Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells

European Journal of Pharmaceutical Sciences

Volumn 16, Issue 1-2, 2002, Pages 1-13

  Friedrichsen, Gerda Marie ^a,d   Chen, Weiqing ^b   Begtrup, Mikael ^a   Lee, Chao Pin ^c   Smith, Philip L ^c   Borchardt, Ronald T ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF KANSAS   (United States)

^c GLAXOSMITHKLINE   (United States)

^d LEO PHARMA A S   (Denmark)

Author keywords

Caco 2 cells; L Valacyclovir; PepT1; Structure transport relationships

Indexed keywords

BIOSYNTHESIS; CELLS; ENZYMES; METABOLISM; MONOLAYERS; NITROGEN COMPOUNDS; SUBSTITUTION REACTIONS;

STRUCTURE TRANSPORT RELATIONSHIPS (STR);

DRUG PRODUCTS;

7 AZAINDOLE; ACICLOVIR DERIVATIVE; BENZIMIDAZOLE; CARRIER PROTEIN; ESTER; ESTERASE; GUANINE; INDOLE DERIVATIVE; OLIGOPEPTIDE; PURINE; UNCLASSIFIED DRUG; VALACICLOVIR; ACICLOVIR; ANTIVIRUS AGENT; COTRANSPORTER; DRUG DERIVATIVE; PEPTIDE TRANSPORTER 1; PRODRUG; SLC15A1 PROTEIN, HUMAN; VALINE;

ARTICLE; CELL STRAIN CACO 2; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG METABOLISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; TRANSCYTOSIS; BIOLOGICAL MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; SYNTHESIS; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ACYCLOVIR; ANTIVIRAL AGENTS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMAN; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PRODRUGS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; VALINE; HUMANS; SYMPORTERS;

EID: 0036020060     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00047-7     Document Type: Article

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