Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 3, 1999, Pages 1141-1147

  Domanski, Tammy L ^a   Schultz, Kathleen M ^b,c   Roussel, Fabienne ^a   Stevens, Jeffrey C ^b   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Dept Drug Metab and Pharmacokin ^*  (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; CARBON 14; COUMARIN DERIVATIVE; CYTOCHROME P450; TESTOSTERONE;

ARTICLE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; MOLECULAR CLONING; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BACULOVIRIDAE; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SOFTWARE; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0032803537     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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