Neuroprotective effects of creatine administration against NMDA and malonate toxicity

Brain Research

Volumn 860, Issue 1-2, 2000, Pages 195-198

  Malcon, Cesar ^a   Kaddurah Daouk, Rima ^b   Beal, M Flint ^a,c,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Avicena Group   (United States)

^c WEILL CORNELL MEDICAL CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Creatine; Excitotoxicity; Free radical; Malonate; Mitochondria; N methyl D aspartate; Nicotine

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CREATININE; KAINIC ACID; MALONIC ACID; N METHYL DEXTRO ASPARTIC ACID; NICOTINAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DRUG EFFECT; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM; CORPUS STRIATUM; CREATINE; ENERGY METABOLISM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; KAINIC ACID; MALE; MALONATES; MITOCHONDRIA; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; NIACINAMIDE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034737380     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02038-2     Document Type: Article

References (28)

1. R.L. Albin, J.T. Greenamyre, Alternative excitotoxic hypotheses, Neurology 42 (1992) 733.
2. M.F. Beal, Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?, Ann. Neurol. 31 (1992) 119-130.
3. 10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate, Ann. Neurol. 36 (1994) 882-888.
4. Y.M. Bordelon, M.F. Chesselet, D. Nelson, F. Welsh, M. Erecinska, Energetic dysfunction in quinolinic acid-lesioned rat striatum, J. Neurochem. 69 (1997) 1629-1639.
5. S.L. Budd, R.F. Castilho, D.G. Nicholls, Mitochondrial membrane potential and hydroethidine-monitored Superoxide generation in cultured cerebellar granule cells, FEES Lett. 415 (1997) 21-24.
6. 31 P NMR magnetization transfer, J. Cereb. Blood Flow Metab. 14 (1994)1070-1077.
7. V.L. Dawson, T.M. Dawson, D.A. Bartley, G.R. Uhl, S.H. Snyder, Mechanisms of nitric oxide mediated neurotoxicity in primary brain cultures, J. Neurosci. 13 (1993) 2651-2661.
8. 2+ exchanger, Exp. Neurol. 145 (1997) 38-45.
9. L.L. Dugan, S.L. Sensi, L.M.T. Canzoniero, S.D. Handran, S.M. Rothman, T.-S. Lin, M.P. Goldberg, D.W. Choi, Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate, J. Neurosci. 15 (1995) 6377-6388.
10. W. Hemmer, T. Wallimann, Functional aspects of creatine kinase in brain, Dev. Neurosci. 15 (1993) 249-260.
11. P. Klivenyi, R.J. Ferrante, R.T. Matthews, M.B. Bogdanov, A.M. Klein, O.A. Andreassen, G. Mueller, M. Wermer, R. Kaddurah-Daouk, M.F. Beal, Neuroprotective effects of creatine in a transgenic animal model of ALS, Nat. Med. 5 (1999) 347-350.
12. R.T. Matthews, R.J. Ferrante, P. Klivenyi, L. Yang, A.M. Klein, G. Mueller, R. Kaddurah-Daouk, M.F. Beal, Creatine and cyclocreatine attenuate MPTP neurotoxicity, Exp. Neurol. 157 (1999) 142-149.
13. R.T. Matthews, L. Yang, B.G. Jenkins, R.J. Ferrante, B.R. Rosen, R. Kaddurah-Daouk, M.F. Beal, Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease, J. Neurosci. 18 (1998) 156-163.
14. A. Mitani, S. Takeyasu, H. Yanase, Y. Nakamura, K. Kataoka, Changes in intracellular Ca2 + and energy levels during in vitro ischemia in the gerbil hippocampal slice, J. Neurochem. 62 (1994) 626-634.
15. E. O'Gorman, G. Beutner, M. Dolder, A.P. Koretsky, D. Brdiczka, T. Wallimann, The role of creatine kinase inhibition of mitochondrial permeability transition, FEBS Lett. 414 (1997) 253-257.
16. E. O'Gorman, G. Beutner, T. Wallimann, D. Brdiczka, Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain, Biochim. Biophys. Acta 1276 (1996) 161-170.
17. T.I. Peng, J.T. Greenamyre, Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors, Mol. Pharmacol. 53 (1998)974-980.
18. I.J. Reynolds, T.G. Hastings, Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation, J. Neurosci. 15 (1995) 3318-3327.
19. R. Sattler, Z. Xiong, W. Y. Lu, M. Hafner, J.F. Mac Donald, M. Tymianski, Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein, Science 284 (1999) 1845-1848.
20. A. Sauter, M. Rudin, Determination of creatine kinase parameters in rat brain by NMR magnetization transfer: correlation with brain function, J. Biol. Chem. 268 (1993) 13166-13171.
21. A.F. Schinder, E.C. Olson, N.C. Spitzer, M. Montai, Mitochondrial dysfunction is a primary event in glutamate neurotoxicity, J. Neurosci. 16(1996)6125-6133.
22. O. Stachowiak, M. Dolder, T. Wallimann, C. Richter, Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation, J. Biol. Chem. 273 (1998) 16694-16699.
23. 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies, Cell 89 (1997) 93-103.
24. A.K. Stout, H.M. Raphael, B.I. Kanterewicz, E. Klann, I.J. Reynolds, Glutamate-induced neuron death requires mitochondrial calcium uptake, Nat. Neurosci. 1 (1998) 366-373.
25. K. Tsuji, Y. Nakamura, T. Ogata, T. Shibata, K. Kataoka, Rapid decrease in ATP content without recovery phase during glutamateinduced cell death in cultured spinal neurons, Brain Res. 662 (1994) 289-292.
26. M. Tymianski, M.P. Charlton, P.L. Carlen, C.H. Tator, Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons, J. Neurosci. 13 (1993) 2085-2104.
27. R.J. White, I.J. Reynolds, Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure, J. Neurosci. 16 (1996) 5688-5697.
28. C.J. Xu, W.E. Klunk, J.N. Kanfer, Q. Xiong, G. Miller, J.W. Pettegrew, Phosphocreatine-dependent glutamate uptake by synaptic vesicles, J. Biol. Chem. 271 (1996) 13435-13440.