Enzyme dynamics along the reaction coordinate: Critical role of a conserved residue

Biochemistry

Volumn 45, Issue 8, 2006, Pages 2636-2647

  Kovrigin, Evgenin L ^a   Loria, J Patrick ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTIONS; CONFORMATIONS; DATA ACQUISITION; ENZYMES; NUCLEAR MAGNETIC RESONANCE; SUBSTRATES;

CONFORMATIONAL FLEXIBILITY; ENZYME DYNAMICS; NMR SPIN-RELAXATION TECHNIQUES; STRUCTURAL TRANSITIONS;

ENZYME KINETICS;

ALANINE; ASPARTIC ACID; RIBONUCLEASE A;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MATHEMATICAL MODEL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUTATION; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; WILD TYPE; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; ASPARTIC ACID; ENZYME STABILITY; HISTIDINE; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; RIBONUCLEASE, PANCREATIC;

EID: 33644556820     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0525066     Document Type: Article

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