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Volumn 154, Issue 1, 2008, Pages 141-151

Hypothetical review: Thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes

Author keywords

AIRE; APECED; Autoantibody; Autoimmunity; Autoimmunization; Myasthenia gravis; Self tolerance; Thymic epithelial cells; Thymoma; Thymus; Type I interferon

Indexed keywords

ALPHA INTERFERON; AUTOIMMUNE REGULATOR PROTEIN; BETA INTERFERON; GAMMA INTERFERON; INTERFERON; INTERFERON ANTIBODY; INTERFERON LAMBDA; NEUTRALIZING ANTIBODY; OMEGA INTERFERON; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 51349151253     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03739.x     Document Type: Review
Times cited : (28)

References (103)
  • 1
    • 13144261691 scopus 로고    scopus 로고
    • Foxp3 acts as a rheostat of the immune response
    • Ochs H D, Ziegler S F, Torgerson TR. Foxp3 acts as a rheostat of the immune response. Immunol Revs 2005 203 : 156 64.
    • (2005) Immunol Revs , vol.203 , pp. 156-64
    • Ochs, H.D.1    Ziegler, S.F.2    Torgerson, T.R.3
  • 2
    • 28444434811 scopus 로고    scopus 로고
    • IPEX and FOXP3: Clinical and research perspectives
    • Suppl
    • Wildin RS, Freitas A. IPEX and FOXP3: clinical and research perspectives. J Autoimmun 2005 25 (Suppl 56 62.
    • (2005) J Autoimmun , vol.25 , pp. 56-62
    • Wildin, R.S.1    Freitas, A.2
  • 3
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007 445 : 766 70.
    • (2007) Nature , vol.445 , pp. 766-70
    • Wan, Y.Y.1    Flavell, R.A.2
  • 4
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007 8 : 457 62.
    • (2007) Nat Immunol , vol.8 , pp. 457-62
    • Zheng, Y.1    Rudensky, A.Y.2
  • 5
    • 33747662305 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab 2006 91 : 2843 50.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2843-50
    • Perheentupa, J.1
  • 6
    • 84882905388 scopus 로고    scopus 로고
    • Polyendocrine syndromes
    • In: Rose, N., Mackay, I.R., eds. edn. Amsterdam: Elsevier, Academic press
    • Peterson P, Uibo AR, Kampe O. Polyendocrine syndromes. In : Rose N, Mackay IR, eds. The autoimmune diseases, 4th edn. Amsterdam : Elsevier, Academic press, 2007 : 515 26.
    • (2007) The Autoimmune Diseases, 4th , pp. 515-26
    • Peterson, P.1    Uibo, A.R.2    Kampe, O.3
  • 7
    • 10744233772 scopus 로고    scopus 로고
    • Prevalence and clinical association of 10 defined autoantibodies in autoimmune polyendocrine syndrome type 1
    • Söderbergh A, Myhre AG, Ekwall O et al. Prevalence and clinical association of 10 defined autoantibodies in autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab 2004 89 : 557 62.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 557-62
    • Söderbergh, A.1    Myhre, A.G.2    Ekwall, O.3
  • 8
    • 33751064042 scopus 로고    scopus 로고
    • Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens
    • Brännström J, Hässler S, Peltonen L, Herrmann B, Winqvist O. Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens. Clin Immunol 2006 121 : 265 73.
    • (2006) Clin Immunol , vol.121 , pp. 265-73
    • Brännström, J.1    Hässler, S.2    Peltonen, L.3    Herrmann, B.4    Winqvist, O.5
  • 9
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski B, Klein L. A central role for central tolerance. Annu. Revs. Immunol 2006 24 : 571 606.
    • (2006) Annu. Revs. Immunol , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 10
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson MS, Venanzi ES, Klein L et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002 298 : 1395 401.
    • (2002) Science , vol.298 , pp. 1395-401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3
  • 11
    • 7244227646 scopus 로고    scopus 로고
    • Gene dosage - Limiting role of Aire in thymic expression, clonal deletion, and organ-specific auto-immunity
    • Liston A, Gray DH, Lesage S et al. Gene dosage - limiting role of Aire in thymic expression, clonal deletion, and organ-specific auto-immunity. J Exp Med 2004 200 : 1015 26.
    • (2004) J Exp Med , vol.200 , pp. 1015-26
    • Liston, A.1    Gray, D.H.2    Lesage, S.3
  • 12
  • 14
    • 33751513054 scopus 로고    scopus 로고
    • Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    • DeVoss J, Hou Y, Johannes K et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med 2006 203 : 2727 35.
    • (2006) J Exp Med , vol.203 , pp. 2727-35
    • Devoss, J.1    Hou, Y.2    Johannes, K.3
  • 15
    • 33646413687 scopus 로고    scopus 로고
    • Alteration of intra-pancreatic target-organ specificity by abrogating Aire in NOD mice
    • Niki S, Oshikawa K, Mouri Y et al. Alteration of intra-pancreatic target-organ specificity by abrogating Aire in NOD mice. J Clin Invest 2006 116 : 1292 301.
    • (2006) J Clin Invest , vol.116 , pp. 1292-301
    • Niki, S.1    Oshikawa, K.2    Mouri, Y.3
  • 16
    • 33745290201 scopus 로고    scopus 로고
    • Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen
    • Chin RK, Zhu M, Christiansen PA et al. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol 2006 177 : 290 7.
    • (2006) J Immunol , vol.177 , pp. 290-7
    • Chin, R.K.1    Zhu, M.2    Christiansen, P.A.3
  • 17
    • 34250336454 scopus 로고    scopus 로고
    • RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    • Rossi SW, Kim MY, Leibbrandt A et al. RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med 2007 204 : 1267 72.
    • (2007) J Exp Med , vol.204 , pp. 1267-72
    • Rossi, S.W.1    Kim, M.Y.2    Leibbrandt, A.3
  • 18
    • 13544262691 scopus 로고    scopus 로고
    • Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
    • Kuroda N, Mitani T, Takeda N et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol 2005 174 : 1862 70.
    • (2005) J Immunol , vol.174 , pp. 1862-70
    • Kuroda, N.1    Mitani, T.2    Takeda, N.3
  • 20
    • 32944474710 scopus 로고    scopus 로고
    • Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator
    • Ramsey C, Hassler S, Marits P et al. Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator. Eur J Immunol 2006 36 : 305 17.
    • (2006) Eur J Immunol , vol.36 , pp. 305-17
    • Ramsey, C.1    Hassler, S.2    Marits, P.3
  • 21
    • 27644454109 scopus 로고    scopus 로고
    • CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
    • Ryan KR, Lawson CA, Lorenzi AR, Arkwright PD, Isaacs JD, Lilic D. CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. J All Clin Immunol 2005 116 : 1158 9.
    • (2005) J All Clin Immunol , vol.116 , pp. 1158-9
    • Ryan, K.R.1    Lawson, C.A.2    Lorenzi, A.R.3    Arkwright, P.D.4    Isaacs, J.D.5    Lilic, D.6
  • 22
    • 33846203837 scopus 로고    scopus 로고
    • A defect of regulatory T cells in patients with auto-immune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Kekalainen E, Tuovinen H, Joensuu J et al. A defect of regulatory T cells in patients with auto-immune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol 2007 178 : 1208 15.
    • (2007) J Immunol , vol.178 , pp. 1208-15
    • Kekalainen, E.1    Tuovinen, H.2    Joensuu, J.3
  • 23
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells
    • Aschenbrenner K, D'Cruz LM, Vollmann EH et al. Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells. Nat Immunol 2007 8 : 351 8.
    • (2007) Nat Immunol , vol.8 , pp. 351-8
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3
  • 24
    • 33749524196 scopus 로고    scopus 로고
    • Aire- deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients
    • Pöntynen N, Miettinen A, Arstila TP et al. Aire- deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients. J Autoimmun 2006 27 : 96 104.
    • (2006) J Autoimmun , vol.27 , pp. 96-104
    • Pöntynen, N.1    Miettinen, A.2    Arstila, T.P.3
  • 25
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P, Bennett ST, Todd JA et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997 15 : 289 92.
    • (1997) Nat Genet , vol.15 , pp. 289-92
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3
  • 26
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A, Zeller M, Fernandez A et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997 15 : 293 7.
    • (1997) Nat Genet , vol.15 , pp. 293-7
    • Pugliese, A.1    Zeller, M.2    Fernandez, A.3
  • 27
    • 34548151158 scopus 로고    scopus 로고
    • An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
    • Giraud M, Taubert R, Vandiedonck C et al. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 2007 448 : 934 7.
    • (2007) Nature , vol.448 , pp. 934-7
    • Giraud, M.1    Taubert, R.2    Vandiedonck, C.3
  • 28
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi J, Rainbow D, Serra P et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 2007 39 : 329 37.
    • (2007) Nat Genet , vol.39 , pp. 329-37
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3
  • 29
    • 9644262469 scopus 로고    scopus 로고
    • Interferons, interferon-like cytokines, and their receptors
    • Pestka S., Krause CD, Walter MR. Interferons, interferon-like cytokines, and their receptors. Immunol Revs 2004 202 : 8 32.
    • (2004) Immunol Revs , vol.202 , pp. 8-32
    • Pestka, S.1    Krause, C.D.2    Walter, M.R.3
  • 30
    • 0037236826 scopus 로고    scopus 로고
    • IL-28, IL-29 and their class II cytokine receptor IL-28R
    • Sheppard P, Kindsvogel W, Xu W et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 2003 4 : 63 8.
    • (2003) Nat Immunol , vol.4 , pp. 63-8
    • Sheppard, P.1    Kindsvogel, W.2    Xu, W.3
  • 31
    • 0037243222 scopus 로고    scopus 로고
    • IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
    • Kotenko S, Gallagher G, Baurin VV et al. IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003 4 : 69 77.
    • (2003) Nat Immunol , vol.4 , pp. 69-77
    • Kotenko, S.1    Gallagher, G.2    Baurin, V.V.3
  • 32
    • 9644295708 scopus 로고    scopus 로고
    • Issues in t-helper 1 development - Resolved and unresolved
    • Berenson LS, Ota N, Murphy KM. Issues in t-helper 1 development - resolved and unresolved. Immunol Rev 2004 202 : 157 74.
    • (2004) Immunol Rev , vol.202 , pp. 157-74
    • Berenson, L.S.1    Ota, N.2    Murphy, K.M.3
  • 33
    • 0032773794 scopus 로고    scopus 로고
    • Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    • Cella M, Jarrossay D, Facchetti F et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999 5 : 919 23.
    • (1999) Nat Med , vol.5 , pp. 919-23
    • Cella, M.1    Jarrossay, D.2    Facchetti, F.3
  • 34
    • 34250161921 scopus 로고    scopus 로고
    • Activation of interferon gene expression through Toll-like receptor-dependent and -independent pathways
    • In: Meager, A., ed. Weinheim: Wiley VCH
    • Nakhaei P, Paz S, Hiscott J. Activation of interferon gene expression through Toll-like receptor-dependent and -independent pathways. In : Meager A, ed. The interferons: characterization and application. Weinheim : Wiley VCH, 2004 : 35 61.
    • (2004) The Interferons: Characterization and Application. , pp. 35-61
    • Nakhaei, P.1    Paz, S.2    Hiscott, J.3
  • 35
    • 32444451688 scopus 로고    scopus 로고
    • The type I interferon system in systemic lupus erythematosus
    • Ronnblom L, Eloranta ML, Alm GV. The type I interferon system in systemic lupus erythematosus. Arthritis Rheum 2006 54 : 408 20.
    • (2006) Arthritis Rheum , vol.54 , pp. 408-20
    • Ronnblom, L.1    Eloranta, M.L.2    Alm, G.V.3
  • 36
    • 33748447541 scopus 로고    scopus 로고
    • Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau J, Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006 25 : 383 92.
    • (2006) Immunity , vol.25 , pp. 383-92
    • Banchereau, J.1    Pascual, V.2
  • 37
    • 0345359586 scopus 로고    scopus 로고
    • Induction of clinical autoimmune disease by therapeutic interferon alpha
    • Gota C, Calabrese L. Induction of clinical autoimmune disease by therapeutic interferon alpha. Autoimmunity 2003 36 : 511 18.
    • (2003) Autoimmunity , vol.36 , pp. 511-18
    • Gota, C.1    Calabrese, L.2
  • 38
    • 33845357261 scopus 로고    scopus 로고
    • Syndromes and complications of interferon therapy
    • Borg FA, Isenberg DA. Syndromes and complications of interferon therapy. Curr Opin Rheumatol 2007 19 : 61 6.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 61-6
    • Borg, F.A.1    Isenberg, D.A.2
  • 39
    • 34548438559 scopus 로고    scopus 로고
    • High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus
    • Niewold TB, Hua J, Lehman TJ, Harley JB, Crow MK. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007 8 : 492 502.
    • (2007) Genes Immun , vol.8 , pp. 492-502
    • Niewold, T.B.1    Hua, J.2    Lehman, T.J.3    Harley, J.B.4    Crow, M.K.5
  • 40
    • 33646477141 scopus 로고    scopus 로고
    • Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p
    • Zhuang H, Kosboth M, Lee P et al. Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p. Arthritis Rheum 2006 54 : 1573 9.
    • (2006) Arthritis Rheum , vol.54 , pp. 1573-9
    • Zhuang, H.1    Kosboth, M.2    Lee, P.3
  • 41
    • 40649121122 scopus 로고    scopus 로고
    • Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 reveals a novel 5bp length polymorphism as strong risk factor for systemic lupus erythematosus
    • Sigurdsson S, Göring HH, Kristjansdottir G et al. Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 reveals a novel 5bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum Mol Genet 2008 17 : 872 81.
    • (2008) Hum Mol Genet , vol.17 , pp. 872-81
    • Sigurdsson, S.1    Göring, H.H.2    Kristjansdottir, G.3
  • 42
    • 33646368404 scopus 로고    scopus 로고
    • A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
    • Graham RR, Kozyrev SV, Baechler EC et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006 38 : 550 5.
    • (2006) Nat Genet , vol.38 , pp. 550-5
    • Graham, R.R.1    Kozyrev, S.V.2    Baechler, E.C.3
  • 43
    • 33845877145 scopus 로고    scopus 로고
    • Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus
    • Bauer JW, Baechler EC, Petri M et al. Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Med 2006 3 : e491.
    • (2006) PLoS Med , vol.3
    • Bauer, J.W.1    Baechler, E.C.2    Petri, M.3
  • 44
    • 0019964510 scopus 로고
    • Antibodies to alpha-interferon in a patient with systemic lupus erythematosus
    • Panem S, Check IJ, Henriksen D, Vilcek J. Antibodies to alpha-interferon in a patient with systemic lupus erythematosus. J Immunol 1982 129 : 1 3.
    • (1982) J Immunol , vol.129 , pp. 1-3
    • Panem, S.1    Check, I.J.2    Henriksen, D.3    Vilcek, J.4
  • 45
    • 0037356935 scopus 로고    scopus 로고
    • Incidence of autoantibodies against type I and type II interferons in a cohort of systemic lupus erythematosus patients in Slovakia
    • Slavikova M, Schmeisser H, Kontsekova E, Mateicka F, Borecky L, Kontsek P. Incidence of autoantibodies against type I and type II interferons in a cohort of systemic lupus erythematosus patients in Slovakia. J Interferon Cytokine Res 2003 23 : 143 7.
    • (2003) J Interferon Cytokine Res , vol.23 , pp. 143-7
    • Slavikova, M.1    Schmeisser, H.2    Kontsekova, E.3    Mateicka, F.4    Borecky, L.5    Kontsek, P.6
  • 46
    • 0037387254 scopus 로고    scopus 로고
    • Anti-cytokine autoantibodies in autoimmunity: Preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis
    • Meager A, Wadhwa M, Dilger P et al. Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin Exp Immunol 2003 132 : 128 36.
    • (2003) Clin Exp Immunol , vol.132 , pp. 128-36
    • Meager, A.1    Wadhwa, M.2    Dilger, P.3
  • 47
    • 0030742739 scopus 로고    scopus 로고
    • In vivo development of antibody to interferons: An up-date to 1996
    • Suppl.
    • Antonelli G. In vivo development of antibody to interferons: an up-date to 1996. J Interferon Cytokine Res 1997 17 (Suppl. 1 S39 46.
    • (1997) J Interferon Cytokine Res , vol.17 , Issue.1
    • Antonelli, G.1
  • 48
    • 0033984950 scopus 로고    scopus 로고
    • Neutralizing antibodies to granulocyte-macrophage colony-stimulating factor, interleukin-1α and interferon-α but not other cytokines in human immunoglobulin preparations
    • Wadhwa M, Meager A, Dilger P et al. Neutralizing antibodies to granulocyte-macrophage colony-stimulating factor, interleukin-1α and interferon-α but not other cytokines in human immunoglobulin preparations. Immunology 2000 99 : 113 23.
    • (2000) Immunology , vol.99 , pp. 113-23
    • Wadhwa, M.1    Meager, A.2    Dilger, P.3
  • 49
    • 0347720220 scopus 로고    scopus 로고
    • Thymic tumours and their autoimmune associations
    • In: Souhami, R.L., Tannock, I., Hohenberger, P., Horiot, J-C, eds. edn. Oxford: Oxford University Press
    • Willcox N., Sheppard M, Loehrer PJ. Thymic tumours and their autoimmune associations. In : Souhami RL, Tannock I, Hohenberger, P, Horiot J-C, eds. Oxford textbook of oncology, 2nd edn. Oxford : Oxford University Press, 2002 : 2143 52.
    • (2002) Oxford Textbook of Oncology, 2nd , pp. 2143-52
    • Willcox, N.1    Sheppard, M.2    Loehrer, P.J.3
  • 50
    • 0033934538 scopus 로고    scopus 로고
    • Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma)
    • Kadota Y, Okumura M, Miyoshi S et al. Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma). Clin Exp Immunol 2000 121 : 59 68.
    • (2000) Clin Exp Immunol , vol.121 , pp. 59-68
    • Kadota, Y.1    Okumura, M.2    Miyoshi, S.3
  • 51
    • 33947694597 scopus 로고    scopus 로고
    • Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1)
    • Ströbel P, Murumagi A, Klein R et al. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J Pathol 2007 211 : 563 71.
    • (2007) J Pathol , vol.211 , pp. 563-71
    • Ströbel, P.1    Murumagi, A.2    Klein, R.3
  • 52
    • 34547899524 scopus 로고    scopus 로고
    • Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas
    • Scarpino S, Di Napoli A, Stoppacciaro A et al. Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. Clin Exp Immunol 2007 149 : 504 12.
    • (2007) Clin Exp Immunol , vol.149 , pp. 504-12
    • Scarpino, S.1    Di Napoli, A.2    Stoppacciaro, A.3
  • 53
    • 33746423947 scopus 로고    scopus 로고
    • Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type-1
    • Meager A, Visvalingam K, Peterson P et al. Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type-1. PloS Med 2006 3 : e289.
    • (2006) PloS Med , vol.3
    • Meager, A.1    Visvalingam, K.2    Peterson, P.3
  • 54
    • 0037855934 scopus 로고    scopus 로고
    • Scenarios for auto-immunization of T and B cells in myasthenia gravis
    • Shiono H, Roxanis I, Zhang W et al. Scenarios for auto-immunization of T and B cells in myasthenia gravis. Ann NY Acad Sci 2003 998 : 237 56.
    • (2003) Ann NY Acad Sci , vol.998 , pp. 237-56
    • Shiono, H.1    Roxanis, I.2    Zhang, W.3
  • 55
    • 33847142674 scopus 로고    scopus 로고
    • Immunodeficiency: UNC-93B gets a toll call
    • Conley ME. Immunodeficiency: UNC-93B gets a toll call. Trends Immunol 2007 28 : 99 100.
    • (2007) Trends Immunol , vol.28 , pp. 99-100
    • Conley, M.E.1
  • 56
    • 25444487466 scopus 로고    scopus 로고
    • Anti-IFN-gamma autoantibodies in disseminated non-tuberculous mycobacterial infections
    • Patel SY, Ding L, Brown MR et al. Anti-IFN-gamma autoantibodies in disseminated non-tuberculous mycobacterial infections. J Immunol 2005 175 : 4769 76.
    • (2005) J Immunol , vol.175 , pp. 4769-76
    • Patel, S.Y.1    Ding, L.2    Brown, M.R.3
  • 57
    • 33846990524 scopus 로고    scopus 로고
    • Autoimmune polyendocrine syndrome type 1 in Norway: Phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene
    • Wolff AS, Erichsen MM, Meager A et al. Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene. J Clin Endocrinol Metab 2007 92 : 595 603.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 595-603
    • Wolff, A.S.1    Erichsen, M.M.2    Meager, A.3
  • 58
    • 0034749749 scopus 로고    scopus 로고
    • A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly co-segregating with hypothyroid autoimmune thyroiditis
    • Cetani F, Barbesino G, Borsari S et al. A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly co-segregating with hypothyroid autoimmune thyroiditis. J Clin Endocrinol Metab 2001 86 : 4747 52.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4747-52
    • Cetani, F.1    Barbesino, G.2    Borsari, S.3
  • 59
    • 0037961060 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: Time to review diagnostic criteria?
    • Buzi F, Badolato R, Mazza C et al. Autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria? J Clin Endocrinol Metab 2003 88 : 3146 8.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3146-8
    • Buzi, F.1    Badolato, R.2    Mazza, C.3
  • 60
    • 4043091960 scopus 로고    scopus 로고
    • Prediction of autoantibody positivity and progression to type I diabetes. Diabetes autoimmunity study in the young (DAISY)
    • Barker JM, Barriga KJ, Yu L et al. Prediction of autoantibody positivity and progression to type I diabetes. Diabetes autoimmunity study in the young (DAISY). J. Clin Endocrinol Metab 2004 89 : 3896 902.
    • (2004) J. Clin Endocrinol Metab , vol.89 , pp. 3896-902
    • Barker, J.M.1    Barriga, K.J.2    Yu, L.3
  • 61
    • 43049101640 scopus 로고    scopus 로고
    • The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    • Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 2008 118 : 1680 90.
    • (2008) J Clin Invest , vol.118 , pp. 1680-90
    • Guo, B.1    Chang, E.Y.2    Cheng, G.3
  • 62
    • 41449110468 scopus 로고    scopus 로고
    • Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • Milner JD, Brenchley JM, Laurence A et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008 452 : 773 6.
    • (2008) Nature , vol.452 , pp. 773-6
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3
  • 63
    • 45949104818 scopus 로고    scopus 로고
    • IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi
    • Romani L, Zelante T, De Luca A, Fallarino F, Puccetti P. IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi. J Immunol 2008 180 : 5157 62.
    • (2008) J Immunol , vol.180 , pp. 5157-62
    • Romani, L.1    Zelante, T.2    De Luca, A.3    Fallarino, F.4    Puccetti, P.5
  • 64
    • 34249672361 scopus 로고    scopus 로고
    • Recurrent herpes simplex virus infection in a patient with auto-immune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations
    • Nagafuchi S, Umene K, Yamanaka F et al. Recurrent herpes simplex virus infection in a patient with auto-immune polyendocrinopathy-candidiasis- ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations. J Intern Med 2007 261 : 605 10.
    • (2007) J Intern Med , vol.261 , pp. 605-10
    • Nagafuchi, S.1    Umene, K.2    Yamanaka, F.3
  • 65
    • 51349111750 scopus 로고    scopus 로고
    • Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes
    • in press).
    • Kisand K, Link M, Wolff AS et al. Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes. Blood 2008 (in press).
    • (2008) Blood
    • Kisand, K.1    Link, M.2    Wolff, A.S.3
  • 66
    • 0033461161 scopus 로고    scopus 로고
    • The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures
    • Flohr F, Schneider-Schaulies S, Haller O, Kochs G. The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures. FEBS Lett 1999 463 : 24 8.
    • (1999) FEBS Lett , vol.463 , pp. 24-8
    • Flohr, F.1    Schneider-Schaulies, S.2    Haller, O.3    Kochs, G.4
  • 67
    • 0025089339 scopus 로고
    • The distribution of immunoreactive interferon-alpha in formalin-fixed paraffin-embedded normal human foetal and infant tissues
    • Khan NU, Gibson A, Foulis AK. The distribution of immunoreactive interferon-alpha in formalin-fixed paraffin-embedded normal human foetal and infant tissues. Immunology 1990 71 : 230 5.
    • (1990) Immunology , vol.71 , pp. 230-5
    • Khan, N.U.1    Gibson, A.2    Foulis, A.K.3
  • 68
    • 33845265075 scopus 로고    scopus 로고
    • Stimulated plasmacytoid dendritic cells impair human T-cell development
    • Schmidlin H, Dontje W, Groot F et al. Stimulated plasmacytoid dendritic cells impair human T-cell development. Blood 2006 108 : 3792 800.
    • (2006) Blood , vol.108 , pp. 3792-800
    • Schmidlin, H.1    Dontje, W.2    Groot, F.3
  • 69
    • 45249108484 scopus 로고    scopus 로고
    • Autoimmunizing mechanisms in thymoma and thymus
    • Willcox N, Leite MI, Kadota Y et al. Autoimmunizing mechanisms in thymoma and thymus. Ann N Y Acad Sci 2008 1132 : 163 173.
    • (2008) Ann N Y Acad Sci , vol.1132 , pp. 163-173
    • Willcox, N.1    Leite, M.I.2    Kadota, Y.3
  • 70
    • 22344438901 scopus 로고    scopus 로고
    • Plasmacytoid predendritic cells initiate psoriasis through interferon-{alpha} production
    • Nestlé FO, Conrad C, Tun-Kyi A et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-{alpha} production. J Exp Med 2005 202 : 135 43.
    • (2005) J Exp Med , vol.202 , pp. 135-43
    • Nestlé, F.O.1    Conrad, C.2    Tun-Kyi, A.3
  • 71
    • 32244448339 scopus 로고    scopus 로고
    • Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
    • Chan CW, Crafton E, Fan HN et al. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med 2006 12 : 207 13.
    • (2006) Nat Med , vol.12 , pp. 207-13
    • Chan, C.W.1    Crafton, E.2    Fan, H.N.3
  • 72
    • 33846546257 scopus 로고    scopus 로고
    • Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self
    • Lee JW, Epardaud M, Sun J et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 2007 8 : 181 90.
    • (2007) Nat Immunol , vol.8 , pp. 181-90
    • Lee, J.W.1    Epardaud, M.2    Sun, J.3
  • 73
    • 1642459098 scopus 로고    scopus 로고
    • Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis
    • Ma-Krupa W, Jeon MS, Spoerl S, Tedder TF, Goronzy JJ, Weyand CM. Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J Exp Med 2004 199 : 173 83.
    • (2004) J Exp Med , vol.199 , pp. 173-83
    • Ma-Krupa, W.1    Jeon, M.S.2    Spoerl, S.3    Tedder, T.F.4    Goronzy, J.J.5    Weyand, C.M.6
  • 74
    • 0345448056 scopus 로고    scopus 로고
    • Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model
    • Turley S, Poirot L, Hattori M, Benoist C, Mathis D. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med 2003 198 : 1527 37.
    • (2003) J Exp Med , vol.198 , pp. 1527-37
    • Turley, S.1    Poirot, L.2    Hattori, M.3    Benoist, C.4    Mathis, D.5
  • 75
    • 0033153482 scopus 로고    scopus 로고
    • The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice
    • Maldonado MA, Kakkanaiah V, MacDonald GC et al. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J Immunol 1999 162 : 6322 30.
    • (1999) J Immunol , vol.162 , pp. 6322-30
    • Maldonado, M.A.1    Kakkanaiah, V.2    MacDonald, G.C.3
  • 76
    • 15244353241 scopus 로고    scopus 로고
    • Role of anti-C1q autoantibodies in the pathogenesis of lupus nephritis
    • Trouw LA, Daha MR. Role of anti-C1q autoantibodies in the pathogenesis of lupus nephritis. Expert Opin Biol Ther 2005 5 : 243 51.
    • (2005) Expert Opin Biol Ther , vol.5 , pp. 243-51
    • Trouw, L.A.1    Daha, M.R.2
  • 77
    • 34948820567 scopus 로고    scopus 로고
    • Class a scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus
    • Wermeling F, Chen Y, Pikkarainen T et al. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med 2007 204 : 2259 65.
    • (2007) J Exp Med , vol.204 , pp. 2259-65
    • Wermeling, F.1    Chen, Y.2    Pikkarainen, T.3
  • 78
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • Obeid M, Tesniere A, Ghiringhelli F et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007 13 : 54 61.
    • (2007) Nat Med , vol.13 , pp. 54-61
    • Obeid, M.1    Tesniere, A.2    Ghiringhelli, F.3
  • 79
    • 34347272251 scopus 로고    scopus 로고
    • Interferon-alpha and cancer: Mechanisms of action and new perspectives of clinical use
    • Ferrantini M, Capone I, Belardelli F. Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 2007 89 : 884 93.
    • (2007) Biochimie , vol.89 , pp. 884-93
    • Ferrantini, M.1    Capone, I.2    Belardelli, F.3
  • 80
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • Hanayama R, Tanaka M, Miyasaka K et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 2004 304 : 1147 50.
    • (2004) Science , vol.304 , pp. 1147-50
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3
  • 81
    • 0036164008 scopus 로고    scopus 로고
    • Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus
    • Baumann I, Kolowos W, Voll RE et al. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum 2002 46 : 191 201.
    • (2002) Arthritis Rheum , vol.46 , pp. 191-201
    • Baumann, I.1    Kolowos, W.2    Voll, R.E.3
  • 82
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005 202 : 1131 9.
    • (2005) J Exp Med , vol.202 , pp. 1131-9
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3
  • 84
    • 34249707811 scopus 로고    scopus 로고
    • TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    • Baccala R, Hoebe K, Kono DH, Beutler B, Theofilopoulos AN. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 2007 13 : 543 51.
    • (2007) Nat Med , vol.13 , pp. 543-51
    • Baccala, R.1    Hoebe, K.2    Kono, D.H.3    Beutler, B.4    Theofilopoulos, A.N.5
  • 85
    • 33644889894 scopus 로고    scopus 로고
    • Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I IFNs predominantly through a toll-like receptor 9-independent pathway
    • Martin DA, Elkon KB. Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I IFNs predominantly through a toll-like receptor 9-independent pathway. Arthritis Rheum 2006 54 : 951 62.
    • (2006) Arthritis Rheum , vol.54 , pp. 951-62
    • Martin, D.A.1    Elkon, K.B.2
  • 86
    • 33645402377 scopus 로고    scopus 로고
    • All is not Toll: New pathways in DNA recognition
    • Wagner H, Bauer S. All is not Toll: new pathways in DNA recognition. J Exp Med 2006 203 : 265 8.
    • (2006) J Exp Med , vol.203 , pp. 265-8
    • Wagner, H.1    Bauer, S.2
  • 87
    • 17644393549 scopus 로고    scopus 로고
    • DNA degradation in development and programmed cell death
    • Nagata S. DNA degradation in development and programmed cell death. Annu Revs Immunol 2005 23 : 853 75.
    • (2005) Annu Revs Immunol , vol.23 , pp. 853-75
    • Nagata, S.1
  • 88
    • 33746522835 scopus 로고    scopus 로고
    • Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection
    • Crow YJ, Leitch A, Hayward BE et al. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet 2006 38 : 910 6.
    • (2006) Nat Genet , vol.38 , pp. 910-6
    • Crow, Y.J.1    Leitch, A.2    Hayward, B.E.3
  • 89
    • 33845579097 scopus 로고    scopus 로고
    • Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides
    • Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur J Immunol 2006 36 : 3256 67.
    • (2006) Eur J Immunol , vol.36 , pp. 3256-67
    • Diebold, S.S.1    Massacrier, C.2    Akira, S.3    Paturel, C.4    Morel, Y.5    Reis Sousa, E.C.6
  • 90
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci S, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999 5 : 1249 55.
    • (1999) Nat Med , vol.5 , pp. 1249-55
    • Gallucci, S.1    Matzinger, P.2
  • 91
    • 35748942876 scopus 로고    scopus 로고
    • The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A et al. The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev 2007 220 : 47 59.
    • (2007) Immunol Rev , vol.220 , pp. 47-59
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3
  • 92
    • 2442595192 scopus 로고    scopus 로고
    • Aire downregulates multiple molecules that have contradicting immune-enhancing and immune-suppressive functions
    • Sato K, Sato U, Tateishi S et al. Aire downregulates multiple molecules that have contradicting immune-enhancing and immune-suppressive functions. Biochem Biophys Res Commun 2004 318 : 935 40.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 935-40
    • Sato, K.1    Sato, U.2    Tateishi, S.3
  • 93
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 2007 204 : 2521 8.
    • (2007) J Exp Med , vol.204 , pp. 2521-8
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 94
    • 38349110211 scopus 로고    scopus 로고
    • AIRE's card revealed; A new structure for central tolerance provokes transcriptional plasticity
    • Ferguson BJ, Alexander CE, Rossi SW et al. AIRE's card revealed; a new structure for central tolerance provokes transcriptional plasticity. J Biol Chem 2008 283 : 1723 31.
    • (2008) J Biol Chem , vol.283 , pp. 1723-31
    • Ferguson, B.J.1    Alexander, C.E.2    Rossi, S.W.3
  • 95
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    • Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 2005 6 : 49 56.
    • (2005) Nat Immunol , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 96
    • 0037321024 scopus 로고    scopus 로고
    • Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
    • Kawane K, Fukuyama H, Yoshida H et al. Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat Immunol 2003 4 : 138 44.
    • (2003) Nat Immunol , vol.4 , pp. 138-44
    • Kawane, K.1    Fukuyama, H.2    Yoshida, H.3
  • 97
    • 34447098797 scopus 로고    scopus 로고
    • Multistep pathogenesis of autoimmune disease
    • Goodnow CC. Multistep pathogenesis of autoimmune disease. Cell 2007 130 : 25 35.
    • (2007) Cell , vol.130 , pp. 25-35
    • Goodnow, C.C.1
  • 98
    • 19544383576 scopus 로고    scopus 로고
    • The importance of being a pDC in antiviral immunity: The IFN mission versus Ag presentation?
    • Haeryfar SM. The importance of being a pDC in antiviral immunity: the IFN mission versus Ag presentation? Trends Immunol 2005 26 : 311 7.
    • (2005) Trends Immunol , vol.26 , pp. 311-7
    • Haeryfar, S.M.1
  • 99
    • 0041331693 scopus 로고    scopus 로고
    • Subcellular localization of Toll-like R 3 in human DC
    • Matsumoto M, Funami K, Tanabe M et al. Subcellular localization of Toll-like R 3 in human DC. J Immunol 2003 171 : 3154 62.
    • (2003) J Immunol , vol.171 , pp. 3154-62
    • Matsumoto, M.1    Funami, K.2    Tanabe, M.3
  • 100
    • 0036295743 scopus 로고    scopus 로고
    • Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules
    • Romi F, Bø L, Skeie GO, Myking A, Aarli JA, Gilhus NE. Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules. J Neuroimmunol 2002 128 : 82 9.
    • (2002) J Neuroimmunol , vol.128 , pp. 82-9
    • Romi, F.1    Bø, L.2    Skeie, G.O.3    Myking, A.4    Aarli, J.A.5    Gilhus, N.E.6
  • 101
    • 0033588955 scopus 로고    scopus 로고
    • Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
    • Casciola-Rosen L, Andrade F, Ulanet D, Wong WB, Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med 1999 190 : 815 26.
    • (1999) J Exp Med , vol.190 , pp. 815-26
    • Casciola-Rosen, L.1    Andrade, F.2    Ulanet, D.3    Wong, W.B.4    Rosen, A.5
  • 102
    • 2342486756 scopus 로고    scopus 로고
    • Nodal and extra-nodal tumor-forming accumulation of plasmacytoid monocytes/interferon-producing cells associated with myeloid disorders
    • Vermi W., Facchetti F, Rosati S et al. Nodal and extra-nodal tumor-forming accumulation of plasmacytoid monocytes/interferon-producing cells associated with myeloid disorders. Am J Surg Pathol 2004 28 : 585 95.
    • (2004) Am J Surg Pathol , vol.28 , pp. 585-95
    • Vermi, W.1    Facchetti, F.2    Rosati, S.3
  • 103
    • 12344299197 scopus 로고    scopus 로고
    • Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus
    • Blanco P, Pitard V, Viallard JF, Taupin JL, Pellegrin JL, Moreau JF. Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 2005 52 : 201 11.
    • (2005) Arthritis Rheum , vol.52 , pp. 201-11
    • Blanco, P.1    Pitard, V.2    Viallard, J.F.3    Taupin, J.L.4    Pellegrin, J.L.5    Moreau, J.F.6


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