Aire downregulates multiple molecules that have contradicting immune-enhancing and immune-suppressive functions

Biochemical and Biophysical Research Communications

Volumn 318, Issue 4, 2004, Pages 935-940

  Sato, Kojiro ^a   Sato, Utako ^b   Tateishi, Shoko ^a   Kubo, Kanae ^a   Horikawa, Reiko ^b   Mimura, Toshihide ^c   Yamamoto, Kazuhiko ^a   Kanda, Hiroko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

AIRE; APECED; CREB binding protein; IL 1 receptor antagonist; MHC class II molecule

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSFECTION; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CREB-BINDING PROTEIN; CYTOKINES; DOWN-REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOLOGIC FACTORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIPOPOLYSACCHARIDES; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; POLYENDOCRINOPATHIES, AUTOIMMUNE; PROMOTER REGIONS (GENETICS); RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; RNA, MESSENGER; SIALOGLYCOPROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

MURINAE;

EID: 2442595192     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.04.116     Document Type: Article

References (25)

1. Ahonen P. Autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED): autosomal recessive inheritance. Clin. Genet. 27:1985;535-542
2. Aaltonen J., Bjorses P., Sandkuijl L., Perheentupa J., Peltonen L. An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21. Nat. Genet. 8:1994;83-87
3. Nagamine K., Peterson P., Scott H.S., Kudoh J., Minoshima S., Heino M., Krohn K.J., Lalioti M.D., Mullis P.E., Antonarakis S.E., Kawasaki K., Asakawa S., Ito F., Shimizu N. Positional cloning of the APECED gene. Nat. Genet. 17:1997;393-398
4. The Finnish-German APECED Consortium - Group 1: Johanna Aaltonen, Petra Bjorses, Jaakko Perheentupa, Nina Horelli-Kuitunen, Aarno Palotie, Leena Peltonen; Group 2: Yeon Su Lee, Fiona Francis, Steffen Hennig, Cora Thiel, Hans Lehrach, Marie-Laure Yaspo. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED consortium. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, Nat. Genet. 17 (1997) 399-403
5. Rosatelli M.C., Meloni A., Devoto M., Cao A., Scott H.S., Peterson P., Heino M., Krohn K.J., Nagamine K., Kudoh J., Shimizu N., Antonarakis S.E. A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis- ectodermal dystrophy patients. Hum. Genet. 103:1998;428-434
6. Zlotogora J., Shapiro M.S. Polyglandular autoimmune syndrome type I among iranian jews. J. Med. Genet. 29:1992;824-826
7. Gibson T.J., Ramu C., Gemund C., Aasland R. The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. Trends Biochem. Sci. 23:1998;242-244
8. Rinderle C., Christensen H.M., Schweiger S., Lehrach H., Yaspo M.L. AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers. Hum. Mol. Genet. 8:1999;277-290
9. Bjorses P., Halonen M., Palvimo J.J., Kolmer M., Aaltonen J., Ellonen P., Perheentupa J., Ulmanen I., Peltonen L. Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein. Am. J. Hum. Genet. 66:2000;378-392
10. Pitkanen J., Doucas V., Sternsdorf T., Nakajima T., Aratani S., Jensen K., Will H., Vahamurto P., Ollila J., Vihinen M., Scott H.S., Antonarakis S.E., Kudoh J., Shimizu N., Krohn K., Peterson P. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275:2000;16802-16809
11. Zuklys S., Balciunaite G., Agarwal A., Fasler-Kan E., Palmer E., Hollander G.A. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED). J. Immunol. 165:2000;1976-1983
12. Kogawa K., Nagafuchi S., Katsuta H., Kudoh J., Tamiya S., Sakai Y., Shimizu N., Harada M. Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol. Lett. 80:2002;195-198
13. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 298:2002;1395-1401
14. Liston A., Lesage S., Wilson J., Peltonen L., Goodnow C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4:2003;350-354
15. Yoshida E., Nakajima T., Murakami K., Fukamizu A. Identification of N-terminal minimal transactivation domain of CBP, p300 and Caenorhabditis elegans homologues. Gene. 208:1998;307-314
16. Imai Y., Matsushima Y., Sugimura T., Terada M. A simple and rapid method for generating a deletion by PCR. Nucleic Acids Res. 19:1991;2785
17. Sato K., Hida S., Takayanagi H., Yokochi T., Kayagaki N., Takeda K., Yagita H., Okumura K., Tanaka N., Taniguchi T., Ogasawara K. Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta. Eur. J. Immunol. 31:2001;3138-3146
18. Taniguchi T., Ogasawara K., Takaoka A., Tanaka N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19:2001;623-655
19. Fontes J.D., Kanazawa S., Jean D., Peterlin B.M. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19:1999;941-947
20. Kretsovali A., Agalioti T., Spilianakis C., Tzortzakaki E., Merika M., Papamatheakis J. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18:1998;6777-6783
21. Wynn T.A., Freund Y.R., Paulnock D.M. TNF-alpha differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines. Cell Immunol. 140:1992;184-196
22. Ramsey C., Winqvist O., Puhakka L., Halonen M., Moro A., Kampe O., Eskelin P., Pelto-Huikko M., Peltonen L. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11:2002;397-409
23. Dripps D.J., Brandhuber B.J., Thompson R.C., Eisenberg S.P. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J. Biol. Chem. 266:1991;10331-10336
24. Granowitz E.V., Clark B.D., Mancilla J., Dinarello C.A. Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J. Biol. Chem. 266:1991;14147-14150
25. Van't Wout J.W., Van der Meer J.W., Barza M., Dinarello C.A. Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1. Eur. J. Immunol. 18:1988;1143-1146