Using buried water molecules to explore the energy landscape of proteins

Nature Structural Biology

Volumn 3, Issue 6, 1996, Pages 505-509

  Denisov, Vladimir P ^a   Peters, Jörg ^b   Hörlein, Hans Dietrich ^b   Halle, Bertil ^a  

^a LUND UNIVERSITY   (Sweden)

^b BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENERGY; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

APROTININ; ENERGY TRANSFER; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; TEMPERATURE; WATER;

BOVINAE;

EID: 0029994817     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0696-505     Document Type: Article

References (12)

1. Wagner, G. Characterization of the distribution of internal motions in the basic pancreatic trypsin inhibitor using a large number of internal NMR probes. Q. Rev. Biophys. 16, 1-57 (1983).
2. McCammon, J.A. & Harvey, S.C. Dynamics of Proteins and Nucleic Acids (Cambridge Univ. Press, Cambridge, 1987).
3. Frauenfelder, H., Sligar, S.G. & Wolynes, P.G. The energy landscapes and motions of proteins. Science 254, 1598-1603 (1991).
4. Frauenfelder, H. et al. Proteins and pressure. J. Phys. Chem. 94, 1024-1037 (1990).
5. Steinbach, P.J. et al. Ligand binding to heme proteins: Connection between dynamics and function. Biochemistry 30, 3988-4001 (1991).
6. Young, R.D. et al. Time and temperature dependence of large-scale conformational transitions in myoglobin. Chem. Phys. 158, 315-327 (1991).
7. Zwanzig, R. Diffusion in a rough potential. Proc. Natl. Acad. Sci. USA 85, 2029-2030 (1988).
8. Bryngelson, J.D. & Wolynes, P.G. Intermediates and barrier crossing in a random energy model (with applications to protein folding). J. Phys. Chem. 93, 6902-6915 (1989).
9. Panchenko, A.R., Wang, J., Nienhaus, G.U. & Wolynes, P.G. Analysis of ligand binding to heme proteins using a fluctuating path description. J. Phys. Chem. 99, 9278-9282 (1995).
10. Baker, E.N. Solvent interactions with proteins as revealed by X-ray crystallographic studies. In Protein-Solvent Interactions (R.B. Gregory, ed) 143-189 (M. Dekker, New York. 1995).
11. Wlodawer, A., Walter, J., Huber, R. & Sjölin, L. Structure of bovine pancreatic trypsin inhibitor. J. Mol. Biol. 180, 301-329 (1984).
12. Berndt, K.D., Güntert, P., Orbons, L.P.M. & Wüthrich, K. Determination of a high-quality nuclear magnetic resonance solution structure of the bovine pancreatic trypsin inhibitor and comparison with three crystal structures. J. Mol. Biol. 227, 757-775 (1992).