: 21-46
-
(1998)
J. Pharmcokinet. Biopharm
, vol.26
, pp. 21-46
-
-
Nestorov, I.A.1
Aarons, L.J.2
Arundel, P.A.3
Rowland, M.4
-
134
-
-
0035001331
-
Ontogenic and longitudinal activity of Na+-nucleoside transporters in the human intestine
-
Ngo, L. Y., Patil, S. D., Unadkat, J. D. (2001) Ontogenic and longitudinal activity of Na+-nucleoside transporters in the human intestine. Am. J. Physiol. 280: G475-G481
-
(2001)
Am. J. Physiol
, vol.280
-
-
Ngo, L.Y.1
Patil, S.D.2
Unadkat, J.D.3
-
135
-
-
14044260589
-
Role of organic anion transporter OATP1BC (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecan: In vitro evidence and effect of single nucleotide polymorphism
-
Nozawa, T., Minami, H., Sugiura, S., Tsuji, A., Tamai, I (2005) Role of organic anion transporter OATP1BC (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecan: in vitro evidence and effect of single nucleotide polymorphism. Drug Metab. Dispos. 33: 434-439
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 434-439
-
-
Nozawa, T.1
Minami, H.2
Sugiura, S.3
Tsuji, A.4
Tamai, I.5
-
136
-
-
0016592245
-
Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons
-
Nybsäck, H. V., Walters, J. R., Aghajanian, G. K., Roth, R. H. Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons. Eur. J. Pharmacol. 32: 302-312
-
Eur. J. Pharmacol
, vol.32
, pp. 302-312
-
-
Nybsäck, H.V.1
Walters, J.R.2
Aghajanian, G.K.3
Roth, R.H.4
-
137
-
-
0032733974
-
Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes
-
Obach, R. S. (1999) Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab. Dispos. 27: 1350-1359
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 1350-1359
-
-
Obach, R.S.1
-
138
-
-
0029020221
-
Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver
-
Oinonen, T., Lindros, K. O. (1995) Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver. Biochem. J. 309: 55-61
-
(1995)
Biochem. J
, vol.309
, pp. 55-61
-
-
Oinonen, T.1
Lindros, K.O.2
-
139
-
-
34748833728
-
Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to a lysine aldehyde in elastin of human aorta
-
Oitate, M., Hirota, T., Murai, T., Miura, S., Ikeda, T. (2007) Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to a lysine aldehyde in elastin of human aorta. Drug Metab. Dispos. 35: 1846-1852
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1846-1852
-
-
Oitate, M.1
Hirota, T.2
Murai, T.3
Miura, S.4
Ikeda, T.5
-
140
-
-
34247381161
-
Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme a thioester intermediate in rats
-
Olsen, J., Li, C., Skonberg, C., Bjørnsdottir, I., Sidenius, U., Benet, L. Z., Hansen, S. H. (2007) Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme a thioester intermediate in rats. Drug Metab. Dispos. 35: 758-764
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 758-764
-
-
Olsen, J.1
Li, C.2
Skonberg, C.3
Bjørnsdottir, I.4
Sidenius, U.5
Benet, L.Z.6
Hansen, S.H.7
-
141
-
-
0013228058
-
Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol
-
Olson, R. D., Mushlin, P. S., Brenner, D. E., Fleischer, S., Cusack, B. J., Chang, B. K., Boucek, R. I. Jr. (1988) Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc. Natl Acad. Sci. USA 85: 3585-3589
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 3585-3589
-
-
Olson, R.D.1
Mushlin, P.S.2
Brenner, D.E.3
Fleischer, S.4
Cusack, B.J.5
Chang, B.K.6
Boucek Jr., R.I.7
-
142
-
-
0029738490
-
First-pass metabolism of midazolam by the human intestine
-
Paine, M. F., Shen, D. D., Kunze, K. L., Perkins, J. D., Marsh, C. L., McVicar, J. P., Barr, D. M., Gilles, B. S., Thummel, K. E. (1996) First-pass metabolism of midazolam by the human intestine. Clin. Pharmacol. Ther. 60: 14-24
-
(1996)
Clin. Pharmacol. Ther
, vol.60
, pp. 14-24
-
-
Paine, M.F.1
Shen, D.D.2
Kunze, K.L.3
Perkins, J.D.4
Marsh, C.L.5
McVicar, J.P.6
Barr, D.M.7
Gilles, B.S.8
Thummel, K.E.9
-
143
-
-
0031445547
-
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
-
Paine, M. F., Khalighi, M., Fisher, J. M., Shen, D. D., Kunze, K. L., Marsh, C. L., Perkins, J. D., Thummel, K. E. (1997) Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J. Pharmacol. Exp. Ther. 283: 1552-1562
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, pp. 1552-1562
-
-
Paine, M.F.1
Khalighi, M.2
Fisher, J.M.3
Shen, D.D.4
Kunze, K.L.5
Marsh, C.L.6
Perkins, J.D.7
Thummel, K.E.8
-
144
-
-
0022371766
-
A review of metabolite kinetics
-
Pang, K. S. (1985a) A review of metabolite kinetics. J. Pharmacokinet. Biopharm. 13: 632-662
-
(1985)
J. Pharmacokinet. Biopharm
, vol.13
, pp. 632-662
-
-
Pang, K.S.1
-
145
-
-
52949122993
-
A modern view of metabolite kinetics
-
Barnett, G, Chiang, C. N, eds Pharmacokinetics and pharmacodynamics of psychoactive drugs, Biomedical Publications, Foster City, pp
-
Pang, K. S. (1985b) A modern view of metabolite kinetics. In: Barnett, G., Chiang, C. N. (eds) Pharmacokinetics and pharmacodynamics of psychoactive drugs. A Research Monograph. Biomedical Publications, Foster City, pp 323-379
-
(1985)
A Research Monograph
, pp. 323-379
-
-
Pang, K.S.1
-
146
-
-
0012741114
-
Modeling of metabolite disposition
-
D'Argenio, D. Z, ed, Plenum Press, New York, pp
-
Pang, K. S. (1995) Modeling of metabolite disposition. In: D'Argenio, D. Z. (ed) Advanced methods of pharmacokinetic and pharmacodynamic system analysis, volume 11. Plenum Press, New York, pp 3-26
-
(1995)
Advanced methods of pharmacokinetic and pharmacodynamic system analysis
, vol.11
, pp. 3-26
-
-
Pang, K.S.1
-
147
-
-
0345275778
-
Modeling of intestinal drug absorption. Roles of transporters and metabolic enzymes (for the Gillette Series)
-
Pang, K. S. (2003) Modeling of intestinal drug absorption. Roles of transporters and metabolic enzymes (for the Gillette Series). Drug Metab. Dispos. 31: 1507-1519
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 1507-1519
-
-
Pang, K.S.1
-
148
-
-
0018121698
-
Kinetics of metabolite formation and elimination in the perfused rat liver preparation: Differences between the elimination of preformed cetaminophen and acetaminophen formed from phenacetin
-
Pang, K. S., Gillette, J. R. (1978) Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed cetaminophen and acetaminophen formed from phenacetin. J. Pharmacol. Exp. Ther. 207: 178-194
-
(1978)
J. Pharmacol. Exp. Ther
, vol.207
, pp. 178-194
-
-
Pang, K.S.1
Gillette, J.R.2
-
149
-
-
0018765448
-
Sequential first-pass elimination of a metabolite derived from a precursor
-
Pang, K. S., Gillette, J. R. (1979) Sequential first-pass elimination of a metabolite derived from a precursor. J. Pharmacokinet. Biopharm. 7 275-290
-
(1979)
J. Pharmacokinet. Biopharm
, vol.7
, pp. 275-290
-
-
Pang, K.S.1
Gillette, J.R.2
-
150
-
-
0020598354
-
A Commentary. Methods and assumptions in the kinetic estimation of metabolite formation
-
Pang, K. S., Kwan, K. C. (1983) A Commentary. Methods and assumptions in
-
(1983)
Drug Metab. Dispos
, vol.11
, pp. 79-84
-
-
Pang, K.S.1
Kwan, K.C.2
-
151
-
-
52949094378
-
-
Erratum (1984) Drug Metab. Dispos. 12: 674
-
Erratum (1984) Drug Metab. Dispos. 12: 674
-
-
-
-
152
-
-
0019424955
-
Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats
-
Pang, K. S., Terrell, J. A. (1981a) Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats. J. Pharmacol. Exp. Ther. 216: 339-346
-
(1981)
J. Pharmacol. Exp. Ther
, vol.216
, pp. 339-346
-
-
Pang, K.S.1
Terrell, J.A.2
-
153
-
-
0019440962
-
Conjugation kinetics of acetaminophen by the perfused rat liver preparation
-
Pang, K. S., Terrell, J. A. (1981b) Conjugation kinetics of acetaminophen by the perfused rat liver preparation. Biochem. Pharmacol. 30: 1959-1965
-
(1981)
Biochem. Pharmacol
, vol.30
, pp. 1959-1965
-
-
Pang, K.S.1
Terrell, J.A.2
-
154
-
-
0019407087
-
Aberrant pharmacokinetics of harmol in the perfused rat liver preparation: Sulfate and glucuronide conjugations
-
Pang, K. S., Koster, H., Halsema, I. C. M., Scholtens, E., Mulder, G. J. (1981) Aberrant pharmacokinetics of harmol in the perfused rat liver preparation: Sulfate and glucuronide conjugations. J. Pharmacol. Exp. Ther. 219: 134-140
-
(1981)
J. Pharmacol. Exp. Ther
, vol.219
, pp. 134-140
-
-
Pang, K.S.1
Koster, H.2
Halsema, I.C.M.3
Scholtens, E.4
Mulder, G.J.5
-
155
-
-
0020701998
-
Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation
-
Pang, K. S., Koster, H., Halsema, I. C. M., Scholtens, E., Mulder, G. J., Stillwell, R. N. (1983) Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation. J. Pharmacol. Exp. Ther. 224: 647-653
-
(1983)
J. Pharmacol. Exp. Ther
, vol.224
, pp. 647-653
-
-
Pang, K.S.1
Koster, H.2
Halsema, I.C.M.3
Scholtens, E.4
Mulder, G.J.5
Stillwell, R.N.6
-
156
-
-
0021967370
-
Metabolism of acetaminophen and phenacetin by isolated rat hepatocytes: A system in which the spatial organization inherent in the liver is disrupted
-
Pang, K. S., Kong, P., Terrell, J. A., Billings, R. E. (1985a) Metabolism of acetaminophen and phenacetin by isolated rat hepatocytes: a system in which the spatial organization inherent in the liver is disrupted. Drug Metab. Dispos. 13: 42-50
-
(1985)
Drug Metab. Dispos
, vol.13
, pp. 42-50
-
-
Pang, K.S.1
Kong, P.2
Terrell, J.A.3
Billings, R.E.4
-
157
-
-
0022263297
-
Disposition of enalapril in the perfused rat intestine-liver preparation: Absorption, metabolism, and first-pass effects
-
Pang, K. S., Cherry, W. F., Ulm, E. H. (1985b) Disposition of enalapril in the perfused rat intestine-liver preparation: Absorption, metabolism, and first-pass effects. J. Pharmacol. Exp. Ther. 233: 788-795
-
(1985)
J. Pharmacol. Exp. Ther
, vol.233
, pp. 788-795
-
-
Pang, K.S.1
Cherry, W.F.2
Ulm, E.H.3
-
158
-
-
0022596263
-
Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation
-
Pang, K. S., Fayz, S., Yuen, V., te Koppele, J., Mulder, G. J (1986) Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation. Drug Metab. Dispos. 14: 102-113
-
(1986)
Drug Metab. Dispos
, vol.14
, pp. 102-113
-
-
Pang, K.S.1
Fayz, S.2
Yuen, V.3
te Koppele, J.4
Mulder, G.J.5
-
159
-
-
0023775227
-
Combined hepatic arterial-portal venous and hepatic arterial-hepatic venous perfusions to probe the abundance of drug metabolizing activities: Perihepatic venous O-deethylation activity for phenacetin and periportal sulfation activity for acetaminophen in the once-through rat liver preparation
-
Pang, K. S., Cherry, W. F., Accaputo, J., Schwab, A. J., Goresky, C. A. (1988) Combined hepatic arterial-portal venous and hepatic arterial-hepatic venous perfusions to probe the abundance of drug metabolizing activities: perihepatic venous O-deethylation activity for phenacetin and periportal sulfation activity for acetaminophen in the once-through rat liver preparation. J. Pharmacol. Exp. Ther. 247: 690-700
-
(1988)
J. Pharmacol. Exp. Ther
, vol.247
, pp. 690-700
-
-
Pang, K.S.1
Cherry, W.F.2
Accaputo, J.3
Schwab, A.J.4
Goresky, C.A.5
-
160
-
-
0025947940
-
Esterases for enalapril hydrolysis are concentrated in the perihepatic venous region of the rat liver
-
Pang, K. S., Barker, F. 3rd, Cherry, W. F., Goresky, C. A. (1991) Esterases for enalapril hydrolysis are concentrated in the perihepatic venous region of the rat liver. J. Pharmacol. Exp. Ther. 257: 294-301
-
(1991)
J. Pharmacol. Exp. Ther
, vol.257
, pp. 294-301
-
-
Pang, K.S.1
Barker 3rd, F.2
Cherry, W.F.3
Goresky, C.A.4
-
161
-
-
0029163529
-
Sulfation of acetaminophen by the perfused rat liver: Effect of red blood cell carriage
-
Pang, K. S., Barker, F. 3rd, Simard, A., Schwab, A. J., Goresky, C. A. (1995) Sulfation of acetaminophen by the perfused rat liver: Effect of red blood cell carriage. Hepatologv 22: 267-282
-
(1995)
Hepatologv
, vol.22
, pp. 267-282
-
-
Pang, K.S.1
Barker 3rd, F.2
Simard, A.3
Schwab, A.J.4
Goresky, C.A.5
-
162
-
-
17344364101
-
The modified dipeptide enalapril, an angiotensin converting enzyme (ACE) inhibitor, is transported by the rat liver organic anion transport protein (oatp1)
-
Pang, K. S., Wang, P. J., Chung, A. F. Wolkoff, A. W. (1998a) The modified dipeptide enalapril, an angiotensin converting enzyme (ACE) inhibitor, is transported by the rat liver organic anion transport protein (oatp1). Hepalology 28: 1341-1346
-
(1998)
Hepalology
, vol.28
, pp. 1341-1346
-
-
Pang, K.S.1
Wang, P.J.2
Chung, A.F.3
Wolkoff, A.W.4
-
163
-
-
0343515369
-
Probing the structure and function of the liver with the multiple indicator dilution technique
-
Bassingthwaigthe, J, Goresky, C. A, Lenihan, J. N, eds, Springer-Verlag, pp
-
Pang, K. S., Geng, W., Schwab, A. J. Goresky, C. A. (1998b) Probing the structure and function of the liver with the multiple indicator dilution technique. In: Bassingthwaigthe, J., Goresky, C. A., Lenihan, J. N. (eds) Whole organ approach to cellular metabolism: capillary permeation, cellular transport and reaction kinetics. Springer-Verlag, pp 325-368
-
(1998)
Whole organ approach to cellular metabolism: Capillary permeation, cellular transport and reaction kinetics
, pp. 325-368
-
-
Pang, K.S.1
Geng, W.2
Schwab, A.J.3
Goresky, C.A.4
-
164
-
-
15244344542
-
Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man
-
Parrott, N., Jones, H., Paquerau, N., Lavé, T. (2005) Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man. Basic Clin. Pharmacol. Toxicol. 96: 193-199
-
(2005)
Basic Clin. Pharmacol. Toxicol
, vol.96
, pp. 193-199
-
-
Parrott, N.1
Jones, H.2
Paquerau, N.3
Lavé, T.4
-
165
-
-
28144440176
-
Pathways of carbamazepine bioactivation in vitro: Ii. the role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene
-
Pearce, R. E., Uetrecht, J. P., Leeder, J. S. (2005) Pathways of carbamazepine bioactivation in vitro: ii. the role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene. Drug Metab. Dispos. 33: 1819-1826
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1819-1826
-
-
Pearce, R.E.1
Uetrecht, J.P.2
Leeder, J.S.3
-
166
-
-
0028867425
-
Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors conjugated with bile acids
-
Petzinger, E., Nickau, L., Horz, J. A., Schulz, S., Wess, G., Enhsen, A., Falk, E., Baringhaus, K. H., Glombik, H., Hoffmann, A., Mülliner, S., Neckermann, G., Kramer, W. (1995) Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors conjugated with bile acids. Hepatologv 22: 1801-1811
-
(1995)
Hepatologv
, vol.22
, pp. 1801-1811
-
-
Petzinger, E.1
Nickau, L.2
Horz, J.A.3
Schulz, S.4
Wess, G.5
Enhsen, A.6
Falk, E.7
Baringhaus, K.H.8
Glombik, H.9
Hoffmann, A.10
Mülliner, S.11
Neckermann, G.12
Kramer, W.13
-
167
-
-
33750465538
-
Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine
-
Pierra, C., Amador, A., Benzaria, S., Cretton-Scott, E., D'Amours, M., Mao, J., Mathieu, S., Moussa, A., Bridges, E. G., Standring, D. N., Sommadossi, J. P. , Storer, R., Gosselin, G. (2006) Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine. J. Med. Chem. 49:6614-6620
-
(2006)
J. Med. Chem
, vol.49
, pp. 6614-6620
-
-
Pierra, C.1
Amador, A.2
Benzaria, S.3
Cretton-Scott, E.4
D'Amours, M.5
Mao, J.6
Mathieu, S.7
Moussa, A.8
Bridges, E.G.9
Standring, D.N.10
Sommadossi, J.P.11
Storer, R.12
Gosselin, G.13
-
168
-
-
0017673657
-
The glutathione S-transferases as a possible detoxification system of rat intestinal epithelium
-
Pinkus, L. M., Ketley, J. N., Jakoby, W. B. (1977) The glutathione S-transferases as a possible detoxification system of rat intestinal epithelium. Biochem. Pharmacol. 26: 2359-2363
-
(1977)
Biochem. Pharmacol
, vol.26
, pp. 2359-2363
-
-
Pinkus, L.M.1
Ketley, J.N.2
Jakoby, W.B.3
-
169
-
-
0026073901
-
The fate of diastereomeric glutathione conjugates of alpha-bromoisovalerylurea in blood in the rat in vivo and in the perfused liver. Stereoselectivity in biliary and urinary excretion
-
Polhuijs, M., Meijer, D. K., Mulder, G. J. (1991) The fate of diastereomeric glutathione conjugates of alpha-bromoisovalerylurea in blood in the rat in vivo and in the perfused liver. Stereoselectivity in biliary and urinary excretion. J. Pharmacol. Exp. Ther. 256: 458-461
-
(1991)
J. Pharmacol. Exp. Ther
, vol.256
, pp. 458-461
-
-
Polhuijs, M.1
Meijer, D.K.2
Mulder, G.J.3
-
170
-
-
0027521754
-
Stereoselectivity in glutathione conjugation and amidase catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single pass perfused rat liver
-
Polhuijs, M., Gasinska, I., Cherry, W. F., Mulder, G. J., Pang, K. S. (1993) Stereoselectivity in glutathione conjugation and amidase catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single pass perfused rat liver. J. Pharmacol. Exp. Ther. 265: 1402-1412
-
(1993)
J. Pharmacol. Exp. Ther
, vol.265
, pp. 1402-1412
-
-
Polhuijs, M.1
Gasinska, I.2
Cherry, W.F.3
Mulder, G.J.4
Pang, K.S.5
-
171
-
-
0028233389
-
Glycopeptide enkephalin analogues produce analgesia in mice: Evidence for penetration of the blood-brain barrier
-
Polt, R., Porreca, F., Szabo, L. Z., Bilsky, E. J., Davis, P., Abbruscato, T. J., Davis, T. P., Harvath, R., Yamamura, H. I., Hruby,V. J. (1994) Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proc. Natl Acad. Sci. USA 91: 7114-7118
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7114-7118
-
-
Polt, R.1
Porreca, F.2
Szabo, L.Z.3
Bilsky, E.J.4
Davis, P.5
Abbruscato, T.J.6
Davis, T.P.7
Harvath, R.8
Yamamura, H.I.9
Hruby, V.J.10
-
172
-
-
0035193545
-
Bioactivation of diclofenac via benzoquinone imine intermediates - identification of urinary mercapturic acid derivatives in rats and humans
-
Poon, G. K., Chen, Q., Teffera, Y., Ngui, J, S., Griffin, P. R., Braun, M. P., Doss, G. A., Freeden, C., Stearns, R. A., Evans, D. C., Baillie, T. A., Tang, W. (2001) Bioactivation of diclofenac via benzoquinone imine intermediates - identification of urinary mercapturic acid derivatives in rats and humans. Drug Metab. Dispos. 29: 1608-1613
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 1608-1613
-
-
Poon, G.K.1
Chen, Q.2
Teffera, Y.3
Ngui, J.S.4
Griffin, P.R.5
Braun, M.P.6
Doss, G.A.7
Freeden, C.8
Stearns, R.A.9
Evans, D.C.10
Baillie, T.A.11
Tang, W.12
-
173
-
-
0036144815
-
Prediction of pharmacokinetics prior to in vivo studies. I. Mechanism-based prediction of volume of distribution
-
Poulin, P., Theil, F.-P. (2002a) Prediction of pharmacokinetics prior to in vivo studies. I. Mechanism-based prediction of volume of distribution. J. Pharm. Sci. 91: 129-156
-
(2002)
J. Pharm. Sci
, vol.91
, pp. 129-156
-
-
Poulin, P.1
Theil, F.-P.2
-
174
-
-
0036075799
-
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition
-
Poulin, P., Theil, F.-P. (2002b) Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. J. Pharm. Sci. 91: 1358-1370
-
(2002)
J. Pharm. Sci
, vol.91
, pp. 1358-1370
-
-
Poulin, P.1
Theil, F.-P.2
-
175
-
-
70449204840
-
The structural and functional unit in the human liver (liver acinus)
-
Rappaport, A. M (1958) The structural and functional unit in the human liver (liver acinus). Anat. Rec. 130: 673-689
-
(1958)
Anat. Rec
, vol.130
, pp. 673-689
-
-
Rappaport, A.M.1
-
176
-
-
0027195825
-
Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver
-
Ratna, S., Chiba, M., Bandyopadhyay, L., Pang, K. S. (1993) Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver. Hepatology 17: 838-853
-
(1993)
Hepatology
, vol.17
, pp. 838-853
-
-
Ratna, S.1
Chiba, M.2
Bandyopadhyay, L.3
Pang, K.S.4
-
177
-
-
0020491456
-
Immunohistochemical localization of glutathione S-transferases in livers of untreated rats
-
Redick, J. A., Jakoby, W. B., Baron, J. (1982) Immunohistochemical localization of glutathione S-transferases in livers of untreated rats. J. Biol. Chem. 257: 15200-15203
-
(1982)
J. Biol. Chem
, vol.257
, pp. 15200-15203
-
-
Redick, J.A.1
Jakoby, W.B.2
Baron, J.3
-
178
-
-
23944451585
-
A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes
-
Riley, R. J., McGinnity, D. F., Austin, R. P. (2005) A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes. Drug Metab. Dispos. 33: 1304-1311
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1304-1311
-
-
Riley, R.J.1
McGinnity, D.F.2
Austin, R.P.3
-
179
-
-
0021715931
-
Antihypertensive metabolites of alpha-methyldopa
-
Robertson, D., Tung, C. S., Goldberg, M. R., Hollister, A. S., Gerkens, J. F., Oates, J. A. (1984) Antihypertensive metabolites of alpha-methyldopa. Hypertension 6: 1145-50
-
(1984)
Hypertension
, vol.6
, pp. 1145-1150
-
-
Robertson, D.1
Tung, C.S.2
Goldberg, M.R.3
Hollister, A.S.4
Gerkens, J.F.5
Oates, J.A.6
-
180
-
-
0036080426
-
Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine
-
Rost, D., Mahner, S., Sugiyama, Y., Stremmel, W. (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am. J. Physiol. 282: G720-G726
-
(2002)
Am. J. Physiol
, vol.282
-
-
Rost, D.1
Mahner, S.2
Sugiyama, Y.3
Stremmel, W.4
-
181
-
-
0033853560
-
Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers
-
Sakaeda, T., Siahaan, T. J., Audus, K. L., Stella, V. J. (2000) Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers. J. Drug Target. 8: 195-204
-
(2000)
J. Drug Target
, vol.8
, pp. 195-204
-
-
Sakaeda, T.1
Siahaan, T.J.2
Audus, K.L.3
Stella, V.J.4
-
182
-
-
22944446132
-
Betamethasone pharmacokinetics after two prodrug formulations in sheep: Implications for antenatal corticosteroid use
-
Samtani, M. N., Lohle, M., Grant, A., Nathanielsz, P. W., Jusko, W. J. (2005) Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab. Dispos. 33: 1124-1130
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1124-1130
-
-
Samtani, M.N.1
Lohle, M.2
Grant, A.3
Nathanielsz, P.W.4
Jusko, W.J.5
-
183
-
-
34247194881
-
Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy
-
Sato, T., Neschadim, A., Konrad, M., Fowler, D. H., Lavie, A., Medin, J. A. (2007) Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. Mol. Ther. 15: 962-970
-
(2007)
Mol. Ther
, vol.15
, pp. 962-970
-
-
Sato, T.1
Neschadim, A.2
Konrad, M.3
Fowler, D.H.4
Lavie, A.5
Medin, J.A.6
-
184
-
-
0022346415
-
Prediction of plasma concentration-time courses of various drugs in humans based on data from rats
-
Sawada, Y., Haraschima. H., Hanano, M., Sugiyama, Y., Iga, T. (1985) Prediction of plasma concentration-time courses of various drugs in humans based on data from rats. J. Pharmacohiodyn. 8: 757-766
-
(1985)
J. Pharmacohiodyn
, vol.8
, pp. 757-766
-
-
Sawada, Y.1
Haraschima, H.2
Hanano, M.3
Sugiyama, Y.4
Iga, T.5
-
185
-
-
0033665191
-
The multiple indicator dilution method and its utility in risk assessment
-
Schwab, A. J., Pang, K. S. (2000) The multiple indicator dilution method and its utility in risk assessment. Environ. Health Perspect. 108 (Suppl 5): 1-15
-
(2000)
Environ. Health Perspect
, vol.108
, Issue.SUPPL. 5
, pp. 1-15
-
-
Schwab, A.J.1
Pang, K.S.2
-
186
-
-
0034967961
-
Hepatic uptake and metabolism of benzoate: A multiple indicator dilution, perfused rat liver study
-
Schwab, A. J., Tao, L., Yoshimura, T., Simard, A., Barker, F., Pang, K. S. (2001) Hepatic uptake and metabolism of benzoate: A multiple indicator dilution, perfused rat liver study. Am. J. Physiol. 280: G1124-G1136
-
(2001)
Am. J. Physiol
, vol.280
-
-
Schwab, A.J.1
Tao, L.2
Yoshimura, T.3
Simard, A.4
Barker, F.5
Pang, K.S.6
-
187
-
-
0021739989
-
Sulfation in isolated enterocytes of guinea pig: Dependence of inorganic sulfate
-
Schwarz, L. R., Schwenk, M. (1984) Sulfation in isolated enterocytes of guinea pig: dependence of inorganic sulfate. Biochem. Pharmacol. 33: 3353-3356
-
(1984)
Biochem. Pharmacol
, vol.33
, pp. 3353-3356
-
-
Schwarz, L.R.1
Schwenk, M.2
-
188
-
-
32044438468
-
Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D- ribofuranosylbenzimidazole
-
Shin, H. C., Kim, J. S., Vig, B. S., Song, X., Drach, J. C., Amidon, G. L. (2006) Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D- ribofuranosylbenzimidazole. Biol. Pharm. Bull. 29: 247-252
-
(2006)
Biol. Pharm. Bull
, vol.29
, pp. 247-252
-
-
Shin, H.C.1
Kim, J.S.2
Vig, B.S.3
Song, X.4
Drach, J.C.5
Amidon, G.L.6
-
190
-
-
85024471761
-
Function of uptake transporters for taurocholate and estradiol 17β-D-glucuronide in cryopreserved human hepatocytes
-
Shitara, Y., Li., A. P., Kato, Y., Lu, C., Ito, K., Itoh, T., Sugiyama, Y. (2003) Function of uptake transporters for taurocholate and estradiol 17β-D-glucuronide in cryopreserved human hepatocytes. Drug Metab. Pharmacokinet. 18: 33-41
-
(2003)
Drug Metab. Pharmacokinet
, vol.18
, pp. 33-41
-
-
Shitara, Y.1
Li, A.P.2
Kato, Y.3
Lu, C.4
Ito, K.5
Itoh, T.6
Sugiyama, Y.7
-
191
-
-
0028800562
-
Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter
-
Shneider, B. L., Dawson, P. A., Christie, D. M., Hardikar, W., Wong, M. H., Suchy, F. J. (1995) Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J. Clin. Invest. 95: 745-754
-
(1995)
J. Clin. Invest
, vol.95
, pp. 745-754
-
-
Shneider, B.L.1
Dawson, P.A.2
Christie, D.M.3
Hardikar, W.4
Wong, M.H.5
Suchy, F.J.6
-
192
-
-
4143076189
-
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes
-
Simmonds, A. C., Reilly, C. A., Baldwin, R. M., Ghanayem, B. I., Lanza, D. L., Yost, G. S., Collins, K. S., Forkert P.-G. (2004) Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes. Drug Metab. Dispos. 32: 1032-1039
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 1032-1039
-
-
Simmonds, A.C.1
Reilly, C.A.2
Baldwin, R.M.3
Ghanayem, B.I.4
Lanza, D.L.5
Yost, G.S.6
Collins, K.S.7
Forkert, P.-G.8
-
193
-
-
0031430085
-
Organ clearance concepts: New perspectives on old principles
-
Sirianni, G. L., Pang, K. S. (1997) Organ clearance concepts: New perspectives on old principles. J. Pharmacokinet. Biopharm. 25: 457-478
-
(1997)
J. Pharmacokinet. Biopharm
, vol.25
, pp. 457-478
-
-
Sirianni, G.L.1
Pang, K.S.2
-
194
-
-
24944563781
-
Commentary. Seeing through the MIST: Abundance versus percentage, commentary on metabolites in safety testing
-
Smith, D. A., Obach, R. S. (2005) Commentary. Seeing through the MIST: Abundance versus percentage, commentary on metabolites in safety testing. Drug Metab. Dispos. 33: 1409-1417
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1409-1417
-
-
Smith, D.A.1
Obach, R.S.2
-
195
-
-
33845748169
-
Metabolites and safety: What are the concerns, and how should we address them?
-
Smith, D. A., Obach, R. S. (2006) Metabolites and safety: What are the concerns, and how should we address them? Chem. Res. Toxicol. 19: 1570-1579
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 1570-1579
-
-
Smith, D.A.1
Obach, R.S.2
-
196
-
-
33747866680
-
Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination
-
Smith, N. F., Figg, W. D., Sparreboom, A. (2005) Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opin. Drug Metab. Toxicol. 1: 429-445
-
(2005)
Expert Opin. Drug Metab. Toxicol
, vol.1
, pp. 429-445
-
-
Smith, N.F.1
Figg, W.D.2
Sparreboom, A.3
-
197
-
-
0027249037
-
Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids
-
Snel, C. A. W., Zhao, Y., Mulder, G. J., Pang, K. S. (1993) Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids. Analyt. Biochem. 212: 28-34
-
(1993)
Analyt. Biochem
, vol.212
, pp. 28-34
-
-
Snel, C.A.W.1
Zhao, Y.2
Mulder, G.J.3
Pang, K.S.4
-
198
-
-
0036194124
-
In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance
-
Soars, M. G., Burhcell, B., Riley, R. J. (2002) In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance. J. Pharmacol. Exp. Ther. 301: 382-390
-
(2002)
J. Pharmacol. Exp. Ther
, vol.301
, pp. 382-390
-
-
Soars, M.G.1
Burhcell, B.2
Riley, R.J.3
-
199
-
-
34748896235
-
A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes
-
Somers, G. I., Lindsay, N., Lowdon, B. M., Jones, A. E., Freathy, C., Ho, S., Woodrooffe, A. J. M., Bayliss, M. K., Manchee, G. R. (2007) A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab. Dispos. 35: 1797-1805
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1797-1805
-
-
Somers, G.I.1
Lindsay, N.2
Lowdon, B.M.3
Jones, A.E.4
Freathy, C.5
Ho, S.6
Woodrooffe, A.J.M.7
Bayliss, M.K.8
Manchee, G.R.9
-
200
-
-
0030960852
-
Localization of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice
-
Stanley, L. A., Mills, I. G., Sim, E. (1997) Localization of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice. Pharmacogenetics 7: 121-130
-
(1997)
Pharmacogenetics
, vol.7
, pp. 121-130
-
-
Stanley, L.A.1
Mills, I.G.2
Sim, E.3
-
201
-
-
0017837459
-
Effect of autonomic blocking agents on chronotropic actions of 1-alpha-acetylmethadol
-
Stickney, J. L. (1978) Effect of autonomic blocking agents on chronotropic actions of 1-alpha-acetylmethadol. Arch. Int. Pharmacodyn. Ther. 231: 70-80
-
(1978)
Arch. Int. Pharmacodyn. Ther
, vol.231
, pp. 70-80
-
-
Stickney, J.L.1
-
202
-
-
0024230394
-
Primary, secondary, and tertiary metabolite kinetics
-
St-Pierre, M. V., Xu, X., Pang, K. S. (1988) Primary, secondary, and tertiary metabolite kinetics. J. Pharmacokinet. Biopharm. 16: 493-527
-
(1988)
J. Pharmacokinet. Biopharm
, vol.16
, pp. 493-527
-
-
St-Pierre, M.V.1
Xu, X.2
Pang, K.S.3
-
203
-
-
0027494540
-
Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver
-
St-Pierre, M. V., Pang, K. S (1993a) Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver. J. Pharmacol. Exp. Ther. 265: 1429-1436
-
(1993)
J. Pharmacol. Exp. Ther
, vol.265
, pp. 1429-1436
-
-
St-Pierre, M.V.1
Pang, K.S.2
-
204
-
-
0027373901
-
Kinetics of sequential metabolism of metabolites. II. Formation and metabolism of nordiazpeam and oxazepam from diazepam in the perfused murine liver
-
St-Pierre, M. V., Pang, K. S. (1993b) Kinetics of sequential metabolism of metabolites. II. Formation and metabolism of nordiazpeam and oxazepam from diazepam in the perfused murine liver. J. Pharmacol. Exp. Ther. 265: 1437-1445
-
(1993)
J. Pharmacol. Exp. Ther
, vol.265
, pp. 1437-1445
-
-
St-Pierre, M.V.1
Pang, K.S.2
-
205
-
-
33751170255
-
Increased estrogen sulfation of estradiol 17β-D glucuronide in metastatic rat tumor livers
-
Sun, H., Liu, L., Pang, K. S. (2006) Increased estrogen sulfation of estradiol 17β-D glucuronide in metastatic rat tumor livers. J. Pharmacol. Exp. Ther. 319: 818-831
-
(2006)
J. Pharmacol. Exp. Ther
, vol.319
, pp. 818-831
-
-
Sun, H.1
Liu, L.2
Pang, K.S.3
-
206
-
-
52949123821
-
Disparity in intestine disposition between formed and preformed metabolites: A theoretical study
-
under review
-
Sun, H., Pang, K. S. (2008) Disparity in intestine disposition between formed and preformed metabolites: A theoretical study. Drug Metab. Dispos., under review
-
(2008)
Drug Metab. Dispos
-
-
Sun, H.1
Pang, K.S.2
-
207
-
-
3042544338
-
Bioactivation of capecitabine in human liver: Involvement of the cytosolic enzyme on 5 -deoxy-5-fluorocytidine formation
-
Tabata, T., Katoh, M., Tokudome, S., Hosakawa, M., Chiba, K., Nakajima, M., Yokoi, T. (2004) Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5 -deoxy-5-fluorocytidine formation. Drug Metab. Dispos. 32: 762-767
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 762-767
-
-
Tabata, T.1
Katoh, M.2
Tokudome, S.3
Hosakawa, M.4
Chiba, K.5
Nakajima, M.6
Yokoi, T.7
-
208
-
-
0037378726
-
Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption
-
Tarn, D., Tirana, R. G., Pang, K. S. (2003) Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption. Drug Metab. Dispos. 31: 373-383
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 373-383
-
-
Tarn, D.1
Tirana, R.G.2
Pang, K.S.3
-
209
-
-
0032735306
-
Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1
-
Tamai, I., Sai, Y., Ono, A., Kido, Y., Yabuuchi, H., Takanaga, H., Satoh, E., Ogihara, T., Amano, O., Izeki, S., Tsuji, A. (1999) Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J. Pharm. Pharmacol. 51: 1113-1121
-
(1999)
J. Pharm. Pharmacol
, vol.51
, pp. 1113-1121
-
-
Tamai, I.1
Sai, Y.2
Ono, A.3
Kido, Y.4
Yabuuchi, H.5
Takanaga, H.6
Satoh, E.7
Ogihara, T.8
Amano, O.9
Izeki, S.10
Tsuji, A.11
-
210
-
-
0035114503
-
Sulfation is rate-limiting in the futile cycling between estrone and estrone sulfate in enriched periportal and perivenous rat hepatocytes
-
Tan, E., Pang, K. S. (2001) Sulfation is rate-limiting in the futile cycling between estrone and estrone sulfate in enriched periportal and perivenous rat hepatocytes. Drug Metab. Dispos. 29: 335-346
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 335-346
-
-
Tan, E.1
Pang, K.S.2
-
211
-
-
0035079045
-
Futile cycling of estrone sulfate and estrone in the recirculating, perfused rat liver
-
Tan, E., Lu, T., Pang, K. S. (2001) Futile cycling of estrone sulfate and estrone in the recirculating, perfused rat liver. J. Pharmacol. Exp. Ther. 297: 423-436
-
(2001)
J. Pharmacol. Exp. Ther
, vol.297
, pp. 423-436
-
-
Tan, E.1
Lu, T.2
Pang, K.S.3
-
212
-
-
0042591218
-
The metabolism of diclofenac - enzymology and toxicology perspectives
-
Tang, W. (2003) The metabolism of diclofenac - enzymology and toxicology perspectives. Curr. Drug Metab. 4: 319-329
-
(2003)
Curr. Drug Metab
, vol.4
, pp. 319-329
-
-
Tang, W.1
-
213
-
-
0030015297
-
Oral first pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism
-
Thummel, K. E., O'Shae, D., Paine, M. F., Shen, D. D., Kunze, K. L., Perkins, J. D., Wilkinson, G. R. (1996) Oral first pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin. Pharmacol. Ther. 59: 491-502
-
(1996)
Clin. Pharmacol. Ther
, vol.59
, pp. 491-502
-
-
Thummel, K.E.1
O'Shae, D.2
Paine, M.F.3
Shen, D.D.4
Kunze, K.L.5
Perkins, J.D.6
Wilkinson, G.R.7
-
214
-
-
0029790412
-
Sequestered endoplasmic reticulum space for sequential metabolism of salicylamide: Coupling of hydroxylation and glucuronidation
-
Tirona, R.G., Pang, K. S. (1996) Sequestered endoplasmic reticulum space for sequential metabolism of salicylamide: Coupling of hydroxylation and glucuronidation. Drug Metab. Dispos. 24: 821-833
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 821-833
-
-
Tirona, R.G.1
Pang, K.S.2
-
215
-
-
0032732616
-
Uptake and glutathione conjugation of ethacrynic acid and efflux of the glutathione adduct by periportal and perivenous rat hepatocytes
-
Tirona, R. G., Tan, E., Meier, G., Pang, K. S. (1999) Uptake and glutathione conjugation of ethacrynic acid and efflux of the glutathione adduct by periportal and perivenous rat hepatocytes. J. Pharmacol. Exp. Ther. 291: 1210-1219
-
(1999)
J. Pharmacol. Exp. Ther
, vol.291
, pp. 1210-1219
-
-
Tirona, R.G.1
Tan, E.2
Meier, G.3
Pang, K.S.4
-
216
-
-
0032861503
-
Tissue selective drug delivery utilizing carrier-mediated transport systems
-
Tsuji, A. (1999) Tissue selective drug delivery utilizing carrier-mediated transport systems. J. Control. Release 62: 239-244
-
(1999)
J. Control. Release
, vol.62
, pp. 239-244
-
-
Tsuji, A.1
-
217
-
-
0029782485
-
Carrier-mediated intestinal transport of drugs
-
Tsuji, A., Tamai, I. (1996) Carrier-mediated intestinal transport of drugs. Pharm. Res. 13: 963-977
-
(1996)
Pharm. Res
, vol.13
, pp. 963-977
-
-
Tsuji, A.1
Tamai, I.2
-
218
-
-
0023157713
-
Action of topical minoxidil in the bald stump-tailed macaque
-
Uno, H., Cappas, A., Brigham, P. (1987) Action of topical minoxidil in the bald stump-tailed macaque. J. Am. Acad. Dermatol. 16: 657-668
-
(1987)
J. Am. Acad. Dermatol
, vol.16
, pp. 657-668
-
-
Uno, H.1
Cappas, A.2
Brigham, P.3
-
219
-
-
26444539011
-
Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions
-
van de Water, F. M., Masereeuw, R., Russel, F. G. (2005) Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metab. Rev. 37: 443-471
-
(2005)
Drug Metab. Rev
, vol.37
, pp. 443-471
-
-
van de Water, F.M.1
Masereeuw, R.2
Russel, F.G.3
-
220
-
-
0036326062
-
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures
-
van Gelder, J., Deferme, S., Naesens, L., De Clercq, E., van den Mooter, G., Kinget, R., Augustijns, P. (2002) Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures. Drug Metab. Dispos. 30: 924-930
-
(2002)
Drug Metab. Dispos
, vol.30
, pp. 924-930
-
-
van Gelder, J.1
Deferme, S.2
Naesens, L.3
De Clercq, E.4
van den Mooter, G.5
Kinget, R.6
Augustijns, P.7
-
221
-
-
0038813439
-
Drug uptake systems in liver and kidney
-
van Montfoort, J. E., Hagenbuch, B., Groothuis, G. M. M., Koepsell, H., Meier, P. J., Meijer, D. K.(2003) Drug uptake systems in liver and kidney. Curr. Drug Metab. 4: 185-211
-
(2003)
Curr. Drug Metab
, vol.4
, pp. 185-211
-
-
van Montfoort, J.E.1
Hagenbuch, B.2
Groothuis, G.M.M.3
Koepsell, H.4
Meier, P.J.5
Meijer, D.K.6
-
222
-
-
0025240977
-
Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug
-
Vickers, S., Duncan, C. A., Chen, I. W., Rosegay, A., Duggan, D. E. (1990) Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug. Drug Metab. Dispos. 18: 138-145
-
(1990)
Drug Metab. Dispos
, vol.18
, pp. 138-145
-
-
Vickers, S.1
Duncan, C.A.2
Chen, I.W.3
Rosegay, A.4
Duggan, D.E.5
-
223
-
-
0015922208
-
Active transport of L-dopa in the intestine
-
Wade, D. N., Mearrick, P. T., Morris, J. L. (1973) Active transport of L-dopa in the intestine. Nature 242: 463-465
-
(1973)
Nature
, vol.242
, pp. 463-465
-
-
Wade, D.N.1
Mearrick, P.T.2
Morris, J.L.3
-
224
-
-
0033638544
-
Expression, transport properties, and chromosomal location of organic anion transporter subtype 3
-
Walters, H. C., Craddock, A. L., Fusegawa, H., Willingham, M. C., Dawson, P. A. (2000) Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am. J. Physiol. 279: G1188-G1200
-
(2000)
Am. J. Physiol
, vol.279
-
-
Walters, H.C.1
Craddock, A.L.2
Fusegawa, H.3
Willingham, M.C.4
Dawson, P.A.5
-
225
-
-
0031940440
-
Disposition and covalent binding of diflunisal and diflunisal acyl glucuronide in the isolated perfused rat liver
-
Wang, M., Dickinson, R. G. (1998) Disposition and covalent binding of diflunisal and diflunisal acyl glucuronide in the isolated perfused rat liver. Drug Metab. Dispos. 26: 98-100
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 98-100
-
-
Wang, M.1
Dickinson, R.G.2
-
226
-
-
85075815326
-
Combinations of thiovir and neuraminidase inhibitors exert synergistic antiviral activity on human, equine and avian influenza in vitro
-
Waninger, S., Ramos, S., Robbins, J. (2007) Combinations of thiovir and neuraminidase inhibitors exert synergistic antiviral activity on human, equine and avian influenza in vitro. Antiviral Res. 74: A82
-
(2007)
Antiviral Res
, vol.74
-
-
Waninger, S.1
Ramos, S.2
Robbins, J.3
-
227
-
-
0032969265
-
First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme
-
Wen, Y., Remmel, R. P., Zimmerman, C. L. (1999) First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme. Drug Metab. Dispos. 27: 113-121
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 113-121
-
-
Wen, Y.1
Remmel, R.P.2
Zimmerman, C.L.3
-
228
-
-
0034535914
-
Variable cytochrome P450 2D6 expression and metabolism of codeine and other opioid prodrugs: Implications for the Australian anaesthetist
-
Wilcox, R. A., Owen, H. (2000) Variable cytochrome P450 2D6 expression and metabolism of codeine and other opioid prodrugs: implications for the Australian anaesthetist. Anaesth. Intensive Care 228: 611-669
-
(2000)
Anaesth. Intensive Care
, vol.228
, pp. 611-669
-
-
Wilcox, R.A.1
Owen, H.2
-
229
-
-
0024326450
-
Effect of sulphasalazine and its active metabolite, 5-amino-salicylic acid, on toxic oxygen metabolite production by neutrophils
-
Williams, J. G., Hallett, M. B. (1989) Effect of sulphasalazine and its active metabolite, 5-amino-salicylic acid, on toxic oxygen metabolite production by neutrophils. Gut 30: 1581-1587
-
(1989)
Gut
, vol.30
, pp. 1581-1587
-
-
Williams, J.G.1
Hallett, M.B.2
-
230
-
-
0028039878
-
Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter
-
Wong, M. H., Oelkers, P., Craddock, A. L., Dawson, P. A. (1994) Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J. Biol. Chem. 269: 1340-1347
-
(1994)
J. Biol. Chem
, vol.269
, pp. 1340-1347
-
-
Wong, M.H.1
Oelkers, P.2
Craddock, A.L.3
Dawson, P.A.4
-
231
-
-
34547203591
-
6-Hydroxybuspirone is a major active metabolite of buspirone: Assessment of pharmacokinetics and 5-hydroxytryptamine 1A receptor occupancy in rats
-
Wong, H., Dockens, R. C., Pajor, L., Yeola, S., Grace, J. E. Jr., Stark, A. D., Taub, R. A., Yocca, F. D., Zaczek, R. C., Li. Y.-W. (2007) 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine 1A receptor occupancy in rats Drug Metab. Dispos. 35: 1387-1392
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1387-1392
-
-
Wong, H.1
Dockens, R.C.2
Pajor, L.3
Yeola, S.4
Grace Jr., J.E.5
Stark, A.D.6
Taub, R.A.7
Yocca, F.D.8
Zaczek, R.C.9
Li, Y.-W.10
-
232
-
-
0038347273
-
Mouse liver and kidney carboxylesterase (M-LK) rapidly hydrolyzes antitumor prodrug irinotecan and the N-terminal three quarter sequence determines substrate selectivity
-
Xie, M., Yang, D., Wu, M., Xue. B., Yan, B. (2003) Mouse liver and kidney carboxylesterase (M-LK) rapidly hydrolyzes antitumor prodrug irinotecan and the N-terminal three quarter sequence determines substrate selectivity. Drug Metab. Dispos. 31: 21-27
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 21-27
-
-
Xie, M.1
Yang, D.2
Wu, M.3
Xue, B.4
Yan, B.5
-
233
-
-
0024956848
-
Hepatic modeling of metabolite kinetics in sequential and parallel pathways: Salicylamide and gentisamide metabolism in perfused rat liver
-
Xu, X., Pang, K. S. (1989) Hepatic modeling of metabolite kinetics in sequential and parallel pathways: salicylamide and gentisamide metabolism in perfused rat liver. J. Pharmacokinet. Biopharm. 17: 645-671
-
(1989)
J. Pharmacokinet. Biopharm
, vol.17
, pp. 645-671
-
-
Xu, X.1
Pang, K.S.2
-
234
-
-
0025281356
-
Sequential metabolism of salicylamide exclusively to gentisamide-5-glucuronide and not gentisamide sulfate conjugates in single pass in situ perfused rat liver
-
Xu, X., Tang, B. K., Pang, K. S. (1990) Sequential metabolism of salicylamide exclusively to gentisamide-5-glucuronide and not gentisamide sulfate conjugates in single pass in situ perfused rat liver. J. Pharmacol. Exp. Ther. 253: 963-973
-
(1990)
J. Pharmacol. Exp. Ther
, vol.253
, pp. 963-973
-
-
Xu, X.1
Tang, B.K.2
Pang, K.S.3
-
235
-
-
0028155963
-
Salicylamide sulfate cell entry in perfused rat liver: A multiple indicator dilution study
-
Xu, X., Schwab, A. J. Barker F. 3rd. Goresky, C. A., Pang, K. S. (1994) Salicylamide sulfate cell entry in perfused rat liver: A multiple indicator dilution study. Hepatology 19: 229-244
-
(1994)
Hepatology
, vol.19
, pp. 229-244
-
-
Xu, X.1
Schwab, A.J.2
Barker 3rd, F.3
Goresky, C.A.4
Pang, K.S.5
-
236
-
-
36348943537
-
Multiple isoforms of drug transporters contributed to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor
-
Yamada, A., Maeda, K., Kamiyama, E., Sugiyama, D., Kondo, T., Shiroyanagi, Y., Nakazawa, H., Okano, T., Adachi, M., Schuetz, J. D., Adachi, Y., Hu, Z., Kusuhara, H., Sugiayama, Y. (2007) Multiple isoforms of drug transporters contributed to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab. Dispos. 35: 2166-2176
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 2166-2176
-
-
Yamada, A.1
Maeda, K.2
Kamiyama, E.3
Sugiyama, D.4
Kondo, T.5
Shiroyanagi, Y.6
Nakazawa, H.7
Okano, T.8
Adachi, M.9
Schuetz, J.D.10
Adachi, Y.11
Hu, Z.12
Kusuhara, H.13
Sugiayama, Y.14
-
237
-
-
0037636516
-
Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinonc methide intermediate in rats
-
Zhang, D., Ogan, M., Gedamke. R., Roongta, V., Dai, R., Zhu, M., Rinehart, J. K., Klunk, L., Mitroka, J. (2003) Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinonc methide intermediate in rats. Drug Metab. Dispos. 31: 837-845
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 837-845
-
-
Zhang, D.1
Ogan, M.2
Gedamke, R.3
Roongta, V.4
Dai, R.5
Zhu, M.6
Rinehart, J.K.7
Klunk, L.8
Mitroka, J.9
-
238
-
-
0027375830
-
Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique
-
Zhao, Y., Snel, C. A., Mulder, G. J., Pang, K. S. (1993) Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique. Drug Metab. Dispos. 21: 1070-1078
-
(1993)
Drug Metab. Dispos
, vol.21
, pp. 1070-1078
-
-
Zhao, Y.1
Snel, C.A.2
Mulder, G.J.3
Pang, K.S.4
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