Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease

Journal of Neuroscience

Volumn 18, Issue 1, 1998, Pages 156-163

  Matthews, Russell T ^a   Yang, Lichuan ^a   Jenkins, Bruce G ^a   Ferrante, Robert J ^b   Rosen, Bruce R ^a   Kaddurah Daouk, Rima ^c   Beal, M Flint ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Avicena Group Inc   (United States)

Author keywords

3 nitropropionic acid; 3 nitrotyrosine; ATP; Creatine; Huntington; Oxidative injury

Indexed keywords

3 NITROPROPIONIC ACID; 3 NITROTYROSINE; ADENOSINE TRIPHOSPHATE; BENZOIC ACID DERIVATIVE; CREATINE; CREATINE PHOSPHATE; CYCLOCREATINE; HYDROXYL RADICAL; LACTIC ACID; SALICYLIC ACID DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIET SUPPLEMENTATION; DRUG EFFECT; HUNTINGTON CHOREA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 0031964359     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-01-00156.1998     Document Type: Article

References (6)

1. Albin RL, Greenamyre JT (1992) Alternative excitotoxic hypotheses. Neurology 42:733.
2. Annesley TM, Walker JB (1980) Energy metabolism of skeletal muscle containing cyclocreatine phosphate. J Biol Chem 255:3924-3930.
3. Balsom PD, Soderlund K, Ekblom B (1994) Creatine in humans with special reference to creatine supplementation. Sports Med 18:268-280.
4. Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119-130.
5. Beal MF (1995) Aging, energy and oxidative stress in neurodegenerative diseases. Ann Neurol 38:357-366.
6. Beal MF, Matson WR, Swartz KJ, Gamache PH, Bird ED (1990) Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid. J Neurochem 55:1327-1339.