Bioactivation of diclofenac via benzoquinone imine intermediates - Identification of urinary mercapturic acid derivatives in rats and humans

Drug Metabolism and Disposition

Volumn 29, Issue 12, 2001, Pages 1608-1613

  Poon, G K ^a   Chen, Q ^a   Teffera, Y ^a   Ngui, J S ^a   Griffin, P R ^a   Braun, M P ^a   Doss, G A ^a   Freeden, C ^a   Stearns, R A ^a   Evans, D C ^a   Baillie, T A ^a   Tang, W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' HYDROXY 3' (N ACETYLCYSTEIN S YL)DICLOFENAC; 5 HYDROXY 4 (N ACETYLCYSTEIN S YL)DICLOFENAC; ACETYLCYSTEINE DERIVATIVE; BENZOQUINONE DERIVATIVE; DICLOFENAC; DICLOFENAC DERIVATIVE; DRUG METABOLITE; IMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DETERMINATION; DRUG METABOLISM; DRUG OXIDATION; DRUG URINE LEVEL; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REFERENCE VALUE; TANDEM MASS SPECTROMETRY; URINALYSIS;

ACETYLCYSTEINE; ANIMALS; BENZOQUINONES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; HUMANS; IMINES; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0035193545     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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