Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

Biochemistry

Volumn 47, Issue 35, 2008, Pages 9227-9233

  Boehr, David D ^a   Dyson, H Jane ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGES; DIHYDROFOLATE REDUCTASE;

ESCHERICHIA COLI;

DIHYDROFOLATE REDUCTASE; TETRAHYDROFOLIC ACID;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; KINETICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; THERMODYNAMICS;

BINDING SITES; CATALYSIS; ESCHERICHIA COLI; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 50849111095     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801102e     Document Type: Article

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