Hepatic uptake and metabolism of benzoate: A multiple indicator dilution, perfused rat liver study

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 280, Issue 6 43-6, 2001, Pages

  Schwab, Andreas J ^a,b   Tao, Lei ^c   Yoshimura, Tsutomu ^c   Simard, André ^a   Barker, Ford ^c   Pang, K Sandy ^c,d  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Glycine conjugation; Mathematical models; Membrane permeability; Mitochondria

Indexed keywords

ALBUMIN; BENZOIC ACID; GLYCINE; HIPPURIC ACID; INDICATOR; SUCROSE; WATER;

ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; CONJUGATION; DILUTION; DRUG METABOLISM; DRUG UPTAKE; ERYTHROCYTE; ISOTOPE LABELING; LIVER CYTOSOL; LIVER METABOLISM; LIVER MITOCHONDRION; LIVER PERFUSION; LIVER SINUSOID; MALE; MATHEMATICAL MODEL; MEMBRANE PERMEABILITY; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT;

EID: 0034967961     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.280.6.g1124     Document Type: Article

References (38)

1. Drug biotransformation interactions in man. II. A pharmacokinetic study of the simultaneous conjugation of benzoic and salicylic acids with glycine
2. Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study
3. The fate of benzoic acid in various species
4. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis
5. Post-mortem survival of hippuric acid formation in rat and human cadaver tissue samples
6. The monocarboxylate carrier from rat liver mitochondria. Purification and kinetic characterization in a reconstituted system
7. Glycine conjugation activity of benzoic acid and its acinar localization in the perfused rat liver
8. Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations
9. Analysis of exponential curves by a method of moments, with special attention to sedimentation equilibrium and fluorescence decay
10. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1
11. The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics
12. The localization of hippurate synthesis in the matrix of rat liver mitochondria
13. Differences in excretion of hippurate, as a metabolite of benzoate and as an administered species, in the single-pass isolated perfused rat kidney explained
14. Carrier-mediated uptake and excretion of bromosulfophthalein-glutathione in perfused rat liver: A multiple indicator dilution study
15. Hepatic uptake of bromosulfophthalein-glutathione in perfused Eisai hyperbilirubinemic mutant rat liver: A multiple-indicator dilution study
16. Initial distribution and rate of uptake of sulfobromophthalein in the liver
17. Effects of saturating metabolic uptake on space profiles and tracer kinetics
18. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors
19. The analysis of fluorescence decay by a method of moments
20. Isolation and characterization of mitochondrial acyl-CoA:glycine N-acyltransferases from kidney
21. Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations
22. A new method for quantitating intracellular transport: Application to the thyroid hormone 3,5,3′-triiodothyronine
23. Transport of drugs through human erythrocyte membranes: pH dependence of drug transport through labeled human erythrocytes in the presence of band 3 protein inhibitor
24. Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization
25. Sulfation of acetaminophen by the perfused rat liver: The effect of red blood cell carriage
26. 2O, as a reference indicator in liver multiple-indicator dilution studies
27. Extension of the theory of the multiple-indicator dilution technique to metabolic systems with an arbitrary number of rate constants
28. Transfer of enalaprilat across rat liver cell membranes is barrier limited
29. Transport of D-lactate in perfused rat liver
30. Transport and metabolism of L-lactate in perfused rat liver studied by multiple pulse labelling
31. Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver
32. Transcellular transport of benzoic acid across Caco-2 cells by a pH- dependent and carrier-mediated transport mechanism
33. Isolation from bovine liver mitochondria and characterization of three distinct carboxylic acid:CoA ligases with activity toward xenobiotics
34. Salicylamide sulfate cell entry in perfused rat liver: A multiple-indicator dilution study
35. Hepatic uptake of hippurate: A multiple-indicator dilution, perfused rat liver study