Substrate routes to the buried active site may vary among cytochromes P450: Mutagenesis of the F-G region in P450 2B1

Chemical Research in Toxicology

Volumn 15, Issue 11, 2002, Pages 1407-1413

  Scott, Emily E ^a   He, You Qun ^a   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZPHETAMINE; COUMARIN DERIVATIVE; CYTOCHROME P450; MICROSOME ENZYME; RESORUFIN DERIVATIVE; TESTOSTERONE; 7 ETHOXY 4 TRIFLUOROMETHYLCOUMARIN; 7-ETHOXY-4-TRIFLUOROMETHYLCOUMARIN; CYTOCHROME P450 2B1; PEPTIDE FRAGMENT; PRIMER DNA;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MUTAGENESIS; STEADY STATE; BINDING SITE; COMPARATIVE STUDY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS);

BASE SEQUENCE; BINDING SITES; COUMARINS; CYTOCHROME P-450 CYP2B1; DNA PRIMERS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TESTOSTERONE;

EID: 0036851805     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx020057u     Document Type: Article

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