Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS

Neurology

Volumn 47, Issue 2, 1996, Pages 583-585

  Ikejiri, Y ^a   Mori, E ^a   Ishii, K ^a   Nishimoto, K ^a   Yasuda, M ^a   Sasaki, M ^a  

^a Hyogo Inst Aging Brain Cogn D   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IDEBENONE;

ADULT; ARTICLE; BRAIN BLOOD FLOW; CASE REPORT; DOSE RESPONSE; HUMAN; MALE; MELAS SYNDROME; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RELIABILITY;

EID: 0029834971     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.47.2.583     Document Type: Article

References (13)

1. Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: a distinctive clinical syndrome. Ann Neurol 1984;16:481-488.
2. Frackowiak RSJ, Herold S, Petty RKH, Morgan-Hughes JA. The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases. Brain 1988;111:1009-1024.
3. 10. Neurology 1986; 36:45-53.
4. 10. Neurology 1988;38:892-899.
5. 31P NMR study. Neurology 1989;39:399-403.
6. 10 in a patient with mitochondrial encephalomyopathy. J Neurol 1987;234:62-63.
7. 10 and idebenone. J Neurol Sci 1989;90:263-271.
8. Abe K, Fujimura H, Nishikawa Y, et al. Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Acta Neurol Scand 1991;83:356-359.
9. Torii H, Yoshida K, Kobayashi T, Tsukamoto T, Tanayama S. Disposition of idebenone (CV-2619), a new cerebral metabolism improving agent, in rats and dogs. J Pharmacobiodyn 1985;8:457-467.
10. Sugiyama Y, Fujita T. Stimulation of the respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV-2619), a new agent improving cerebral metabolism. FEBS Lett 1985;184:48-51.
11. Imada I, Fujita T, Sugiyama Y, Okamoto K, Kobayashi Y. Effects of idebenone and related compounds on respiratory activities of brain mitochondria, and on lipid peroxidation of their membranes. Arch Gerontol Geriatr 1989;8:323-341.
12. Koo B, Becker LE, Chuang S, et al. Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS): clinical, radiological, pathological, and genetic observations. Ann Neurol 1993;34:25-32.
13. 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 1980;4:727-736.