P450 active site architecture and reversibility: Inactivation of cytochromes P450 2B4 and 2B4 T302A by tert-butyl acetylenes

Biochemistry

Volumn 44, Issue 10, 2005, Pages 3831-3844

  Blobaum, Anna L ^a   Harris, Danni L ^b   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE; DIALYSIS; ENZYMES; ETHERS; HYDROGEN BONDS; IRON; MOLECULAR DYNAMICS; OXIDATION; OXYGEN; PROTONS;

ACTIVE SITE ARCHITECTURE; ARTIFICIAL OXIDANTS; CYTOCHROMES; PEROXOIRON SPECIES;

CYTOLOGY;

ACETYLENE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2B4; CYTOCHROME P450 T302A; ETHER DERIVATIVE; GLUTAMIC ACID; HEMOPROTEIN; MUTANT PROTEIN; TERT BUTYL 1 METHYL 2 PROPYNYL ETHER; TERT BUTYL ACETYLENE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DIALYSIS; ENZYME INACTIVATION; ENZYME KINETICS; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTON TRANSPORT; WILD TYPE;

ALANINE; ALKYNES; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; ETHERS; HEME; HYDROGEN BONDING; MODELS, MOLECULAR; OXIDANTS; PEROXIDES; RABBITS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THREONINE;

EID: 14844347491     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0478953     Document Type: Article

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