Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase

DNA Repair

Volumn 7, Issue 2, 2008, Pages 162-169

  Luo, Yuhong ^a   Walla, Mike ^a   Wyatt, Michael D ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antifolates; Base excision repair; Thymidylate deprivation; Uracil DNA glycosylase

Indexed keywords

CELL ENZYME; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; FLOXURIDINE; FLUOROURACIL; FOLIC ACID ANTAGONIST; GENOMIC DNA; HISTONE H2AX; RALTITREXED; SULFORHODAMINE B; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; THYMIDYLATE TRIPHOSPHATE; UNCLASSIFIED DRUG; URACIL; URACIL DNA GLYCOSIDASE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; CELL LINE; CHEMOTHERAPY; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EXCISION REPAIR; GENOME; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

BLOTTING, WESTERN; CELL CYCLE; CELL LINE; DEOXYCYTIDINE; DNA; DNA PRIMERS; DNA REPAIR; FLUOROURACIL; GREEN FLUORESCENT PROTEINS; HUMANS; MASS SPECTROMETRY; QUINAZOLINES; THIOPHENES; THYMIDYLATE SYNTHASE; URACIL; URACIL-DNA GLYCOSIDASE;

EID: 37549072672     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.09.001     Document Type: Article

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