Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator

European Journal of Immunology

Volumn 36, Issue 2, 2006, Pages 305-317

  Ramsey, Chris ^a   Hässler, Signe ^b,c   Marits, Per ^b,c   Kämpe, Olle ^b   Surh, Charles D ^a   Peltonen, Leena ^d,e   Winqvist, Ola ^b,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Antigen presenting cell; Autoimmunity; Clinical immunology; Knockout mice; Microarray

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CD4 ANTIGEN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HYBRIDOMA; LYMPH NODE; LYMPHOCYTE ACTIVATION; MALE; MONOCYTE; MOUSE; MULTIPLE ENDOCRINE ADENOMATOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; T LYMPHOCYTE; UPREGULATION;

ANIMALS; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASES; CELL ADHESION; DENDRITIC CELLS; ENDOCRINE SYSTEM DISEASES; EPITHELIAL CELLS; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MONOCYTES; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 32944474710     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535240     Document Type: Article

References (67)

1. Aaltonen, J., Björses, P., Sandkuijl, L., Perheentupa, J. and Peltonen, L., An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21. Nat. Genet. 1994. 8: 83-87.
2. The Finnish German APECED Consortium, An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Nat. Genet. 1997. 17: 399-403.
3. Nagamine, K., Peterson, P., Scott, H. S., Kudoh, J., Minoshima, S., Heino, M., Krohn, K. J. et al., Positional cloning of the APECED gene. Nat. Genet. 1997. 17: 393-398.
4. Ramsey, C., Winqvist, O., Puhakka, L., Halonen, M., Moro, A., Kämpe, O., Eskelin, P. et al., Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 2002. 11: 397-409.
5. Anderson, M., Venanzi, E. S., Klein, L., Chen, Z., Berzins, S. P., Turley, S. J., von Boehmer, H. et al., Projection of an immunological self shadow within the thymus by the Aire protein. Science 2002. 298: 1395-1301.
6. Ahonen, P., Koskimies, S., Lokki, M. L., Tiilikainen, A. and Perheentupa, J., The expression of autoimmune polyglandular disease type 1 appears associated with several HLA-a antigens but not with HLA-DR. J. Clin. Endocrinol. Metab. 1988. 66: 1152-1157.
7. Eisenbarth, G. S., Wilson, P. W., Wards, F., Buckley, C. and Lebovitz, H., The polyglandular failure syndrome: disease inheritance, HLA type, and immune function. Ann. Int. Med. 1979. 91: 528-533.
8. Bjorses, P., Aaltonen, J., Vikman, A., Perheentupa, J., Ben-Zion, G., Chiumello, G., Dahl, N. et al., Genetic homogeneity of autoimmune polyglandular disease type I. Am. J. Hum. Genet. 1996. 59: 879-886.
9. Rosatelli, M., Meloni, A., Meloni, A., Devoto, M., Cao, A., Scott, H., Peterson, P. et al., A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Hum. Genet. 1998. 103: 428-434.
10. Zlotogora, J. and Shapiro, M., Polyglandular autoimmune syndrome type I among Iranian Jews. J. Med. Genet. 1992. 29: 824-826.
11. Eisenbarth, G. S. and Gottlieb, P. A., Autoimmune polyendocrine syndromes. N. Engl. J. Med. 2004. 350: 2068-2079.
12. Winqvist, O., Gustafsson, J., Rorsman, F., Karlsson, F. A. and Kämpe, O., Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. J. Clin. Invest. 1993. 92: 2377-2385.
13. Soderbergh, A., Myhre, A. G., Ekwall, O., Gebre-Medhin, G., Hedstrand, H., Landgren, E., Miettinen, A. et al., Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I. J. Clin. Endocrinol. Metab. 2004. 89: 557-562.
14. Ahonen, P., Myllärniemi, S., Sipilä, I. and Perheentupa, J., Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N. Engl. J. Med. 1990. 322: 1829-1836.
15. Pitkanen, J., Doucas, V., Sternsdorf, T., Nakajima, T., Aratani, S., Jensen, K., Will, H. et al., The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 2000. 275: 16802-16809.
16. Bjorses, P., Halonen, M., Palvimo, J. J., Kolmer, M., Aaltonen, J., Ellonen, P., Perheentupa, J. et al., Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune-polyendocrinopathy-candidiasis-ectodermal -dystrophy-protein. Am. J. Hum. Genet. 2000. 66: 378-392.
17. Pitkanen, J., Vahamurto, P., Krohn, K. and Peterson, P., Subcellular localization of the autoimmune regulator protein. Characterization of nuclear targeting and transcriptional activation. J. Biol. Chem. 2001. 276: 19597-19602.
18. Ramsey, C., Bukrinsky, A. and Peltonen, L., Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting. Hum. Mol. Genet. 2002. 11: 3299-3308.
19. Uchida, D., Hatakeyama, S., Matsushima, A., Han, H., Ishido, S., Hotta, H., Kudoh, J. et al., AIRE functions as an E3 ubiquitin ligase. J. Exp. Med. 2004. 199: 167-172.
20. Bottomley, M. J., Stier, G., Pennacchini, D., Legube, G., Simon, B., Akhtar, A., Sattler, M. and Musco, G., NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. J. Biol. Chem. 2005. 280: 11505-11512.
21. Zuklys, S., Balciunaite, G., Agarwal, A., Fasler-Kan, E., Palmer, E. and Holländer, G., Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J. Immunol. 2000. 165: 1976-1983.
22. Halonen, M., Pelto-Huikko, M., Eskelin, P., Peltonen, L., Ulmanen, I. and Kolmer, M., Subcellular location and expression pattern of autoimmune reguator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED). J. Histochem. Cytochem. 2001. 49: 197-208.
23. Heino, M., Peterson, P., Kudoh, J., Nagamine, K., Lagerstedt, A., Ovod, V., Ranki, A. et al., Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 1999. 257: 821-825.
24. Heino, M., Peterson, P., Sillanpää, N., Guérin, S., Wu, L., Anderson, G., Scott, H. S. et al., RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 2000. 30: 1884-1893.
25. Liston, A., Lesage, S., Wilson, J., Peltonen, L. and Goodnow, C. G., Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 2003. 4: 350-354.
26. Johnnidis, J. B., Venanzi, E. S., Taxman, D. J., Ting, J. P., Benoist, C. O. and Mathis, D. J., Chromosomal clustering of genes controlled by the aire transcription factor. Proc. Natl. Acad. Sci. USA 2005. 102: 7233-7238.
27. Derbinski, J., Gabler, J., Brors, B., Tierling, S., Jonnakuty, S., Hergenhahn, M., Peltonen, L. et al., Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 2005. 202: 33-45.
28. Kuroda, N., Mitani, T., Takeda, N., Ishimaru, N., Arakaki, R., Hayashi, Y., Bando, Y. et al., Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 2005. 174: 1862-1870.
29. Haneji, N., Nakamura, T., Takio, K., Yanagi, K., Higashiyama, H., Saito, I., Noji, S. et al., Identification of a-fodrin as a candidate autoantigen in primary Sjogren's syndrome. Science 1997. 276: 604-607.
30. Bouneaud, C., Kourilsky, P. and Bousso, P., Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 2000. 13: 829-840.
31. Schwartz, R. H., T cell anergy. Annu. Rev. Immunol. 2003. 21: 305-334.
32. Green, D. R., Droin, N. and Pinkoski, M., Activation-induced cell death in T cells. Immunol. Rev. 2003. 193: 70-81.
33. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389-400.
34. Sato, K., Sato, U., Tateishi, S., Kubo, K., Horikawa, R., Mimura, T., Yamamoto, K. and Kanda, H., Aire downregulates multiple molecules that have contradicting immune-enhancing and immune-suppressive functions. Biochem. Biophys. Res. Commun. 2004. 318: 935-940.
35. Sillanpaa, N., Magureanu, C. G., Murumagi, A., Reinikainen, A., West, A., Manninen, A., Lahti, M. et al., Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage. Mol. Immunol. 2004. 41: 1185-1198.
36. Barnden, M. J., Allison, J., Heath, W. R. and Carbone, F. R., Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 1998. 76: 34-40.
37. Ardavin, C., Hoyo, G. M. d., Martin, P., Anjuere, F., Arias, C. F., Marin, A. R., Ruiz, S. et al., Origin and differentiation of dendritic cells. Trends Immunol. 2001. 22: 691-700.
38. Andrian, U. H. v. and Mackay, C. R., T-cell function and migration: two sides of the same coin. N. Engl. J. Med. 2000. 343: 1020-1034.
39. Rice, G. E., Munro, J. M., Corless, C. and Bevilacqua, M. P., Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues. Am. J. Pathol. 1991. 138: 385-393.
40. Freedman, A. S., Munro, J. M., Rice, G., Bevilacqua, M. P., Morimoto, C., McIntyre, B. W., Rhynart, K. et al., Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-10. Science 1990. 249: 1030-1033.
41. + T cells. Proc. Natl. Acad. Sci. USA 1991. 88: 6403-6407.
42. Bevilacqua, M. P., Pober, J. S., Mendrick, D. L., Cotran, R. S. and Gimbrone, M. A. Jr., Identification of an inducible endothelial-leukocyte adhesion molecule. Proc. Natl. Acad. Sci. USA 1987. 84: 9238-9242.
43. Mayet, W. J., Schwarting, A., Orth, T., Duchmann, R. and Meyer zum Buschenfelde, K. H., Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1). Clin. Exp. Immunol. 1996. 103: 259-267.
44. Masinovsky, B., Urdal, D. and Gallatin, W. M., IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J. Immunol. 1990. 145: 2886-2895.
45. Haraldsen, G., Kvale, D., Lien, B., Farstad, I. N. and Brandtzaeg, P., Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J. Immunol. 1996. 156: 2558-2565.
46. Chin, Y. H., Cai, J. P. and Johnson, K., Lymphocyte adhesion to cultured Peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines. J. Immunol. 1990. 145: 3669-3677.
47. Lim, Y. C., Garcia-Cardena, G., Allport, J. R., Zervoglos, M., Connolly, A. J., Gimbrone, M. A. Jr. and Luscinskas, F. W., Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am. J. Pathol. 2003. 162: 1591-1601.
48. Fukushi, J., Ono, M., Morikawa, W., Iwamoto, Y. and Kuwano, M., The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13. J. Immunol. 2000. 165: 2818-2823.
49. Alfonso, C., Han, J. O., Williams, G. S. and Karlsson, L., The impact of H2-DM on humoral immune responses. J. Immunol. 2001. 167: 6348-6355.
50. Liston, A., Gray, D. H., Lesage, S., Fletcher, A. L., Wilson, J., Webster, K. E., Scott, H. S. et al., Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 2004. 200: 1015-1026.
51. Gebre-Medhin, G., Husebye, E. S., Gustafsson, J., Winqvist, O., Goksoyr, A., Rorsman, F. and Kämpe, O., Cytochrome P450IA2 and aromatic 1-amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I. FEBS Lett. 1997. 412: 439-445.
52. Cavadini, P., Vermi, W., Facchetti, F., Fontana, S., Nagafuchi, S., Mazzolari, E., Sediva, A. et al., AIRE deficiency in thymus of 2 patients with Omenn syndrome. J. Clin. Invest. 2005. 115: 728-732.
53. Anderson, M., Venanzi, ES., Chen, Z., Berzins, SP., Benoist, C., and Mathis, D., The cellular mechanism of Aire control of T cell tolerance. Immunity 2005. 23: 277-239.
54. Miller, D. H., Khan, O. A., Sheremata, W. A., Blumhardt, L. D., Rice, G. P. A., Libonati, M. A., Willmer-Hulme, A. J. et al., A controlled trial of Natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 2003. 348: 15-23.
55. Ghosh, S., Goldin, E., Gordon, F. H., Malchow, H. A., Rask-Madsen, J., Rutgeerts, P., Vyhnalek, P. et al., Natalizumab for active Chrohn's disease. N. Engl. J. Med. 2003. 348: 24-32.
56. Schlegel, P. G., Vaysburd, M., Chen, Y., Butcher, E. C. and Chao, N. J., Inhibition of T cell costimulation by VCAM-1 prevents murine graft versus host disease across minor histocompatibility barriers. J. Immunol. 1995. 155: 3856-3865.
57. Jiang, W., Anderson, M. S., Bronson, R., Mathis, D. and Benoist, C., Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 2005. 202: 805-815.
58. Kogawa, K., Nagafuchi, S., Katsuta, H., Kudoh, J., Tamiya, S., Sakai, Y., Shimizu, N. and Harada, M., Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol. Lett. 2002. 80: 195-198.
59. Figdor, C. G., van Kooyk, Y. and Adema, G. J., C-type lectin receptors on dendritic cells and Langerhans cells. Nat. Rev. Immunol. 2002. 2: 77-84.
60. Geijtenbeek, T. B., van Vliet, S. J., Engering, A., t Hart, B. A. and van Kooyk, Y., Self- and nonself-recognition by C-type lectins on dendritic cells. Annu. Rev. Immunol. 2004. 22: 33-54.
61. Kolosov, M., Kolosova, I. and Ieu, R. W., Stimulation of machrophage synthesis of complement C1q by intereferon-gamma mediated endogenous intereferon-alpha/beta. J. Intereferon Cytokine Res. 1996. 3: 245-249.
62. Reid, K. B., Colomb, M., Petry, F. and Loos, M., Complement component C1 and the collectins-first-line defense molecules in innate and acquired immunity. Trends Immunol. 2002. 23: 115-117.
63. Pittoni, V. and Valesini, G., The clearance of apoptotic cells: implications for autoimmunity. Autoimmun. Rev. 2002. 3: 154-161.
64. Steinman, R. M., Hawiger, D. and Nussenzweig, M. C., Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003. 21: 685-711.
65. Gallegos, A. M. and Bevan, M. J., Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 2004. 200: 1039-1049.
66. Wakeland, E., Morel, L., Achey, K., Yui, M. and Longmate, J., Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol. Today 1997. 10: 472-477.
67. Liljedahl, M., Winqvist, O., Surh, C., Wong, P., Ngo, K., Teyton, L., Peterson, P. et al., Altered antigen presentation in mice lacking H2-O. Immunity 1998. 8: 233-243.