P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: Induction studies with pregnenolone-16α-carbonitrile

Drug Metabolism and Disposition

Volumn 34, Issue 9, 2006, Pages 1468-1479

  Liu, Shanjun ^a   Tam, Debbie ^a   Chen, Xianghai ^b   Pang, K Sandy ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CYTOCHROME P450 3A; DIGOXIGENIN BISDIGITOXOSIDE; DIGOXIN; GLYCOPROTEIN P; PREGNANE X RECEPTOR; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BILAYER MEMBRANE; CHEMICAL MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BINDING; DRUG ELIMINATION; DRUG METABOLISM; INTESTINE PERFUSION; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION; VASCULAR DISEASE; WATER ANALYSIS; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL AVAILABILITY; COMPUTER SIMULATION; CYTOCHROME P-450 CYP3A; DIGOXIN; DRUG ADMINISTRATION ROUTES; ENZYME INDUCTION; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; PERFUSION; PREGNENOLONE CARBONITRILE; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM; WATER;

EID: 33747821713     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.008227     Document Type: Article

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