In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 1, 2002, Pages 382-390

  Soars, M G ^a   Burchell, B ^a   Riley, R J ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; ETHINYLESTRADIOL; FUROSEMIDE; GEMFIBROZIL; GLUCURONOSYLTRANSFERASE; IMIPRAMINE; KETOPROFEN; MORPHINE; NALOXONE; NAPROXEN; PROPOFOL; URIDINE DIPHOSPHATE; VALPROIC ACID;

ARTICLE; CORRELATION ANALYSIS; CRYOPRESERVATION; DIAGNOSTIC ACCURACY; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STABILITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTESTINE ABSORPTION; KIDNEY CLEARANCE; LIVER CELL; LIVER CLEARANCE; LIVER METABOLISM; LIVER MICROSOME; METABOLIC CLEARANCE RATE; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING;

ALBUMINS; ALGORITHMS; ANIMALS; BODY WEIGHT; DIALYSIS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; INTESTINES; KIDNEY; KINETICS; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; ORGAN SIZE; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036194124     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.1.382     Document Type: Article

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