2,2',3,3',6,6'-Hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11

Chemical Research in Toxicology

Volumn 12, Issue 8, 1999, Pages 690-699

  Waller, Stephen C ^a,c   He, You Ai ^b   Harlow, Greg R ^d   He, You Qun ^b   Mash, Eugene A ^c   Halpert, James R ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d Hoechst Marion Roussel   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CYTOCHROME P450; HEXACHLOROBIPHENYL; ISOLEUCINE; LEUCINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; ESCHERICHIA COLI; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MASS SPECTROMETRY; NONHUMAN; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; SYNTHESIS;

ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROXYLATION; MUTAGENESIS, SITE-DIRECTED; POLYCHLORINATED BIPHENYLS; RECOMBINANT PROTEINS; STEROID HYDROXYLASES;

EID: 0345034802     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx990030j     Document Type: Article

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