Selection of Human Cytochrome P450 1A2 Mutants with Enhanced Catalytic Activity for Heterocyclic Amine N-Hydroxylation

Biochemistry

Volumn 43, Issue 4, 2004, Pages 981-988

  Kim, Donghak ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CATALYSIS; ENZYMES; HYDROXYLATION; METABOLISM; MUTAGENESIS; MUTAGENS; TOXICITY;

BIOACTIVATION; GENOTOXICITY;

BIOCHEMISTRY;

2 AMINO 3,5 DIMETHYLIMIDAZO[4,5 F]QUINOLINE; ASPARAGINE; ASPARTIC ACID; CYTOCHROME P450 1A2; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HETEROCYCLIC AMINE; HISTIDINE; HYDROGEN PEROXIDE; METHYL GROUP; MUTAGENIC AGENT; MUTANT PROTEIN; QUINOLINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GENOTOXICITY; HYDROXYLATION; MOLECULAR MODEL; MUTATION; NONHUMAN; OPEN READING FRAME; OXIDATION; PRIORITY JOURNAL; X RAY ANALYSIS;

ESCHERICHIA COLI; FELIS CATUS; ORYCTOLAGUS CUNICULUS;

EID: 0942301388     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035593f     Document Type: Article

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