Creatine and cyclocreatine attenuate MPTP neurotoxicity

Experimental Neurology

Volumn 157, Issue 1, 1999, Pages 142-149

  Matthews, Russell T ^a   Ferrante, Robert J ^c,d   Klivenyi, Peter ^a   Yang, Lichuan ^a   Klein, Autumn M ^c,d   Mueller, Gerald ^a   Kaddurah Daouk, Rima ^b   Beal, M Flint ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Avicena Group Inc   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

Creatine; Cyclocreatine; Free radicals; Mitochondria; MPTP; Parkinson's; Phosphocreatine

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CREATINE; CYCLOCREATINE; FREE RADICAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINE METABOLISM; ENERGY METABOLISM; MITOCHONDRIAL MEMBRANE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PARKINSONISM; PRIORITY JOURNAL; RECEPTOR BLOCKING; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION;

EID: 0032914740     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7049     Document Type: Article

References (40)

1. Alam Z. I., Daniel S. E., Lees A. J., Marsden D. C., Jenner P., Halliwell B. A generalized increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J. Neurochem. 69:1997;1326-1329.
2. Annesley T. M., Walker J. B. Energy metabolism of skeletal muscle containing cyclocreatine phosphate. J. Biol. Chem. 255:1980;3924-3930.
3. Beal M. F. Aging, energy and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38:1995;357-366.
4. Beal M. F., Matson W. R., Swartz K. J., Gamache P. H., Bird E. D. Kynurenine pathway measurements in Huntington's disease striatum: Evidence for reduced formation of kynurenic acid. J. Neurochem. 55:1990;1327-1339.
5. Brdiczka D., Kaldis P., Wallimann T. In vitro complex formation between the octamer of mitochondrial creatine kinase and porin. J. Biol. Chem. 269:1994;27640-27644.
6. Brouillet E., Beal M. F. NMDA antagonists partially protect against MPTP neurotoxicity in mice. NeuroReport. 4:1993;387-390.
7. Carter A. J., Muller R. E., Pschorn U., Stransky W. Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices. J. Neurochem. 64:1995;2691-2699.
8. Chan P., DeLanney L. E., Irwin I., Langston J. W., DiMonte D. Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain. J. Neurochem. 57:1991;348-351.
9. 3131. J. Cereb. Blood Flow Metab. 14:1994;1070-1077.
10. Dunant Y., Loctin F., Marsal J., Muller D., Parducz A., Rabasseda X. Energy metabolism and quantal acetylcholine release: Effects of botulinum toxin, 1-fluoro-2,4-dinitrobenzene, and diamide in the Torpedo electric organ. J. Neurochem. 50:1988;431-439.
11. Elgebaly S. A., Wei Z., Tyles E., Elkerm A. F., Houser S. L., Gillies C., Kaddurah-Daouk R. Enhancement of the recovery of rat hearts after prolonged cold storage by cyclocreatine phosphate. Transplantation. 57:1994;803-806.
12. Ferrante R. J., Schulz J. B., Kowall N. W., Beal M. F. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res. 753:1997;157-162.
13. Franklin K. B. J., Paxinos G. The Mouse Brain in Stereotaxic Coordinates. 1997;Academic Press, San Diego.
14. Gainetdinov R. R., Fumagalli F., Jones S. R., Caron M. G. Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter. J. Neurochem. 69:1997;1322-1325.
15. Gluck M. R., Krueger M. J., Ramsey R. R., Sabin S. O., Singer T. P., Nicklas W. J. Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparation. J. Biol. Chem. 269:1994;3167-3174.
16. Griffiths G. R., Walker J. B. Accumulation of analog of phosphocreatine in muscle of chicks fed 1-carboxymethyl-2-iminoimidazolidine (cyclocreatine). J. Biol. Chem. 251:1976;2049-2054.
17. Heikkila R. E., Manzino L., Cabbat F. S., Duvoisin R. C. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature. 311:1984;467-469.
18. Hemmer W., Wallimann T. Functional aspects of creatine kinase in brain. Dev. Neurosci. 15:1993;249-260.
19. Kaldis P., Hemmer W., Zanolla E., Holtzman D., Wallimann T. 'Hot spots' of creatine kinase localization in brain: Cerebellum, hippocampus and choroid plexus. Dev. Neurosci. 18:1996;542-554.
20. Kernec F., Le Tallec N., Nadal L., Begue J.-M., Le Rumeur E. Phosphocreatine synthesis by isolated rat skeletal muscle mitochondria is not dependent upon external ADP: A 31P NMR study. Biochem. Biophys. Res. Commun. 225:1996;819-825.
21. Langston J. W., Irwin I., Langston E. B. Pargyline prevents MPTP-induced parkinsonism in primates. Science. 225:1984;1480-1482.
22. Maraganore D. M., Harding A. E., Marsden C. D. A clinical and genetic study of familial Parkinson's disease. Movement Disord. 6:1991;205-211.
23. Matthews R. T., Yang L., Jenkins B. G., Ferrante R. J., Rosen B. R., Kaddurah-Daouk R., Beal M. F. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J. Neurosci. 18:1998;156-163.
24. O'Gorman E., Beutner G., Dolder M., Koretsky A. P., Brdiczka D., Wallimann T. The role of creatine kinase inhibition of mitochondrial permeability transition. FEBS Lett. 414:1997;253-257.
25. O'Gorman E., Beutner G., Wallimann T., Brdiczka D. Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim. Biophys. Acta. 1276:1996;161-170.
26. 31. Cardiology. 80:1992;184-195.
27. Roberts J. J., Walker J. B. Feeding a creatine analogue delays ATP depletion and onset of rigor in ischemic heart. Am. J. Physiol. 243:1982;H911-H916.
28. Sauter A., Rudin M. Determination of creatine kinase parameters in rat brain by NMR magnetization transfer: Correlation with brain function. J. Biol. Chem. 268:1993;13166-13171.
29. 10. Exp. Neurol. 132:1995a;279-283.
30. Schulz J. B., Matthews R. T., Muqit M. M. K., Browne S. E., Beal M. F. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J. Neurochem. 64:1995b;936-939.
31. +. Neurobiol. Aging. 14:1993;295-301.
32. Storey E., Hyman B. T., Jenkins B., Brouillet E., Miller J. M., Rosen B. R., Beal M. F. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J. Neurochem. 58:1992;1975-1978.
33. Swerdlow R. H., Parks J. K., Miller S. W., Tuttle J. B., Trimmer P. A., Sheehan J. P., Bennett J. P. Jr., Davis R. E., Parker W. D. Jr. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann. Neurol. 40:1996;663-671.
34. Tipton K. F., Singer T. P. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61:1993;1191-1206.
35. Turner D. M., Walker J. B. Enhanced ability of skeletal muscle containing cyclocreatine phosphate to sustain ATP levels during ischemia following b-adrenergic stimulation. J. Biol. Chem. 262:1987;6605-6609.
36. Wallimann T., Wyss M., Brdiczka D., Nicolay K., Eppenberger H. M. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasis. Biochem. J. 281:1992;21-40.
37. Whittingham T. S., Lipton P. Cerebral synaptic transmission during anoxia is protected by creatine. J. Neurochem. 37:1981;1618-1621.
38. Wooten G. F., Currie L. J., Bennett J. P., Harrison M. B., Trugman J. M., Parker J. Maternal inheritance in Parkinson's disease. Ann. Neurol. 41:1997;265-268.
39. Woznicki D. T., Walker J. B. Utilization of cyclocreatine phosphate, an analogue of creatine phosphate, by mouse brain during ischemia and its sparing action on brain energy reserves. J. Neurochem. 34:1980;1247-1253.
40. Xu C. J., Klunk W. E., Kanfer J. N., Xiong Q., Miller G., Pettegrew J. W. Phosphocreatine-dependent glutamate uptake by synaptic vesicles. J. Biol. Chem. 271:1996;13435-13440.