Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

Carcinogenesis

Volumn 26, Issue 3, 2005, Pages 547-555

  Andersen, Sonja ^b   Heine, Tina ^c   Sneve, Ragnhild ^b   König, Imbritt ^b   Krokan, Hans E ^b   Epe, Bernd ^c   Nilsen, Hilde ^a,d  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

FLOXURIDINE; FLUOROPYRIMIDINE; FLUOROURACIL; 2'-DEOXYURIDYLIC ACID; DEOXYURIDINE PHOSPHATE; DNA; DNA GLYCOSYLTRANSFERASE; PYRIMIDINE DERIVATIVE; URACIL DNA GLYCOSIDASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DEAMINATION; DNA DAMAGE; DNA REPLICATION; FIBROBLAST; FLOW CYTOMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL LINE; DEOXYURACIL NUCLEOTIDES; DNA; DNA DAMAGE; DNA GLYCOSYLASES; FIBROBLASTS; MICE; PYRIMIDINES; URACIL-DNA GLYCOSIDASE;

EID: 16244423009     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh347     Document Type: Article

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