Haplotype structure and allele frequencies of CYP2B6 in a Korean population

Drug Metabolism and Disposition

Volumn 32, Issue 12, 2004, Pages 1341-1344

  Cho, Joo Youn ^a   Lim, Hyeong Seok ^a   Chung, Jae Yong ^a   Yu, Kyung Sang ^a   Kim, Jung Ryul ^a   Shin, Sang Goo ^a   Jang, In Jin ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B6; DNA;

ADULT; ALGORITHM; ALLELE; ARTICLE; ASIAN; ENZYME ACTIVITY; ENZYME METABOLISM; FEMALE; GENE FREQUENCY; GENETIC CODE; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; KOREA; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; RECEPTOR BINDING; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; ARYL HYDROCARBON HYDROXYLASES; DNA; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE FREQUENCY; HAPLOTYPES; HUMANS; ISOENZYMES; KOREA; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 9444288227     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.001107     Document Type: Article

References (13)

1. Ariyoshi N, Miyazaki M, Toide K, Sawamura Y, and Kamataki T (2001) A single nucleotide polymorphism of CYP2B6 found in Japanese enhances catalytic activity by autoactivation. Biochem Biophys Res Commun 281:1256-1260.
2. Excoffier L and Slatkin M (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a dipioid population. Mol Biol Evol 12:921-927.
3. Gervot L, Rochat B, Gamier JC, Bohnenstengel F, Kroemer H, de Berardinis V, Martin H, Beaune P, and de Waziers I (1999) Human CYP2B6: expression, inducibility and catalytic activities. Pharmacogenetics 9:295-306.
4. Hesse LM, He P, Krishnaswamy S, Hao Q, Hogan K, von Moltke LL, Greenblatt DJ, and Court MH (2004) Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes. Pharmacogenetics 14:225-238.
5. Hiratsuka M, Takekuma Y, Endo N, Narahara K, Hamdy SI, Kishikawa Y, Matsuura M, Agatsuma Y, Inoue T, and Mizugaki M (2002) Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population. Eur J Clin Pharmacol 58:417-421.
6. Jinno H, Tanaka-Kagawa T, Ohno A, Makino Y, Matsushima E, Hanioka N, and Ando M (2003) Functional characterization of cytochrome P450 2B6 allelic variants. Drug Metab Dispos 31:398-403.
7. Kirchheiner J, Klein C, Meineke I, Sasse J, Zanger U, Mürdter TE, Roots I, and Brockmöller J (2003) Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6, Pharmacogenetics 13:619-626.
8. Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, Fackenthal JD, Rogan PK. Ring B, Wrighton SA, and Schuetz EG (2003) Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 307:906-922.
9. Lang T, Klein K, Fischer J, Nussler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, and Zanger UM (2001) Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 11:399-415.
10. Lang T, Klein K, Richter T, Zibat A, Kerb R, Eichelbaum M, Schwab M, and Zanger UM (2004) Muitiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther 311:34-43.
11. Podvinec M, Kaufmann MR, Handschin C, and Meyer UA (2002) NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol Endocrinol 16:1269-1279.
12. Tsuchiya K, Gatanaga H, Tachikawa N, Teruya K, Kikuchi Y, Yoshino M, Kuwahara T, Shirasaka T, Kimura S, and Oka S (2004) Homozygous CYP2B6*6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. Biochem Biophys Res Commun 319:1322-1326.
13. Xie HJ, Yasar U, Lundgren S, Griskevicius L, Terelius Y, Hassan M, and Rane A (2003) Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation. Pharmacogenet J 3:53-61.