Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation

Nature Immunology

Volumn 4, Issue 2, 2003, Pages 138-144

  Kawane, Kohki ^a   Fukuyama, Hidehiro ^a,e   Yoshida, Hideyuki ^a   Nagase, Hiroko ^a   Ohsawa, Yoshiyuki ^a   Uchiyama, Yasuo ^a   Okada, Kazuhisa ^b   Iida, Tetsuya ^b   Nagata, Shigekazu ^a,c,d  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE II; DNA; ENDONUCLEASE; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL DEATH; CELL MATURATION; CONTROLLED STUDY; DNA DEGRADATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; GENETIC REGULATION; IMMUNITY; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALS; APOPTOSIS; DEOXYRIBONUCLEASES; DNA; DNA FRAGMENTATION; ENDODEOXYRIBONUCLEASES; FEMALE; INTERFERON-ALPHA; INTERFERON-BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PREGNANCY; THYMUS GLAND;

EID: 0037321024     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni881     Document Type: Article

References (53)

1. Kerr, J.F., Wyllie, A.H. & Currie, A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257 (1972).
2. Jacobson, M.D., Weil, M. & Raff, M.C. Programmed cell death in animal development. Cell 88, 347-354 (1997).
3. Vaux, D.L. & Korsmeyer, S.J. Cell death in development. Cell 96, 245-254 (1999).
4. Raff, M. Cell suicide for beginners. Nature 396, 119-122 (1998).
5. Ashkenazi, A. Apoptosis by death factor. Cell 88, 355-365 (1997).
6. Ashkenazi, A. & Dixit, V.M. Death receptors: signalling and modulation. Science 281, 1305-1308 (1998).
7. Green, D.R. & Reed, J.C. Mitochondria and apoptosis. Science 281,1309-1312 (1998).
8. Thornberry, N.A. & Lazebnik, Y. Caspases: enemies within. Science 281, 1312-1316 (1998).
9. Eearnshaw, W.C., Martins, L.M. & Kaufmann, S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68, 383-424 (1999).
10. Los, M., Wesselborg, S. & Schulze-Osthoff, K. The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. Immunity 10, 625-639 (1999).
11. Savill, J. & Fadok, V. Corpse clearance the meaning of cell death. Nature 407, 784-788 (2000).
12. Wyllie, A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556 (1980).
13. Nagata, S., Nagase, H., Kawane, K., Mukae, N. & Fukuyama, H. Degradation of chromosomal DNA during apoptosis. Cell Death Differ. (in the press).
14. Enari,M. et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50 (1998).
15. Liu, X., Zou, H.,Slaughter, C. & Wang, X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175-184 (1997).
16. Sakahira, H., Enari, M. & Nagata, S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391, 96-99 (1998).
17. McCarty, J.S., Toh, S.Y. & Li, P. Multiple domains of DFF45 bind synergistically to DFF40: roles of caspase cleavage and sequestration of activator domain of DFF40. Biochem. Biophys. Res. Commun. 264, 181-185 (1999).
18. Sakahira, H. & Nagata, S. Co-translational folding of caspase-activated DNase with Hsp70, Hsp40 and inhibitor of caspase-activated DNase. J. Biol. Chem. 277, 3364-3370 (2002).
19. Zhang, J. et al. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl. Acad. Sci. USA 95, 12480-12485 (1998).
20. Mcllroy, D. et al. An auxillary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev. 14, 549-558 (2000).
21. Li, L.Y., Lou, X. & Wang, X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412, 95-99 (2001).
22. Parrish, J. et al. Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 412, 90-94 (2001).
23. van Loo, G. et al. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ. 8, 1136-1142 (2001).
24. Hanayama, R. et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 417, 182-187 (2002).
25. Bernardi, G. in The Enzymes (ed. Boyer, P.D.) 271-287 (Academic Press, New York and London, 1971).
26. Kawane, K. et al. Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science 292, 1546-1549 (2001).
27. Krieser, R.J. et al. Deoxyribonuclease IIa is required during the phagocytic phase of apoptosis and its loss causes lethality. Cell Death Differ. 9, 956-962 (2002).
28. Kawane, K. et al. Structure and promoter analysis of murine CAD and ICAD genes. Cell Death Differ. 6, 745-752 (1999).
29. Oberhammer, F. et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12, 3679-3684 (1993).
30. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150, 4244-4252 (1993).
31. Yaegashi, Y., Nielsen, P., Sing, A., Galanos, C. & Freudenberg, M.A. Interferon β, a cofactor in the interferon γ production induced by gram-negative bacteria in mice. J. Exp. Med. 181, 953-960 (1995).
32. - thymocytes. Immunology 90, 543-549 (1997).
33. Lin, Q., Dong, C. & Cooper, M.D. Impairment of T and B cell development by treatment with a type I interferon. J. Exp. Med. 187, 79-87 (1998).
34. Montgomery, R.A. & Dallman, M.J. Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontgeny. Cytokine 9, 717-726 (1997).
35. Arends, M.J., Morris, R.G. & Wyllie, A.H. The role of endonuclease. Am. J. Pathol. 136, 593-608 (1993).
36. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501 (1992).
37. Staley, K., Blaschke, A. & Chun, J. Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends. Cell Death Differ. 4, 66-75 (1997).
38. Peitsch, M.C. et al. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12, 371-377 (1993).
39. Susin, S.A. et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446 (1999).
40. Wu, Y.C., Stanfield, G.M. & Horvitz, H.R. NUC-1, a Caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis. Genes Dev. 14, 536-548 (2000).
41. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y. & Nagata, S. Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Genes Dev. 16, 2662-2671 (2002).
42. Durrieu, F. et al. Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes. Exp. Cell Res. 240, 165-175 (1998).
43. Binder, D., Fehr, J., Hengartner, H. & Zinkernagel, R.M. Virus-induced transient bone marrow aplasia: major role of interferon-α/β during acute infection with the noncytophatic lymphocytic choriomeningitis virus. J. Exp. Med. 185, 517-530 (1997).
44. Doly, J., Civas, A., Navarro, S. & Uze, G. Type I interferons: expression and signalization. Cell Mol. Life Sci. 54, 1109-1121 (1998).
45. Krieg, A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760 (2002).
46. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
47. Bird, A.P. CpG-rich islands and the function of DNA methylation. Nature 321, 209-213 (1986).
48. Leadbetter, E.A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002).
49. Kondoh, G. et al. Eeasy assessment of ES cell clone potency for chimeric development and germ-line competency by an optimized aggregation method. J. Biochem. Biophys. Methods 39, 137-142 (1999).
50. Platt, N., Suzuki, H., Kurihara, Y., Kodama, T. & Gordon, S. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc. Natl. Acad. Sci. USA 93, 12456-12460 (1996).
51. Takeshita, S., Kaji, K. & Kudo, A. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J. Bone Miner. Res. 15, 1477-1488 (2000).
52. Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991).
53. Sambrook, J. & Russell, D.W. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 2001).