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Volumn 252, Issue 1, 2005, Pages 36-41

Creatine supplementation lowers brain glutamate levels in Huntington's disease

Author keywords

Creatine; Glutamate; Huntington's disease; Neuroprotection; Proton magnetic resonance spectroscopy

Indexed keywords

BRAIN ENZYME; CHOLINE; CREATININE; GLUTAMIC ACID; N ACETYLASPARTIC ACID;

EID: 19944431628     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-005-0595-4     Document Type: Article
Times cited : (107)

References (54)
  • 2
    • 0035051503 scopus 로고    scopus 로고
    • Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation
    • Andreassen OA, Jenkins BG, Dedeoglu A, Ferrante KL, Bogdanov MB, Kaddurah-Daouk R, Beal MF (2001) Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. J Neurochem 77:383-390
    • (2001) J Neurochem , vol.77 , pp. 383-390
    • Andreassen, O.A.1    Jenkins, B.G.2    Dedeoglu, A.3    Ferrante, K.L.4    Bogdanov, M.B.5    Kaddurah-Daouk, R.6    Beal, M.F.7
  • 3
    • 0028050667 scopus 로고
    • Creatine in humans with special reference to creatine supplementation
    • Balsom PD, Soderlund K, Ekblom B (1994) Creatine in humans with special reference to creatine supplementation. Sports Med 18:268-280
    • (1994) Sports Med , vol.18 , pp. 268-280
    • Balsom, P.D.1    Soderlund, K.2    Ekblom, B.3
  • 4
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119-130
    • (1992) Ann Neurol , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 5
    • 0026043565 scopus 로고
    • Chronic quinolinic acid lesions in rats closely resemble Huntington's disease
    • Beal MF, Ferrante RJ, Swartz KJ, Kowall NW (1991) Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. J Neurosci 11: 1649-1659
    • (1991) J Neurosci , vol.11 , pp. 1649-1659
    • Beal, M.F.1    Ferrante, R.J.2    Swartz, K.J.3    Kowall, N.W.4
  • 6
    • 0036345741 scopus 로고    scopus 로고
    • Impaired glutamate transport and glutamate-glutamine cycling: Downstream effects of the Huntington mutation
    • Behrens PF, Franz P, Woodman B, Lindenberg KS, Landwehrmeyer GB (2002) Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 125:1908-1922
    • (2002) Brain , vol.125 , pp. 1908-1922
    • Behrens, P.F.1    Franz, P.2    Woodman, B.3    Lindenberg, K.S.4    Landwehrmeyer, G.B.5
  • 7
    • 0034637146 scopus 로고    scopus 로고
    • Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter
    • Bellocchio EE, Reimer RJ, Fremeau RT Jr, Edwards RH (2000) Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289:957-960
    • (2000) Science , vol.289 , pp. 957-960
    • Bellocchio, E.E.1    Reimer, R.J.2    Fremeau Jr., R.T.3    Edwards, R.H.4
  • 8
    • 0034006323 scopus 로고    scopus 로고
    • Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons
    • Brewer GJ, Wallimann TW (2000) Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J Neurochem 74:1968-1978
    • (2000) J Neurochem , vol.74 , pp. 1968-1978
    • Brewer, G.J.1    Wallimann, T.W.2
  • 10
    • 0035145453 scopus 로고    scopus 로고
    • On the mechanisms of neuroprotection by creatine and phosphocreatine
    • Brustovetsky N, Brustovetsky T, Dubinsky JM (2001) On the mechanisms of neuroprotection by creatine and phosphocreatine. J Neurochem 76: 425-434
    • (2001) J Neurochem , vol.76 , pp. 425-434
    • Brustovetsky, N.1    Brustovetsky, T.2    Dubinsky, J.M.3
  • 12
    • 0021917344 scopus 로고
    • Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases
    • Butterworth J, Yates CM, Reynolds GP (1985) Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases. J Neurol Sci 67:161-171
    • (1985) J Neurol Sci , vol.67 , pp. 161-171
    • Butterworth, J.1    Yates, C.M.2    Reynolds, G.P.3
  • 13
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 14
    • 0017167057 scopus 로고
    • Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea
    • Coyle JT, Schwarcz R (1976) Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 263:244-246
    • (1976) Nature , vol.263 , pp. 244-246
    • Coyle, J.T.1    Schwarcz, R.2
  • 15
    • 0034019630 scopus 로고    scopus 로고
    • Compartmentation of brain glutamate metabolism in neurons and glia
    • Daikhin Y, Yudkoff M (2000) Compartmentation of brain glutamate metabolism in neurons and glia. J Nutr 130: 1026S-1031S
    • (2000) J Nutr , vol.130
    • Daikhin, Y.1    Yudkoff, M.2
  • 16
    • 0032852064 scopus 로고    scopus 로고
    • Increase of total creatine in human brain after oral supplementation of creatine-monohydrate
    • Dechent P, Pouwels PJ, Wilken B, Hanefeld F, Frahm J (1999) Increase of total creatine in human brain after oral supplementation of creatine- monohydrate. Am J Physiol 277:R698-R704
    • (1999) Am J Physiol , vol.277
    • Dechent, P.1    Pouwels, P.J.2    Wilken, B.3    Hanefeld, F.4    Frahm, J.5
  • 17
    • 0038115294 scopus 로고    scopus 로고
    • Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice
    • Dedeoglu A, Kubilus JK, Yang L, Ferrante KL, Hersch SM, Beal MF, Ferrante RJ (2003) Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. J Neurochem 85: 1359-1367
    • (2003) J Neurochem , vol.85 , pp. 1359-1367
    • Dedeoglu, A.1    Kubilus, J.K.2    Yang, L.3    Ferrante, K.L.4    Hersch, S.M.5    Beal, M.F.6    Ferrante, R.J.7
  • 18
    • 0025196959 scopus 로고
    • Metabolism and role of glutamate in mammalian brain
    • Erecinska M, Silver IA (1990) Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 35: 245-296
    • (1990) Prog Neurobiol , vol.35 , pp. 245-296
    • Erecinska, M.1    Silver, I.A.2
  • 23
    • 0030997707 scopus 로고    scopus 로고
    • Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid
    • Guyot MC, Hantraye P, Dolan R, Palfi S, Maziere M, Brouillet E (1997) Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid. Neuroscience 79:45-56
    • (1997) Neuroscience , vol.79 , pp. 45-56
    • Guyot, M.C.1    Hantraye, P.2    Dolan, R.3    Palfi, S.4    Maziere, M.5    Brouillet, E.6
  • 24
    • 0031035154 scopus 로고    scopus 로고
    • Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: A proton magnetic resonance spectroscopy study
    • Harms L, Meierkord H, Timm G, Pfeiffer L, Ludolph AC (1997) Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study. J Neurol Neurosurg Psychiatry 62:27-30
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , pp. 27-30
    • Harms, L.1    Meierkord, H.2    Timm, G.3    Pfeiffer, L.4    Ludolph, A.C.5
  • 25
    • 85009332113 scopus 로고    scopus 로고
    • Unified Huntington's Disease Rating Scale: Reliability and consistency
    • Huntington Study Group (1996) Unified Huntington's Disease Rating Scale: reliability and consistency. Mov Disord 11:136-142
    • (1996) Mov Disord , vol.11 , pp. 136-142
  • 27
    • 0027741301 scopus 로고
    • Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy
    • Jenkins BG, Koroshetz WJ, Beal MF, Rosen BR (1993) Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology 43:2689-2695
    • (1993) Neurology , vol.43 , pp. 2689-2695
    • Jenkins, B.G.1    Koroshetz, W.J.2    Beal, M.F.3    Rosen, B.R.4
  • 29
    • 0032409057 scopus 로고    scopus 로고
    • Oral creatine supplementation and athletic performance: A critical review
    • Juhn MS, Tarnopolsky M (1998) Oral creatine supplementation and athletic performance: a critical review. Clin J Sport Med 8:286-297
    • (1998) Clin J Sport Med , vol.8 , pp. 286-297
    • Juhn, M.S.1    Tarnopolsky, M.2
  • 30
    • 0023074631 scopus 로고
    • Mechanism of transport and storage of neurotransmitters
    • Kanner BI, Schuldiner S (1987) Mechanism of transport and storage of neurotransmitters. CRC Crit Rev Biochem 22:1-38
    • (1987) CRC Crit Rev Biochem , vol.22 , pp. 1-38
    • Kanner, B.I.1    Schuldiner, S.2
  • 31
    • 0034629141 scopus 로고    scopus 로고
    • Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ
    • Kay L, Nicolay K, Wieringa B, Saks V, Wallimann T (2000) Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ. J Biol Chem 275:6937-6944
    • (2000) J Biol Chem , vol.275 , pp. 6937-6944
    • Kay, L.1    Nicolay, K.2    Wieringa, B.3    Saks, V.4    Wallimann, T.5
  • 34
    • 0034426013 scopus 로고    scopus 로고
    • Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
    • Li H, Li SH, Johnston H, Shelbourne PF, Li XJ (2000) Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat Genet 25:385-389
    • (2000) Nat Genet , vol.25 , pp. 385-389
    • Li, H.1    Li, S.H.2    Johnston, H.3    Shelbourne, P.F.4    Li, X.J.5
  • 38
    • 0037197778 scopus 로고    scopus 로고
    • Alteration of nuclear glyceraldehyde-3-phosphate dehydrogenase structure in Huntington's disease fibroblasts
    • Mazzola JL, Sirover MA (2002) Alteration of nuclear glyceraldehyde-3- phosphate dehydrogenase structure in Huntington's disease fibroblasts. Brain Res Mol Brain Res 100:95-101
    • (2002) Brain Res Mol Brain Res , vol.100 , pp. 95-101
    • Mazzola, J.L.1    Sirover, M.A.2
  • 40
    • 0025096709 scopus 로고
    • What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies
    • Perry TL, Hansen S (1990) What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies. Neurology 40:20-24
    • (1990) Neurology , vol.40 , pp. 20-24
    • Perry, T.L.1    Hansen, S.2
  • 41
    • 0023258197 scopus 로고
    • Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brain
    • Reynolds GP, Pearson SJ (1987) Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brain. Neurosci Lett 78: 233-238
    • (1987) Neurosci Lett , vol.78 , pp. 233-238
    • Reynolds, G.P.1    Pearson, S.J.2
  • 42
    • 0033615021 scopus 로고    scopus 로고
    • In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics
    • Rothman DL, Sibson NR, Hyder F, Shen J, Behar KL, Shulman RG (1999) In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc Lond B Biol Sci 354:1165-1177
    • (1999) Philos Trans R Soc Lond B Biol Sci , vol.354 , pp. 1165-1177
    • Rothman, D.L.1    Sibson, N.R.2    Hyder, F.3    Shen, J.4    Behar, K.L.5    Shulman, R.G.6
  • 44
    • 0034717594 scopus 로고    scopus 로고
    • Creatine reduces 3-nitropropionicacid-induced cognitive and motor abnormalities in rats
    • Shear DA, Haik KL, Dunbar GL (2000) Creatine reduces 3- nitropropionicacid-induced cognitive and motor abnormalities in rats. Neuroreport 11: 1833-1837
    • (2000) Neuroreport , vol.11 , pp. 1833-1837
    • Shear, D.A.1    Haik, K.L.2    Dunbar, G.L.3
  • 45
    • 0019444436 scopus 로고
    • Huntington disease: Functional capacities in patients treated with neuroleptic and antidepressant drugs
    • Shoulson I (1981) Huntington disease: functional capacities in patients treated with neuroleptic and antidepressant drugs. Neurology 31: 1333-1335
    • (1981) Neurology , vol.31 , pp. 1333-1335
    • Shoulson, I.1
  • 48
    • 0035002174 scopus 로고    scopus 로고
    • Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
    • Tarnopolsky MA, Beal MF (2001) Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann Neurol 49:561-574
    • (2001) Ann Neurol , vol.49 , pp. 561-574
    • Tarnopolsky, M.A.1    Beal, M.F.2
  • 52
    • 0029993078 scopus 로고    scopus 로고
    • Phosphocreatine-dependent glutamate uptake by synaptic vesicles. A comparison with atp-dependent glutamate uptake
    • Xu CJ, Klunk WE, Kanfer JN, Xiong Q, Miller G, Pettegrew JW (1996) Phosphocreatine-dependent glutamate uptake by synaptic vesicles. A comparison with atp-dependent glutamate uptake. J Biol Chem 271:13435-13440
    • (1996) J Biol Chem , vol.271 , pp. 13435-13440
    • Xu, C.J.1    Klunk, W.E.2    Kanfer, J.N.3    Xiong, Q.4    Miller, G.5    Pettegrew, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.